Yan He, PhD
Senior Scientist
Drug Discovery Support
Boehringer Ingelheim Pharmaceutical Inc
Ridgefield, Conn
PhD (2005)
Advisor: Samuel Yalkowsky
My dissertation focused on the theory and application of most commonly used solubilization techniques: pH adjustment, micellization, complexation and pH adjustment combined with one of the other techniques. The high efficiency of the combinations of pH adjustment with either cosolvency, micellization or complexation is evaluated, emphasized and illustrated by the studied eight ionizable compounds. This dissertation provides guidance for the selection of a solubilization technique for a compound based on the physicochemical properties and the dose requirement.