Michael Mayersohn, PhD
Professor; Investigator, Center For Toxicology
Department:
Pharmacy Practice and Science
(520) 626-1938
Fax:
(520) 626-4063
E-mail:
Location:
Pharmacy 000424
Bio / Research:
Research activities in recent years have emphasized the pharmacokinetics and toxicology of drugs of abuse (e.g.,methamphetamine, cocaine) Past and current research activities are broadly based and fall into the general areas of pharmacokinetics, biopharmaceutics, toxicokinetics and pharmacodynamics. The purpose of such research (in animals and humans) is to quantitatively describe the disposition of a drug or toxicant and metabolites in the body. These studies involve the measurement of drug/toxicant and metabolite concentrations in biological fluids and tissues in order to describe the various processes that such compounds undergo in the body (i.e., absorption, distribution, metabolism and excretion). Such data usually allow the development of a biological and mathematical model, which may be used to help explain what is happening to a substance and/or predict what would happen if the system (i.e., the body) were to undergo a change. An additional important aspect of these experiments is to quantitatively measure responses to the drug/toxicant and relate that behavior to the dose-concentration-time profiles. interaction (e.g., cocaine-ethanol) and response-concentration relationships. Sensitive and specific analytical methods need to be developed for all such studies (e.g., enantiomer-selective assays and metabolites). Additional activities include: theoretical and practical applications of physiologically-based pharmacokinetic models; prevention of absorption of drugs/toxicants following an acute oral overdose; quantitative relationships between in vitro and in vivo drug metabolism.
Dr. Mayersohn teaches PhSc 807 and 808a and graduate courses in pharmacokinetics and toxicokinetics. His research interests are in the areas of pharmacokinetics and biopharmaceutics. Dr. Mayersohn received the Basic Science Pharmacy Educator of the Year award four times from the college.
Education:BS, Columbia University College of Pharmacy, 1966
PhD, School of Pharmacy, State University of New York, 1970
J.S. Valdez, D.K. Martin and M. Mayersohn, "Sensitive and Selective Gas Chromatographic Methods for the Quantitation of Camphor, Menthol and Methyl Salicylate from Human Plasma", J. Chromatogr. B, 729, 163-171 (1999).
T. Kakkar, H. Boxenbaum and M. Mayersohn, "Estimation of Ki in a Competitive Enzyme-Inhibition Model: Comparisons Among Three Methods of Data Analysis", Drug Metab. Disposition, 27, 756-762 (1999).
H. Boxenbaum, S. Tannenbaum, F. Oleson and M. Mayersohn, "Pharmacokinetic Tricks and Traps: Dosage Adjustment in Renal Failure", J. Pharm. Pharmaceut. Sci., 2, 2-5 (1999).
H.J. Pieniaszek, Jr., M. Mayersohn, M.P. Adams, R.J. Reinhart and J.S. Barett, "Moricizine Bioavailability via Simultaneous, Dual, Stable Isotope Administration: Bioequivalence Implications, " J. Clin. Pharmacol., 39, 817-825 (1999).
H.J. Pieniaszek, Jr., A.F. Davidson, F.E. Chaney, L. Shum, C.A. Robinson and M. Mayersohn, "Human Moricizine Metabolism.II. Quantification and Pharmacokinetics of Plasma and Urinary Metabolites", Xenobiotica, 29, 945-955 (1999).
V. Sinha, K. Brendel and M. Mayersohn, "A Simple Isolated Perfused Rat Liver Apparatus: Characterization and Measurement of Extraction Ratios of Selected Drugs", Life Sci., 66, 1795-1804 (2000).
T. Sanghvi, N. Ni, M. Mayersohn and S.H. Yalkowsky, “Predicting Passive Intestinal Absorption Using a Single Parameter”, QSAR 22, 247-257 (2003).
Y. Pak, R. Patek and M. Mayersohn, “Sensitive and Rapid Isocratic HPLC Method for the Quantitation of Curcumin in Plasma”, J. Chromatography B, 796, 339-346 (2003).
H. Tang, Y. Pak and M. Mayersohn, “Protein Expression of P-glycoprotein Along the Gastrointestinal Tract of the Yucatan Micropig”, J. Biochem. Molecular Tox., 18, 1-5 (2004).
D. Martin, J. Valdez, J. Boren and M. Mayersohn, “Absorption of Camphor, Menthol and Methyl Salicylate in Human Subjects Following Application of Dermal Patches”, J. Clin. Pharmacol., 44, 1151-1157 (2004).
B. Lund, S.A. Seifert and M. Mayersohn, “Efficacy of Sustained Low-Efficiency Dialysis in the Treatment of Salicylate Toxicity”, Nephrol. Dial. Transplantation 20, 1483-1484 (2005).
H. Tang and M. Mayersohn, “Accuracy of Allometrically-Predicted Pharmacokinetic Parameters in Humans – Role of Species Selection”, Drug Metab. Dispos. 33: 1288-1293 (2005).
H. Tang and M. Mayersohn, “A Mathematical of the Functionality of Correction Factors Used in Allometry for Predicting Human Clearance”, Drug Metab. Dispos. 33: 1294-1296 (2005).
H. Tang and M. Mayersohn, “A Novel Method for Prediction of Human Drug Clearance by Allometric Scaling”, Drug Metab. Dispos. 33, 1297-1303 (2005).
Y. Pak, K. Stollberg-Zagar and M. Mayersohn, “A Porcine Model for Fixed Drug Eruptions- A Case of Antipyrine in the Yucatan Micropig”, J. Appld. Toxicol., 26, 1-4 (2006).
H. Tang and M. Mayersohn, “A Global Examination of Allometric Scaling for Predicting Human Clearance and the Prediction of Large Vertical Allometry”, J. Pharm. Sci., 95, 1783-1799 (2006).
H. Tang and M. Mayersohn, “Response to Comments on ‘A Mathematical Description of the Functionality of Correction Factors Used in Allometry for Predicting Human Drug Clearance’”, Drug Metab. Dispos. 34, 510-511 (2006)
H. Tang and M. Mayersohn, “On the Observed Large Inter-Species Over-Prediction of Human Clearance (“Vertical Allometry”) of UCN-01: Further Support for a Proposed Model Based Upon Plasma Protein Binding”, J. Clin. Pharmacol., 46, 398-400 (2006).
Chapters
M. Mayersohn, “Toxicokinetics: Measurement of Disposition Half-Life, Clearance and Residence Times”, Chapter 5-3 in Current Protocols in Toxicology, M. Maines, editor-in-chief, John Wiley and Sons, New York, NY, 2000, pp. 5-3.1 – 5-3.29
M. Mayersohn, "Principles of Drug Absorption," Chapter 2, in Modern Pharmaceutics, 4thed.,G.S.
Banker and C.T. Rhodes (eds.), Marcel Dekker, New York, 2002.
M. Mayersohn, “Principles and Applications of Pharmacokinetics”, Chapter 79 in: Medical
Toxicology, 3rd ed., RC Dart (ed.), Lippincott, Williams and Wilkins, New York, 2004, pp. 282-337.