MS & PHD STUDENTS

Brittany Admire, PhD

Degree: 
PhD
Program: 
Pharmaceutical Sciences
Track: 
Pharmaceutics and Pharmacokinetics
Dissertation Title: 
"The Estimation of Biologically and Environmentally Relevant Properties of Organic Compounds"

Alumna
Year Graduated: 2015
Career Type: Industry
Scientist at Ventana Medical Systems, Roche Tissue Diagnostics

Academic & Professional Updates
My research has focused on developing and expanding the UPPER model. The UPPER (Unified Physicochemical Property Estimation Relationships) model uses additive and non-additive parameters to estimate 21 biologically and environmentally important physicochemical properties of organic compounds. Thermodynamically sound relationships are used to predict boiling and melting points, aqueous and octanol solubilities, vapor pressure and the air-octanol, air-water and octanol-water partition coefficients. These properties determine the distribution and fate of organic compounds in biological and environmental systems. The model has been validated on a data set of 2000 hydrocarbons and polyhalogenated hydrocarbons, provides a simple and accurate method to predict the properties studied.

Education
B.S. Chemical Engineering (2009) The University of Florida

Honors & Achievements
1. Graduate Track Awards: Academic Excellence, 2012-13.
2. College of Pharmacy Graduate Student Representative and Graduate Student Council Treasurer, 2012.

Publications
1. Frett, B.; Carlomagno, F.; Moccia, L; Brescia, A.; Federico, G.; De Falco, V.; Admire, B.; Chen, Z.; Qi, W.; Massimo, S.; Li, H. 2015. Fragment-based discovery of a dual pan-RET/VEGFR2 kinase inhibitor optimized for single-agent polypharmacology. Angewandte Chemie DOI: 10.1002/anie.201501104R2.
2. Patel, R.B., Admire, B., Yalkowsky, S.H., 2014. The rule of unity for human intestinal absorption 2: Application to pharmaceutical drugs marketed as salts, Current Drug Delivery, DOI: 10.2174/1567201811666141022100320.
3. Admire, B., Lian, B., Yalkowsky, S.H., 2014. Estimating the physicochemical properties of polyhalogenated aromatic and aliphatic compounds using UPPER: Part 2. Aqueous Solubility, octanol solubility and octanol-water partition coefficient, Chemosphere, DOI: 10.1016/j.chemosphere.2014.10.031.
4. Admire, B., Lian, B., Yalkowsky, S.H., 2014. Estimating the physicochemical properties of polyhalogenated aromatic and aliphatic compounds using UPPER: Part 1. Boiling point and Melting point, Chemosphere, DOI: 10.1016/j.chemosphere.2014.06.053.
5. Admire, B., Yalkowsky, S.H., 2013. Predicting the octanol solubility of organic compounds, J. Pharm. Sci., 102, 2112-2119.
Originally posted: August 28, 2014
Last updated: November 9, 2016
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