Publications by Drs. Monks and Lau

Selected Publications: Oncotic/necrotic cell death

Jeong, J.K., Stevens, J.L., Lau, S.S., and Monks, T.J. Quinone-thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells. Molec. Pharmacol., 50:592-598, 1996.
Jeong, J.K., Huang, Q., Lau, S.S., and Monks, T.J. The response of renal epithelial cells to physiological-and chemical-induced growth arrest. J. Biol.Chem., 272:7511-7518, 1997.
Jeong, J.K., Dybing, E., Søderlund, E., Brunborg, G., Holme, J.A., Lau, S.S., and Monks, T.J. DNA damage, gadd153 expression, and cytotoxicity in plateau phase renal proximal tubular epithelial cells treated with a quinol-thioether. Arch. Biochem. Biophys., 341:300-308, 1997.
Huang, Q., Lau, S.S., and Monks, T.J. Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine. Biochem. J., 341:225-231, 1999.
Jeong, J.K., Wogan, G.N., Lau, S.S., and Monks, T.J. Quinol-glutathione conjugate-induced mutation spectra in the supf gene replicated in human AD293 cells and bacterial MBL50 cells. Cancer Res., 59:3641-3645, 1999.
Tikoo, K., Lau, S.S., and Monks, T.J. Histone H3 phosphorylation is coupled to poly (ADP-ribosylation) and reactive oxygen species-induced cell death in renal proximal tubular epithelial cells. Molec. Pharmacol. 60:394-402, 2001.
Ramachandiran, S., Huang, Q., Dong, J., Lau, S.S., and Monks, T.J. Mitogen activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem. Res, Toxicol., 15, 1635-1642, 2002.
Dong, J., Everitt, J., Lau, S.S., and Monks, T.J. Induction of ERK1/2 and histone H3 phosphorylation within the outer stripe of the outer medulla of the Eker rat by 2,3,5-tris-(glutathion-S-yl)hydroquinone. Toxicol Sci. 80, 350-357, 2004.

Selected Publications: Apoptotic cell death

Bratton, S.B., Lau, S.S., and Monks, T.J. Identification of quinol-thioethers in bone marrow of hydroquinone/phenol treated rats and mice, and their potential role in benzene-mediated hematotoxicity. Chem. Res. Toxicol., 10:859-865, 1997.
Bratton, S.B., Lau, S.S., and Monks, T.J. The putative benzene metabolite, 2,3,5-tris-(glutathion-S-yl)hydroquinone, depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in Hl-60 cells. Chem. Res, Toxicol., 13:550-556, 2000.

Selected Publications: Neurotoxicology of Ecstasy

Miller, R.T., Lau, S.S., and Monks, T.J. Metabolism of 5-(glutathion-S-yl)-a-methyldopamine following intracerebroventricular administration to male Sprague Dawley rats. Chem. Res. Toxicol., 8:634-641, 1995.
Miller, R.T., Lau, S.S., and Monks, T.J. Effects of 5-(glutation-S-yl)-a-methyldopamine on dopamine, serotonin, and norepinephrine concentrations following intracerebroventricluar administration to male Sprague Dawley rats. Chem. Res. Toxicol., 9:457-465, 1996.
Miller, R.T., Lau, S.S., and Monks, T.J. 2,5-bis-(Glutathion-S-yl)-a-methyldopamine, a putative metabolite of (±)-3,4-methylenedioxyamphetamine, produces long-term decreases in brain serotonin concentrations. Eur. J. Pharmacol., 323:173-180, 1997.
Monks, T.J., Ghersi-Egea, J-F., Philbert, M.A., Cooper, A.J.L., and Lock, E.A. The role of glutathione in neuroprotection and neurotoxicity. Toxicol. Sci., 51:161-177, 1999.
Bai. F., Lau, S.S., and Monks, T.J. Glutathione and N-acetylcysteine conjugates of a-methyldopamine produce serotonergic neurotoxicity. Possible role in methylenedioxyamphetamine-mediated neurotoxicity. Chem. Res. Toxicol., 12:1150-1157, 1999. Bai, F., Lau, S.S., and Monks, T.J. The serotonergic neurotoxicity of 3,4-(±)-methylenedioxy-amphetamine and 3,4-(±)-methylenedioxymetamphetamine (ecstasy) is potentiated by inhibition of g-glutamyl transpeptidase. Chem. Res. Toxicol. 14: 863-870, 2001.
Monks, T.J.,Bai, F., Miller, R.T., Lau, S.S. Serontonergic neurotoxicity of of methylenedioxy-amphetamine and methylenedioxymetamphetamine. Adv. Exp. Med. Biol., 500, 397-406, 2001.
Monks, T.J., Jones, D.C., Bai, F., and Lau, S.S. The role of metabolism in 3,4-(±)-methylenedioxy-amphetamine and 3,4-(±)-methylenedioxymethamphetamine (ecstasy) neurotoxicity. Ther. Drug Monitoring, 26, 132-136, 2004.
Jones, D.C., Lau, S.S., and Monks, T.J. Thioether metabolites of 3,4-(±)-methylenedioxy-amphetamine and 3,4-(±)-methylenedioxymethamphetamine inhibit hSERT function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells. J Pharmacol Exp Ther. 2004 May 28 [Epub ahead of print] PMID: 15169827.

Selected Publications: Molecular basis of renal carcinogenesis

Peters, M.M., Jones, T.W., Monks, T.J. and Lau, S.S. Cytotoxicity and cell proliferation induced by the nephrocarcinogen hydroquinone, and its nephrotoxic metabolite 2,3,5-tris-(glutathion-S-yl)hydroquinone. Carcinogenesis, 18:2393-2401, 1997.
Towndrow, K.M., Mertens, J.J.W.M., Jeong, J.K., Weber, T.J., Monks, T.J., and Lau, S.S. Stress- and growth related gene expression are independent of chemical-induced prostaglandin E2 synthesis in renal epithelial cells. Chem. Res. Toxicol., 13:111-117, 2000
Lau, S.S., Monks, T.J., Everitt, J.I., Kleymenova, E., and Walker, C.W. Carcinogenicity of a nephrotoxic metabolite of the "non-genotoxic" carcinogen hydroquinone. Chem. Res. Toxicol., 14:25-33, 2001.
Yoon, H.S., Walker, C.L., Monks, T.J., and Lau, S.S. Transformation of kidney epithelial cells by quinol-thioethers via inactivation of the tuberous sclerosis-2 tumor suppressor gene. Molec. Carcinogenesis, 31:37-45, 2001.
Weber, T.J., Huang, Q., Monks, T.J., and Lau, S.S. Differential regulation of redox responsive transcription factors by the nephrocarcinogen, 2,3,5-tris-(glutathion-S-yl)hydroquinone. Chem. Res. Toxicol. 14: 814-821, 2001.
Yoon, H.S., Monks, T.J., Everitt, J.I., Walker, C.L., and Lau, S.S. Cell proliferation is insufficient but loss of tuberin is necessary for chemically induced nephrocarcinogenicity. Am. J. Physiol. Renal Physiol. 283: F262-F270, 2002.
Habib, S.L., Phan, M.F., Monks, T.J., and Lau, S.S. Reduced constitutive 8-oxogaunine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis, 24, 573-582, 2003.
Patel, S.K., Ma, N., Monks, T.J., and Lau, S.S. Changes in gene expression during chemical-induced nephrocarcinogenesis in the Eker rat. Molec. Carcinogenesis, 38, 141-154, 2003.
Yoon, H-S., Ramachandiran, S., Chacko, M.A.S., Monks, T.J., and Lau, S.S. The tuberous sclerosis-2 tumor suppressor modulates ERK and b-Raf activity in transformed renal epithelial cells. Am. J. Physiol. Renal Physiol., 286, F417-F424, 2004.

Selected Publications: Proteomics in Toxicology

Person, M.D., Monks, T.J., and Lau, S.S. An integrated approach to identifying chemically induced post-translational modifications using comparative MALDI-MS and targeted HPLC-ESI-MS/MS. Chem. Res, Toxicol., 16, 598-608, 2003.
Person, M.D., Mason, D.E., Liebler, D.C., Monks, T.J., and Lau, S.S. Alkylation of cytochrome c by (glutathion-S-yl)-1,4-benzoquinone and iodoacetamide demonstrates compound dependent site specificity. Chem. Res. Toxicology, Accepted pending revision, 6/30/04.

Selected Publications: Prostaglandin-mediated Cytoprotection

Weber, T.J., Lau, S.S., and Monks, T.J. PGE2 -mediated cytoprotection in renal epithelial cells. Evidence for a pharmacologically distinct receptor. Amer. J. Physiol., 273 (Renal Physiol. 42):F507-F515, 1997.
Weber, T.J., Monks, T.J., and Lau, S.S. DDM-PGE2-mediated cytoprotection in renal epithelial cells by a thromboxane A2 receptor coupled to NF-kB. Amer. J. Physiol. Renal Physiol, 278:F270-F278, 2000.
Towndrow, K.M., Jia, Z., Lo, H-H., Person, M.D., Monks, T.J., and Lau, S.S. 11-Deoxy-16,16-dimethylprostaglandin E2 induces specific proteins in association with its ability to protect against oxidative stress. Chem. Res, Toxicol., 16, 312-319, 2003.
Person, M.D., Lo, H-H., Towndrow, K.M., Jia, Z., Monks, T.J., and Lau, S.S. Comparative identification of prostanoid-inducible proteins by LC-ESI MS/MS and MALDI-TOF mass spectrometry. Chem. Res, Toxicol., 16, 757-767, 2003.
Jia, Z., Person, M.D., Shen, J., Hensley, S.C., Stevens, J.L., Monks, T.J., and Lau, S.S. GRP78/Bip is essential for 11-deoxy-16,16-dimethylprostaglandin mediated cytoprotection in renal epithelial cells. Am. J. Physiol. Renal Physiol. 287, F000-F000, 2004 Jun 29 [Epub ahead of print] PMID: 15226156

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