Faculty who teach in the Drug Discovery and Development research track are listed below. They are grouped by core faculty and associate faculty.
Eli Chapman, PhD, Assistant Professor, Drug Discovery and Development
Our lab uses chemistry, biochemistry, biophysics, structural biology, and cell and molecular biology to discover targeted modulators of a diverse array of pathologically relevant targets.
Chris Hulme, PhD, Professor, Drug Discovery and Development
Discovery and development of novel anticancer therapeutics; high-throughput Medicinal Chemistry and the development of novel chemistries with iterative efficiency to expedite the drug discovery process; Microwave Assisted Organic Synthesis (MAOS), Flow chemistry, Multicomponent reactions (MCRs) and C-H bond activation methodologies utilizing hypervalent iodine reagents for the design of peptidomimetics.
Rick Schnellmann, PhD, Dean and Professor, Drug Discovery and Development
Identifying and developing drugs to treat acute kidney injury, diabetic kidney disease, stroke, spinal cord injury and Parkinson’s disease.
Daekyu Sun, PhD, Associate Professor, Drug Discovery and Development
Discovery and development of novel anti-angiogenic agents targeting transcriptional activation of VEGF and HIF-1alpha genes; Study of the mechanism of action of novel anticancer agents derived from natural products: Investigation of DNA-repair interference as a potential approach for cancer treatment.
Jun Wang, PhD, Assistant Professor, Drug Discovery and Development
Elucidating the drug resistance mechanism of influenza viruses; design and synthesis broad-spectrum and resistance-refractory antiviral drugs; studying virus-host interactions and immune responses; drug discovery and structural biology of ion channels; exploring peptide and miniprotein-based therapeutics.
Todd Camenisch, PhD, Associate Professor, Pharmacology & Toxicology
Investigating the integration between extracellular matrix and growth factor receptor signaling during heart morphogenesis.
Qin Chen, PhD, Professor, Pharmacology
Molecular mechanisms of oxidative injury and adaptation, stress signal transduction pathways, stress gene expression, senescence, apoptosis and cardiac hypertrophy.
Yin Chen, PhD, Associate Professor, Pharmacology & Toxicology
Research interest is to understand the dysfunction of airway epithelium in the pathogenesis of a variety of acute and chronic airway diseases.
Nathan Cherrington, PhD, Professor, Pharmacology & Toxicology
Molecular mechanisms of variable drug response that make certain individuals more sensitive to adverse drug reactions. We study what factors alter the expression and function of the drug metabolizing enzymes and transporters that determine the fate of drugs.
Bernard Futscher, PhD, Professor, Pharmacology & Toxicology
Functional genomics; molecular biology of cancer; cancer pharmacology.
Walter Klimecki, PhD, Associate Professor, Pharmacology & Toxicology
My laboratory studies how the genes that people inherit from their ancestors set the stage for unique interactions with the environments that those people are exposed to throughout their life, to increase or decrease their susceptibility to disease. Those environmental exposures could be diverse, ranging from environmental toxicant chemicals to airborne bacterial contaminants to prescribed drugs. The combination of humans' diverse genetic backgrounds and equally diverse environmental exposures present both challenges and opportunities to understand individual variability in disease susceptibility.
R. Clark Lantz, PhD, Professor, Pharmacology & Toxicology
Pulmonary toxicology of air pollutants, especially metals; effects of air pollutants on neonatal lung growth and development.
Aikseng Ooi, PhD, Assistant Professor, Pharmacology & Toxicology
Molecular carcinogenesis; Mutation-driven transcriptional and metabolic reprogramming; Carcinogen-driven transcriptional and metabolic reprogramming; Computational biology.
John Regan, PhD, Professor, Pharmacology & Toxicology
Molecular pharmacology of G-protein coupled receptors: use of cloning, mutagenesis and expression to study receptor structure and the interaction of receptors with second messenger systems.
Catharine Smith, PhD, Associate Professor, Pharmacology & Toxicology
Epigenetic mechanisms of gene regulation, steroid receptor action in breast cancer, signal transduction and cell cycle control, mechanism of anti-cancer drug action.
Richard Vaillancourt, PhD, Associate Professor, Pharmacology & Toxicology
Molecular and biochemical characterization of serine/threonine protein kinases that function as part of sequential protein kinase pathways.
Donna Zhang, PhD, Professor, Pharmacology & Toxicology
The research projects in my laboratory are focused on (1) Mechanistic studies of the Nrf2/Keap1
signaling pathway that is activated by oxidative stress and chemopreventive compounds, (2) the protective role of Nrf2 in arsenic-induced toxicity and carcinogenicity (this project is funded by NIEHS R01 award), and (3) regulation of gene expression by the ubiquitination and proteasomal degradation pathway.