Barbara Timmermann, PhD
Professor Emeritus
Department:
Pharmacology and Toxicology
E-mail:
Location:
Pharmacy 408A
Bio / Research:
Dr. Timmerman's work at The University of Arizona was in biodiversity prospecting and drug discovery. She retired from UA in July 2005. She is currently a faculty member at the University of Kansas.
Biodiversity prospecting offers a valuable opportunity to directly address one of the most important relationships between biodiversity and human health -- our dependence on nature for medicine. Drug discovery from natural products, if appropriately designed and carried out, can provide economic incentives for the conservation of the diversity of plants, animals, and microorganisms on Earth. While natural products drug discovery has a long history, the idea that this process could yield conservation and development benefits is relatively new.
Education:BS, Universidad Nacional de Cordoba, Argentina, 1970, Biology
MA, University of Texas, Austin, 1977, Botany (Phytochemistry)
PhD, University of Texas, Austin, Texas, 1980, Botany (Phytochemistry)
Honors, Awards
1982, Nominated as an Outstanding Professor, The University of Arizona
2000, Regents Professor, The University of Arizona
Timmermann, B.N., S. Valcic, Y-L. Liu, and G. Montenegro. 1995. Flavonoids from Cryptocarya alba. Z. Naturforsch C 50(11-12): 898-899.
Zhou, L., B.N. Timmermann, C. Grittini, M.A. Bruck and J.H. Enemark. 1996. Tarapacol 15-acetate, a new diterpenoid from Grindelia tarapacana. Acta Cryst C52: 1042-1044.
Valcic, S., B. N. Timmermann, D. S. Alberts, G.A. Wächter, M. Krutzsch, J. Wymer and J. Guillen. 1996. Inhibitory Effect of Six Green Tea Catechins and Caffeine on the Growth of Four Selected Human Tumor Cell Lines. Anti Cancer Drugs 7: 461-468.
Gensler, H., B.N. Timmermann, S. Valcic, and G. Wächter. 1996. Prevention of Photo-carcinogenesis by Topical Administration of Pure Epigallocatechin Gallate Isolated from Green Tea. 1996. Nutrition and Cancer 26(3): 325-335.
He, K., S. Valcic, B.N. Timmermann and G. Montenegro. 1997. Indole Alkaloids from Aristotelia chilensis (Mol.) Stuntz. Intl. J. Pharmacognosy 35 (3): 215-217.
Miketova, P., K. H. Schram, J. Whitney, E. Kerns, S. Valcic, B. N. Timmermann and K. J. Volk. 1998. Mass spectrometry of selected components of biological interest in green tea extracts. J. Nat. Prod. 61: 461-467.
Glendinning, J.I., S. Valcic and B. N. Timmermann. 1998. Maxillary palps can mediate taste-rejection of plant allelochemicals by caterpillars. J. Comp. Physiol. A. 183(1): 35-43.
Valcic, S., G. Montenegro and B. N. Timmermann. 1998. Lignans from Chilean propolis. J. Nat. Prod. 61: 771-775.
Wächter, G., S.G. Franzblau, G. Montenegro, E. Suarez, R.H. Fortunato, E. Saavedra, and B.N. Timmermann. 1998. A New Antitubercular Mulinane Diterpenoid from Azorella madreporica Clos. J. Nat. Prod. 61(7): 965-968.
Barthelman, M., W.B. Bair III, K.K. Stickland, W. Chen, B.N. Timmermann, S. Valcic, Z. Dong, and G.T. Bowden. 1998. (-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity. Carcinogenesis. 19(12): 2201-2204.
Chen, W., Dong, Z., Valcic, S., Timmermann, B.N., Bowden, G.T. 1999. Inhibition of Ultraviolet B-induced c-fos Gene Expression and p38 Mitogen-Activated Protein Kinase Activation by (-)-Epigallocatechin Gallate in a Human Keratinocyte Cell Line. Molecular Carcinogenesis (cover article) 24(2): 79-84.
Dvorakova, K., R. T. Dorr, S. Valcic, B. N. Timmermann, and D. S. Alberts. 1999. Pharmacokinetics of the green tea derivative, EGCG, by the topical route of administration in mouse and human skin. Cancer Chemotherapy and Pharmacology 43: 331-335.
Valcic, S., A. Muders, N.E. Jacobsen, D.L. Liebler, B.N. Timmermann. 1999. Antioxidant chemistry of green tea catechins. Identification of products of (-)-epigallocatechin gallate (EGCG) reaction with by peroxyl radicals. Chem. Res. in Toxicol. (cover article) 12(4): 382-386.
Valcic, S., G. Montenegro, A.M. Mujica, G. Avila, S. Franzblau, M.P. Singh, W.M. Maiese, and B.N. Timmermann. 1999. Phytochemical, morphological and biological investigations of propolis from central Chile. Z. Naturforsch 54c: 406-416.
Wächter, G., G. Matooq, J.J. Hoffmann, W.M. Maiese, M.P. Singh, G. Montenegro, and B.N. Timmermann. 1999. Antibacterial Diterpenoid Acids from Azorella compacta. J. Natural Products 62(9): 1319-1321.
Miketova, P., K. H. Schram, J. Whitney, E. Kerns and B.N. Timmermann. 1999. Mass spectrometry of 3,5? and 4,5?dicaffeoylquinic acids and selected derivatives. J. Mass Spectrom 34: 1240-1252.
Flagg, M., S. Valcic, G. Montenegro, M. Gomez, and B.N. Timmermann. 1999. Pentacyclic Triterpenes from Chuquiraga ulicina. Phytochemistry 52(7): 1345-1350.
Wächter, G., S. Valcic, M.L. Flagg, S.G. Franzblau, G. Montenegro, E. Suarez and B.N. Timmermann. 1999. Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile. Phytomedicine 6(5): 341-345.
Timmermann, B.N., G. Wachter, S. Valcic, B. Hutchinson, J. Henzel, C. Casler, S. Ram, F. Currim, R. Manak, S. Franzblau, W. Maiese, D. Galinis, E. Suarez, R. Fortunato, E. Saavedra, R. Bye, R. Mata and G. Montenegro. 1999. The Latin American ICBG: The First Five Years. Pharm. Biol. 37, Supplement, 35-54.
Miketova, P., K. H. Schram, J. Whitney, M. Li, R. Huang, E. Kerns, S. Valcic, B.N. Timmermann, R. Rourick and S. Klohr. 2000. Tandum mass spectrometry studies of green tea catechins. Identification of three minor components in the polyphenolic extract of green tea. J. Mass Spectrom 35: 860-869.
Arora, A., S. Valcic, S. Cornejo, M. Nair, B.N. Timmermann, and D.C. Liebler. 2000. Reactions of Genistein with Alkylperoxyl Radicals. Chem. Res. Toxicol. 13(7): 638-645.
Valcic, S., J.A. Burr, B.N. Timmermann, and D.C. Liebler. 2000. Antioxidant Chemistry of Green Tea Catechins. New oxidation products of (-)- epigallocatechin gallate and (-)- epigallocatechin from their reactions with peroxyl radicals. Chem. Res. Toxicol.13(A): 801-810.
Caldwell, C., S.G. Franzblau, E. Suarez and B.N. Timmermann. 2000. Oleanane triterpenes from Junellia tridens. J. Nat. Prod. 63(12): 1611-1614.
Flagg, M. L., Waechter G. A., Davis, A.L., G. Montenegro and B. N. Timmermann. 2000. Two novel flavanones from Greigia sphacelata. J. Nat. Prod. 63(12), 1689-1691.
Waechter, G., Valcic, S, Franzblau, S., Suarez, E., and Timmermann, B.N. 2001. Antitubercular activity of triterpenoids from Lippia turbinata. J. Nat. Prod. 64: 37-41.