Search Standards Needed to Help Prevent Drug-Drug Interactions

Tucson, AZ – HOPE Center researchers published a new study assessing methods used by drug interaction experts to find evidence about potential drug-drug interactions (PDDIs). This study was part of a grant funded by the US National Library of Medicine to prevent drug-drug interactions by developing computerized tools to assist researchers and clinicians. Preventing drug-drug interactions would improve patient outcomes and could save the health care system millions of dollars. The 20 drug interaction experts surveyed in this study relied on various search strategies to identify PDDI evidence, without standard use of search engines, compendia, web sources, databases, or search terms. The study team recommends greater automation and standardization across search strategies, and will conduct further research validating search strategies that efficiently retrieve the most complete and precise PDDI evidence possible.

This study represents a successful collaboration of HOPE Center investigators Daniel Malone, RPH, PhD, FAMCP, and Amy Grizzle, PharmD, with those at the University of Pittsburgh Department of Biomedical Informatics (with Principal Investigator, Richard Boyce, PhD), University of Washington School of Pharmacy, and University of Illinois School of Information Sciences.

Grizzle AJ, Horn J, Collins C, Schneider J, Malone DC, Stottlemyer B, Boyce RD. Identifying Common Methods Used by Drug Interaction Experts for Finding Evidence About Potential Drug-Drug Interactions: Web-Based Survey. J Med Internet Res 2019;21(1):e11182 DOI: 10.2196/11182 PMID: 30609981