Todd D Camenisch, PhD
Associate Professor
Department:
Pharmacology and Toxicology
(520) 626-0240
Fax:
(520) 626-2466
E-mail:
Location:
Pharmacy 234
Bio / Research:
The focus of the laboratory is investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis. The emphasis is on heart septae and valve formation.
We have established that hyaluronan, a matrix sugar, is able to modulate receptor tyrosine kinase activity during early heart valve morphogenesis. We believe the EGFR family of receptors and cognate ligands play integral functions during heart development. This growth factor signaling activity is most likely context specific in regards to matrix components, proteases and growth factor presence. Thus experimental approaches are designed to decipher this complex developmental process.
BS, University of Arizona, Tucson, 1991, Microbiology/Immunology
PhD, University of North Carolina at Chapel Hill, 1998, Microbiology/Immunology
Research Articles
1. Harris, D.T., Kapur, R., Frye, C., Acevedo, A., Camenisch, T.D., Jaso-Fredmann, L., and Evans, D.L. A species conserved NK cell antigen receptor is a novel vimentin like molecule. Dev. and Comp. Immunol. 16(5): 395-403, 1992.
2. Harris, D.T., Camenisch, T.D., Jaso-Friedman, L., and Evans, D. Expression of an evolutionary conserved function-associated molecule on sheep, horse, and cattle natural killer cells. Veterinary Immunol. and Immunopathol. 38(3-4):273-282, 1993.
3. Camenisch, T.D., Jaso-Friedman, L., Evans, D., and Harris, D.T. Expression of a novel function-associated molecule on cells mediating spontaneous cytolysis in swine. Dev. and Comp. Immunol. 17: 277-282, 1993.
4. Nguyen, M., Camenisch, T., Snouwaert, J.N., Hicks, E., Coffman, T.M., Anderson, P.A., Malouf, N.N., Koller, B.H. The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature 390(6655):78-81, 1997.
5. Camenisch, T. D., Koller, B.H., Earp, H.S., Matsushima, G.K. A novel receptor tyrosine kinase, Mer, inhibits TNF-a and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162: 3498-3503, 1999.
6. Lu, Q., Gore, M., Zhang, Q., Camenisch, T.D., Boast, S., Casagrande, F., Laio, C., Skinner, M., Klein, R., Matsushima, G.K., Earp, H.S., Goff, S.P. and Lemke. G. Tyro 3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.
7. Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M.L., Calabro, A. Jr., Kubalak, S., Klewer, S.E., and McDonald, J.A. Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme. J. Clin. Invest. 106:349-360, 2000 (cover).
8. Camenisch, T. D., and J. A. McDonald. Perspective: Hyaluronan-Is bigger better? Am. J. Respir. Cell. Mol. Biol. 23:1-3, 2000.
9. Camenisch, T.D., Biesterfeldt, J., Brehm-Gibson, T., Bradley, J., and McDonald, J.A. Regulation of cardiac cushion development by hyaluronan. Exp. Clin. Cardiol. 6:4-10, 2001.
10. Dor., Y., Camenisch, T. D., Itin, A., Fishman, G. I., McDonald, J. A., Carmeliet, P. and Keshet, E. A novel role for VEGF in endocardial cushion formation and its potential contribution to heart septation defects. Development 128:1531-1538, 2001.
11. Cohen, P.L., Caricchio, R., Abraham, V., Camenisch, T.D., Jennette, J.C., Roubey, R.A.S., Earp, H.S., Matsushima, G, and Reap, E.A. Delayed apoptotic cell clearance and Lupus-like autoimmunity in mice lacking the c-mer transmembrane tyrosine kinase. J Exp. Med. 196:135-140, 2002.
12. Camenisch, T.D., Molin, D.G.M., Person, A., Runyan, R., Gittenberger-de Groot, A.C., McDonald, J.A., and Klewer, S. E. Temporal and distinct TGFb ligand requirements during mouse and avian endocardial cushion morphogenesis. Dev. Biol. 248: 170-181, 2002.
13. Camenisch, T. D., Schroeder, J. A., Bradley, J., Klewer, S. E., and McDonald, J. A. Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2-ErbB3 receptors. Nat. Medicine 8: 850-855, 2002.
14. Dor, Y., Klewer, S.E., McDonald, J. A., Keshet, E., and Camenisch, T.D. VEGF modulates early heart valve formation. Anat. Rec. 271A: 202-208, 2003.
15. Schroeder, J.A., Adriance, M.C., Thompson, M.C., Camenisch, T.D., and Gendler, S. J. MUC1 alters β-catenin-dependent tumor formation and promotes cellular invasion. Oncogene 22: 1324-1332, 2003.
16. Enciso, J.M., Gratzinger, D., Camenisch, T.D., Canosa, S., Pinter, E., and Madri, J.A. Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: modulation by PECAM-1 and MMP-2. J. Cell Biol. 160: 605-615, 2003.
17. Schroeder, J.A., Jackson, L.F., Lee, D.C., and Camenisch, T.D. Form and Function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J Mol Med. 81: 392-403, 2003.
18. McDonald, J.A., and Camenisch, T.D. Hyaluronan: Genetic insights into the complex biology of a simple polysaccharide. Glycoconjugate J. 19: 331-339, 2003.
19. Camenisch, T. D., Lopez, J.I., Stevens, M. V., Sands, B. J., McDonald, J. A. and Schroeder, J. A. CD44 attenuates metastatic invasion during breast cancer progression. Cancer Res 65: 6755-6763, 2005. Research Article
20. Klewer, S. E., Yatskievych, T., Pogreba, K., Antin, P.B., and Camenisch, T.D. Defining Has2 expression during cardiogenesis and its insusceptibility to BMP regulation. Gene Exp. 6: 462-470, 2006.
21. Stevens, M.V., Parker, P., Vaillancourt, R. R., and Camenisch, T.D. MEKK4 regulates developmental EMT in the embryonic heart. Dev. Dyn. 235: 2761 – 2770, 2006.
22. Rodgers, L., Lalani, S., Hardy, K., Xiang, X., Broka, D., Antin, P.B., and Camenisch, T.D. Depolymerized hyaluronan induces VEGF, a negative regulator of developmental epithelial to mesenchymal transformation. Circ. Res 99: 583-589, 2006.
23. Heather M. Seitz, Todd D. Camenisch, Greg Lemke, H. Shelton Earp, and Glenn K. Matsushima. Macrophages and dendritic cells use different Axl/Mertk/Tyro3 receptors in clearance of apoptotic cells. J Immunol. 178: 5635-5642. 2007.
24. Hays A.M., Lantz, R.C., Rodgers, L.S., Sollome, J.J., Andrew, A.S., Hamilton, J.W., Vaillancourt, R.R., and Camenisch, T.D. Arsenic downregulates vascular matrix. (submitted, Toxicol Letters ms07-00211, 2007).