Clinical Pharmacokinetics Rotation

(Also refer to the general goals and objectives for PhPr 803)

Goals

  • Develop an extensive knowledge base of the pharmacokinetics of drugs that are commonly monitored in patients.
  • Achieve competence in the application of pharmacokinetic principles to patient care situations.

Objectives
At the completion of this rotation, the student should be able to:

  1. Define the following pharmacokinetic terms: elimination rate constant, half life, volume of distribution, clearance, one-compartment model, two-compartment model, first-order elimination, and zero-order elimination.
  2. Identify the therapeutic range, average half-live, and average volume of distribution for all routinely monitored drugs including aminoglycosides, vancomycin, digoxin, quinidine, procainamide, lidocaine, theophylline, phenobarbital, phenytoin, valproic acid, carbamazepine, and primidone.
  3. Identify the appropriate equation to use in each of the following situations: IV bolus, continuous IV infusion, intermittent IV infusion, multiple oral dosing, and oral dosing with controlled release products.
  4. Given a specific patient case, calculate the elimination rate constant, volume of distribution, half-life, and clearance prospectively based on average population parameters as well as retrospectively based on serum drug concentrations for the drugs listed in objective #2.
  5. Given a specific patient case, estimate lean body weight, adjusted body weight, creatinine clearance, and a measured creatinine clearance (with urine collection data).
  6. Review a patient's medical history and drug therapy and assess the indications for drug therapy, the patient's response to therapy, presence or potential for adverse effects, and appropriateness of monitoring.
  7. Discuss the effects of renal disease, liver disease, cardiac disease, and obesity on the pharmacokinetics of the drugs listed in objective #2.
  8. Describe the differences between peritoneal dialysis, hemodialysis and hemoperfusion and the effect of these procedures on the clearance of the drugs listed in objective #2.
  9. Given a specific patient, identify potential pharmacokinetic drug interactions and discuss the significance of these.
  10. Discuss Bayesian pharmacokinetic analysis and the role of this method in patient care.
  11. Evaluate the medical literature with respect to study design and analysis of pharmacokinetic data.
  12. Utilize appropriate written and verbal communication skills when providing recommendations to patients and health care professionals.

 

Originally posted: August 29, 2013
Last updated: July 1, 2016
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