Course Information

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The courses described below are required in the Drug Discovery and Development research track. For more information, consult the UA course catalog.
A minimum of 38 units of course work in the area of the major subject including 4 seminar credits, 6 laboratory rotation units, and a maximum of 4 research conference credits must be completed. In addition, 9 units of course work in the minor subject, and 18 units of dissertation must be completed.  Courses in the Drug Discovery and Development program are listed under two different prefixes to the course numbers:  PHSC and PCOL.  All research and dissertation units are registered under PHSC.
 
Year 1:
PHSC 530:       Proteins and Nucleic Acids as Drug Targets (3 units, fall)
CHEM 550:      Synthetic & Mechanistic Organic Chem (3 units, fall)
BIOC 565:        Proteins and Enzymes (3 units, fall)
PHSC 670:        Principles in Drug Discovery, Design, and Development (3 units, spring)
 
GRAD 795a      ABBS Laboratory rotations (first year only; 2 units per rotation; fall & spring: 6 units total)
                          BCP Laboratory rotations with ABBS participating faculty (together with BCP Journal Club)
 
PHSC 596a       Seminar (1 unit, fall & spring semester: attendance required when enrolled; 4 units minimum)
MCB 695e        Science, Society & Ethics (fall, or spring, or summer, 1 unit)
 
Year 2:
PHSC 537 a:     Medicinal Chemistry II (3 units, fall)
PHSC 537 b:     Medicinal Chemistry III (2 units, spring)
PCOL695a        Research Conference (1 unit; fall & spring; second year and beyond: 4 units minimum)
 
Electives:
A minimum of 6 units total during year 1 and 2.  There are many elective possibilities from a variety of graduate programs.  Some possibilities offered by Chemistry/Biochemistry, Pharmacology and Toxicology, and Cancer Biology are shown here. 
 
Fall Electives:
PCOL 601a:  Epigenetics in Development and Disease (1 unit)
PCOL 601b:  Proteomics (1 unit)
PCOL 630B: Cell communication & Signaling (3 units)
CBIO 597a: Experimental Design (1 unit)
CBIO 552: Cancer Biology (4 units)
CHEM 584: Nuclear Magnetic Resonance Spectroscopy (3 units)
CHEM 543:  Structural Organic Chemistry (3 units)
Spring Electives:
PCOL 550:  Drug Metabolism and Disposition (2 units)
BIOC 585:  Biological Structure I (4 units)
BIOC 568:  Nucleic Acids (4 units)
CBIO553: Advanced Topics in Cancer Biology (4 units)
CBIO 597a: Grant Writing for Graduate Student (1 unit)
PCOL 630A: Cell communication & Signaling (3 units)
CHEM 541: Mechanisms of Organic Reactions (3 units)
CHEM 548 Advanced Synthetic Chemistry (3 units)
CHEM 587: Intro to Molecular Spectroscopy (3 units)
CHEM 534A/B: Practical NMR Spectroscopy (3 units)
Proteins and Nucleic Acids as Drug Targets (PHSC 530)

This course is intended to familiarize first year graduate or senior undergraduate students with critical classic and comtemporary concepts of drug discovery.  Part of the course will involve a 'flipped classroom" format and discussion of the primary literature allowing students to engage and teach each other.

Principles of Drug Discovery, Design and Development (PHSC 670)
An introduction to principles of drug discovery, design and development covering processes and tools such as computational chemistry, combinatorial chemistry and subjects such as molecular target identification, drug receptor interactions, DNA and proteins as molecular targets, drug metabolism and drug delivery systems.

Synthetic & Mechanistic Organic Chemistry (CHEM 550)

Proteins and Enzymes (BIOC 565)

Medicinal Chemistry (PHSC 537a/b)

Continuation of the comprehensive survey of the medicinal chemistry of drugs, including agents acting on the autonomic, cardiovascular, hematopoietic, inflammatory, and gastrointestinal systems, vitamins and radiopharmaceuticals.

Drug Discovery and Development Seminar (PHSC 596a)
The development and exchange of scholarly information in a small group setting. The scope of work shall consist of research by course registrants, with the exchange of the results of such research through discussion, reports, and/or papers.

Genomics and Proteomics (PCOL 601)
Lecture and laboratory on the qualitative and quantitative effects of toxic substances on mammalian genes and proteins.

Drug Metabolism and Disposition (PCOL 550)
Principles of absorption, distribution, and excretion of drugs, with emphasis on mechanisms of drug metabolism.

Originally posted: August 8, 2014
Last updated: February 20, 2017
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