Pharmaceutics & Pharmacokinetics Courses
Pharmacokinetics (PHSC 507)
Quantitative description of the processes of drug absorption, distribution and elimination and factors affecting those processes. Application of kinetic principles to chronic drug administration. Graduate-level requirements include an in-depth analysis of a pharmacokinetic problem.
Pharmacokinetics Discussion (PHSC 508a)
Discussion related to the application of pharmacokinetic principles with case-study examples. Graduate-level requirements include an in-depth analysis of a pharmacokinetic problem.
Advanced Physical Pharmacy (PHSC 601)
This course will give the student a working knowledge of the various means of controlling the solubility and dissolution rate of a drug or other solute in an aqueous medium. While solubility and solubilization will be approached from both a conceptual and a practical point of view, emphasis will be placed upon the latter. The course will first explore the thermodynamic aspects of solubility, isolating the effects entropy and enthalpy of solution and the effect of the crystalline phase on solubility. The bulk of the course is devoted to the various techniques available for alteration of the solubility and dissolution rate of organic compounds in aqueous media. The most commonly used solubility enhancers: buffers, cosolvents, surfactants, and complexants, are discussed in detail. A conceptual basis for understanding the degree of solubilization of a solute will be provided for each technique along with a large number of examples of its application.
Drug Delivery Systems (PHSC 555)
The purpose of this course is to focus on different types of drug delivery systems. Emphasis will be placed on discussing the rational choice of an appropriate drug delivery system from a chemical and pharmalogical basis. Critical to the course are an understanding of how to formulate drugs in these dosage forms and how the formulation can have an impact on pharmacology. Some of the different delivery systems to be discussed are: oral inhalation drug delivery, nasal drug delivery, transdermal drug delivery, needleless injections, depot injections, liposomal delivery and a variety of other polymer-based controlled release systems. Sixty percent of the course will consist of traditional didactic lecture and written examination. The course will also give each student an opportunity to independently research and report, through an oral presentation, on a specific drug delivery topic.
Physiochemical Factors Influencing Drug Action (602)
This course investigates the chemical structure and physical properties of organic compounds and how these properties affect the biopharmaceutical properties of drug substances. This course reviews molecular descriptors, intermolecular forces, polymers, crystals, as well as additive and non-additive methodologies for the prediction of pertinent biologically relevant physico-chemical properties.
Industrial Pharmacy (PHSC 606)
This course will focus on the practical aspects of the drug development process from an industrial perspective. The course will cover the progression pharmaceutical characterization of drug candidates from drug discovery, through Phase I, II and III and eventual NDA submission. Focus will be given to the conduction of data in an environment regulated by the Food and Drug administration (FDA).
Advanced Pharmacokinetics (PHSC 609 a/b)
Quantitative treatment of kinetics of drug absorption, distribution, metabolism, excretion and pharmacological response, including development of mathematical models for these processes and use of digital computer for simulation and nonlinear regression analysis.
Pharmaceutics Seminar (PHSC 596c)
The development and exchange of scholarly information, usually in a small group setting. The scope of work shall consist of research by course registrants, with the exchange of the results of such research through oral presentations.
The development and exchange of scholarly information, usually in a small group setting. The scope of work shall consist of research by course registrants, with the exchange of the results of such research through discussion, reports and/or papers.
Research/Group Seminar (596D)
The development and exchange of scholarly information, usually in a small group setting. The scope of work shall consist of research by course registrants, with the exchange of the results of such research through discussion, reports and/or papers.
Further information
For general questions regarding the graduate programs in the College of Pharmacy, contact Nancy Colbert, program coordinator, (520) 626-7265 or by fax (520)626-2466