Elaine L Jacobson, PhD
Professor
Department:
Pharmacology and Toxicology
(520) 626-5957
Secondary Phone:
(520) 626-5953
Fax:
(520) 626-8567
E-mail:
Location:
Cancer Center 3985C
Bio / Research:
My research group is working to understand molecular and cellular responses to genotoxic stresses, particularly UV radiation, and to translate that information to clinical applications in the prevention and treatment of skin cancer. We have had a long-standing interest in multiple cancer therapeutic targets that are modulated by niacin and/or NAD dependent signal transduction. These include: poly(ADP-ribose) (PARP) and poly(ADP-ribose) glycohydrolase (PARG); the nicotinic acid receptor and downstream signaling through leptin; and energy metabolism involving sirtuins. The above examples and others are being studied to validate them as drug targets, and to identify agents that are likely lead compounds for skin cancer treatment and prevention.
Laboratory Rotation After exploration of areas of interest, students will develop a specific research hypothesis and pursue research on a problem within the overall interest of the laboratory. Students will interact with Dr. Jacobson and other members of the research group and attend laboratory group meetings, etc.
Education:BS, Kansas State University, Manhattan, 1967, Biochemistry
PhD, Kansas State University, Manhattan, 1970, Biochemistry
Postdoctoral Training
1971-1972, University of Utah, Salt Lake City
1972-1973, Mayo Clinic and Foundation, Rochester, Minnesota
Honors and Awards:
1968 NDEA Title IV Predoctoral Fellowship
1972 NIH Postdoctoral Fellowship-Mayo Fellowship
1984 Sigma Xi Outstanding University Professor Award
1996 Mentor, Chris Watt, Best Student Paper, Molecular & Cellular Biology section, Kentucky Academy of Sciences
1996 Elected member of Alpha Eta National Honor Society, University of Kentucky
2003 Visiting Foreign Scientist, Foundation for Promotion of Cancer Research, National Cancer Center Research Institute, Tokyo, Japan
2005 The E. Bruce Street, Sr./Roger J. Williams Award in Preventive Nutrition, University of North Texas Health Science Center at Fort Worth
2006 Outstanding University Achievement Award, University of Arizona
2006 Invited Visiting Lecturer, University of Saskatchewan, College of Pharmacy and Nutrition
2007 Alumni Fellow, College of Arts & Sciences, Kansas State University
2007 Bioscience Company of the Year, Arizona
Selected Publications
Jacobson, E.L., Kim, H., Kim, M. and Jacobson, M.K. Niacin: Vitamin and Antidyslipidemic Drug. (2008) In: Water-Soluble Vitamins: Subcellular Biochemistry, Stanger, O. (ed), Springer-Verlag publishers, Berlin, Heidelberg, New York, in press.
Williams, J.D., Jacobson, E.L., Kim, H., Kim, M. and Jacobson, M.K. Folate in Skin Cancer Prevention. (2008) In: Water-Soluble Vitamins: Subcellular Biochemistry, Stanger, O. (ed), Springer-Verlag publishers, Berlin, Heidelberg, New York, in press.
Wondrak, G.T. and Jacobson, E.L. Vitamin B6: Beyond Coenzyme Functions. (2008) In: Water-Soluble Vitamins: Subcellular Biochemistry, Stanger, O. (ed), Springer-Verlag publishers, Berlin, Heidelberg, New York, in press.
Tashtoush, B.M., Jacobson, E.L. and Jacobson, M.K. Validation of a Simple and Rapid HPLC Method for Determination of Metronidazole in Dermatological Formulations. (2008) Drug Development and Industrial Pharmacy, 34(8), 840-844.
Tashtoush, B.M., Qandil, A.M., Jacobson, E.L. and Jacobson, M.K. Analysis and Stability Study of Octyl Nicotinate in Aqueous Solutions and Skin Homogenate by LC. (2008) Chromatographia, 68(1-2), 135-138.
Benavente, C.A. and Jacobson, E.L. Niacin Restriction Upgregulates NADPH Oxidase and reactive oxygen species (ROS) in Human Keratinocytes. (2008) Free Radical Biology and Medicine, 44, 527-37.
Tashtoush, B.M., Jacobson, E.L. and Jacobson, M.K. UVA is the Major Contributor to Photodegradation of Tretinoin and Isotretinoin: Implications for Development of Improved Pharmaceutical Formulations. (2008) International Journal of Pharmaceutics, 352(1-2), 123-128.
Tashtoush B.M., Kim, H., Jacobson, E.L. and Jacobson, M.K. Formulation Compatibility of Myristyl Nicotinate with Drugs Used to Treat Dermatological Conditions Involving an Impaired Skin Barrier. (2007) Drug Development and Industrial Pharmacy, 33, 1176-82.
Jacobson, M.K. Kim, H., Coyle, W.R., Kim, M., Coyle, D.L., Rizer, R.L. and Jacobson, E.L. Effect of Myristyl Nicotinate on Retinoic Acid Therapy for Facial Photodamage. (2007) Experimental Dermatology, 16, 927-35.
Meyer, R.G., Meyer-Ficca, M.L., Whatcott, C.J., Jacobson, E.L. and Jacobson, M.K. Two Small Enzyme Isoforms Mediate Mammalian Mitochondrial Poly(ADP-ribose) Glycohydrolase (PARG) Activity. (2007) Experimental Cell Research, 313, 2920-36.
Young, G.S., Jacobson, E.L. and Kirkland, J.B. Water Maze Performance in Young Male Long-Evans Rats is Inversely Affected by Dietary Intakes of Niacin and May Be Linked to Levels of the NAD+ Metabolite cADPR. (2007) Journal of Nutrition, 137, 1050-1057.
Gao, H., Coyle, D.L., Meyer-Ficca, M.L., Meyer, R.G., Jacobson, E.L., Wang, Z-Q and Jacobson, M.K. Altered Poly(ADP-ribose) Metabolism Impairs Cellular Responses to Genotoxic Stress in a Hypomorphic Mutant of Poly(ADP-ribose) Glycohydrolase. (2007) Experimental Cell Research, 313, 984-996.
Jacobson, E.L. Kim, H., Kim, M., Williams, J.D., Coyle, D.L., Coyle, W.R., Grove, G., Rizer, R.L., Stratton, M.S. and Jacobson, M.K. A Topical Lipophilic Niacin Derivative Increases NAD, Epidermal Differentiation and Barrier Function in Photodamaged Skin. (2007) Experimental Dermatolology, 16, 490-499.
Tashtoush, B.M., Qasem, J., Williams, J.D., DeWald, T.P., Jacobson, E.L. and Jacobson M.K. Analysis and Stability Study of Myristyl Nicotinate in Dermatological Preparations by High-Performance Liquid Chromatography. (2007) Journal of Pharmaceutical and Biomedical Analysis, 43, 893-899.
Tashtoush, B.M., Jacobson, E.L. and Jacobson, M.K. A Rapid HPLC Method for Simultaneous Determination of Tretinoin and Isotretinoin in Dermatological Formulations. (2007) Journal of Pharmaceutical and Biomedical Analysis, 43, 859-864.
Cervantes-Laurean, D., Schramm, D.D., Jacobson, E.L., Halaweish, I., Bruckner, G.G. and Boissonneault, G.A. Inhibition of Advanced Glycation End Product Formation on Collagen by Rutin and Its Metabolites. (2006) Journal of Nutritional Biochemistry, 17, 531-540.
Wondrak, G.T., Jacobson, M.K. and Jacobson, E.L. Antimelanoma Activity of Apoptogenic Carbonyl Scavengers. (2006) Journal of Pharmacology and Experimental Therapeutics, 316, 805-814.
Wondrak, G.T., Jacobson, M.K. and Jacobson, E.L. Endogenous UVA-Photosensitizers: Mediators of Skin Photodamage and Novel Targets for Skin Photoprotection. (2006) Photochemical and Photobiological Sciences, 5, 215-237. Selected for inclusion in the RSC’s Chemical Biology Virtual Journal.
Draelos, Z.D., Jacobson, E.L., Kim, H., Kim, M. and Jacobson, M.K. A Pilot Study Evaluating the Efficacy of Topically Applied Niacin Derivatives for Treatment of Female Pattern Alopecia. (2005) Journal of Cosmetic Dermatology, 4, 258-261.
Catz, P., Shinn, W., Kapetanovic, I.M., Kim, H., Kim, M., Jacobson, E.L., Jacobson, M.K. and Green, C.E. Simultaneous Determination of Myristyl Nicotinate, Nicotinic Acid, and Nicotinamide in Rabbit Plasma by Liquid Chromatography—Tandem Mass Spectrometry Using Methyl Ethyl Ketone as a Deproteinization Solvent. (2005) Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 829, 123-135.
Wondrak, G.T., Jacobson, M.K. and Jacobson, E.L. An Emerging Molecular Target in Melanoma: Cellular Carbonyl Stress and the Inhibition of Mitochondrial Survival Pathways by Carbonyl Scavenger Agents. (2005) Current Cancer Therapy Reviews, 1, 271-276.
Jacobson, E.L., Kim, H., Kim, M., Wondrak, G.T. and Jacobson, M.K. Developing Topical Prodrugs for Skin Cancer Prevention. (2005) In Fundamentals of Cancer Prevention, D. Alberts and L. Hess, Eds., Springer-Verlag Publishers, Berlin, Heidelberg, New York, pp. 139-160.
Wondrak, G.T., Jacobson, M.K. and Jacobson, E.L. Identification of Quenchers of Photoexcited States as Novel Agents for Skin Photoprotection. (2005) Journal of Pharmacology and Experimental Therapeutics, 312, 482-491.
Meyer-Ficca, M.L., Meyer, R.G., Jacobson, E.L. and Jacobson, M.K. Poly(ADP-ribose) Polymerases: Managing Genome Stability. (2005) International Journal of Biochemistry and Cell Biology, 37, 920-926.
Cervantes-Laurean, D., Roberts, M.J., Jacobson, E.L. and Jacobson, M.K. Nuclear Proteasome Activation and Degradation of Carboxymethylated Histones in Human Keratinocytes Following Glyoxal Treatment. (2005) Free Radical Biology and Medicine, 38, 786-795.
Meyer, R.G., Meyer-Ficca, M.L., Jacobson, E.L. and Jacobson, M.K. Enzymes in Poly(ADP-Ribose) Metabolism. (2004) In Poly(ADP-Ribosyl)ation, A. Bürkle, Ed., Landes Bioscience/Eurekah.com Publishers, Georgetown, Texas, pp. 1-12.
Meyer-Ficca, M.L., Meyer, R.G., Coyle, D.L., Jacobson, E.L. and Jacobson, M.K. Human Poly(ADP-ribose) Glycohydrolase is Expressed in Alternative Splice Variants Yielding Isoforms that Localize to Different Cell Compartments. (2004) Experimental Cell Research, 297, 521-532.
Wondrak, G.T., Roberts, M.J., Jacobson, M.K. and Jacobson, E.L. 3-Hydroxypyridine Chromophores are Endogenous Sensitizers of Photooxidative Stress in Human Skin Cells. (2004) Journal of Biological Chemistry, 279, 30009-30020.
Cortes, U., Tong, W.-M., Coyle, D.L., Meyer-Ficca, M.L., Meyer, R.G., Petrilli, V., Herceg, Z., Jacobson, E.L., Jacobson, M.K. and Wang, Z.-Q. Depletion of the 110-Kilodalton Isoform of Poly(ADP-Ribose) Glycohydrolase Increases Sensitivity to Genotoxic and Endotoxic Stress in Mice. (2004) Molecular and Cellular Biology, 24, 7163-7178.
Kim, H., Jacobson, E.L., Jacobson, M.K. and Lacko, A.G. ApoA-1 Milano and Regression of Atherosclerosis. (2004) JAMA, 291, 1319.
For Peterson's Guide: Elaine L. Jacobson, Professor; Ph.D., Kansas State University, 1971. Optimizing molecular and cellular responses to UV radiation in skin; inhibition of advanced glycation end-products; DNA damage and repair.