Anika Dzierlenga, PhD

I am currently a trainee study scientist working in an interdisciplinary team setting to investigate the toxicity profiles of various therapeutic or environmental chemicals. My areas of interest include hepatotoxicity, toxicokinetics, and developmental and reproductive toxicology.
Status: 
Alumni
Degree: 
PhD
Program: 
Pharmacology and Toxicology
Track: 
Pharmacology and Toxicology
Dissertation Title: 
Mechanism and Functional Consequence of Mrp2 Mislocalization in Nonalcoholic Steatohepatitis
Year Enrolled: 
2011
Phone: 
520-626-7265
Education: 
Trinity University, BS (2011)
Research Interests: 
Studying the influence of non-alcoholic steatohepatitis on the transport and elimination of drugs.
Honors and Achievements: 
1. The Yuma Friends of Arizona Health Sciences Center Young Investigator Research Award, 2012-13.
2. GPSC Showcase ACS Women in Chemistry Award, 2014-15.
3. GPSC Showcase First Place Poster in Health Sciences, 2014-15.
4. NIEHS Tamburro Liver Symposium Graduate Student Poster Award, 2014-15.
5. NIEHS Training Grant-Environmental Toxicology of Human Diseases, 2014, 2015 (34, 35).
6. SOT Graduate Student Travel Award, 2014-15.
7. SOT Mechanisms Specialty Section Ronald G. Thurman Award, 2014-15.
8. Collaborator Project with Dr. Susan McKarns and Univ. Missouri- Columbia on lumphocyte contribution in the regulation of hepatic sinusoidal uptake and canalicular efflux transporters, 2013.
9. Pharmacology & Toxicology Graduate Student Representative, 2014-16.
Publications: 

1. Karagas, N.E.; Jones, C.N.; Osborn, D.J.; Dzierlenga, A.L.; Oyala, P.; Konkle, M.E.; Whitney, E.M.; Britt, D.R.; Hunsicker-Wang, L.M. "The Reduction Rates of DEPC-Modified Mutant Thermus Thermophilus Rieske Proteins Differ When There Is a Negative Charge Proximal to The Cluster" J Biol. Inorg. Chem., 2014, 19, 1121-1135.
2. Canet, M.J.; Hardwick, R.N., Lake, A.D.; Dzierlenga, A.L.; Clarke, J.D.; Cherrington, N.J. "Modeling Human Nonalcoholic Steatohepatitis-Associated Changes in Drug Transporter Expression Using Experimental Rodent Models" Drug Metab. Dispos., 2014, 42, 586-595.
3. Bodeman, C.E.; Dzierlenga, A.L.; Tally, C.M.; Mulligan, R.M.; Lake, A.D.; Cherrington, N.J.; McKarns, S.C. "Differential Regulation of Hepatic Organic cation Transporter 1. Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export Pump, and Multidrug Resistance-Associated Protein 2.Transporter Expression in Lymphocyte-Deficient Mice Associates with Interleukin-6 Production." J Pharmacol Exp Ther., 2013, 347, 136-144.
4. Konkle, M.E.; Muellner, S.K.; Schwander, A.L.; Dicus, M.M.; Pokhrel, R.; Britt, R.D.; Taylor, A.B.; Hunsicker-Wang, LM. "Effects of pH on the Rieske Protein from Thermus Thermophilus: a Structural and Biophysical Analysis" Biochemistry, 2009, 48, 9848-9857.
5. Clarke, J.D., Dzierlenga, A.L., Nelson, N.R., Li, H., Werts, S., Goedken, M.J., Cherrington, N.J. "Mechanism of Altered Metformin Distribution in Nonalcoholic Steatohepatitis" Diabetes, 2015, in press.
6. Dzierlenga, A.L., Clarke, J.D., Hargraves, T.L., Ainslie, G.R., Vanderah, T.W., Paine, M.F., Cherrington, N.J., "Mechanistic Basis of Altered Morphine Disposition in Nonalcoholic Steatohepatitis." Journal of Pharmacology and Experimental Therapeutics. 2015, 352, 462-470.
7. Canet, M.J., Hardwick, R.N., Lake, A.D., Dzierlenga, A.L., Clarke, J.D., Goedken, M.J., Cherrington, N.J., "Renal Xenobiotic Transporter Expression is Altered in Multiple Experimental Models of Nonalcoholic Steatohepatitis" Drug Metab. Dispos. 2014, 43, 266-272.

 

Alumna or Alumnus: 
Alumna
Alumni Title/Position/Employer: 
Post-doctoral IRTA Fellow in the Division of the National Toxicology Program, National Institute of Environmental Health Sciences
Career Type: 
Government