Paul B Myrdal, PhD
Associate Professor
Department:
Pharmacy Practice and Science
(520) 626-1296
Fax:
(520) 626-4063
E-mail:
Location:
Pharmacy 422
Bio / Research:
Dr. Myrdal is an associate professor in pharmaceutics at The University of Arizona. He received his BS in molecular and cellular biology from The University of Arizona in 1989 and his PhD in physical pharmaceutical chemistry from The University of Arizona in 1994. Dr. Myrdal joined the College of Pharmacy during the fall of 2000.
Before his faculty appointment, Dr. Myrdal worked for Minnesota Mining and Manufacturing (3M) in the Drug Delivery Systems Division. At 3M, he interfaced directly with drug discovery and provided preformulation and formulation support for preclinical and clinical studies.
Dr. Myrdal has 35+ peer-reviewed publications on a variety of aspects of preformulation, formulation and drug delivery. He has theoretical experience that ranges from vapor pressure prediction to the prediction of drug solubility and optimization of solution based formulations. He co-authored, with Dr. Samuel Yalkowsky, chapters on solubility and solubilization of drugs in aqueous media for the Encyclopedia of Pharmaceutical Technology and is co-director of a short course that centers on the solubility and solubilization of drugs. Dr. Myrdal has also generated the data for, and written, chemistry, manufacturing and control (CMC) sections for three different IND submissions.
Dr. Myrdal’s research laboratory is centered on drug delivery with an emphasis on aerosol and topical drug delivery. His current research programs are investigating new tools for the determination of solute solubility in aerosol propellants and for efficiently evaluating product performance of metered-dose inhalers. In addition, he has a technology platform that utilizes the inhalation route for lung cancer chemoprevention. He is also active with a program project that is focused on the development of topical agents for skin cancer chemoprevention.
Selected Publications
Hoye, W., Mogalian, E., and Myrdal, P.B., “Product Performance Evaluation of Two Albuterol Inhalers Under Extreme Temperature Situations”, Am. J. Health Syst. Pharm., (in press 2005).
Mogalian, E., and Myrdal, P.B., “Application of UPS Inlet Extensions to the TSI Impactor System 3306/3200 Using HFA Based Solution Metered Dose Inhalers”, Drug Dev. and Indus. Pharm., (in press 2005).
Gupta, A., and Myrdal, P.B., “Comparison of Two Methods to Determine Solubility of Compounds in Aerosol Propellants”, Int. J. Pharm. Sci., 292, 201-209 (2005).
Gupta, A., Stratton, S., and Myrdal, P.B., “A HPLC Method for Quantitation of Perillyl Alcohol in a Topical Pharmaceutical Cream Formulation”, J. Pharm. and Biomed. Anal., 37, 447-452 (2005).
Stein, S.W., and Myrdal, P.B., “A Theoretical and Experimental Analysis of Formulation and Device Parameters Affecting Solution MDI Size Distributions”, J. Pharm. Sci., 93 (8), 2158-2175 (2004).
Myrdal, P.B., Karlage, K.L., Stein, S.W., Brown, B.A., and Haynes, A., “Optimized Dose Delivery of the Peptide Cyclosporine Using Hyrdrofluoroalkane-Based Metered Dose Inhalers”, J. Pharm. Sci., 93 (4), 1054-1061 (2004).
Gupta, A., and Myrdal, P.B., “Balancing Ethanol Cosolvent Concentration with Product Performance in 134a Based Pressurized Metered Dose Inhalers”, J. Aerosol Medicine, 16 (2): 167-174 (2003).
Stein, S.W., Myrdal, P.B., Gabrio, B.J., Oberreit, D., and Beck, T.J., “Evaluation of a New Aerodynamic Particle Sizer for Size Distribution Measurements of Solution Metered Dose Inhalers”, J. Aerosol Medicine, 16 (2): (2003).
Myrdal, P.B. and Yalkowsky, S.H. (Chapter) “Solubilization of Drugs in Aqueous Media” in J. Swarbrick and J. Boylan Eds.: Encyclopedia of Pharmaceutical Technology, NY: Dekker (2002).
Myrdal P.B. and Yalkowsky, S.H., “Estimating Pure Component Vapor Pressures of Complex Organic Molecules”, Ind. Eng. Chem. Res., 36, 2494-2499 (1997).