RESEARCH EXPERIENCE
2002-Present - Senior Postdoctoral Fellow, Arizona Cancer Center, Tucson, AZ
Mentor: Prof. Laurence H. Hurley
- Serine/threonine and tyrosine protein kinases are an important class of enzymes for the development of new therapeutics because of their involvement in processes associated with the progression of various types of cancers. Designed and synthesized potent, specific and selective dual c-kit and PDGFR tyrosine kinase inhibitors derived from tricyclic pyrimidine scaffolds and were found to be superior to Gleevec (STI571) in pancreatic cancer cells expressing PDGFR. Currently working on the synthesis of quinazoline containing aurora-2 kinase inhibitors involving palladium catalyzed aminations
2000-2002 - Postdoctoral Fellow, Arizona Cancer Center, Tucson, AZ
Mentor: Prof. Laurence H. Hurley
- Since recent studies have shown the biological relevance of chair type G-quadruplex as a transcriptional silencer in the c-MYC promoter, it is necessary to synthesize drugs that has therapeutic selectivity. Designed, synthesized and characterized a novel non-cytotoxic heterocyclic macrocycle that selectively binds to the c-MYC chair type G-quadruplex structure with nanomolar affinity. This binding ability results in the transcriptional control of c-MYC.
1995-2000 - Graduate Assistant, Indian Institute of Technology, Kanpur, India
Advisor: Prof. T.K. Chandrashekar
- Porphyrins and metalloporphyrins are important because of their role in treatment of cancer by photodynamic therapy. Developed efficient one step synthetic methodologies for heterocyclic macrocycles and characterized various new and novel macrocycles with different heteroatoms. Analyzed photo physical and structural properties of porphyrin macrocycles using UV-Visible and fluorescence, cyclic voltammetry and X-ray crystallography. Studied metal binding abilities of different porphyrin macrocycles
1993-1995 - Masters Research Assistant, Pondicherry University, Pondicherry, India
Advisor: Prof. J. Subramaniam
- Synthesized variety of heterocycle containing ligands and studied the properties of those copper complexes by EPR
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