Lajos Szabo, Ph.D. Associate Research Scientist College of Pharmacy Pharmacology and Toxicology szabo@pharmacy.arizona.edu Arizona Cancer Center Room 4949 1515 North Campbell Avenue Tucson, Arizona 85724 Telephone: (520) 626-7818 Fax: (520) 626-5623

Professional Employment : May, 2002 to present: Associate Research Scientist Department of Pharmacology and Toxicology The University of Arizona, Tucson, AZ 85721 The Application of Combinatorial Chemistry for New Lead Quadruplex Ligands Jan., 2001 to April, 2002: Staff Scientist ChemRx, Discovery Partners International Inc. 9040 S. Rita Road #2338, Tucson, AZ 85747 Combinatorial Chemistry Dec., 1997 to Dec., 2001: Senior Scientist Systems Integration Drug Discovery Company 9040 S. Rita Road #2338, Tucson, AZ 85747 Combinatorial Chemistry June, 1990 to Dec., 1997: Research Scientist Department of Chemistry The University of Arizona, Tucson, AZ 85721 Solid phase synthesis of amide linked sugar amino acid oligomers. Towards the saccharopepdides combinatorial chemistry Opioid glycopeptide synthesis for penetration of the blood-brain-barrier Modification of nonsteroidal anti-androgen compounds Application of Schiff-base protected amino acids and various carbohydrates for synthesis of complex carbohydrates. New synthetic methodology Enkephalin glycopeptide analogues synthesis Synthesis of glycopeptide libraries October, 1986 to May, 1990: Research Associate Institute of Biochemistry L. Kossuth University, Debrecen, Hungary 4010 Preparation of acetals of hexopyranosides July, 1985 to Sept., 1986: Postdoctoral Fellowship National Institute of Health, National Institutes on Aging Gerontology Research Center, Macromolecular Chemistry Section Baltimore, MD 21224 Synthesis of prazosin analogue for ?1-adrenoceptors. Preparation of modified digitonin and cyclodextrins Sept., 1981 to June, 1985: Research Assistant Institute of Biochemistry L. Kossuth University, Debrecen, Hungary 4010 Synthesis of immunodeterminant oligosaccharides Professional Preparation 1981-1985 Ph.D., Biochemistry L. Kossuth University, Debrecen, Hungary 4010 1976-1981 M.S., Chemistry L. Kossuth University, Debrecen, Hungary 4010 The Last Five Publications: V. Krchnak, L. Szabo, J. Vagner: A solid phase traceless synthesis of quinoxalinones Tetrahedron Lett., 41(16) (2000) 2835-2838 C.T. Kriss, B.-S. Lou, L.Z. Szabo, S.A. Mitchell, V.J. Hruby, R. Polt: Enkephalin-based drug design: conformational analysis of O-linked glycopeptides by NMR and molecular modeling Tetrahedron: Asymmetry, 11 (2000) 9-25 T.D. Sutherland, G.C. Unnithan, J.F. Andersen, P.H. Evans, M.B.Murataliev, L.Z. Szabo, E.A. Mash, W.S. Bowers, R. Feyereisen: A cytochrome P450 terpenoid hydroxylase linked to the suppression of insect juvenile hormone synthesis Proc. Nat. Acad. Sci. U.S.A., 95 (1998) 12884-12889 L. Szabo, B.L. Smith, K. McReynolds, A.L. Parrill, E.R. Morris, J. Gervay: Solid phase synthesis and secondary structural studies of (1->5)-amide linked sialooligomers J. Org. Chem., 63 (1998) 1074-1078 S.A. Williams, T.J. Abbruscato, L. Szabo, R. Polt, V.J. Hurby: The effect of glycosylation on the uptake of an enkephalin analogue into the central nervous system Biology and Physiology of the Blood-Brain Barrier, Ed., Couraud and Scherman Plenus Press, New York, (1996) 69-77

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1515 North Campbell Avenue
Room 4949
Tucson, Arizona 85724
Phone: 520 626-5621