Angie Davis, PhD

Pharmaceutical Sciences
Drug Discovery and Development
Dissertation Title: 
"Identification of Novel Heat Shock Response Modulators for Experimental Anti-Melanoma Intervention"

Year Graduated: 2015
Career Type: Academia
PostDoctoral Fellow, University of Arizona (Dr. Laurence Hurley)

Academic & Professional Updates
I am currently a postdoctoral research fellow in the laboratory of Dr. Laurence Hurley at the University of Arizona. My postdoctoral research is aimed at the discovery of molecules targeting the i-motif in the promoter region of the MYC oncogene as an innovative strategy to improve the treatment of patients with glioblastoma.

B.S., Chemistry (2000) University of Arizona, Tucson, Arizona Minor in Math and Physics

Honors & Achievements
1. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2013 (33).
2. NIEHS Training Grant - Environmental Toxicology of Human Diseases, 2014 (34).
3. SFRBM Travel Grant - Society of Free Radical and Biology Medicine, 2014.

1. Davis AL, Qio S, Lesson JL, Roja de la  Vega M, Park SL, Seanez CM, GokhaleV, Cabello CM, Wondrak .  The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.  J Biol Chem. 2015 Jan 16; 290(3): 1623-38..
2. Davis AL, Cabello CM, Qiao S, Azimian S, Wondrak GT. 2. Phenotypic Identification of The Redox Dye Methylene Blue as an Antagonist of Heat Shock Response Gene Expression in Metastatic Melanoma Cells. Int J Mol Sci. 2013 Feb 19; 14(2): 4185-202.
3. Smith B, Chang HH, Medda F, Gokhale V, Dietrich J, Davis A, Meuillet EF, Hulme C. Synthesis and Biological Activity of 2-Aminothiazoles as Novel Inhibitors of PGE2  Production in Cells.  Bioorg Med Chem Lett. 2012 May; 22(10): 3567-70.
4. Cabello CM, Lamore, SD, Blair WB, Davis AL, Azimian SM, Wondrak GT. DCPIP (2,6-Dichlorophenolindophenol) as a Genotype-Directed Redox Chemotherapeutic Targeting  NQO1*2 Breast Carcinoma. Free Radical Res. 2011 Mar; 45(3): 276-92.
5. Cabello CM, Lamore SD, Blair WB, Davis AL, Lesson JL, Wondrak GT. Switching Enemies: The Redox Antimalarial Dihydroartemisinin Targets Human Metastatic Melanoma Cells but Not Primary Melanocytes Through Induction of NOXA-Dependent  Apoptosis. Free Radical Biology and Medicine. Volume 49, Supplement 1, 2010, Pages S73-S74.
6. Cabello CM, Qiao S, Blair WB, Davis AL, Lesson JL, Wondrak  GT. GLO1 Downregulation in Human Renal Cell Carcinoma Enables Targeted Chemotherapeutic Intervention Using Methylglyoxal as Cytotoxic Heat Shock Inducer. Free Radical Biology and Medicine, Volume 49, Supplement 1, 2010, Page S73.
Originally posted: August 28, 2014
Last updated: October 29, 2015
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