Evonne Rezler, Ph.D. Research Associate College of Pharmacy Pharmacology and Toxicology rezler@pharmacy.arizona.edu Arizona Cancer Center Room 4949 1515 North Campbell Avenue Tucson, Arizona 85724 Telephone: (520) 626-9494 Fax: (520) 626-5623

Education: The University of Sydney Bachelor of Science (Honors I) 1990-1995 PhD (Medicinal Chemistry) 1996-2001 Current Project: 2002- The current project involves a structural analysis of the various types of secondary DNA structures, such as G-quadruplexes, using molecular biology techniques and spectroscopy. The G-quadruplexes of interest can form in the guanine-rich nuclease hypersensitive elements that are located in the promotor regions of some oncogenes and their role may include transcriptional activation or deactivation of these oncogenes. Hence various drugs that can stabilise the specific G-quadruplexes formed in the different oncogenes are also being investigated. Previous Projects/Experience: PhD Project Novel bidentate diamine ligands and their corresponding chiral platinum(II) complexes were developed and synthesised and the interactions of these complexes with DNA were studied using computer based molecular modelling methods and direct binding to DNA and shorter oligonucleotides. Other Projects The waters of Australian caves were studied using analytical techniques and these water environments were modelled using computer simulations to gain an understanding of the development of caves and the impact of pollution on cave water systems. Hobbies: Netball and Windsurfing

Comments to Webmaster, Last Updated: July 2, 2002
All contents copyright © 2002. Laurence H. Hurley, Ph.D.

1515 North Campbell Avenue
Room 4949
Tucson, Arizona 85724
Phone: 520 626-5621