A. Jay Gandolfi, Ph.D.

Curriculum Vitae
Table of Contents


[ Education] [ Major Field ] [ Academic & Professional Appointments ] [ Teaching ]
[ Honors, Awards, Prizes, Fellowships, Research Grants, etc. ] [ Service Activities ]
[ Publications ] [ Abstracts ] [ Scholarly Presentations ]


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November 2009

A. Jay Gandolfi, Ph.D.

Curriculum Vitae
             Birthplace: San Mateo, California
Birthdate:  December 11, 1946

A. Education:

1964-1966 College of San Mateo, San Mateo, California; Premedical

1966-1968 University of California, Davis, California; B.A., Chemistry

1968-1972 Oregon State University, Corvallis, Oregon; Ph.D., Biochemistry and Biophysics Minor - Toxicology and Pharmacology Doctoral Dissertation: Hexachlorophene: Its Absorption Distribution, Excretion, and Biotransformation in the Rat and Rabbit and In VitroInteraction with Rat Liver Microsomes. D.R. Buhler, Ph.D. - Major Advisor.

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B. Major Field:

Major effort is in research and teaching in the areas of biochemical pharmacology and toxicology with special emphasis on the mechanism(s) of toxicity.

Specific Areas:

1. Anesthesiology

Disposition of anesthetics
Organ-specific toxicity of anesthetics

2. Biotransformations

Dehalogenation mechanisms
Isolated cell and enzyme systems

3. Organ Specific Toxicity

Inhalation/Lung
Hepatic

Renal

4. Mechanisms of Toxicology

Mechanisms of cellular injury
Antidotes to chemical insults

5. In Vitro Toxicity

Systems Development
Extrapolation to whole animals

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C. Academic & Professional Appointments:

1968              University of California. Senior Research Project. Synthesis and purification of nitrogen mustard derivatives for cancer chemotherapy.
1968-1972    Oregon State University. USPHS trainee in the Environmental Health Sciences Center.
1972-1975    Mayo Clinic. Residency-postdoctoral position in the Department of Anesthesiology.

1974-1975     Mayo Research Fellow, Mayo Clinic, Anesthetic Metabolism by the Lung.

1975-1978     Battelle Pacific Northwest Laboratories. Senior Research Scientist.

1978-1983     University of Arizona. Research Assistant Professor of Toxicology and Research Associate in Anesthesiology.

1983-1985     University of Arizona. Assistant Professor of Anesthesiology and Pharmacology.

1985-1989     University of Arizona. Associate Professor of Anesthesiology and Pharmacology. Research Associate Professor of Pharmacology and Toxicology.

1989-             University of Arizona. Professor of Anesthesiology, Pharmacology, and Toxicology.

1993-1996     University of Arizona, Chairman, Graduate Program in Pharmacology and Toxicology.

1999-2007     University of Arizona.  Assistant Dean for Research and Graduate Studies, College of Pharmacy.

1999-             University of Arizona.  Professor, Department of Pharmacology and Toxicology, College of Pharmacy.

2000-2003     University of Arizona.  Acting Chair, Department of Pharmacology, Toxicology and Medicinal Chemistry, College of Pharmacy.

2003-             Chair, Department of Pharmaceutical Sciences, College of Pharmacy.

2007-             Associate Dean for Research and Graduate Studies, College of Pharmacy.

2009-            Professor, Division of Community, Environment, and Policy, Mel and Enid Zuckerman College of Public Health


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D. Teaching

Courses:

Anesthetic Metabolism and Toxicity Bloc: Lectures for Department of Anesthesiology; 1978, 1979, 1981, 1982, 1984, 1987, 1989, 1992, 1994, 1995, 35 Residents. Searle Life Support Systems; February 6­8, 1980. A short course in Anesthesiology/Neonatology.

Toxicology 454: Industrial Toxicology Lectures (Inhalation Toxicology, Biotransformation, Chemical Carcinogenesis); 1979, 1980.

Toxicology 596: Toxicology Seminar. Presented to the Toxicology and Industrial Hygiene Students. 10­15 Students. 1978­1981.

Toxicology 601: (Spectral Techniques), 1982.

Biotoxicology 602: (Lecture and Laboratory): Lectures (Lung, Inhalation Toxicology, Renal Toxicology, In vitro toxicology, biochemical pathology, hematotoxicity, (Laboratory Experiments); Absorption, distribution, biotransformation, liver toxicity, cell injury; 1978­present.

Pharmacology 550-Biochemical Pharmacology: Drug Metabolism and Disposition (Biotransformation Enzymes, Factors Affecting Biotransformation, Laboratory Experiments); 1978­1996, Special Topic 1997, Phase II, Special Topic 1998, 1999, Coordinator 2000-present.

Pharmacology 208: Drug Metabolism, University of California, Berkeley, Summer 1980­1994.

Environmental Toxicology 576: Instructor-Coordinator, 1980. Disposition of chemicals in environment, 1981. Inhalation Toxicology, 1982. Air Pollutants, 1983.

Pharmacology/Toxicology: Special Toxics, Independent Study. Environmental Toxicology, 1987.

Pharmacology 596: Student Seminar, Coordinator 1983­1989.

Immunotoxicology: Molecular mechanisms of metabolism. 1985. 30 Students.

Pharmacology 501/801: Medical Pharmacology, Drug Metabolism, 1987, 1994-1998, 2002, 80­130 Students. POPS - 1994, 1995. 75 students.

Molecular Pharmacology 551: Microtubule assembly, 1989.

Toxicology Special Topics: Literature Review. 1990. 2 Students.

Vet Sciences 443/543: Experimental Animal Methods. 1991 (1 hr), Animal research methods and ethics, 1992 (2 hr).

Pharmacy 471a: Absorption, distribution, excretion, biotransformation lectures, 1992, 2002-present.

Short Course in Toxicology:  National University, Mexico City, Pulmonary, Renal, and Cellular Toxicology, August 9-13, 1993.

CB10 597a: Mechanisms of Cancer Prevention. Chemoprotection against Cancer by Detoxification Enzymes, 1993.

Tox 610: In Vitro Toxicology, Use of renal slices, 1993.

Tox 195: Toxicology, The Poisons Around Us, 15 students-Spring, 1995; 18 students-Fall, 1995, 25 students-Fall, 1996, 20 students-Fall, 1997, 1998, 24 students, 1999, 25 students, 2000-present.

Tox 302: Undergraduate Environmental Toxicology, 50 students, 1995-2000.

Summer Minority Research Program:  Applying for Graduate School, 1994, 1995, 1996; General principles of toxicology, 8 students.

Biochem 494: Independent Study, 1996.

Center for Toxicology: High School Teacher's Workshop, Principles of Toxicology, June 1996, 8 teachers, (2 hr). 1998 Principles, Metal Toxicology, (3 hr). 1998 Insect Science Workshop - Toxicology, Risk Assessment (3 hr), 10 teachers.  1999 Risk Assessment, 12 teachers. 2000 Biotransformation. 2001 Basic Principles. 2002 Disinfectants.  2003 Teaching Environmental Toxicology.  2004 Teaching Basic Toxicology.  2004 PULSE Teachers: Superfund, Authorization, and Politics.  2006 Environmental Health and Toxicology Literacy.

Pharm 620:  Principle of Pharmacology, Careers in Pharmacology/Toxicology, 18 students, 1996.

PCOL 420, 421: Case Studies in Biochem Pharmacology.  3 sections, 12 students, 1999, 2000; 4 sections, 12 students, 1999-present.

PCOL 610: Molecular and Cellular Toxicology (Immunotoxicology) 2000-2002.  2003 Low-level arsenic toxicity.

PHSC 596H: Special Topics in Pharmaceutical Sciences.  Journal Review, 2 sessions, 2002, 2004.-present

PCOL 474:  Clinical Toxicology, 2 lectures - Role Biotranformation in Clinical Toxicology, 70 students, 2003-present.

Metal Toxicology:  Summer Minority Research Program, 10 students, 1999.

Colloquium:  Superfund Basic Research Program.  Coordinate 10-15 people, 2000-2003.  Co-coordinate, 2003-present.

SWES 518:  Introduction to Human Health Risk Assessment, Risk/Toxicity of Halo-Aliphatics, 30 students, 2002.

Chemistry 599:  Northern Arizona University.  Liver and Kidney Toxicity.  15 students, 2 hr, 2002.

PCOL 595b:  Science Writing/Strategy/Skills. 15 students.  Study Section Panel, 2002.

PCOL 573:  Experimental Models for In Vitro Toxicology.  8 students, 2004.

PCOL 630:  Proteosome Degradation/Signaling, 2 lectures, 20+ students, 2005-present.

Senior Research Projects

Dan Tinlin, 1990

Sheila Duffy, 1996

Vikas Patel, 1997

Jeffrey Catania, 1997-1998

Hugh Nguyen, 1997-1998

Ferleine Bautista, 1999

Kelly Dale, 2000-2001

Steve Weldon, 2002-2005

Sean McGinty, 2002-2003

Derek Dindal, 2003-2004

Erin Blomquist, 2004-2005

Nicole Lane, 2004-2005

Rachel Diaz, 2005-2007

Elyse Taylor, 2005

Andrew Hau, 2005-

Mahima Jain, 2006-2007

Michelle Wild, 2008-

Hio Lam Chao, 2008-

Thesis and Doctoral Committees:

M.S. in Physiology

Lynn Munoz – M.S. 2003.  Characterization of rabbit OAT1 and OAT3.

M.S. in Pharmacology:

Graduate Committee Member

F. Margaret Dingmann - M.S. - Pharmacology 1997.  Novel study of the effects of aprotinium on LLC PK cells.

Art Reigel - M.S. - Pharmacology, 1998. Effects of toluene on dopamine neurons and its implication in inhalant abuse.

Masters Degree – Applied Biosciences

Aaron M. Pershing, PSM, 2006.  Cryopreservation techniques for precision-cut tissue chip technology.

Elizabeth Arnold, PSM.  Alternative ocular testing of personal health care products.

M.S. in Toxicology:

Graduate Committee Member

Thomas Evans - M.S. - Toxicology 1979. Metabolism of melphlan.

Douglas Eisenstein - M.S. - Pharmacology 1979. Pyrrolizidine alkaloids: Extent of population exposure and prevention of toxic effects.

Barbara Larcom - M.S. - Toxicology 1979. Fate of nitrogen mustards, melphalan.

Mary Susan Connors - M.S. 1981. The isolated perfused rat liver - Viability and metabolism studies in an all-glass perfusion apparatus.

Dave Dutton - M.S. - Toxicology 1984. Mechanism of promotion in epidermal cells with TPA.

Debra Randall - M.S. - Toxicology 1984. Promotional effect of trichloroethylene on hepatocellular neoplasia.

Robert Nenad - Masters Candidate - Toxicology 1985. Effect of ranitidine and cimetidine on the disposition of fentanyl.

Laurie Goll - Masters Candidate - Toxicology - (Medical School). Acute renal failure: reversal with oxygen radical scavengers.

Kerry M. Barnhart - M.S. - Toxicology 1985. Activation of oncogenes by etiological agents.

Stephen Teo - M.S. - Toxicology 1985. Metabolism of chloramphenicol: Possible role in aplastic anemia and anemia and leukemia.

Lynnda Reid - M.S. - Toxicology 1990. Effect of benzene on IL­2 production in mice. Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity.

Jefferey Burgess, M.D. - M.S. - Toxicology 1993. Evaluation of the safety of self-contained breathing apparatus at high exertion levels.

Karen Duncan - M.S. - Toxicology 1995.  Mercury chloride induced apoptosis toxicity in renal cell lines.

Ira I. Chadnick - M.S. - Toxicology 1996.  Assessment of carbon monoxide exposure for a newspaper vendor during work at a busy traffic intersection.

Sheila Healy - M.S. - Toxicology 1997.  Arsenic methyl transferase enzymes in the guinea pig and rabbit.

Eric Wildfang - M.S. - Toxicology 1997.  Characterization of the arsenic methyl transferase in hamster liver.

Latressa Billings - Masters Candidate - Toxicology.  Metabolism of methyl styryl ketone.

Robert Kuester - M.S. - Toxicology 2001 - Strain specific hepatotoxicity of cadmium chloride.

Jacob Pritchett - M.S. - Toxicology 2001 - In vitro biotransformation of bisphenol A in human, mouse, and rat hepatocytes.

Hamid Badghisi - M.S. - Toxicology 2001 - Identification of styrene oxide aducts to hemoglobin using LCI MS/MS.

Laura Tiscareno – M.S. – Toxicology 2004 – Analysis of pancreatic disease by global  proteomic profiling.

Advisor/Co-Advisor

Matthew Miller - M.S. - Toxicology (advisor) 1979. Disposition of enflurane in the obese.

Richard Jee - M.S. - Toxicology (co-advisor) 1979. Halothane hepatotoxicity.

Carl Potter - M.S. - Toxicology (co-advisor) 1980. Renal toxicity of volatile fluorocarbons.

Lorrene Buckley - M.S. - Toxicology (co-advisor) 1980. Evaluation of the nephrotoxic effects of inhaled chlorotrifluoroethylene in the rat: A subacute study.

John MacDonald - M.S. - Toxicology (co-advisor) 1981. Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.

Frank Plescia - M.S. - Toxicology (advisor) 1981. The disposition and hepatotoxicity of 1,2-dibromoethane.

Kathy Cater - M.S. - Toxicology (co-advisor) 1982. An evaluation of the newborn mouse as a potential method for the bioassay of liver carcinogenesis using histological and histochemical markers.

Debra Jaffe - M.S. - Toxicology (advisor) 1982.  Genotoxicity of S-(trans-1,2-dichlorovinyl) -L-cysteine in renal tissue.

Ronald MacFarland - M.S. - Toxicology (co-advisor) 1982. Biotransformation of ethylene dibromide in extrahepatic tissues.

Richard Lind - M.S. - Toxicology (advisor) 1982. The role of endotoxin in halothane hepatotoxicity.

Janet Durham - M.S. - Toxicology (advisor) 1983. Hepatotoxicological evaluation of dantrolene sodium.

Stephen Glass - M.S. - Toxicology (advisor) 1983. Effect of cimetidine, ranitidine, and halothane on lidocaine pharmacokinetics.

Susan Meadows - M.S. - Toxicology (advisor) 1985. Persistent nephrotoxicity and renal tumor promotion in Swiss-Webster mice following exposure to dichlorovinylcysteine.

Betsy Corsino - M.S. - Toxicology (co-advisor) 1986. The pulmonary response induced by glass fibers.

Jennifer Phelps - M.S. - Toxicology (advisor) 1986. In vitro nephrotoxicity of cisplatin.

Majid Saidat Pajouh - M.S. - Microbiology and Immunology (co-advisor) 1986. Generation of halothane induced antibody in guinea pigs.

Leslie Pustilnik - M.S. - Toxicology (co-advisor) 1987. Pulmonary response to fibers in murine model of silicosis.

Lawrence Vernetti - M.S. - Toxicology (co-advisor) 1988. Effect of cyclosporin A on PtK2 cells and their cytoskeleton.

Cynthia Nowlin - M.S. - Toxicology 1992. Examination of mitochondria exposed to 1,2-dimethyl hydrazine using atomic force microscopy and other techniques.

Carmen Burton - M.S. - Toxicology 1994. Effect of glutathione on HgCl2 and NaAsO2 toxicity and uptake in rabbit renal cortical slices.

Andrea Payne - M.S. - Toxicology 1995.  Biotransformation of sevoflurane by rat neonates liver slices.

Mingli Chen - M.S. - Toxicology 1996.  Role of immune system in multiple halothane exposure induced liver injury.

Rainer Sell - M.S.  - Toxicology 1996.  Precision-cut rat liver slices: An in vitro model for the study of cold preservation injury.

Hong Bing Wei - M.S. Toxicology 1997.  Effect of GSH conjugates on uptake and toxicity in rabbit renal tubules.

Rodney Keith - M.S. Toxicology 1997.  Use of proton induced x-ray emission on uptake of metals in renal tissue.

Karen Turney - M.S. Toxicology 1999.  Selective activation of the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices.

Sarah Buffington – M.S. Toxicology 2008. Chronic exposure to monomethylarsonous acid induces changes in human UROtsa cells consistent with urothelial tumorigenesis.

Ph.D. in Pharmacology and Toxicology:

Graduate Committee Member

Carl Potter - Ph.D. - Pharmacology 1982.  Metabolic alterations of 1,2,7,8-tetrachlorodibenzo -p-dioxin to rats.

Mark Lafranconi - Ph.D. - Pharmacology 1983. Toxicology of the pulmonary epithelium.

Debra Jaffe - Ph.D. - Molecular Biology 1987. Mouse skin tumor initiation by ionizing radiation and the detection of dominant transforming genes.

Natalie Miller - Ph.D. - Pharmacology 1987. Mechanism-based inactivation of rat liver cytochromes P­450 by analogues of chloramphenicol.

Eric Stine - Ph.D. - Pharmacology 1987. Hepatotoxicity of dichlorobenzene isomers.

Ala El-Sisi - Ph.D. - Pharmacology 1987. Elucidation of the mechanism of vitamin A potentiation of carbon tetrachloride - included liver injury.

William Bellamy - Ph.D. - Pharmacology 1988. Mechanisms of doxurubicin drug resistance.

Pam Shubat - Ph.D. - Pharmacology - 1988. Pulmonary vascular toxicity of monocrotaline.

Scott Mobley - Ph.D. - Pharmacology - 1991. Effect of vitamin A on Kupfer cell toxicity.

Janet Firrilo - Ph.D. - Pharmacology - 1992. Disposition and toxicity of cobalt naphthenate.

Stacie Wild - Ph.D. - Pharmacology - 1993. Detection of pyrrole in the biotransformation of pyrridizidine alkaloids.

Walter Klimecki - Ph.D. - Pharmacology - 1994. P-glycoprotein: Expression and function in normal circulating leukocytes.

Greg Bogdan - Ph.D. - Pharmacology - 1994. A 450K arsenite binding protein of the rabbit liver cytosol.

Amy Ham - Ph.D. - Pharmacology - 1995. Antioxidant reactions of vitamin E in rat liver.

Torka Poet - Ph.D. - Pharmacology - 1995. Cytochromes P450 involved in the bioactivation of cocaine in the rat.

John-Michael Sauer - Ph.D. - Pharmacology - 1996. All trans-retinal modulation of chemical-induced lung and liver toxicity.

Kristina Hatlelid - Ph.D. - Pharmacology - 1996. In vitro investigation of the toxic mechanism of action of arsine on the erythrocytes.

Stephanie Born - Ph.D. - Pharmacology - 1996.  Characterization of canine cytochrome P450s 2B and 3A.

Steve Waters - Ph.D. - Pharmacology - 1996.  Neuropeptidases as sites of peptide regulation by dopaminergic drugs.

Russell Ingersol - Ph.D. - Pharmacology - 1996.  Central nervous system toxicity of manganese.

Edward Bilsky - Ph.D. - Pharmacology - 1996.  Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence.

Shannon Winski - Ph.D. - Pharmacology - 1997.  Metabolism and toxicity of sodium arsenite in human erythrocytes.

Kevin K. Divine - Ph.D. - Pharmacology - 1997.  Modeled speciation of Hg and endogenous thiols.  Their comparative toxicity in LLC-PK1 cells.

Maralee McVean - Ph.D. - Pharmacology - 1997 - Photoprotective activity of vitamin E in mouse skin.

Thomas Abbruscato - Ph.D. - Pharmacology - 1997.  Opioid peptide permeation across the blood-brain barrier.

Raymond Robledo - Ph.D. - Pharmacology - 1998.   Pulmonary toxicity of JP-8 jet fuel.

Karissa Adkins - Ph.D. - Pharmacology - 1998.  Glucocorticoid regulation of GM-CSF in bronchial epithelial cells.

Robert Landsman - Ph.D. - Pharmacology - 1999.  The human cannabinoid receptor expressed in CHO cells as a model to study cannabinoids.

Felix Ayala - Ph.D. - Pharmacology, 1999.  Tissue specificity for metabolism and toxicity of arsine and arsenate.

Qingbo Tang - Ph.D. - Pharmacology, 2000.  Nonopoid actions of dynorphin and neuropathic pain.

Di Bian - Ph.D. - Pharmacology, 2000.  Peripheral and spinal mechanisms of neuropathis pain in the rat.

Marc Oshiro - Ph.D. - Pharmacology, 2000 - Role of IL-6 signaling via the Jak/Stat pathway in human myeloma.

Daniel Mason - Ph.D.  - Pharmacology 2003.  Mass spectral analysis of hydroquinone adducts.

Beau Hansen - Ph.D. - Pharmacology 2005.  Proteomics methods for detection of modified peptides.

Husam Younis - Ph.D. - Pharmacology, 2001.  The molecular and cellular mechanisms of 1, 2-dichlorobenzene induced liver injury in F344 and S-D rats.

Jason Halliday - Ph.D. - Pharmacology 2002.  Comparative pharmacokinetic and disposition of a surrogate mineral hydrocarbon.

Jay F. Petrick - Ph.D.- Pharmacology 2003.  Arsenic: Metabolism, cytotoxicity, and toxigenomic alterations in the developing lung.

Shannon Conley – Ph.D. – Pharmacology 2005.  Selinium effects of on human trabecular meshwork.

Linda Manza - Ph.D.  - Pharmacology 2007.  Characterization of protein sumoylation in response to alkylation stress.

Lisa Ahern – Ph.D. – Pharmacology 2008.  Mechanism of hepatoprotectoin during hepatic cholestasis.

Taylor Jensen – Ph.D. - Pharmacology 2008.  Epigenetic remodeling during arsenical-induced malignant transformation.

Craig Fisher – Ph.D. – Pharmacology 2008.  Non-alcoholic fatty liver disease alters the three phases of hepatic drug metabolism.

Monica Yellowhair – Doctoral candidate.  Depleted uranium genotoxicity in human bronchial epithelial cells.

Matt Merrell – Doctoral Candidate – Induction of MRP2 in biliary cells.

Alicia Bolt – Doctoral candidate.  Genomic effect of inhaled dust on lung performace.

Paulina Gomez Rubio – Doctoral candidate.  Arsenic and lung function.

Advisor/Co-Advisor

Russell White - Ph.D. - Pharmacology (advisor) 1981. Genotoxicity of 1,2-dibromoethane.

Christopher Hassal - Ph.D. - Pharmacology (co-advisor) 1983. Biotransformation and nephrotoxicity of halogenated ethylenes.

John MacDonald - Ph.D. - Pharmacology (co-advisor) 1984. Reversal of hepatotoxicity with free sulfhydryl compounds.

Peter Smith - Ph.D. - Pharmacology (co-advisor) 1985. A novel organ culture for the study of hepatotoxicity.

Leslie Rylander - Ph.D. - Pharmacology (advisor) 1985. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins.

Paul Silber - Ph.D. - Pharmacology (co-advisor) 1986. Early indicators of renal proximal tubular injury.

Charles Ruegg - Ph.D. - Pharmacology (advisor) 1987. Mechanisms underlying regioselective acute tubular necrosis of renal proximal tubular segments.

Grushenka Wolfgang - Ph.D. - Pharmacology (advisor) 1989. DCVC induced cellular injury in rabbit renal cortical slices.

Nancy Shipp - Ph.D. - Pharmacology (co-advisor) 1990. Cardiotoxicity of chemotherapeutic agents.

Mary Stefaniak - Ph.D. - Pharmacology (co-advisor) 1990. Precision-cut rat lung slices.

Lawrence Vernetti - Ph.D. - Pharmacology (co-advisor) 1991. The effect of cyclosporin on cytokeratin intermediate filament phosphorylation.

Alan Brown - Ph.D. - Pharmacology (advisor) 1992. Generation and expression of halothane derived protein adducts in the guinea pig liver.

Hilary Sheevers - Ph.D. - Pharmacology (advisor) 1993. Site-specific injury due to transport mechanisms.

Stephen Waters - Ph.D. - Pharmacology (advisor) - 1993. In vivo and in vitro hepatotoxicity of M741.

Jon-Pierre Michaud - Ph.D. - Pharmacology (co-advisor) 1994. Precision-cut rat liver slice culture: An in vitro tool for assessing hepatotoxic interactions of organohalides.

Steve Hasal - Ph.D. - Pharmacology (co-advisor) 1998. A model for the multistage metabolism and nephrotoxicity of chlorotrifluoroethylene.

Donald Kirkpatrick - Ph.D. - Pharmacology 2003.  The effects of arsenic on the ubiquitin dependent proteolytic pathway.

Marjorie Peraza – Ph.D. – Pharmacology 2003.  Subcytotoxic inorganic arsenic effects on mitochondria in a human proximal tubule cell line.

Elizabeth Casarez – Ph.D. – Pharmacology 2004.  The influence of microorganisms on the bioavailability and toxicity of arsenic in soils.

Jeffrey Catania – Ph.D. – Pharmacology 2006.  Derivations of tissue slice technology as toxicological screening systems.

Tiffany Bredfeldt – Ph.D. – Pharmacology 2006.  Low-level arsenic toxicity in human bladder cells.

Kylee Eblin – Ph.D. – Pharmacology 2008. The effects of arsenical-induced reactive oxygen species on human bladder cells.

Ph.D./M.S. Committees - Other Disciplines

Janet Ludwig - Ph.D. - Agricultural Biochemistry and Nutrition 1981. Mechanism of the zinc protective effects against CCl4 hepatotoxicity.

Vikram Sinha - Doctoral candidate - Pharmaceutical Sciences - Pharmacokinetics of therapeutic agents.

Jeri Lott. Doctoral Candidate - Chemistry. An evaluation of biological markers for lead poisoning by proton induced x-ray emission.

Betsy C. Risendal - Ph.D. - Epidemiology 1998 - Cancer screening among urban Southwestern American Indian women.

Tarundeep Kakkar - Ph.D. - Pharmaceutical Sciences 1999 - Theoretical studies on enzyme inhibition kinetics.

Timothy Radabaugh - Doctoral Candidate - Genetics. Characterization of the human liver cytosolic arsenic reductase.

Lynn Munoz – M.S. – Physiology 2003. Characterization of OAT1 and OAT3 transporters.

Huadong Tang – Ph.D. 2005 – Pharmaceutical Sciences.  Allometric sealing for predicting human drug clearance.

Pilar Carranza – Ph.D. – Biological Sciences 2004.  Characterization of the morphology and functionality of OK cell model for intoxication by mercury. University of Nuevo Leon.

Roberta Bruhn – Ph.D. – Epidemiology 2008.  Relationship between glaucoma and selenium levels in plasma and aqueous humor. 

Zelieann Rivera-Craig – Ph.D. – Physiological Sciences 2009.  Characterization of residual ovarian tissue in mice following 4-vinylcyclohexene-induced ovarian failure.

Visiting Graduate Students:

Pilar Carranza (2000-2003) 2004, 2005 - Ph.D. - School of Medicine, University of Neuvo Leon, Mexico.  Effect of DMDS and DMSA on BSA transepithelial transport by OK cells exposed to HgCl2.

Mercedes Meza (2001-2004) – Ph.D. - Sonora Institute of Technology, Cuidad Obregon, Sonora, Mexico.  Arsenic drink water exposure and urinary excretion in Yaqui Valley, Sonora, Mexico.

Laura Cruz (2005) – Relationship between arsenic exposure and diabetes.

Andrea Diaz (2005) – Relationship between arsenic exposure and diabetes.

Jorge Alegria (2006) – Polymorphisms in apoptosis markers in response to DDT.

Research Associates:

Andrea Hubbard (Callis), Ph.D., Immunology, 1983­85.

Gregory M. Becker, Ph.D., 1984.

Shana Azri, Ph.D. 1987-1990.

Hanan Ghantous, Ph.D., 1988-1991.

Ken Hastings, Dr. P.H., 1988-1991.

Sharon J. McGuinness, Ph.D., 1991-1992.

Janet B. Clarke, Ph.D., 1991-1993.

Patricia Ijomah, Ph.D. - 1991-1993.

Sylvia Furst, Ph.D. - 1994-1996.

Jayanthika Wijeweera, Ph.D. - 1992-1997.

Alan Parrish, Ph.D. - 1996 - 1999.

Artemio Fernandez, Ph.D. – 2003

Clinical Research Fellows:

John B. Bentley, M.D., 1980­1981.

James D. Borel, M.D., 1981­1982.

Karen Knieriem, M.D., Ph.D., 1984­1985.

Edward Frink, M.D., 1987­1988.

David Nyman, D.O., 2000-2004.

Foreign Research Fellows:

Gustavo Martinez Zedillo, Ph.D., 1980­1981.

Tetsuro Fukui, M.D., 1982­1983.

Ola Dale, M.D., Ph.D., Fogerty Fellowship. 1985­1986.

Bjorn Hagen, M.D., Ph.D., 1990.

Bupesh Kaul, M.D., 1990-1991.

Gerard Stinjtjes; Free University, The Netherlands, 1991.

Claudia Escudero, Mexico, 2008-

Graduate School Referee (Foreign University):

Kathie Knights - Doctoral Candidate. The Department of Pharmacology. Flinders University, South Australia, 1984.

Soma Mitra – Doctoral Cadidate.  Role Nutrition in Clinical Expression Arsenic Toxicity.  Jadavpur University, India, 2003.


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E. Honors, Awards, Prizes, Fellowships, Research Grants, etc.:

Honors:

1968­1972   USPHS Trainee in Environmental Health and Science, Oregon State University.

1974­1975   Mayo Graduate School of Medicine Fellowship, Mayo Clinic.

1998           Founders Day Speaker, College of Medicine, University of Arizona, November 17, 1998.

2004           Education Award, Society of Toxicology.

 2007          Findlay E. Russell MD, PhD, Distinguished Citizen Award, College of Pharmacy

Research Grants:

1978-­1979   American Cancer Society, Institutional Cancer Research Grant. Role of "C-S" Lyase in halogenated vinyl cysteine toxicity. $3,000. Completed.

1978-­1980   National Cancer Institute, Organohalogen Carcinogenicity, Co-investigator. $189,410. Completed.

1979-­1982   National Institutes of Health, NIAMD, Studies of Inhalation Anesthetic Hepatotoxicity, Co-investigator. $178,000. Completed.

1979-­1980   Ohio Medical Products, Research Grant, Comparative Biotransformation of Ethane and Halothane in Obese Patients, Co-Investigator. $30,000. Completed.

1980           Biomedical Research Support Grant, College of Medicine, University of Arizona, Detection method for determination of fentanyl and its metabolites, Co-Investigator. $4,000. Completed.

1980            Biomedical Research Support Grant, College of Pharmacy, University of Arizona, Mechanism of sulfhydryl-type therapeutic agents in counteracting chemically induced liver toxicity, Co-Investigator. $6,000. Completed.

1980-­1982   National Institute of Health, NIAMD, Supplemental Grant -Studies of Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $3,000. Completed.

1983             Norwich Eaton, Pilot Grant, Hepatotoxicity of Dantrolene Sodium, Co-Investigator. $1,000. Completed.

1983             Perkin Elmer, Pilot Grant, Utilization of Flame Photometry for Ca Analyses, Investigator. $1,500. Completed.

1981-­1984   Janssen Pharmaceutica, Inc. Clinical evaluation and pharmacokinetics of sufentanil, Co-Investigator. $24,000. Completed.

1982-­1987   National Institute of Health, NIAMD, Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $570,000. Completed.

1982-­1984   Ohio Medical Products, Determination of the impurities in "yellow" Forane, Investigator. $25,000. Completed.

1984-­1985   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins. Investigator. $20,000.

1984            Biomedical Research Support Grant, College of Medicine, University of Arizona, Thin tissue slicer apparatus and studies. Co-Investigator. $8,000. Completed.

1984-­1987   National Institutes of Health, NIEHS. Animal Models of Alcohol-Related Cancers, Co-Investigator. $300,000.

1983-­1984   University of Arizona, Institutional Research Grant, American Chemical Society. Ethanol and Esophageal Carcinogenesis. Co-Investigator. $8,000.

1984             Deborah Heart and Lung Center. Metabolism of halothane in cyanotic and acyanotic pediatric cardiac patients. R.A. Moore (Investigator), Co-Investigator. $5,000. Completed.

1985-­1986   Janssen Pharmaceutica, Inc. Evaluation and pharmacokinetics of sufentanil in renal failure patients. Co-Investigator. $20,000. Completed.

1985-­1986   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for nephrotoxicity. Investigator. $17,000. Completed.

1985-­1988   NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $276,000. Completed.

1985-­1989   NIEHS. Methods of development to assess human metabolism of chemical xenobiotics. Co-Investigator. $1.2 Million. Completed.

1985-­1986   NIH. Fogarty International Research Fellowship. Volatile Anesthetics. Interaction with other drugs. Co-Investigator. $30,000. Completed.

1986-­1987   University of Arizona. Small Grants Program. The cytoskeleton as a target for toxic agents. $5,000. Completed.

1986-­1987   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules and positional renal slices for nephrotoxicity. Investigator. $17,000. Completed.

1987-­1988   Johns Hopkins Center For Alternatives to Animal Testing. Evaluation of precision-cut positional renal slices for nephrotoxicity studies. Investigator. $17,000. Completed.

1987-­1990   NIH, NIDDK. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $367,000. Completed.

1987-­1991   NIH, NIGMS. In Vitro Toxicology: Precision Tissue Slice Technology. Co-Principal Investigator. $528,000. Completed.

1988-­1989   Maruishi Pharmaceutical Co., Japan. Disposition and toxicity of sevoflurane. Co-Investigator. $20,000. Completed.

1988-­1989   Upjohn Company. Methods development towards establishment of an in vivo organ slice based tissue bank for the assessment of metabolism of chemical xenobiotics. Co-Investigator. $15,000. Completed.

1988-­1992   NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $467,000.

1988-­1989   Arizona Kidney Foundation. Toxic effects of cyclosporin on the cytoskeleton of renal cells. Co-Investigator. $6,570. Completed.

1989-­1991   NATO (CRG). Drug Interactions/Anesthetics. Co-Investigator. $5,000. Completed.

1989-­1994   NIH P01. Renal Handling of Organic Ions. In vitro renal toxicity: role of transport. Co-Investigator. $450,000.

1990-1992   NIEHS. Use of precision-cut tissue slices for interactive toxicity studies. Co-Investigator, $240,000. Completed.

1990-­1993   NIH, NIGMS MARC Program. Society of Toxicology. Co-investigator 5%. $74,408. Completed.

1990-1993   NIH NIGMS. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $424,000.

1991-1996   NIEHS. Precision Tissue Slice Technology. Co-Principal Investigator. $540,000.

1991-1994   Arizona Disease Control Commission. Cultured Myocardial Slices as an Alternative In Vitro Tool for Toxicity Evaluation. Co-Investigator. $75,000.

1992-1995   NIEHS. Interactive toxicity studies of chemical waste dumps using renal cortical slices. Investigator. $300,000.

1992-1995   NIEHS. Xenobiotic metabolism in cryopreserved human liver slices. Co-Investigator. $362,000.

1993-1998   NIEHS.  Studies of chemical disposition in mammals.  Co-Investigator 5%, Year 1 - $314,824, total $1,734,000.

1994            Procter & Gamble. Examining idiosyncratic chemical reactions.  Co-Investigator.  $78,125.

1995-2000   NIEHS.  Metal-metal interactions in the kidney.  Investigator, $85,000/yr, $425,000 total.

1997             Colgate-Palmolive Visiting Professorship, Indiana University, $12,000.

1997-1999   Procter & Gamble.  Use of confocal microscopy to study toxic events in precision-cut tissue slices. $82,000.

1997-2002   NIEHS.  Hepatoprotective mechanisms of DMSO.  Investigator, $107,000/yr, total $321,000.

1997-1998   Ohmeda, Inc.  Hypersensitivity of compound A.  $14,500.

1997-1998   Ohmeda, Inc.  Sequential biotransformation and toxicity of compound A in tissue slices.  $39,000.

2000-2005    Southwest Hazardous Waste NIEHS Superfund, Principal Investigator.  $1.6 M/yr.

2000-2005    NIH Clinical Research Curriculum Award, Co-Director. $185,000/yr.

 2001-2003   NIEHS.  Development of toxicity screen from transgenic mice with fluorescent protein markers.   Principal Investigator. $120,000.

 2001-2005   Department of Defense (Algan-P.I.).  Dynamic Tissue Culture System from Prostate Biopsy Specimens.  Co-Investigator. $510,000.

 2002-2003   NSF.  Arsenic in Biology and Medicine.  Principal Investigator. $17,250.

 2002-2005   NCI.  Tissue Chips for Toxicology Evaluation.  Principal Investigator. $151,414/yr.

 2002-2004   USGS/NIWR (Field-P.I.).  Agricultural Chemicals as a Major Non-Point Source of Arsenic: Microbial Transformation of Organic Arsenicals.  Co-Investigator. $69,000/yr.

2003  NIEHS Southwest Environmental Health Sciences Center (Interim Director) $870,000/yr (1999-2000).

2003-2006  NIH Optical Spectroscopy of Ovarian Cancer (Urs Utzinger, PI).  Co-Investigator.  $250,000/yr.

2003-2008  Prostate Carcinoma: Invasion and Metastasis Factors (Raymond Nagle, PI).  Core Leader.  $75,000/yr.

Training Grants

NIEHS.  Training Program in Environmental Toxicology. Participant.

NIGMS. Clinical Pharmacology Research Training, Participant.

NIEHS.  Toxicology Training Grant, Participant. $150,000/yr.

NIEHS.  Training Grant for Environmental Science Graduate Students in Toxicology.  $172,000.

Postdoctoral Grants

1989-­1991  Azri, Shana. Carbon tetrachloride: In vitro slice toxicology. NIH National Research Science Award.

1997-1999  Parrish, Alan.  Alterations in cadherin/catenin complexes by oxidative stress in precision-cut liver slices. $67,000.

Center Grants

1993-           NIEHS, Southwest Environmental Health Sciences Center, Cell Injury Research Program Director, Year 1 $700,000.

1999-2004   NIEHS Southwest Environmental Health Science Center, Research Program Director. $1 M/yr.


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F. Service Activities

1. University and College Committees:

College of Medicine

College of Medicine, Administrative Review Committee, Department of Anesthesiology, 1979,  1985.

College of Medicine, Medical Student Interviewer, 1983-1987.

College of Medicine, DAR Review Committee, University of Arizona, 1985.

Biomedical Research Laboratories Management Committee, 1985-1999.

College of Medicine, Student Progress Committee, 1987 1988.

Dean’s Research Council, College of Medicine, 1991-1995, Ad Hoc 1995-2000.

Committee of Nine, 1993-1995.

Search Committee, Chair, Department of Anesthesiology, 1994-1995.

Promotion and Tenure Committee, 1996-1999.

Advisory Board, Circulatory Science Program, 1995-1997.

LCME Accreditation, Research/Graduate Education Subcommittee, 1996-present.
 
Architect Selection Committee, Life Sciences North Shell Space, 1996.

Life Science North Construction Committee, 1997.

Chair, BRL Space Committee 1996-1997.

Advisory Board, University of Arizona Pain Institute, 1996-1999.

Chair, COM/DRC Space Committee 1997-1999.

Long Range Planning/Dean’s Research Council Sub-Committee for College of Medicine Strategic Plan, 1997-1999.

Chair, Promotion and Tenure Committee, 1998-1999.

Donald Shear Memorial Student Award Committee, 1999-present.

College of Medicine, Department of Pharmacology

Graduate Program in Pharmacology and Toxicology, Review Committee, 1987 1988.

Department of Pharmacology, Research Review Committee - Chairman, 1987.

Academic Program Review Self Study Committee, 1998.
   
College of Medicine, Department of Anesthesiology

Department of Anesthesiology, Promotion and Tenure Committee, 1986-2000.

Chair, Promotion and Tenure Committee, 1994.

Director, Anesthesiology Research Laboratories, 1985-1998.

Executive Committee, 1996-1998.

Graduate Program in Pharmacology and Toxicology

Coordinate Recruiting in State and Recruiting Information, 1989-1990.

Chair, Graduate Program in Pharmacology and Toxicology, 1993-1996.

Graduate Program Executive Committee, 1993-2000.

Self Study Committee for Pharmacology and Toxicology IDP and Academic Program Review 1997-1998.

Academic Program Review Self Study Committee, 1997-1998.

College of Pharmacy

College of Pharmacy, Masters of Toxicology Admissions Committee, 1984-1999.

College of Pharmacy, Department of Pharmacology/Toxicology, Committee for Reorganization of Toxicology Courses Content, 1984.

Chair, Re-Organization Committee for College Departments and Graduate Programs, 2000.

Department Chair (Pharmacy Practice and Science) Search Committee, 2003-

Chair, Space Committee, 2005-present.

Pharm Practice/Science Search Committee, 2007-present.

Center for Toxicology

Organizing Committee, Fourth International Meeting, Biological Reactive Intermediates, Tucson, Arizona, 1990.

Organizational Committee 1991.

National Advisory Board Meeting, "In vitro toxicology studies", April 8, 1991.

Organizing Committee, A Joint United States/Mexico Conference, Fate, Transport, and Interactions of Metals, Tucson, AZ, 1993.

Organizing Committee, 5th International Society for the Study of Xenobiotics, Tucson, AZ, 1993.

Organizing Committee.  Modulation of Chemical Toxicity and Risk Assessment.  Meeting in Tucson, AZ, June 1996.

Superfund

Superfund - University of California, Berkeley Superfund Program.  External Advisory Board, 1996-1998.

Organizing Committee. Metals-Risk considerations for environmental health and safety. Meeting in Tucson, AZ, January 8-9, 1998.

Steering Committee, United States/Mexico Conference on hazardous waste management and technologies, Tucson, AZ, August 9-11, 1998.

Program Committee, EPA/Tri-University Superfund Research Programs.  University of California, Berkeley, CA, October 26-27, 1998.

Organize and host 2002 Superfund Basic Research Program Annual Meeting, University Marriott Hotel, Tucson, AZ  November 3-6, 2002.

Program Committee.  Superfund Basic Research Program Annual Meeting, Dartmouth College, November 2003.

Program Committee.  Superfund Basic Research Program Annual Meeting, University of Washington, November 2004.

Advisory Board, Dartmouth Superfund Program, 2003-present (Chair, 2005-present).

Advisory Board, University of Washington Superfund Program, 2005-present (Chair, 2007-present).

Advisory Board, Texas A&M Superfund Program, 2005-2008.

Advisory Board, OSU-PNL Superfund Program, 2007-present.

Superfund Director’s Association, President, 2005-2007.

Program Committee, NIEHS Superfund/Worker Training 20th Anniversary, April 2008.

Arizona Health Sciences Center

Bobbi Olson Building - Research Themes Committee, 2001-2002.

University

Selection Committee UA/VA Veterinarian 1989.

University Animal Care Committee, 1987 1989.  Chairman 1989-1991.

DAR Expansion and Facilities Committee, 1987-1991.

Earth Day 20th Anniversary, April 25, 1990.  Chemicals in the Environment.  Presented "Why We Need Chemicals".

Academic Review Committee of Department of Anatomy, Co-Chair, 1991-1992.

Tucson Veterans Administration, Research and Development Committee, 1993-1995.

Graduate Program in Pharmacology and Toxicology, Chairman, 1993-1996.

Associate Director, University of Arizona Superfund Program, 1994-1999.

Director, University of Arizona Superfund Program, 2000-present.

Academic Program Review.  Physiological Sciences Interdisciplinary Graduate Program, May 1996.

Tri-College Promotion and Tenure Committee, Chair, 1996-1997.

Academic Program Review Self Study Committee, Graduate Program in Pharmacology and Toxicology, 1997-1998.

NCA 2000 University Accreditation Steering Committee, 1998-2000.

Search Committee, College of Sciences Dean, 1999.

Search Committee, Vice President for Health/Dean-College of Medicine, 2000-2001.

Special Committee for Defining Vice President for Health Goals, October-December, 2000.

Proposition 301 Subcommittees for Water and Biotechnology, November-present, 2000.

Associate Dean’s Advisory Group (to VP Research), 2002-2006.

IBSB Director Oversight Committee, 2003.

IBSB Director Search Committee, 2003-2004

Undergraduate Biology Research Program (UBRP), Selection Committee, 2004-

Committee on Soft Money for Faculty Salaries, 2004-

University Compensation Advisory Committee, 2003-2004.

Undergraduate Biology Research Program (UBRP) – Data Blitz Presentation, Feb 2005.

University of Arizona, Honorary Degrees Committee, 2006-2007.

IMSB Advisory Commettee, 2006-present.

GIGA Award, Grad College, 2006-2008.

Faculty Senate, Research Policy Committee, 2008-present.

U.S. Mexico Binational Center

Director, 2005-

Organizing Committee, Inaugural Binational Meeting, March 12-14, 2007.

Organizing Committee, San Luis Potosi Workshop, June 2007.

Organizing Committee, Cuidad Obregon Workshop, October 2008.

American College of Toxicology, Symposium Coordinator, Regional Toxicology, Tucson, November 2008.

International

Co-Chaired/Coordinated American/Japanese Conference on Arsenic in Medicine and Biology, December 11-15, 2002, Honolulu, Hawaii.

2.  National Committees

Member Delphi Group, Metabolism and Toxicity, Scientific Advisory Board to the Association of University Anesthetists, 1980.

NIEHS.  Site Review Member.  Environmental Health Science Centers Grants, Nashville, February, 1984.

Biological Sciences Section Committee.  American Association for the Advancement of Science (SCIENCE), 1985 1987.

American Society for Pharmacology and Experimental Therapeutics.  Committee on Core and Use of Research Animals, 1991-1994.

Organizing Committee, Fifth Northern American ISSX Meeting, Tucson, AZ, Oct. 17-21, 1993.

Johns Hopkins Center for Alternatives to Animal Testing, Advisory Board, 1995-2008.

International

EVCAM/CAAT Workshop Participant. Mechanisms of Toxicity, April 1996.

USAID TIES Meetings
    Mexico City, 2004
    Ensenada, Baja California, Mexico, 2005

Society of Toxicology

Appointed Positions

Program Committee, 1983-­1986.

Public Relations Committee, Mechanisms of Specialty Section, 1981-­1984.

Refresher Course on Endotoxins, Coordination Committee, 1984 Meetings.

Fluorinated Volatile Anesthetic Symposium Organizer, Coordinator, Chairman, 1984 Meetings.

Technical Committee, 1986-­1988.

Tox 90's Education Issue Ad Hoc Committee, Chairman, 1988-1991.

Undergraduate Toxicology Ad hoc Committee, 1990-1994.

Nominating Committee, Mechanisms, Chair, 1991.

Toxicology Education Foundation, 2000-2002.

Board of Publications, 2005-2009; Chair 2008-2009.

Elected Positions

President, Mechanisms Specialty Section, 1989-­1990.

Vice President, Mechanisms Specialty Section, 1988-­1989.

Vice-President Elect, Mechanisms Specialty Section, 1987-­1988.

Secretary-Treasurer, Mechanisms Specialty Section, 1984-­1986.

Education Committee, SOT, 1988-­1991.

Nominating Committee, SOT, 1992-1994.

Secretary, Society of Toxicology, 1997-2000.

Awards Committee, 2007-2009

3. Additional Professional Activities:

Professional Societies: (member since)

Society of Toxicology (1976)

American Society for Pharmacology and Experimental Therapeutics (1980)

Arizona Society of Anesthesiologists (1982)

American Society of Anesthesiologists (1982)

International Society for the Study of Xenobiotics (1982)

American Association for the Advancement of Science (1982)

American Association of Liver Diseases (1990)

Editor:

MECHANISMS Newsletter (Society of Toxicology), 1982-­1985.

Associate Editor:

Toxicology Applied Pharmacology, 1986-1994.

In Vitro Toxicology, 1986-present

Area Editor:

Drug Chemical Toxicology, 1986-present.

Editorial Advisory Board:

Life Sciences, 1984-1993

In Vitro Toxicology, 1986-2001

Drug and Chemical Toxicology, 1983-­1985

CRC Press. Molecular and In Vitro Toxicology, 1987-1996

Toxicology Applied Pharmacology, 1997-2000

Cell Biology and Toxicology, 1998-

Toxicology 2003-

Reviewer for following journals:

Life Sciences

J. Pharmacology and Experimental Therapeutics

Toxicology Applied Pharmacology

Drug Metabolism and Disposition

Chemical Biological Interactions

Biochemical Pharmacology

Molecular Pharmacology

Anesthesiology

Toxicology

Reviews of Contamination and Toxicology

Toxicologic Pathology

Environmenatl Health Perspectives

Sections Chaired National Meetings:

Organohalogen Section, Federation Meetings, Anaheim, California, 1980.

Renal Pharmacology and Toxicology, American Society Pharmacology and Experimental Therapeutics and Pharmacology Society of Canada, Calgary, Alberta Canada, 1981.

General Toxicology, Society of Toxicology, Las Vegas, Nevada, 1983.

Liver, Third International Congress on Toxicology, San Diego, 1983.

Fluorinated Volatile Anesthetic Symposium, 1984 Society of Toxicology Meetings.

Refresher Course on Endotoxins, Coordination Committee, Society of Toxicology 1984 Meetings.

Renal Toxicology, Society of Toxicology, 1985 Meetings, San Diego.

Mechanisms of Renal Toxicology, (Co-Chair), Society of Toxicology, 1989 Meetings, Atlanta.

Forum for New Investigators. NIH funding for new investigators. Society of Toxicology, February 27, 1991.

Mechanisms of Renal Toxicity, Society of Toxicology, 1992, Poster-Discussion Session, Co-Chair.

In Vitro Models: Liver, Society of Toxicology, 1993, Poster-Discussion Session, Co-Chair.

Toxicology Information via Use of Precision-Cut Tissue Slices, Society of Toxicology, 1994, Poster-Discussion Session, Co-Chair.

Modulation of Chemical Toxicity and Risk Assessment. Natural toxicants in foods, Tucson, AZ, June 1996.

Formation and Toxicities of Mono- and Diepoxides.  Mountain West SOT, Salt Lake City, October 4, 1996.

International Consortium for the Environment.  Water Quality Session, San Antonio, TX, March 11-15, 2000.

In Vitro/Animal Alternatives Model.  Session Chair.  Society of Toxicology Annual Meeting, Baltimore, MD.  March 22, 2004.

Plenary Discussion Session:  “Integrating Research Approaches Across Disciplines”, NIEHS Superfund Annual Meeting, University of Washington, November 2004.

Gene Regulations: Metals.  Session Chair.  Society of Toxicology Annual Meetings, New Orleans, LA.  March 8, 2005.

SBRP Annual Meeting, Colloquium: Visions for the future.  Durham, NC, December 5, 2007.

Regional Issues in Environmental Toxicology (organizer and chair) American College of Toxicology, Tucson, AZ, November 9-12, 2008.

Commentator at National Meetings:

International Anesthesia Research Society, Reno, Nevada, March 9­13, 1980.

Renal Pharmacology and Toxicology, Round Table Discussion, Pharmacologist 23:189, 1981.

Gull Harbour Anesthesia Toxicity Symposium, June 25­27, 1982. Gull Harbour, Manitoba, Canada.

Third International Conference on Molecular and Cellular Mechanisms of Anesthesia, Workshop on Metabolism and Toxicity of Anesthesia. University of Calgary, Calgary, Alberta, Canada, June 13­15, 1984.

American Society of Anesthesiologist, Discussant, Drug Disposition and Anesthetic Action, Atlanta, October 1996.

15th Annual International Society of Exposure Analysis.  “Exposure to Arsenic” session.  Panelist.  Tucson, AZ  November 1-3, 2005.

Consultantship:

Battelle, Pacific Northwest Laboratories, Consult in area of the biochemistry and biomedical pharmacology of fossil fuel pollutants. 1978-­1979.

Gibson-Stephens Neuropharmaceuticals, Inc., Tucson, AZ, Toxicology- Biotransformation, 1982-present. 1978-­1979.

Anaquest, BOC Technical Center. Toxicology. 1989-1996.

3M Company 1997-present.  Halocarbon Toxicity.

Grant Reviewer:

Ad Hoc Reviewer. Clinical Sciences Study Section, National Institutes of Health. September 17, 1984.

Ad Hoc Reviewer. March of Dimes. Anesthetics and Birth defects. July 3, 1984.

National Science Foundation, 1988.

Arizona Kidney Foundation, 1989.

Ad Hoc Reviewer. Toxicology Study Section. National Institutes of Health. February 1990.

Johns Hopkins CAAT Awards, 1988, 1990, 1992, 1995-present.

Toxicology Study Section. National Institutes of Health. October 1990- 1994.

U. S. Department of Veterans Affairs, 1994.

John Sealy Memorial Endowment Fund, University of Texas at Galveston, 1991, 1993, 1994, 1995, 1996, 1997, 1998.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, February 1995.

External Reviewer, Toxicology Study Section, National Institutes of Health, June 1995.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, June 1996.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, March 1998, June 1998.

NSF Grant Reviewer, March 2001.

Ad Hoc Reviewer, NIEHS, K03 Awards, May 2001.

Ad Hoc Reviewer, Alcohol-Toxicology Study Section, February, October 2002.

NIH Special Emphasis Panel, “High throughput molecular screening assay development.” August 5-6, 2004.

Colgate Palmolive Alternative Animal Testing.  Reviewer – Society of Toxicology.  September 2005.


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G. Publications:

A. Books

1. Comprehensive Toxicology, Elsevier, AJ Gandolfi, CA McQueen, IG Sipes - Editors-in-Chief. 12 Volumes, 374 Chapters, 8000 pages, 1996-1997.

2.  Comprehensive Toxicology, Elsevier-Academic Press, IG Sipes, CA McQueen, AJ Gandolfi.  Volume 14.  Cellular and Molecular Toxicology (Vanden, Heuvel, Greenlee, Perdew, Maltes) 644 pages, 2002.

B. Bookchapters

1.  Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Third Edition, pp. 64-99, 1986.

2.  Gandolfi AJ, Hubbard, AK, and Nunn JF. Hepatic and renal toxicity of inhalational anaesthetics: metabolic effects of nitrous oxide. In: General Anesthetics, 5th Edition, Nunn JF, Utting JE, Brown BR (editors) Butterworth, Publishers, Sonehan, MA, 1988, pp. 86-95.

3.  Ruegg CE, Wolfgang GHI, Gandolfi AJ, Brendel K, and Krumdieck CL. Preparation and utilization of positional renal slices for In Vitro nephrotoxicity studies. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, 1988.

4.  Smith PF, Fisher R, McKee R, Gandolfi AJ, Krumdieck CL, and Brendel K. Precision-cut liver slices: A new in vitro tool in toxicology. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, pp. 93-130, 1989.

5.  Hubbard AK, Roth TP, and Gandolfi AJ. Immunological methods for investigating the mechanisms of halothane hepatotoxicity. In: Hepatotoxicity (Meeks, Bull, Editors) CRC Press, pp. 647-665, 1991.

6.  Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Fourth Edition, 1990.

7.  Clarke JB and Gandolfi AJ. Volatile anesthetics mechanisms of potential hepatotoxicity. Clinical Anesthesia Updates. Barash PG, Cullen BF, Stoelting RK, Editors), J.B. Lippincott Co, Philadelphia, Volume 3, pp. 1-10, 1992.

8.  Clarke JB, Lind RC, and Gandolfi AJ. Mechanisms of Hepatotoxicity of Volatile Anesthetics. In: Advances in Anesthesia 10:219-246, 1992 (Stoelting RK, Barash PG, Gallagher TJ, editors).

9.  Brendel K, Fisher RL, Krumdieck CL, and Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. In: In Vitro Biological Systems Volume 1, Tyson CA and Frazier JM (Editors), Academic Press, San Diego, pp 222-230, 1993.

10. Gandolfi AJ, Brendel K, and Fernando Q. Preparation and use of precision-cut renal cortical slices in renal toxicology. In: Methods in Renal Toxicology (RK Zalups and LH Lash, editors), CRC Press, Boca Raton, FL, pp. 109-122, 1996.

11. Clarke JB, Lind RC, and Gandolfi AJ. Biotransformation and hepatotoxicity of inhalation anesthetics. In: General Anesthesia (Brown BR, Prys-Roberts C, Editors), Butterworth-Heinemann, Oxford, Sixth Edition, 1995.

12. Furst SM and Gandolfi AJ. Immunologic mediation of chemical-induced hepatotoxicity. In: Toxicology of the Liver (William Hewitt and Gabriel Plaa, editors), Raven Press, pp.259-295 1995.

13. Kirkpatrick DS and Gandolfi AJ.  In vitro techniques in screening and mechanistic studies: organ perfusion, slices, and nephron components.  In: Toxicology and the Kidney - Third Edition (J.B. Tarloff and L.H. Lash, Editors) Chapter 4, 40 pages, 2004.

C. Refereed Journal Articles

1.  Bottini AT, Dev V, Dowden BF, and Gandolfi AJ. Structure activity relationships of ethylenimines. VIII. Optically active methyl-substituted ethylenimines. J Med Chem 12:32-333, 1969.

2.  Gandolfi AJ and Van Dyke RA. Dechlorination of chlorethane with a reconstituted liver microsomal system. Biochem Biophys Res Comm 53:687-692, 1973.

3.  Gandolfi AJ, Nakaue HS, and Buhler DR. Effect of hexachlorophene on hepatic drug-metabolizing enzymes in the rat. Biochem Pharmacol 23:1997­2003, 1974.

4.  Van Dyke RA and Gandolfi AJ. Studies on irreversible binding of radioactivity from (14C) halothane ro rat hepatic microsomal liids and protein. Drug Metab Disp 2:469-476, 1974.

5.  Gandolfi AJ and Buhler DR. Biliary metabolites and enterohepatic circulation of hexachlorophene in the rat. Xenobiotica 4:693-704, 1974.

6.  Van Dyke RA and Gandolfi AJ. Characteristics of a microsomal dechlorination system. Mol Pharmacol 11:809-817, 1975.

7.  Van Dyke RA and Gandolfi AJ. Anaerobic release of fluoride from halothane: relationship to the binding of halothane metabolites to hepatic cellular constituents. Drug Metab Disp 4:40­44, 1976.

8.  Widger AL, Gandolfi AJ, and Van Dyke RA. Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anesthesiology 44:197-201, 1976.

9.  Tinker JH, Gandolfi AJ, and Van Dyke RA. Evaluation of human plasma bromide levels in patients following halothane anesthesia: time correlation with total halothane dosage. Anesthesiology 44:194­196, 1976.

10. Wood CL, Gandolfi AJ, and Van Dyke RA. Lipid binding of a halothane metabolite: in vitro comparison with lipid peroxidation. Drug Metab Disp 4:305­313, 1976.

11. Gandolfi AJ and Buhler DR. Metabolism of hexachlorophene in the rabbit: excretion, tissue distribution and characterization of the urinary glucuronide conjugate. J Agricul Food Chem 25:21­25, 1977.

12. Blitt CD, Brown BR Jr., Wright BJ, and Gandolfi AJ, Sipes IG. Pulmonary biotransformation of methoxyflurane: An in vitro study in the rabbit. Anesthesiology 51:528­531, 1979.

13. Maiorino RM, Sipes IG, Gandolfi AJ, and Brown BR Jr. Quantitative determination of volatile halothane metabolites in biological tissues. J Chromatog 164:63­72, 1979.

14. Miller MS and Gandolfi AJ. A rapid sensitive method for quantification of enflurane in blood. Anesthesiology 51:542­544, 1979.

15. Bentley JB, Vaughan RW, Miller MS, Calkins JM, and Gandolfi AJ. Serum inorganic fluoride levels in obese patients during and after enflurane anesthesia. Anesth Analg 58:409­412, 1979.

16. Renne RA, Smith LG, McDonald KE, Shields CA, Gandolfi AJ, and Lund JE. Morphologic and biochemical effects of intratracheally administered oil shale in rats. J Envir Path Tox 3:397­406, 1980.

17. Soltis JJ and Gandolfi AJ. A simple method for the determination of organic fluoride using sodium fusion. Anesth Analg 59:61­64, 1980.

18. Jee R, Gandolfi AJ, Sipes IG, and Brown BR Jr. Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol ApplPharm 52:267­277, 1980.

19. Pelroy RA and Gandolfi, AJ. Use of a mixed function amine oxidase for metabolic activation in the Ames/Salmonella assay system. Mut Res 72:329­334, 1980.

20. Sipes IG, Gandolfi AJ, Pohl LR, Krishna G., and Brown BR. Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharm Exp Therap 214:716­720, 1980.

21. Gandolfi AJ, White RW, Sipes IG, and Pohl LR. Bioactivation and binding of halothane in vitro: Studies with 3H and 14C halothane. J Pharm Exp Therap 214:721­725, 1980.

22. Vaughan RW, Gandolfi AJ, and Bentley JB. Biochemical considerations of morbid obesity. Life Sciences 26:2215­2221, 1980.

23. Miller MS, Gandolfi AJ, Vaughan RW, and Bentley JB. Disposition of enflurane in obese patients. J Pharm Exp Therap 215:292­296, 1980.

24. Miller MS and Gandolfi AJ. Enflurane biotransformation in humans. Life Sciences 27:1465­1468, 1980.

25. Maiorino RM, Gandolfi AJ, Sipes IG, and Brown BR. Gas chromatographic method for the halothane metabolites, trifluoroacetic acid and bromide, in biological fluids. J Anal Tox 4:250­254, 1980.

26. Maiorino RM, Sipes IG, Gandolfi AJ, Brown BR, and Lind RC. Factors affecting the formation of chlorotrifluoroethane and chlorodifluoro-ethylene from halothane. Anesthesiology 54:383­389, 1981.

27. Blitt CD, Gandolfi AJ, Soltis JJ, and Brown BR. Extrahepatic biotransformation of halothane and enflurane. Anesth Analg 60:129­132, 1981.

28. Potter CL, Gandolfi AJ, Nagle R, and Clayton JW. Renal toxicity of chlorotrifluoroethylene and hexafluoropropene in the rat. Toxicol ApplPharm 59:431­440, 1981.

29. Gandolfi AJ, Sipes IG, and Brown BR. Detection of covalently bound halothane metabolites in the rat hypoxic model for halothane hepatotoxicity. Fund Appl Tox 1:255­259, 1981.

30. Bentley JB, Vaughan RW, Cork RC, and Gandolfi AJ. Does evidence of reductive biotransformation correlate with hepatic binding of metabolites in obese patients. Anesth Analg 60:548­551, 1981.

31. Gillespie TJ, Gandolfi AJ, Maiorino RM, and Vaughan RW. Gas chromatographic determination of fentanyl and its analogues in human plasma. J Anal Tox 5:133­137, 1981.

32. White RD, Sipes IG, Gandolfi AJ, and Bowden GT. Characterization of hepatic DNA damage caused by exposure to 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis 2:839­844, 1981.

33. Cunningham ML, Gandolfi AJ, Brendel K, and Sipes IG. Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes. Biochem Biophys Res Comm 29:1207­1212, 1981.

34. Gandolfi AJ, Nagle RB, Soltis JJ, and Plescia F. Nephrotoxicity of halogenated vinylcysteine compounds. Res Commun Chem Path Pharm 33:249­261, 1981.

35. Bonhaus DW and Gandolfi AJ. Conjugation and bioactivation of chlorotrifluoroethylene. Life Sciences 29:2399­2405, 1981.

36. Maiorino RM, Gandolfi AJ, Brendel KB, MacDonald JR, and Sipes IG. Chromatographic resolution of amino acid adducts of aliphatic halides. Chem Biol Inter 38:175­188, 1982.

37. DiRenzo AB, Gandolfi AJ, and Sipes IG. Microsomal bioactivation and covalent binding of aliphatic halides to DNA. Tox Letters 11:243­252, 1982.

38. Bentley JB, Vaughan RV, Gandolfi AJ, and Cork RC. Halothane metabolism in obese versus nonobese patients. Anesthesiology 57:94­97, 1982.

39. MacDonald JR, Gandolfi AJ, and Sipes IG. Potentiation of 1,1­2-trichloroethane hepatotoxicity by acetone pretreatment. Tox Letters 13:57­69, 1982.

40. Bentley JB, Borel JD, Vaughan RV, and Gandolfi AJ. Weight: succinyl choline requirement and pseudocholinesterase activity. Anesthesiology 57:48­49, 1982.

41. Gillespie TJ, Gandolfi AJ, Davis T, and Morano RA. Identification and quantification of methylfentanyl in postmortem samples. J Anal Tox 6:139­142, 1982.

42. Borel JD, Bentley JB, Vaughan RV, and Gandolfi AJ. Enflurane blood-gas solubility: Influence of weight, hemoglobin and hematocrit. Anesth Analg 61:1006­1009, 1982.

43. Buckley LA, Gandolfi AJ, Nagle RB, and Clayton JW. Chlorotrifluoroethylene nephrotoxicity in the rat: A subacute study. Fund Appl Tox 2:181­186, 1982.

44. DiRenzo AB, Gandolfi AJ, Sipes IG, and McDougal JN. Effect of senescence on the bioactivation of aliphatic halides. Res Comm Chem Path Pharmacol 36:493­502, 1982.

45. MacDonald JR, Gandolfi AJ, and Sipes IG. Covalent binding of 14C­1,1,2-trichloroethane to microsomal proteins and lipids following acetone pretreatment in vitro and in vivo. Drug Chem Tox 5:233­247, 1982.

46. Hassall CD, Brendel K, and Gandolfi AJ. Effect of halogenated vinyl cysteine conjugates on renal tubular transport. Toxicology 26:285­294, 1983.

47. Jaffe DR, Hassall CD, Brendel K, and Gandolfi AJ. In vivo and in vitro nephrotoxicity of the cysteine conjugates of hexachlorobutadiene. J Tox Env Health 11:857­867, 1983.

48. Hassall CD, Gandolfi AJ, and Brendel K. Reversal of DCVC-induced inhibition of renal tubular transport by glutathione. J Appl Toxicol 3:321­325, 1983.

49. Hassall CD, Gandolfi AJ, and Brendel K. Correlation of the in vivo and in vitro renal toxicity of S-(1,2-dichlorovinyl)-L-cysteine. Drug Chem Tox 6:507­520, 1983.

50. MacDonald JR, Gandolfi AJ, and Sipes IG. Cysteine treatment of chemically induced liver injury. In: Developments in the Science and Practice of Toxicology, (Hayes, Schnell, Miya, eds.), Elsevier Science Publishers, pp 463­466, 1983.

51. White RD, Gandolfi AJ, Bowden CT, and Sipes IG. The deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane. Toxicol ApplPharm 69:170­178, 1983.

52. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. The involvement of endotoxin in halothane-associated liver injury. Anesthesiology 61:544­550, 1984.

53. Hassall CD, Gandolfi AJ, and Brendel K. The formation and biotransformation of cysteine conjugates of halogenated ethylenes by rabbit renal tubules. Chem Biol Interact 49:283­297, 1984.

54. Fukui T, Hameroff SR, and Gandolfi AJ. Alterations in plasma alpha­1-acid glycoprotein and beta-endorphin in chronic pain patients. Anesthesiology 60:494­496, 1984.

55. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of galactosamine-induced hepatotoxicity in rats. Toxicol ApplPharm 73:551­558, 1984.

56. Durham JA, Gandolfi AJ, and Bentley JB. Hepatotoxicological evaluation of dantrolene sodium. Drug Chem Tox 7:23­40, 1984.

57. Jaffe DR, Gandolfi AJ, and Nagle RB. Chronic toxicity of S-(trans­1,2,-dichlorovinyl)-L-cysteine (DCVC) in mice. J Appl Toxicol 4:315­319, 1984.

58. MacDonald JR, Lind RC, Sipes IG, and Gandolfi AJ. Determination of hepatic tissue calcium levels by flame emission spectrometry. J Anal Tox 8:155­157, 1984.

59. DiRenzo AB, Gandolfi AJ, Sipes IG, Brendel K, and Byard JL. Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat hepatocyte cultures. Xenobiotica 14:521­525, 1984.

60. MacFarland RT, Gandolfi AJ, and Sipes IG. Extrahepatic GSH-dependent metabolism of 1,2-dibromoethane and 1,2-dibromo­3-chloropropane. Drug Chem Tox 7:213­217, 1984.

61. Cater KC, Sipes IG, and Gandolfi AJ. A sequential quantitative study of dimethylnitrosamine (DMN) - induced hepatic hyperplastic nodules in the newborn mouse model using histochemical and histoenzymatic markers. J Toxicologic Path 13:3­9, 1985.

62. Jaffe DR, Hassall CS, Gandolfi AJ, and Brendel K. Production of DNA single strand breaks in rabbit renal tissue after exposure to 1,2-dichlorovinyl cysteine. Toxicology 35:25­33, 1985.

63. Smith PF, Gandolfi AJ, Krumdieck CL, Putnam CW, Zukowski CF, Davis WM, and Brendel K. Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sciences 36:1367­1375, 1985.

64. Weldon ST, Gandolfi AJ, Williams-Van Alstyne SA, and Blitt CD. Characterization and quantitation of impurities in isoflurane vaporizers. Anesth Analg 64:634­639, 1985.

65. Lind RC, Shivley JW, Sipes IG, Gandolfi AJ, and Brown BR. The rat model of halothane-associated hepatitis. Comparative Pathology Bulletin 17:3­4, 1985.

66. Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, and Perry DS. Post-operative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology 63:708­710, 1985.

67. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Comparison of the requirements for hepatic injury with halothane and enflurane in rats. Anesth Analg 64:955­963, 1985.

68. MacDonald JR, Gandolfi AJ, and Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol ApplPharm 81:17­24, 1985.

69. Weldon ST, Perry DS, Cork RC, and Gandolfi AJ. Detection of picogram levels of sufentanil by capillary gas chromatography. Anesthesiology 63:684­687, 1985.

70. DiRenzo AB, Gandolfi AJ, Brooks SD, and Brendel K. Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocytes. Drug Chem Tox 8:207­218, 1985.

71. MacDonald JR, Gandolfi AJ, and Sipes IG. Hepatic cysteamine and nonprotein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. Drug Chem Tox 8:483­494, 1985.

72. Jackson JE, Bentley JB, Glass SJ, Fukui T, Gandolfi AJ, and Plachetka JR. Effects of H2-Receptor blockade on lidocaine pharmacokinetics. Clin Pharmacol Therap 37:544­548, 1985.

73. MacDonald JR, Gandolfi AJ, and Sipes IG. Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. Toxicology 39:135­148, 1986.

74. Lind RC, Gandolfi AJ, Sipes IG, Brown BR, and Waters SJ. Oxygen requirements for the reductive defluorination of halothane by rat hepatic microsomes. Anesth Analg 65:835­839, 1986.

75. Smith PF, Krack G, McKee RL, Johnson DG, Gandolfi AJ, Hruby VL, Krumdieck CL, and Brendel K. Maintenance of adult rat liver slices in dynamic organ culture. In Vitro Tox 22:706­712, 1986.

76. Lind RC, Gandolfi AJ, and Brown BR. Are the requirements for hepatic injury with halothane and enflurane in rats really different? Anesth Analg 65:545­547, 1986.

77. DiRenzo AB, Gandolfi AJ, Brendel K, and Krack G. Effect of volatile anesthetics on protein synthesis and secretion in rat hepatocyte suspensions. Drug Chem Tox 9:223­237, 1986.

78. Silber PM, Gandolfi AJ, and Brendel K. Adaption of a gamma-glutamyl transpeptidase assay to microtiter plates. Anal Biochem 158:68­71, 1986.

79. Silber PM, Gandolfi AJ, and Brendel K. Early biological indicators of S-(1,2-dichlorovinyl) cysteine nephrotoxicity in the rabbit. Drug Chem Tox 9:285­303, 1986.

80. Moore RA, McNicholas KM, Gallagher JD, Gandolfi AJ, Sipes IG, Kerns D, and Clark DL. Halothane metabolism in acyanotic and cyanotic patients undergoing open heart surgery. Anesthesiology 65:1257­1262, 1986.

81. Ruegg CE, Gandolfi AJ, and Brendel K. Preparation and incubation of precision-cut, positional renal slices. Pharmacol Methods 17:111­123, 1987.

82. Callis AH, Brooks SD, Roth TP, Gandolfi AJ, and Brown BR. Characterization of a halothane-induced humoral response in rabbits. Clin Exptl Immunol 67:343­351, 1987.

83. Brown BR and Gandolfi AJ. Adverse effects of volatile anaesthetics. Br J Anaesth 59:14­23, 1987.

84. Smith PF, Fisher R, Shubat PJ, Gandolfi AJ, Krumdieck CL, and Brendel K. In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system. Toxicol ApplPharm 87:509­522, 1987.

85. Lind RC, Gandolfi AJ, Brown BR, and Hall PM. Halothane hepatotoxicity in guinea pigs. Anesth Analg 66:222­228, 1987.

86. Sipes IG, Fisher RL, Smith PF, Gandolfi AJ, and Brendel K. A dynamic liver culture system: A tool for studying chemical biotransformation and toxicity. Arch Toxicol, Suppl 11, 20­33, 1987.

87. Brendel K, Gandolfi AJ, Krumdieck CL, and Smith PF. Organ slices revisited. Trends Pharmacol Sci 8:11­15, 1987.

88. Rylander LA, Phelps JS, Gandolfi AJ, and Brendel K. In vitro nephrotoxicity: Toxicity of cadmium chloride and dichlorovinyl cysteine to isolated renal tubules. In Vitro Tox 1:111­127, 1987.

89. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or anoxic conditions. Toxicol ApplPharm 90:261­273, 1987.

90. Becker GM, Gandolfi AJ, and Nagle RB. Effects of cyclosporin A and G on a kidney epithelial cell line (LLC-PK). Res Comm Chem Path Pharmacol 56:277­286, 1987.

91. Phelps JS, Gandolfi AJ, Dohr R, and Brendel K. Cisplatin nephrotoxicity: In vitro studies with precision cut renal cortical slices. Toxicol ApplPharm 90:501­512, 1987.

92. Siadat-Pajouh M, Callis AH, Roth TP, and Gandolfi AJ. Generation of halothane induced immune response in a guinea pig model for halothane hepatitis. Anesth Analg 66:209­1214, 1987.

93. McKee RL, Hruby VJ, Trivedi DB, Johnson DG, Gandolfi AJ, Krumdieck CL, and Brendel K. A perifused precision-cut liver slice system for the study of hormone regulated hepatic glucose metabolism. J Pharmacol Methods 19:339-354, 1987.

94. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Chronology of halothane induced antigen expression in halothane-exposed rabbits. Clin Expt Immunol 72:330­336, 1988.

95. Dale O, Gandolfi AJ, and Brendel K. Rat liver slices and diazepam metabolism: In vitro interaction with volatile anaesthetic drugs and albumin. Br J Anaesth 60:692­696, 1988.

96. Meadows SD, Gandolfi AJ, and Nagle RB. Genotoxic effects of 1,2-dichlorovinyl cysteine: Initiation and promotion effects in Swiss-Webster Mice. Drug Chem Tox 11:307­318, 1988.

97. Hubbard AK, Roth TP, Gandolfi AJ, and Brown BR. Halothane hepatitis patients generate an antibody response toward a metabolite of halothane. Anesthesiology 68:791­796, 1988.

98. Lind RC and Gandolfi AJ. Hypoxia and anesthetic-associated liver injury in guinea pigs. Anesthesiology 68:974­976, 1988.

99. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity. Anesthesiology 70:649­653, 1988.

100. Hubbard AK, Roth TP, Schuman S, and Gandolfi AJ. Localization of halothane-induced antigen in situ by specific anti halothane metabolite antibodies. Clin Exp Immun 76:422­427, 1989.

101. Hubbard AK, Gandolfi AJ, and Brown BR, Jr. Immunological basis of anesthetic-induced hepatotoxicity. Anesthesiology 69:814­817, 1988.

102. Wolfgang GHI, Gandolfi AJ, and Brendel K. Evaluation of organic nephrotoxins in rabbit renal cortical slices. Tox In Vitro 3:341­350, 1989.

103. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine. Toxicology 58:33­42, 1989.

104. Lind RC, Gandolfi AJ, and Hall P. Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs. Anesthesiology 71:878­884, 1989.

105. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. N-Acetyl S-(1,2-dichlorovinyl)-L-Cysteine produces a similar toxicity to S-(1,2- dichlorovinyl)-L-Cysteine in rabbit renal slices: Differential transport and metabolism. Toxicol ApplPharm 101:205­219, 1989.

106. Fisher R, Smith PF, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. Toxicity of chlorobenzenes in cultured rat liver slices. In Vitro Tox 3:181­194, 1990.

107. Lind RC, Gandolfi AJ, and Hall PM. Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. J Appl Toxicol 10:161-165, 1990.

108. Azri S, Gandolfi AJ, and Brendel K. Carbon tetrachloride toxicity in precision-cut rat liver slices. In Vitro Tox 3:127­138, 1990.

109. Connors S, Rankin DR, Gandolfi AJ, Krumdieck CL, Koep LJ, and Brendel K. Cocaine hepatotoxicity in cultured liver slices: a species comparison. Toxicology 61:171­183, 1990.

110. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. Drug Metab Disp 18:514­518, 1990.

111. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. Toxicology 62:59­69, 1990.

112. Hubbard AK, Levy JP, Roth TP, and Gandolfi AJ. Use of structural alterations in the synthesis of halothane metabolite antigens to mimic halothane-induced immunogens. Drug Chem Tox 13:93-112, 1990.

113. Wolfgang G, Gandolfi AJ, Nagle R, Brendel K, and Stevens J. Assessment of S-(1,2-Dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity. Chemico-Biological Interactions 75:153- 170, 1990.

114. Gandolfi AJ and Brendel K. In vitro systems for nephrotoxicity studies. Tox In Vitro 4:337­345, 1990.

115. Lind RC, Gandolfi AJ, and Hall PM. Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. Anesthesiology 73:1208-1213, 1990.

116. Azri S, Gandolfi AJ, and Brendel K. Precision-cut liver slices: An in vitro system for profiling potential hepatotoxicants. In Vitro Tox 3:309-320, 1990.

117. Ghantous HN, Fernando J, Morgan SE, Gandolfi AJ, and Brendel K. Precision-cut guinea pig liver slices as a tool to study the toxicity of volatile anesthetics. ATLA 18:191-199, 1990.

118. Fisher R, Putnam CW, Koep LJ, Sipes IG, Gandolfi AJ, and Brendel K. Cryopreservation of pig and human liver slices. Cryobiology 28:131-142, 1991.

119. Brown AP, Hastings KL, and Gandolfi AJ. Generation and detection of neoantigens in guinea pig liver slices incubated with halothane. Int J Immunopharmac 13:429-435, 1991.

120. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Minimal biotransformation and toxicity of desflurane in guinea pig liver slices. Anesth Analg 72:796-800, 1991.

121. Vernetti LA, Nowlin CLA, Hameroff SR, Gandolfi AJ, Lee YC, and Sarid D. Scanning tunneling microscopy resolution of surface features on cytokeratin protein is enhanced by prolonged exposure of protein to cold temperatures. J Vacuum Sci Technol 9:1223-1226, 1991.

122. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Putnam CL, Krumdieck CL, and Brendel K. Biotransformation activity in vitrified human liver slices. Cryobiology 28:216-226, 1991.

123. Fisher R, Nau H, Gandolfi AJ, and Brendel K. Toxicity of valproic acid in liver slices from Sprague-Dawley rat and domestic pigs. Toxic In Vitro 5: 201-205, 1991.

124. Fisher R, Nau H, Gandolfi AJ, Putnam CW, and Brendel K. Valproic acid hepatotoxicity in human liver slices. Drug Chem Tox 14:375-394, 1991.

125. Hastings KL, Schuman S, Thomas C, Brown AP, Hubbard AK, and Gandolfi AJ. Screening for antibodies associated with halothane hepatitis. Br J Anaesth 67:722-728, 1991.

126. Fisher R, Barr J, Zukoski CF, Putnam CW, Sipes IG, Gandolfi AJ, and Brendel K. In vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices. Human Exptl Toxicol 10:357-363, 1991.

127. Stefaniak MS, Krumdieck CL, Spall RD, Gandolfi AJ, and Brendel K. Biochemical and histological characterization of Agar-filled precision cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Tox 5:7-19, 1992.

128. Frink EJ, Ghantous H, Malan TP, Morgan S, Fernando J, Gandolfi AJ, and Brown BR, Jr. Plasma inorganic fluoride with sevoflurane anesthesia: Correlation with indices of hepatic and renal function. Anesth Analg 74:231-235, 1992.

129. Ghantous HN, Fernando JL, Keith RL, Gandolfi AJ, and Brendel K. Effects of halothane and other volatile anaesthetics on protein synthesis and secretion in guinea pig liver slices. Br J Anaesth 68:172-177, 1992.

130. Azri S, Mata HP, Reid LL, Gandolfi AJ, and Brendel K. Further examination of the selective toxicity of CCl4 in rat liver slices. Toxicol ApplPharm 112:81-86, 1992.

131. Vernetti L, Sarid D, Gandolfi AJ, Nagle RB, Hameroff S, McCuskey R, and Cress AE. The topographical structure of cytokeratin intermediate filaments using scanning tunneling microscopy. Nanobiology 1:379-386, 1992.

132. Lind RC, Gandolfi AJ, and Hall PM. Subanesthetic halothane is hepatotoxic in the guinea pig. Anesth Analg 74:559-563, 1992.

133. Connors S, Gandolfi AJ, and Brendel K. Mini-review: Cocaine hepatotoxicity. In press, 1992.

134. Parrish AR, Shipp NG, Spall RD, Dorr RT, Krumdieck CL, Gandolfi AJ, and Brendel K. Organ culture of rat myocardial slices: An alternative in vitro tool in organ specific toxicology. Toxicology Methods 2:101-111, 1992.

135. Fisher R, Hanzlik RP, Gandolfi AJ, and Brendel K. Toxicity of ortho-substituted bromobenzenes in rat liver slices: A comparison to isolated hepatocytes and the whole animal. In Vitro Tox 4:173-186, 1991.

136. Brown AP, Hastings KL, Gandolfi AJ, Liebler DC, and Brendel K. Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane. Toxicology 73:281-195, 1992.

137. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicity. Anesth Analg 75:436-440, 1992.

138. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The hepatotoxicity of chloroform in precision-cut rat liver slices. Toxicology 73:239-250, 1992.

139. Lind RC, Gandolfi AJ, and Hall PM. Glutathione depletion enhances subanesthetic halothane hepatotoxicity in guinea pigs. Anesthesiology 77:721-727, 1992.

140. Ghantous H, Fernando J, Mata E, Gandolfi AJ, and Brendel K. Chronology of toxic events produced by halothane in guinea pig liver slices. In Vitro Tox 5:137-146, 1992.

141. Dale O, Frink EJ, Thommesen L, and Gandolfi AJ. Hepatic elimination of diazepam: Interactions with albumin, desflurane, and sevoflurane. Br J Anaesth 70:454-455, 1993.

142. Stinjntjes GJ, Commandeur JNM, te Koppele JM, McGuinness S, and Gandolfi AJ, Vermeulen NPE. Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue      slices. Toxicology 79:67-79, 1993.

143. Lind RC and Gandolfi AJ. Concentration dependent inhibition of halothane biotransformation in the guinea pig. Drug Metab Disp 21:386-389, 1993.

144. McGuinness SG, Gandolfi AJ, and Brendel K. Use of renal slices and renal tubule suspensions for in vitro toxicity studies. In Vitro Toxicology 6:1-24, 1993.

145. Lowe T, Fernando Q, Keith R, and Gandolfi AJ. Elemental analysis of renal slices by proton induced x-ray emission. Env Health Perspectives 101:302-308, 1993.

146. Fisher RL, Hasal SJ, Sanuik JT, Scott KS, Gandolfi AJ, and Brendel K. Cold- and cryo-preservation of human liver and kidney slices. Cryobiology 30:250-261, 1993.

147. Hubbard AK, Lohr CL, Hastings K, Clarke J, and Gandolfi AJ. Immunogenicity studies of a synthetic antigen of alpha methyl dopa. International J Immunopharm Immunotox 15:621-637, 1993.

148. Lind RC, Gandolfi AJ, and Hall PM. A guinea pig model of halothane-associated hepatitis. Comparative Pathology Bulletin XXV (No. 3):3-4, 1993.

149. Fisher RL, Gandolfi AJ, Sipes IG, and Brendel K. Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver. Drug Chem Tox 16:321-339, 1993.

150. Reid LL, Hastings KL, Gandolfi AJ, and Van Ert M. Use of staphylococcal enterotoxin A - induced interleukin 2 production as an indicator of immunotoxicity. Drug Chem Tox 17:1-14, 1994.

151. Morgan SE, Frink EJ, and Gandolfi AJ. A simplified gas chromatographic method for quantifying the sevoflurane metabolite, hexafluoroisopropanol. Anesthesiology 80:201-205, 1994.

152. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slices. Fund Appl Toxicol 22:172-177, 1994.

153. Brown AP and Gandolfi AJ. Glutathione-S-transferase is a target for covalent modification by a halothane reactive intermediate in guinea pig liver. Toxicology 89:35-47, 1994.

154. Parrish AR, Wishnies SR, Dorr RT, Gandolfi AJ, and Brendel K. Coculture of rabbit liver and myocardial slices: Potentiation of the cardiotoxicity of allyl alcohol but not allylamine. In Vitro Toxicology 7:53-57, 1994.

155. Parrish AR, Dorr RT, Gandolfi AJ, and Brendel K. Adult rat myocardial slices: A tool for studies of comparative cardiotoxicity. Tox In Vitro 8:1233-1237, 1994.

156. Lind RC, Gandolfi AJ, and Hall P. A model for fatal halothane hepatitis in guinea pigs. Anesthesiology 81:478-487, 1994.

157. Christen U, Quinn J, Yeaman SJ, Kenna JG, Clarke JB, Gandolfi AJ, and Gut J. Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis: molecular mimicry of CF3CO-Lys by lipoic acid. Europ J Biochem 223:1035-1047, 1994.

158. Sheevers HV, Brendel K, Wright SH, Nagle RB, and Gandolfi AJ. Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices. Toxic In Vitro 8:1243-1251, 1994.

159. Michaud JP, Gandolfi AJ, and Brendel K. Toxic responses to defined chemical mixtures: Mathematical models and experimental designs. Life Sciences 55:635-651, 1994.

160. Fisher RL, Sanuik JT, Nau H, Gandolfi AJ, and Brendel K. Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humans. Toxic in Vitro 8:371-379, 1994.

161. Michaud JP, Gandolfi AJ, and Brendel K. Methods of assessing toxic interactions in vitro: Experimental design and data analysis. Toxicology Methods 5:21-40, 1995.

162. Fisher RL, Smith MS, Hasal SJ, Hasal KS, Gandolfi AJ, and Brendel K. The use of human lung slices in toxicology. Human Exp Tox 13:466-471, 1994.

163. Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Toxicity of cisplatin and mercuric chloride in human kidney cortical slices. Human Exp Tox 13:517-523, 1994.

164. Wysynski AM, Martinez-Zaguilan R, Alden C, Gandolfi AJ, and Gillies RJ. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicology Letters 74:157-166, 1994.

165. Hastings KL, Thomas C, Brown AP, and Gandolfi AJ. Trifluoroacetylation potentiates the humoral immune response to halothane in the guinea pig. Immunopharm Immunotox 17:201-213, 1995.

166. Fisher RL, Hasal SJ, Sipes IG, Gandolfi AJ, and Brendel K. Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fisher-344 and human liver slices. Human Exp Tox 14:414-421, 1995.

167. Lind RC, Gandolfi AJ, and Hall PM. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig. Potentiation of hepatic injury by prior glutathione depletion. Toxicol ApplPharm 134:175-181, 1995.

168. Payne AK, Morgan SE, Gandolfi AJ, and Brendel K. Biotransformation of sevoflurane by rat neonates liver slices. Drug Metab Disp 23:497-500, 1995.

169. Clarke JB, Chen M, Thomas C, Hubbard AH, Hastings KL, and Gandolfi AJ. Halogenated anesthetics form liver adducts and antigens that crossreact with halothane-induced antibodies. Intern Arch Allergy Immuno 108:24-32, 1995.

170. McGuinness SJ, Rankin DR, Bezruvczyk P, Brendel K, and Gandolfi AJ. Nephrotoxicity and transport of celiptium in rabbit renal proximal tubule suspensions. In Vitro Tox 8:169-175, 1995.

171. Frey N, Christen U, Jeno P, Yeaman SJ, Shimomura Y, Kenna JG, Gandolfi AJ, Ranek L, and Gut J. The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. Chem Res Toxicol 8:736-746, 1995.

172. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices. Toxicology 104:35-45, 1995.

173. Gunaratnum NT, Benson J, Gandolfi AJ, and Chen ML. Isoflurane hepatitis in an obese patient with a history of halothane hepatitis. Anesthesiology 83:1361-1364, 1995.

174. Groves CE, Morales MN, Gandolfi AJ, Dantzler WH, and Wright SH. Peritubular paraquat transport in isolated renal proximal tubules. J Pharm Exptl Therap, in revision, 1995.

175. Gandolfi AJ, Brendel K, Fisher RL, and Michaud JP. Use of tissue slices in chemical mixture toxicology and interspecies investigations. Toxicology 105:285-290, 1995.

176. Furst SM, Chen M, and Gandolfi AJ. Use of halothane as a model for investigating chemical-induced autoimmunity. Drug Information Journal 30:301-307, 1996.

177. Fisher RL, Shaughnessy RP, Jenkins PM, Austin ML, Roth GL, Gandolfi AJ, and Brendel K. Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: Optimization of tissue slice culture. Toxicology Methods 5:99-113, 1995.

178. Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices: Optimization of tissue slice culture, Part 2. Toxicology Methods 5:115-130, 1995.

179. Michaud JP, Gandolfi AJ, and Brendel K. Investigation of hepatotoxic interaction using precision-cut rat liver slice culture: Steps towards validation, and comparisons to in vivo findings. In Vitro Toxicology, in press, 1995.

180. Parrish AR, Gandolfi AJ, and Brendel K. Precision-cut tissue slices: Applications in pharmacology and toxicology. Life Sciences 57:1887-1901, 1995.

181. Gandolfi AJ, Wijeweera J, and Brendel K. Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Toxicol Pathology 24:58-61, 1996.

182. Fisher RL, Jenkins PM, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Rainbow trout liver slices: A tool for aquatic toxicology. Toxic Substances Mechanisms 15:13-26, 1996.

183. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K.  Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices.  Fund Appl Toxicol 34:73-83, 1996.

184. Hoivik DJ, Fisher RL, Brendel K, Gandolfi AJ, Khairallah EA, and Cohen SD.  Protein arylation precedes acetaminophen toxicity in a dynamic organ culture of mouse kidney.  Fund Appl Toxicol 34:99-104, 1996.

185. Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, and  Brendel K.  Cold- and cryopreservation of dog liver and kidney slices.  Cryobiology 33:163-171, 1996.

186. Keith RL, Setiarahardjo I, Fernando Q, Aposhian HV, and Gandolfi AJ.  Utilization of renal slices to evaluate the efficacy of chelators to remove mercury from the kidney.  Toxicology 116:67-75, 1997.

187. Lind RC and Gandolfi AJ.  Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and kidney.  Toxicol Appl Pharmacol 142:201-207, 1997.

188. Chen M and Gandolfi AJ.  Characterization of the humoral immune response and hepatotoxicity after multiple-halothane exposures in guinea pigs.  Drug Metabolism Reviews 29:103-122, 1997.

189. Furst SM, Leudke D, Gaw H, Reich R, and Gandolfi AJ.  Demonstration of a cellular immune response in halothane-exposed guinea pigs.  Tox Appl Pharm 143:245-255, 1997.

190. Furst SM, Leudke D, and Gandolfi AJ.  Kupffer cells from halothane exposed guinea pigs carry trifluoroacetylated protein adducts.  Toxicology 120:119-132, 1997.

191. Furst SM, and Gandolfi AJ.  Interaction of lymphocytes with Kupffer cells from halothane- exposed guinea pigs.  Int Arch Allergy Immunol, 114:46-53, 1997.

192. Parrish AR, Fisher R, Bral C, Burghardt RC, Gandolfi AJ, Brendel K, and Ramos KS.  Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut rat liver and kidney slices.  Toxicol. Appl. Pharmacol, 152: 302-308, 1998.

193. Wijeweera J, Gandolfi AJ, and Zheng XH.  Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slices.  Env. Health Perspectives, 106 (Suppl 6) 1319-1323,1998.

194.  Wei H, Qiu L, Divine KK, Fernando Q, and Gandolfi AJ.  Toxicity and transport of three synthesized mercury-thiol-complexes in isolated rabbit renal proximal tubule suspensions.  Drug Chem Tox, 22: 323-341, 1999.

195. Keith RL, Gandolfi AJ, McIntyre LC, Jr., Ashbaugh MD, and Fernando Q.  Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE.  Nuclear Instruments and Methods (B), 149: 167-176, 1999.

196. Lind RC and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide.  I.  Protection when given twenty-four hours after chloroform or bromobenzene.  Tox Path, 27:342-347, 1999.

197. Lind RC and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide.  II.  Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury.  Exp Toxicol Path, 51:537-543, 1999.

198. Parrish AR, Zheng XH, Turney KD, Younis HS, and Gandolfi AJ.  Enhanced transcriptional factor DNA binding and  gene expression induced by arsenite or arsenate in renal slices.  Tox Sci, 50:98-105, 1999.

199. Parrish AR, Catania JM, Orozco J, and Gandolfi AJ.  Chemically-induced oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.  Tox Sci, 51:80-86, 1999.

200.  Turney KD, Parrish AR, Orozco J, and Gandolif AJ.  Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices.  Tox Appl Pharm, 160:262-270, 1999.

201.   Lind RC, Begay CK, and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide III.  Role of inhibition of the bioactivation and covalent binding of chloroform.  Tox Appl Pharm, 166: 145-150, 2000.

202.   Ito Y, Lind RC, Begay CK, Gandolfi AJ, McCuskey MK, and McCuskey RS.  Late administration of dimethyl sulfoxide minimizes the hepatic microvascular inflammatory response to chloroform in rats.  Hepatology Research, 18 (3):203-217 2000.

203.  Wijeweera JB, Gandolfi AJ, Parrish A, and Lantz RC.  Sodium arsenite enhances AP-1 and NFkB DNA binding and induces stress protein expression in precision-cut rat lung slices.  Tox Sci, 61 283-294, 2001.

204.  Catania JM, Parrish AR, and Gandolfi AJ.  Toxicity of a sevoflurane degradation product incubated with liver and renal cortical slices.  Drug Chem Tox, 24:347-357, 2001.

205.  Zheng XH, Begay CK, Lind RC, and Gandolfi AJ.  Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure.   Drug Chem Tox, 24:339-346, 2001.

206. Fisher RL, Gandolfi AJ, and Brendel K.  Human liver is a dominant factor in the outcome of in vitro studies.  Cell Biol Tox, 17:179-189, 2001.

207. Parrish AR, Sallam K, Nyman DW, Orozco J, Cress AE, Dalkin BL, Nagle RB, and Gandolfi AJ.  Culturing precision-cut human prostate slices as an in vitro model of prostate pathobiology.  Cell Biol Tox, 18:205-219, 2002.

208. Fisher RL, Hasal SJ, Lipscomb JC, Gandolfi AJ, and Brendel K.  Cold- and cryopreservation of monkey liver slices.  Cryobiology, Toxicology Mechanisms Methods, 12:119-133, 2002.

209. Kirkpatrick DS, Dale KV, Catnaia JM, and Gandolfi AJ.  Low-level arsenite causes accumulation of ubiquinated proteins in rabbit renal cortical slices and HEK 293 cells. Tox and App Pharm, 186:101-109, No. 2, January 2003.

210. Quanrud DM, Arnold RG, Lansey KE, Begay CK, Ela W, and Gandolfi AJ.  Fate of effluent organic matter during soil aquifer treatment: biodegradability, chlorine reactivity, and genotoxicity. J. Water and Health, 1.1:33-44, 2003. 

211.  Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Henderson CJ, Wolf CR, Clark AJ, Brendel K, Fisher RL, and Gandolfi AJ.  Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.  Toxicology In Vitro, 17:201-205, 2003.

212.  Zheng XH, Watts G, Vaught S, and Gandolfi AJ.  Low-level arsenate induced gene expression in HEK293 cells.  Toxicology, 187:39-48, 2003.

213.  Begay CK and Gandolfi AJ. Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. Tox 185: 79-87, 2003.

214.  Peraza MA, Carter DE, Gandolfi AJ.  Toxicity and metabolism of  subcytotoxic inorganic arsenic in human renal proximal tubule epithelial cells (HK-2). Cell Biology Toxicology, 19:253-264, 2003.

215. Carter DE, Aposhian HV, Gandolfi AJ.  The metabolism of inorganic arsenic, gallium arsenide, and arsine: a toxicochemical review.  Tox Appl Pharm, 193:309-334, 2003.

216. Meza M, Kopplin M, Gandolfi AJ.  Arsenic drinking water exposure and unirnary excretion among adults in the Yaqui Vally, Sonora, Mexico.  Environ Res, 96:119-126, 2004.

217.  Bredfeldt TG,  Kopplin M, Gandolfi AJ.  Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Tox Appl Pharm, 198:412-418, 2004.

218.  Nyman DW, Stratton MS, Kopplin MJ, Dalkin BL, Nagle RB, Gandolfi AJ.  Selenium and selenomethionine levels in prostate cancer patients.  Cancer Detection and Prevention, 28:8-16, 2004.

219.  Field JA, Sierra-Alvarez R, Cortinas I, Feijool G, Moreira MT, Kopplin M, Gandolfi AJ. Facile reduction of arsenate in methanogenic sludge.  Biodegradation, 15:185-196, 2004.

220. Sierra-Alvarez R, Field JA, Cortinas I, Feijoo F, Moreira MT, Kopplin M, Gandolfi AJ. Anaerobic Microbial Mobilization and Biotransformation of Arsenate Adsorbed onto Activated Alumina. Water Research, 39:199-209 (2005).

221. Kirkpatrick DS, Weldon SF, Tsaprailis G, Gygi SP, Liebler DC, Gandolfi AJ.  Proteomic identification of ubiquinated proteins from human cells expressing His-tagged ubiquitin  Proteomics, 5:2104-2111, 2005.     

222.  Schmelz M, Moll R, Hesse U, Prasad AR, Gandolfi AJ, Hasan SR, Bartholdi M, Cress AE.  Identification of a Stem Candidate in the Normal Human Prostate Gland.  European J Cell Biology, 84:341-354, 2005.

223.  Carranza Rosales P, Said-Fernandez S, Sepulveda-Saavedra J, Cruz-Vega DE, Gandolfi AJ.  Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line:  ultrastructural evidence for an apoptotic mechanisms of damage.  Toxicology, 210:111-121, 2005.

224.  Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT.  Developmentally restricted genetic determinants of human arsenic metabolism:  association between urinary methylated arsenic and CYT19 polymorphisms in children.  Env Health Perspetive, 113:775-781, 2005.

225. Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ.  Monomethylarsenous acid induces transformation of human bladder cells.  Tox Appl Pharm, 216:69-79, 2006.

226. Cortinas I, Field JA, Sierra R, Kopplin M, Garbarino J, Gandolfi AJ.  Anaerobic biotransformation of roxarsone and related N-substituted phenylarsonic acids.  Env Sci Technol, 40:2951-2957, 2006.

227. Peraza MA, Carter DE, Gandolfi AJ.  Morphological and functional alterations in human proximal tubular cell line induced by low-level inorganic arsenic: evidence for targeting mitochondria and initiated apoptosis.  J Appl Tox 26:356-367, 2006.

228. Conley SM, McKay BS, Gandolfi AJ, Stamer WD.  Alterations in human trabecular meshwork cell homeostasis by selenium.  Exp Eye Research, 82: 637-647, 2006.

229.  Sierra R, Yenal U, Field JA, Kopplin M, Gandolfi AJ, Garbarino JR.  Anaerobic biotransformation of organoarsenical pesticides, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV).  J. Ag Fd Chem, 54:3959-3966, 2006.

230. Eblin KE, Bowen ME, Cromey D, Bredfeldt TG, Mash EA, Gandolfi AJ.  Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture.  Tox Appl Pharm, 217:7-14, 2006.

231. Eblin KE, Bredfeldt TG, Buffington S, Gandolfi AJ.  Mitogenic, pro-inflammatory signal transduction caused by monomethylarsonous acid in UROtsa cells.  Tox Sci, 95(2): 321-330, 2007.

232. Carranza-Rosales P, Guzman-Delgado N, Cruz-Vega D, Balderas-Renteria I, Gandolfi AJ.  DMPS protective effect on mitochondrial structure and function in OK cells exposed to toxic concentrations of HgCl2.  Cell Biol Toxicology, 23:163-176, 2007.

233. Meza M, Gandolfi AJ, Klimecki WT.  Developmental and genetic modulation of arsenic metabolism:  a gene by environment interaction?  Tox Appl Pharm, 222:381-387, 2007.

234. Catania JM, Pershing AM, Gandolfi AJ.  Precision-cut tissue chips as an in vitro system.  Tox In Vitro, 21:956-961, 2007.

235. Wang X, Sun Z, Chen W, Eblin KE, Gandolfi AJ, Zhang DD.  Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.  Tox Appl Pharm, 225: 206-213, 2007.   

236.  Meza MM, Kopplin MJ, Burgess JL, Gandolfi AJ.  Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicol Environ Chem, 90: 957-970, 2008.

237.  Eblin KE, Bredfeldt TG, Gandolfi AJ.  Immortalized human urothelial cells as a model of arsenic-induced bladder cancer. Toxicology, 248:67-76, 2008.

238.  Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW.  Epigenetic Remodeling During Arsenical-Induced Malignant Transformation.  Carcinogenesis, 29:1500-8, 2008.

239.  Eblin KE, Hau A, Jensen TJ, Buffington SE, Futscher BW, Gandolfi AJ.  The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies.  Toxicology, 250:47-54, 2008.

240.  Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolif AJ.  Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling.  Toxicology, 255: 107-114, 2008.

241.  Jensen TJ, Eblin KE, Wozniak RJ, Gandolfi AJ, Futscher BW.  Epigenetic mediated transcriptional activation of WNT5a participates in arsenical-associated malignant transformation.  Toxicology and Applied Pharmacology, 235: 39-46, 2009.

242.  Wnek SM, Medeiros MK, Eblin KE, Gandolfi AJ.  Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid exposure.  Tox Appl Pharm, 241:202-209, 2009.

243.  Tsow F, Forzani E, Rai A, Tsui R, Mastroianni S, Knobbe C, Gandolfi AJ, Tao NJ.  A wearable and wireless sensor system for real-time monitoring of toxic environmental volatile organic compounds.  IEEE Sensors Journal, 9:1734-1740, 2009.

244.  Alegria-Torres JA, Diaz-Barriga F, Gandolfi AJ, Perez-Maldonado IN.  Mechanisms of p,p’-DDE-induced apoptosis in human peripheral blood mononuclear cells.  Tox in Vitro, 23:1000-1006, 2009.

245.  Jensen TJ, Wnek SM, Novak P, Gandolfi AJ, Futscher BW.  Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells.  Tox Appl Pharm, 241:221-229, 2009.

D. Non-Refereed Journal Articles

1. Gandolfi AJ. Toxicity of TCE in Tucson well water. Southern Arizona Environmental Council Bulletin 11:2­3, 1982.

2. Gandolfi AJ, Blitt CD, and Weldon S. Discoloration and impurities in isoflurane vaporizer. Anesth Analg 62:366, 1983.

3. Gandolfi AJ and Brown BR. Hypoxia and halothane hepatotoxicity. Anesthesiology 62:859-861, 1983.

4. Gandolfi AJ, Cork RC, and Levy JP. Assay for serum sufentanil level not sensitive. Anesthesiology 65:112, 1986.

5. Gandolfi AJ. Book Review. Alternative to Animal Use in Research, Testing, and Education. American Scientist 74:674-675, 1986.

6. Brendel K, McKee RL, Hruby VJ, Johnson DG, Gandolfi AJ, and Krumdieck CL. Precision cut tissue slices in culture: A new tool in pharmacology. Proc West Pharmacol Soc 30:291-293, 1987.

7. Stefaniak MS, Gandolfi AJ, and Brendel K. Adult rat lung in dynamic organ culture: a new tool in pharmacology. Proc West Pharmacol Soc 31:149-151, 1988.

8. Connors MS, Gandolfi AJ, Krumdieck CL, and Brendel K. Lysosomal and cytosolic enzyme release as a measure of organelle-specific toxicity in cultured rat liver slices. Proc West Pharmacol Soc 31:143-147, 1988.

9. Brendel K and Gandolfi AJ. Predicting Toxicity. Arizona Medicine XLVI:4, 1990.

10. Gandolfi AJ. Guest authors discuss alternatives and challenges. Johns Hopkins Center for Alternatives to Animal Testing 9(1):9, 1991.

11. Kramer TH, Cork RC, and Gandolfi AJ. Pharmacokinetics of sufentanil. Can J Anaesth 36:485-486, 1989.

12. Gandolfi AJ, Brendel K, and Krumdieck CL. Tissue slicing and culturing revisited - An update. Alternatives (Bristol Myers Squibb Newsletter) 2, 1992.

13. Wijeweera JB, Gandolfi AJ, and Brendel K. Toxic interaction of drinking water contaminants. Vinylidene chloride and chloroacetic acid studies in precision-cut rat liver slices. SWEHSC Newletter, Winter 1995/1996.

14. Payne AK and Gandolfi AJ. Enzyme deficiency found in rat pup metabolism of new anesthetic intended for use with children. Southwest Association for Education in Biomedical Research, Newsletter, Volume 1, No. 2, 1994.

15. Furst SM and Gandolfi AJ. Adverse chemical reactions: Autoimmunity. SWEHSC Newsletter, Spring, 1995.

16. Gandolfi AJ and Lind RC. A sensitive animal model for testing the hepatotoxic potential of fluorocarbons. SWEHSC Newsletter, Summer, 1995.

17. Parrish AR, Nagle RB, Cass AE, Dalkin BL, and Gandolfi AJ.  Development of precision-cut human prostate slices as an in vitro model for prostate pathobiology.  SWEHSC Newsletter, Fall 1998.

18. Ito Y, Begay CK, Lind RC, Gandolfi AJ, and McCuskey RS.  Utilization of in vitro microscopy to investigate the protective action of DMSO against chloroform-induced injury.  SWEHSC Newsletter, Fall 1998.

19.  Zheng XH,  Parrish AR, and Gandolfi AJ.  Analysis of differential expressed genes in rabbit renal cortical slices exposed to arsenic compounds.  SWEHSC Newsletter, Winter 99-00.

9.         20.  Efecto de los niveles bajos de arsenico sobre los teijidos.  Boletin – Sociedad Quimica de Mexico, Section Nuevo Leon, Mayo – Junio 2004.

E. Technical Manuals and Reports:

1. Gandolfi AJ, Hodgson WH, and Chandon JG. Design and performance of aerosol exposure system. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp 189­191, (1977).

2. Gandolfi AJ and Shields CA. Effect of intratracheally administered oil shale and spent shale on pulmonary biotransformation enzyme activity. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp. 169-171, (1977).

3. Gandolfi AJ and Shields CA. Absorption of benzo-a-pyrene from intratracheally administered spent shale. Pacific Northwest Labs Ann Report to ERDA, Part 1, pp. 171-173, (1977).

4. Gandolfi AJ and Shields CA. Response of lungs to intratracheally administered oil shale dusts. Pacific Northwest Labs Ann Report to DOE, pp. 5.11-5.14, (1978).

5. Gandolfi AJ. Toxicity of TEE in Tucson well water. Southern Arizona Environmental Coundil Bulletin 11:2-3, 1982.

F. Conference Proceedings - Book Articles

1. Sipes IG and Gandolfi AJ. In vitro comparative bioactivatioin of aliphatic halogenated hydrocarbons. In: Mechanisms of Toxicity and Hazard Evaluation, (Holmstedt, Lauwerys, Mercier, Roberfroid, eds.), Elsevier-North Holland, pp. 501-506, 1980.

2. Sipes IG, Gandolfi AJ, and Brown BR. Halothane-associated hepatitis: Evidence for a direct toxicity. In: Drug Reactions in the Liver, (M Davis, JM Tredger, R Williams, eds), Pitman Medical Limited, London, pp. 219-231, 1981.

3. Sipes IG and Gandolfi AJ. Bioactivation of aliphatic organohalogens: formation, detection, and relevance in Toxicology of the Liver. G. Plaa and R. Leibel (editors) Raven Press, pp. 181-212, 1982.

4. Sipes IG and Gandolfi AJ. Role of reactive intermediates in halothane associated liver injury. In: Reactive Intermediates (R. Snyder et al, editor's) Plenum Press, New York, pp. 603­618, 1982.

5. Weldon ST, Gillespie TJ, and Gandolfi AJ. Gas chromatographic analysis for fentanyl. Methodology in Analytical Toxicology, Vol. 3, (I. Sunshine, Editor) CRC Press, Inc., Boca Raton, FL, pp. 89­93, 1985.

6. Callis AH, Brooks SD, Waters SJ, Gandolfi AJ, Lucas DO, Pohl LR, Satoh H, and Sipes IG. Evidence for a role of the immune response in the pathogenesis of halothane hepatitis. Molecular Mechanisms of Anesthesia, Progress in Anesthesiology, Vol. 3 (S. Roth, editor). Raven Press, pp. 441­451, 1985.

7. Meadows SD, Gandolfi AJ, Nagle RB, and Brendel K. Persistent, progressive renal toxicity in male Swiss-Webster mice following subchronic exposure to 1,2-dichlorovinyl cysteine (DCVC). Renal Heterogeneity and Target Cell Toxicity (P.H. Bach, E.A. Lock, editors) John Wiley & Sons, New York, 1985, pp. 157­160.

8. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Renal Heterogeneity and Target Organ Toxicity (P.H. Bach, E.A. Lock, editors), John Wiley & Sons, New York, 1985, pp. 531­534.

9. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Inhibition of organic acid/base transport in isolated rabbit renal tubules by nephrotoxins. In: In Vitro Toxicology Volume D3 (A.M. Goldberg, editor). Mary Ann Liebert, Inc., New York, pp. 235­247, 1985.

10. Phelps JS, Gandolfi AJ, Brendel K. Cisplatinum toxicity in rabbit renal proximal tubule suspensions and precision-cut renal cortical slices. In Vitro Toxicology, Vol. 4 (Goldberg AM, editor), pp. 441­420, 1987.

11. Wolfgang GHI, Gandolfi AJ, Brendel K. Regioselective toxicity by dichlorovinyl cysteine in rabbit renal cortical slices. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. (P.H. Bach and E.A. Lock, editors), Guildford, England, pp. 583­589, 1989.

12. Ruegg CE, Gandolfi AJ, Brendel K. Regioselective acute tubular necrosis in renal cortical slices following HgCl2 and K2Cr2O7: Localization and transport studies. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. Guildford, England, pp. 107­112, 1989.

13. Wolfgang GHI, Gandolfi AJ, Krumdieck CL, Brendel K. Evaluation of organic nephrotoxins using rabbit renal cortical slices. In: Progress in In Vitro Toxicology Vol. 6 (AM Goldberg, Editor). Mary Ann Leibert, Inc. pp. 291­301, 1988.

14. Azri S, Mata HP, Gandolfi AJ, Brendel K. CCl4-induced cytochrome P­450 loss and lipid peroxidation in rat liver slices. Adv. Exp. Med. Biol. 283:669-674, 1991.

15. Brown AP, Hastings KL, Gandolfi AJ, Brendel K. Covalent binding of a halothane metabolite and neoantigen production in guinea pig liver slices. Adv. Exp. Med. Biol. 283:693-697, 1991.

16. Ghantous H, Fernando J, Gandolfi AJ, Brendel K. Inhibition of protein synthesis and secretion by volatile anesthetics in guinea pig liver slices. Adv. Exp. Med. Biol. 283:725-730, 1991.

17. Hastings KL, Schuman S, Brown AP, Thomas C, Gandolfi AJ. S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Adv. Exp. Med. Biol. 283:739-744, 1991.

18. Lind RC and Gandolfi AJ. Covalent binding of oxidative biotransformation reactive intermediates to protein influences halothane-associated hepatotoxicity in guinea pigs. Adv. Exp. Med. Biol. 283:763-766, 1991.

19. Vernetti LA, Gandolfi AJ, Nagle RB. Selective alteration of cytokeratin intermediate filament by cyclosporine A is a lethal toxicity in PtK2 cell cultures. Adv. Exp. Med. Biol. 283:847-851, 1991.

20. Brendel K, Fisher RL, Krumdieck CL, Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. J Amer Col Tox 9:621-627, 1990.

21. Vernetti LA, Sarid D, Gandolfi AJ, Cress AE, Nagle RB, McCuskey R, Hameroff SR. STM images of cytokeratin and binding IgG antibody. In: Scanned Probe Microscopy, AIP Conference Proceedings, Santa Barbara, CA, (H K Wickramasinghe, ed.), American Institute of Physics, New York, pp. 232-234, 1991.

22. Gandolfi AJ. Biotransformation of inhalation anesthetics: Role in producing toxicity. In: Inhalationsanasthesie - eine Standortbestimmung (H Laubenthal, C Puchstein, C Sirtl, eds.), Wissenschaftliche Verlagsabteilung Abbott GmbH, Wiesbaden, Germany, pp. 9-19, 1992.

23. Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ, Curtis LR. Novel mechanisms in chemically-induced hepatotoxicity. FASEB Journal 8:1285-1295, 1994.

24. Gandolfi AJ. Inhalation Anaesthetics: Toxicity and Metabolism. In: Fluorine in Medicine in the 21st Century. (Conference Proceedings) RAPRA (publishers), Paper number 17, pages 1-10, 1994.

25. Burton CA, Hatlelid K, Divine K, Carter DE, Fernando Q, Brendel K, Gandolfi AJ. Glutathione effects on toxicity and uptake of HgCl2 and NaAsO2 in rabbit renal cortical slices. Environ Health Perspect 103:81-84, 1995.

26. Keith RL, McGuinness SJ, Gandolfi AJ, Lowe TP, Chen Q, Fernando Q. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Environ Health Perspect 103:77-80, 1995.

27. McIntyre CC, Leavitt JA, Ashbaugh, MD, Borgardt J, Keith RL, Gandolfi AJ, Qiu L, Lott JR, Fernando Q.  The nuclear microprobe at the University of Arizona, Nuclear Instruments and Methods, 130:45-50, 1997.

28. Keith RL, Gandolfi AJ, McIntyre LC., Jr., Ashbaugh MD, Fernando Q.  Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue.  Nuclear Instruments and Methods, 130:358-361, 1997.

29. Gandolfi AJ.  Hepatotoxicity of hydrofluorocarbons.  In: Abstracts of the Workshop on Toxicity of Alternatives to Chlorofluorocarbons.  (R. Snyder, K. Bakshi, B. Wagner, editors.)  Inhalation Toxicology 9:775-810, 1997.

G. Unpublished Work

Work in Progress

1.   Escudero Lourdes C, Cardenas-Gonzalez MC, Wnek SM, Medeiros MK, Gandolfi AJ.  Low level exposure to MMAIII induced the over-production of pro-inflammatory cytokines through NFKB and c-jun activation.  Tox Appl Pharm, submitted, October  2009.

2.   Escudero Lourdes C, Medeiros MK, Wnek SM, Gandolfi AJ.  The role of IL-8 on the MMAIII-induced malignant transformation of UROtsa cells.  Tox Sci, in preparation, 2009.

3.   Moreno DM, Ramirez MD, Estrella R, Maier RM, Gandolfi AJ, Brusseau ML, Field JA.  Community outreach and research translation efforts of the U.S.-Mexico border region.  Env Health Perspectives, submitted, 2009.

4.  Meza M, Meza D, Klimecki W, Gandolfi AJ.  Arsenic content in water, dust, urban and agricultural soils and their relation with biomarkers in exposed populations, from Sonora, Mexico.  Env Res, in preparation 2009.


5.  Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ.  Short-term, low-level exposure of a human bladder cell line to monomethylarsonous acid produces critical and irreversible events resulting in malignant transformation.  Tox Sci, in preparation, 2009.


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H. Abstracts:

1. Gandolfi AJ, Dost FN, Buhler DR. Absorption, excretion, and metabolism of hexachlorophene in the rat and rabbit. Fed Proc 31:605, 1972.

2. Gandolfi AJ. Hexachlorophene: its absorption, distribution, excretion, and biotransformation in the rat and rabbit and in vitro interaction with rat liver microsomes. Dis Abst Inter 33:4106-B, 1973.

3. Gandolfi AJ, Van Dyke RA. Effects of anesthetics, aniline, aminopyrine and other compounds on the reduction and reoxidation of cytochrome P­450 in reconstituted microsomal systems. Pharmacologist 15:156, 1973.

4. Van Dyke RA, Gandolfi AJ, Wood CL. Evidence for the binding of halothane metabolites to microsomal lipids, page 13. In: Abstracts of Scientific Papers 1973 Annual Meeting, ASA, San Francisco, CA., 1973.

5. Gandolfi AJ, Van Dyke RA. Characterization and isolation of a soluble protein that stimulates microsomal dechlorination. Pharmacol 16:261, 1974.

6. Zujko KE, Gandolfi AJ, Van Dyke RA. Solubilization and partial purification of human cytochrome P­450. Pharmacol 16:321, 1974.

7. Gandolfi AJ, Van Dyke RA. Effect of animal pretreatment on the in vivo covalent binding of halothane metabolites in rat hepatic lipids and protein, No. 72. In: Society of Toxicology, 15th Annual Meeting, Williamsburg, VA., 1975.

8. Gandolfi AJ, Southorn PA, Van Dyke RA. Effect of ketamine on the isolated perfused rat lung. Fed Proc 34:750, 1975.

9. Tinker JH, Gandolfi AJ, Van Dyke RA. Elevation of human plasma bromide levels after halothane anesthesia: correlation with total halothane dosage, p 387. In: Abstracts of Scientific Papers, 1975 Annual Meeting, ASA, Chicago, Ill., 1975.

10. Gandolfi AJ, Lund JE, Renne RA et al. Response of rat to intratracheally administered oil shale dusts. No. 26. In: Society of Toxicology, 17th Annual Meeting, San Francisco, 1978

11. Andrew FD, Gandolfi AJ, Mahlum DD. Developmental effects of synthetic fuel related materials in rats. In: The Teratology Society, 18th Annual Meeting, 1978.

12. Gandolfi AJ, Pelroy RA. Utilization of isolated hepatic biotransformation enzymes in assessing the mutagenic activity of compounds in the salmonella mutagenicity assay. Pharmacologist 20:252, 1978.

13. Jee R, Maiorino R, Gandolfi AJ, Sipes IG, Brown BR. Investigations of hypoxic model for halothane hepatitis. Pharmacologist 20:258, 1978.

14. Cunningham ML, Gandolfi AJ, Brendel K, Sipes IG. Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes. No. 179, Society of Toxicology, 18th Annual Meeting, New Orleans, 1979.

15. Bentley JB, Vaughan RS, Gandolfi AJ, et al. Serum inorganic fluoride levels in obese patients during and after enflurane anesthesia. International Anesthesia Research Society, 53rd Congress, Miami, 1979.

16. Blitt CD, Gandolfi AJ, Soltis JJ, et al. Biotransformation of halothane and enflurane by the lung. International Anesthesia Research Society, 53rd Congress, Miami, 1979.

17. Gandolfi AJ, Sipes IG, White RW. Bioactivation and binding of 3H/14C halothane to microsomal lipids and protein. Fed Proceed 38:684, 1979.

18. Sipes IG, Gandolfi AJ, White RW. Metabolism and toxicity of deuterated halothane. Fed Proceed 38:684, 1979.

19. Jee R, Sipes IG, Gandolfi AJ. Propagation and inhibition of halothane hypoxia hepatotoxicity. Fed Proceed 38:916, 1979.

20. Blitt CD, Soltis JJ, Gandolfi AJ. A simple method for the determination of organic fluoride using sodium fusion. Assoc University Anesthesiologists, Annual Meeting, 1979.

21. Brown BR, Sipes IG, Gandolfi AJ. Characterization of hypoxic model for halothane hepatotoxicity. Anesthesiology 51:5239, 1979.

22. Sipes IG and Gandolfi AJ. Bioactivation and hepatotoxicity of 2H/3H halothane. Anesthesiology 51:5242, 1979.

23. Potter C, Gandolfi AJ, Clayton JW, Nagle R. Renal toxicity of inhaled chlorotrifluoroethylene in male Fischer rats. Pharmacologist 21:185, 1979.

24. Gandolfi AJ, MacDonald JR, Sipes IG. Comparative microsomal bioactivation of organohalogens. Pharmacologist 21:194, 1979.

25. Maiorino RM, Gandolfi AJ, Brendel K, Sipes IG. Resolution of organohalogens adducts to protein. Pharmacologist 21:195, 1979.

26. Miller M, Vaughan RW, Gandolfi AJ. The disposition of enflurane in obese and non-obese humans. Pharmacologist 21:262, 1979.

27. Vaughan RW, Miller MS, Gandolfi AJ, Bentley JB, Paplanus SH. Factors influencing enflurane disposition in the obese. International Anesthesia Research Society, 54th Congress, Reno, 1980.

28. Gandolfi AJ, Nagle RB, Soltis JJ, Plescia F. Nephrotoxicity of halogenated vinyl cysteine compounds. Fed Proc 39:546, 1980.

29. MacDonald JR, Gandolfi AJ, Sipes IG. Potentiation of 1,1,2-trichloroethane hepatotoxicity by acetone pretreatment. Fed Proceed 39:999, 1980.

30. White RD, Sipes IG, Gandolfi AJ. Determination of ethylene bromide induced DNA injury by alkaline elution. Fed Proceed 39:1022, 1980.

31. Sipes IG, Gandolfi AJ. In vitro comparative bioactivation of aliphatic halogenated hydrocarbons. Second International Congress Toxicology, Tox. Letters, Special Issue 1:33, 1980.

32. Gandolfi AJ, Sipes IG, DiRenzo AB. Comparative microsomal bioactivation and covalent binding of organohalogens to DNA. Pharmacologists 22:247, 1980.

33. Sipes IG, Maiorino RM, Gandolfi AJ, Brendel K. Characterization of the organohalogen adducts to protein. Pharmacologist 22:391, 1980.

34. Sipes IG, Gandolfi AJ, Maiorino RM, Brown BR. Rapid analysis of trifluoroacetic acid and bromide. Anesthesiology 53:5257, 1980.

35. Bentley JB, Gandolfi AJ, Vaughan RW. Hepatorenal indices among general anesthetics in obesity. Anesthesiology 53:5259, 1980.

36. Gandolfi AJ, Sipes IG, Brown BR. Non-radiometric detection of covalent binding of halothane. Anesthesiology 53:5236, 1980.

37. Vaughan RV, Bentley JB, Cork RC, Gandolfi AJ. Does evidence of reductive halothane biotransformation correlate with hepatic binding of metabolites in obese patients. International Anesthesia Research Society, 55th Congress, Atlanta, 1980.

38. White RD, Sipes IG, Gandolfi AJ, Bowden GT. Evidence for microsomal bioactivation of 1,2-dibromoethane resulting in mammalian DNA injury. Toxicologist 1:99, 1981.

39. Bonhaus DW, Gandolfi AJ. Conjugation and bioactivation of chlorotrifluoroethylene and trichloroethylene. Toxicologist 1:100, 1981.

40. Buckley LA, Gandolfi AJ, Clayton JW, Nagle RB. A subacute study of the renal toxicity of inhaled chlorotrifluoroethylene in rats. Toxicologist 1:82, 1981.

41. Gandolfi AJ, Lind RC, Sipes IG, Brown BR, and Pohl LR. Profile in urinary radioactivity following exposure to 3H/14C halothane in the hypoxic model. Toxicologist 1:101, 1981.

42. MacDonald JR, Gandolfi AJ, and Sipes IG. Bioactivation and covalent binding of 14C-1,1,2-trichloroethane in acetone treated rats. Toxicologist 1:100, 1981.

43. Maiorino RM, Gandolfi AJ, and Sipes IG. Comparison of chloroform and 1,2-dibromoethane adducts to protein. Toxicologist 1:67, 1981.

44. Borel JD, Bentley JB, Vaughan RW, and Gandolfi AJ. Enflurane blood-gas solubility: Influence of weight, hemoglobin, and hematocrit. Anesthesiology 55:A195, 1981.

45. Bentley JB, Borel JD, Vaughan RW, and Gandolfi AJ. Weight: Succinylcholine requirement and pseudocholinesterase activity? Anesthesiology 55:A213, 1981.

46. Bentley JB, Vaughan RW, Gandolfi AJ, and Cork RC. Altered halothane metabolism: Obese vs. nonobese subjects. Anesthesiology 55:A179, 1981.

47. Bentley JB, Borel JD, Gillespie TJ, Vaughan RW, Gandolfi AJ. Fentanyl pharmacokinetics in obese and nonobese patients. Anesthesiology 55:A177, 1981.

48. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown Jr, BR. Pharmacokinetics of high and low dose alfentanil. Anesthesiology 55:A256, 1981.

49. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown Jr, BR. Pharmacokinetics of intravenous sufentanil. Anesthesiology 55:A251, 1981.

50. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown BR. Sufentanil, alfentanil, and fentanyl kinetics in dogs. Pharmacologist 23:469, 1981.

51. Bentley JB, Borel JD, Gillespie TJ, Vaughan RW, and Gandolfi AJ. Fentanyl pharmacokinetics: obese vs. nonobese patients. Pharmacologist 23:468, 1981.

52. Gandolfi AJ, Plescia FH, White RD, MacFarland RT, and Sipes IG. Disposition and hepatotoxicity of 1,2-dibromoethane. Pharmacologist 23:300, 1981.

53. Cater KC, Gandolfi AJ, and Sipes IG. A sequential quantitative study of dimethylnitrosamine (DMN) - induced hepatic hyperplastic nodules in the newborn mouse model. Pharmacologist 23:337, 1981.

54. Hassall C, Gandolfi AJ, and Brendel K. Depression of tubular active transport by halogenated hydrocarbons and their metabolites. Pharmacologist 23:411, 1981.

55. Gandolfi AJ, DiRenzo AB, McDougal JN, and Sipes IG. Effect of senescence on the bioactivation of aliphatic halides. Toxicologist 2:21, 1982.

56. Cater KC, Gandolfi AJ, and Sipes IG. An evaluation of dimethylnitrosamine (DMN) induced hepatocellular alterations in the newborn mouse model using histochemical and histoenzymatic markers. Toxicologist 2:99, 1982.

57. Vaughan RW, Bentley JB, Gandolfi AJ, and Cork RC. Comparative halothane metabolism in obese vs. nonobese patients. Sixth Asian Australian Congress of Anaesthesiologists, Auckland, New Zealand, 1982.

58. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of carbon tetrachloride induced hepatic damage. Fed Proc 41:1582, 1982.

59. Jaffe DR, Gandolfi AJ, Hassal CD, Bonhaus DB, and Brendel K. Production of DNA single strand breaks in kidney by 1,2-dichlorovinylcysteine (DCVC). Fed Proceed 41:1581, 1982.

60. Hassall CD, Jaffe D, Gandolfi AJ, and Brendel K. Renal toxicity of halogenated vinyl cysteine adducts in the rabbit in vivo and in vitro. Fed Proceed 41:1311, 1982.

61. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Role of endotoxin in the halothane hepatitis model in rats. Anesthesiology 57:A220, 1982.

62. Jaffe D, Hassall CD, Brendel K, and Gandolfi AJ. In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. Pharmacologist 24:A82, 1982.

63. Hassall CD, Gandolfi AJ, and Brendel K. Reversal of DCVC-induced inhibition of renal tubular active transport by glutathione. Pharmacologist 24:175, 1982.

64. MacFarland RT, Gandolfi AJ, and Sipes IG. Extrahepatic GSH-dependent metabolism of 1,2-dibromoethane (DBE) and 1,2-dibromo­3-chloropropane (DBCP) in the rat and mouse. Pharmacologist 24:136, 1982.

65. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Role of endotoxin in halothane hepatitis. Pharmacologist 24:193, 1982.

66. Lee HR, Gandolfi AJ, Sipes IG, and Bentley J. Effect of histamine H-receptors antagonists on fentanyl metabolism. Pharmacologist 24:145, 1982.

67. Bentley JB, Finley JH, Humphrey LR, Gandolfi AJ, and Brown BR. Obesity and alfentanyl pharmacokinetics. Anesth Analg 62:245, 1982.

68. Hassall CD, Gandolfi AJ, and Brendel K. Regulation of DCVC-induced renal tubular toxicity by glutathione. Toxicologist 3:71, 1983.

69. Glass SJ, Bentley JB, Jackson JE, Banner W, Gandolfi AJ, and Plachetka JR. The effect of cimetidine and ranitidine on lidocaine pharmacokinetics. Toxicologist 3:158, 1983.

70. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Endotoxin mediated mechanisms of halothane hepatitis. Toxicologist 3:116, 1983.

71. Jaffe DR, Gandolfi AJ, and Nagle RB. Chronic toxicity of S-(trans­1,2-dichlorovinyl)-L-cysteine (DCVC) in mice. Toxicologist 3:72, 1983.

72. Durham JA, Gandolfi AJ, and Bentley JB. Hepatotoxicological evaluation of dantrolene sodium. Toxicologist 3:130, 1983.

73. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of chemically induced hepatototoxicity. Toxicologist 3:97, 1983.

74. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Mediation of halothane hepatitis by endotoxin. Tox Letters 18:67, 1983.

75. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of chemically induced liver injury. Tox Letters 18:66, 1983.

76. Gandolfi AJ, Hassall CD, Jaffe DR, Brendel K, and Nagle RB. Nephrotoxicity of cysteine conjugates of halogenated alkenes. Tox Letters 18:66:1983.

77. Hassall CD, Gandolfi AJ, and Brendel K. Renal toxicity of dichlorovinyl glutathione in the rabbit. Fed Proceed 42:354, 1983.

78. MacDonald JR, Gandolfi AJ, and Sipes IG. Hepatic Ca++ levels following cystamine treatment of chemically-induced hepatotoxicity. Fed Proceed 42:356, 1983.

79. MacDonald JM, Lind RC, Gandolfi AJ, and Sipes IG. Analysis of hepatic calcium content by flame emission spectrometry. Fed Proceed 42:2068, 1983.

80. Gandolfi AJ, Weldon ST, and Blitt CD. Production and characterization of impurities in isoflurane vaporizers. Anesthesiology 59:A159, 1983.

81. Fukui T, Hameroff SR, and Gandolfi AJ. Alpha­1-acid glycoprotein plasma levels are elevated in chronic pain. Anesthesiology 59:A203, 1983.

82. Bentley JB, Glass SJ, and Gandolfi AJ. The influence of halothane on lidocaine pharmacokinetics in man. Anesthesiology 59:A246, 1983.

83. DiRenzo AB, Gandolfi AJ, Brendel K, Byard JL, and Sipes IG. Effect of hypoxia on the bioactivation and toxicity of CCl4 and halothane in primary rat hepatocyte cultures. Pharmacologist 25:170, 1983.

84. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Comparison of models for halothane and enflurane induced hepatotoxicity. Pharmacologist 25:231, 1983.

85. Sipes IG, DiRenzo AB, Gandolfi AJ, Brendel K, and Byard JL. Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat hepatocyte cultures. lst International Society for the Study of Xenobiotics Meeting, West Palm Beach, Florida, 1983.

86. Blitt CD, Weldon ST, Williams-Van Alstyne SI, and Gandolfi AJ. Survey of impurities in isoflurane and enflurane vaporizers. International Anesthesia Research Society, Reno, Nevada, 1984.

87. Lind RC, Gandolfi AJ, and Sipes IG. Comparison of the protective action of immunopotentiators to CCl4 hepatic injury. Toxicologist 4:78, 1984.

88. MacDonald JR, Gandolfi AJ, and Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicologist 4:78, 1984.

89. Lind RC, Gandolfi AJ, and Sipes IG. Role of induction and normothermia in two models of volatile anesthetic hepatotoxicity. Toxicologist 4:43, 1984.

90. Waters SJ, Gandolfi AJ, and Sipes IG. Reductive metabolism and hepatotoxicity of halothane in Arocolor 1254 pretreated rats. Toxicologist 4:93, 1984.

91. Gandolfi AJ, DiRenzo AB, Lind RC, and Waters SJ. Comparison of the in vivo and in vitro hepatotoxicity of enflurane and halothane. IUPHAR 9th International Congress, London, 1984

92. Brown BR, Gandolfi AJ, Lind RC, and Sipes IG. Conflicting mechanisms of hepatic injury with halothane and enflurane. Anesthesiology 64:A270, 1984.

93. Sipes IG, Gandolfi AJ, Lind RC, and Brown BR. Comparison of the mechanisms of hepatic injury with halothane and enflurane. Third International Conference on Anesthesia, Calgary, 1984.

94. Callis AH, Waters SJ, Gandolfi AJ, Pohl LR, Satoh H, and Sipes IG. Evidence for a role of the immune response in the pathogenesis of halothane hepatitis. Third International Conference on Anesthesia, Calgary, 1984.

95. Meadows SD, Gandolfi AJ, Nagle RB, and Brendel K. Persistent, progressive renal toxicity in male Swiss-Webster mice following subchronic exposure to 1,2-dichlorovinyl cysteine (DCVC). Second International Symposium on Nephrotoxicity, University Surrey, England, 1984.

96. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Second International Symposium on Nephrotoxicity, University of Surrey, England, 1984.

97. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. Preparation of precision liver slices for in vitro toxicology. Pharmacologist 26:194, 1984.

98. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Inhibition of organic acid/base transport in isolated rabbit renal tubules by nephrotoxins. Pharmacologist 26:193, 1984.

99. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. A unique organ culture system for in vitro studies of hepatotoxicity. Johns Hopkins Center for Alternatives to Animal Testing, Third Annual Meeting, Baltimore. October, 1984.

100. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Organic acid/base transport in rabbit proximal tubule suspensions. Effects of halogenated hydrocarbons. Johns Hopkins Center for Alternatives to Animal Testing, Third Annual Meeting, Baltimore. October, 1984.

101. Lind RC, DiRenzo AB, Gandolfi AJ, Sipes IG, and Brendel K. Oxygen requirements for the reductive biotransformation of halothane. Toxicologist 5:244, 1985.

102. DiRenzo AB, Gandolfi AJ, Brooks SD, and Brendel K. Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocyte suspensions. Toxicologist 5:148, 1985.

103. Rylander-Yueh LA, Brendel K, and Gandolfi AJ. Effect of hydrocarbons on renal tubular organic acid/base transport. Toxicologist 5:55, 1985.

104. Lind RC, Gandolfi AJ, and Sipes IG. Halothane hepatotoxicity in several strains of guinea pig. Toxicologist 5:75, 1985.

105. Silber PM, Gandolfi AJ, and Brendel K. Acute nephrotoxicity of 1,2-dichlorovinyl cysteine in New Zealand white rabbits. Toxicologist 5:55, 1985.

106. Smith PF, Shubat PJ, Gandolfi AJ, Krumdieck CL, and Brendel K. Novel dynamic organ culture system for hepatotoxicity studies. Toxicologist 5:151, 1985.

107. Brooks SK, Callis AH, Gandolfi AJ, Sipes IG, and Pohl LR. Induction of an immune response following halothane exposure. Toxicologist 5:42, 1985.

108. Callis AH, Brooks SD, Gandolfi AJ, Sipes IG, and Pohl LR. Specificity of the antibodies induced by halothane exposure. Toxicologist 5:42, 1985.

109. Ruegg CE, Gandolfi AJ, Brendel K, and Krumdieck CL. Positional renal slices for study of site specific toxicity. Toxicologist 5:57, 1985.

110. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of galactosamine-induced hepatic damage. Hepatic non-protein sulfhydryl levels. Toxicologist 5:153, 1985.

111. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. A novel organ culture system for the maintenance of adult rat liver. Fed Proceed 44:627, 1985.

112. Moore RA, Gallagher JD, Gandolfi AJ, Sipes IG, Kerns D, McNicholas KW, and Clark DL. Halothane metabolism in acyanotic and cyanotic congenital heart patients undergoing cardiac surgery. Anesthesiology 65:A539, 1985.

113. Lind RC, Gandolfi AJ, and Brown BR. Halothane hepatotoxicity in both sexes of four strains of guinea pigs. Anesthesiology 65:A541, 1985.

114. Callis AH, Gandolfi AJ, Brooks SD, and Brown BR. Changing specificities in halothane-induced antibody as a pathogenic factor in halothane hepatitis. Anesthesiology 65:A548, 1985.

115. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. In vitro site specific toxicity of mercuric chloride in rabbit renal cortical slices. Pharmacologist 27:130, 1985.

116. Becker GM, Gandolfi AJ, and Nagle RB. Cyclosporine nephrotoxicity in the rat. Society of Toxicology, Mountain States Chapter Meeting, October, 1985.

117. Smith PF, Fisher R, Krack G, Gandolfi AJ, and Brendel K. Bromobenzene and allyl alcohol hepatotoxicity in cultured rat liver slices: II. Inhibition of toxicity by selective enzyme inhibitors. Toxicologist 6:118, 1986.

118. Rylander LA, Phelps JS, Brendel K, and Gandolfi AJ. Rabbit proximal tubule suspensions for the study of early nephrotoxic events. Toxicologist 6:174, 1986.

119. Roth TP, Callis AH, and Gandolfi AJ. Detection of halothane induced antigen using specific anti-halothane metabolite antibodies. Toxicologist 6:66, 1986.

120. Silber PM, Gandolfi AJ, and Brendel K. Glutathionuria induced by mercuric chloride and hexachlorobutadiene. Toxicologist 6:176, 1986.

121. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Differential toxicity of ischemia and HgCl2 in rabbit renal cortical slices. Toxicologist 6:174, 1986.

122. DiRenzo AB, Gandolfi AJ, Brendel K, and Krack G. Effect of volatile anesthetics on protein synthesis and secretion in rat hepatocyte suspensions. Toxicologist 6:116, 1986.

123. Fisher R, Smith PF, Gandolfi AJ, Sipes, and Brendel K. Hepatotoxicity of dichlorobenzene isomers in Sprague Dawley rat liver organ explants. Toxicologist 6:119, 1986.

124. Fisher R, Barr J, Zukoski CF, Putnam CW, Gandolfi AJ, Sipes IG, and Brendel K. Hepatotoxicity of three dichlorobenzene isomers in human liver organ culture. Toxicologist 6:118, 1986.

125. Gandolfi AJ, Rylander LA, Phelps JS, and Brendel K. Utilization of rabbit renal proximal tubules to examine the chronology of injury by nephrotoxic agents. Johns Hopkins Center for Alternatives to Animal Testing. In Vitro Toxicology Symposium. Baltimore, April, 1986.

126. Phelps JS, Gandolfi AJ, and Brendel K. Cisplatin toxicity in rabbit renal proximal tubule suspensions and precision-cut renal cortical slices. Johns Hopkins Center for Alternatives to Animal Testing. In Vitro Toxicology Symposium, Baltimore, April, 1986.

127. Callis AH, Gandolfi AJ, Roth TP, and Brown BR. Circulating anti-halothane antibodies in patients with unexplained hepatitis following halothane exposure. Anesthesiology 65:A235, 1986.

128. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Circulating immune complexes in halothane hepatitis patients correlate with anti-halothane antibody levels. Pharmacologist 28:194, 1986.

129. Dale O, Gandolfi AJ, and Brendel K. Liver slices: In vitro pharmacokinetic drug interaction studies. Pharmacologist 28:205, 1986.

130. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Circulating immune complexes in halothane hepatitis patients correlate with anti-halothane antibody levels. Mountain West Chapter Society of Toxicology 4th Annual Meeting, Tucson, October 1986.

131. Lind RC and Gandolfi AJ. Effect of phenobarbital pretreatment on the guinea pig model of halothane-associated hepatic necrosis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

132. Schuman S, Roth TP, and Gandolfi AJ. Generation of an immune response in the guinea pigs to trifluoroethanol. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

133. Levy JP, Hubbard AK, and Gandolfi AJ. Characterization of antibodies produced in human halothane hepatitis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

134. Adamson CR, Gandolfi AJ, and Brendel K. Biotransformation and toxicity of volatile anesthetics in rat liver slices. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

135. Wolfgang GHI, Ruegg CR, Brendel K, and Gandolfi AJ. Comparison of renal cortical slices incubated in two in vitro systems. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October 1986.

136. Osman K, Roth TP, and Gandolfi AJ. Circulating immune-complexes in halothane-induced hepatic injury in rabbits. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

137. Siadat-Pajouh M, Hubbard AK, and Gandolfi AJ. Halothane induced immune response in a guinea pig model of halothane hepatitis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

138. Fisher R, Wishnies S, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. The effect of different culture media on the toxicity of monochlorobenzene and dichlorobenzenes. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

139. Becker G, Fisher R, Krumdieck CL, Gandolfi AJ, and Brendel K. Valproic acid toxicity in precision-cut liver slices. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.

140. Dale O, Gandolfi AJ, and Brendel K. Volatile anesthetics and diazepam metabolism: Interaction studies with rat liver slices. Fed Proceed 46:866, 1987.

141. Levy JP, Hubbard AK, and Gandolfi AJ. Characterization of antibodies produced in human halothane hepatitis. Toxicologist 7:231, 1987.

142. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Selective in vitro necrosis of proximal tubular segments in renal cortical slices. Toxicologist 7:88, 1987.

143. Roth TP, Osman K, Schuman S, Hubbard AK, and Gandolfi AJ. Chronology of halothane-induced antigen expression in halothane exposed rabbits. Toxicologist 7:232, 1987.

144. Lind RC, Gandolfi AJ, and Brown BR. Effect of phenobarbital pretreatment on the guinea pig model of halothane-associated hepatic necrosis. Toxicologist 7:55, 1987.

145. Wolfgang GHI, Gandolfi AJ, and Brendel K. In vitro toxicity of cephaloridine and hexachlorobutadiene in rabbit cortical slices. Toxicologist 7:90, 1987.

146. Siadat-Pajouh M, Roth TP, Hubbard AK, and Gandolfi AJ. Halothane induced immune response in a guinea pig model of halothane hepatitis. Toxicologist 7:231, 1987.

147. Adamson CR, Gandolfi AJ, and Brendel K. Toxicity of volatile anesthetics in rat liver slices. Toxicologist 7:60, 1987.

148. Fisher RL, Wishnies SM, Sipes IG, Gandolfi AJ, and Krumdieck CL. The effect of different culture media on the toxicity of monochlorobenzine and the dichlorobenzenes. Toxicologist 7:60, 1987.

149. Brendel K, Becker GM, Fisher RL, Smith PF, Gandolfi AJ, and Krumdieck CL. Organ slice technology: A tool to evaluate regioselective toxicity. Toxicologist 7:59, 1987.

150. Brendel K, Krumdieck CL, Gandolfi AJ, and McKee RM. Precision cut tissue slices in culture: A new tool in pharmacology. Western Pharmacology Society Meetings, Hawaii, 1987.

151. Dale O, Gandolfi AJ, and Brendel K. Rat liver slices and diazepam metabolism: In vitro interactions with volatile anesthetics and albumin. Norwegian Society of Pharmacology and Toxicology. Beito, Norway, 1987.

152. Dale O, Gandolfi AJ, and Brendel K. Elimination of diazepam in rat liver slices: Interactions with albumin and volatile anesthetics. The 19th Scandinavian Congress of Anesthesiologists, Sweden, 1987.

153. Wolfgang GHI, Gandolfi AJ, and Brendel K. In vitro toxicity of dichlorovinyl cysteine in rabbit renal cortical slices. Pharmacologist 29:A540, 1987.

154. Wolfgang GHI, Gandolfi AJ, and Brendel K. Regioselective toxicity by dichlorovinyl cysteine in rabbit renal cortical slices. Third International Symposium on Nephrotoxicity, University of Surrey, Guildford, England, 1987.

155. Ruegg CE, Gandolfi AJ, and Brendel K. Regioselective acute tubular necrosis in renal cortical slices following HgCl2 and K2Cr2O7: Localization and transport studies. Third International Symposium on Nephrotoxicity, University of Surrey, Guildford, England, 1987.

156. Cork RC, Gallo JA, Weiss LB, Plezia P, Kramer T, Levy JP, and Gandolfi AJ. Sufentanil infusion: Pharmacokinetics compared to bolus. IARS 62nd Congress, 1988.

157. Cork RC, Gallo JA, Smith R, Copeland J, Kramer T, Plezia P, Levy J, and Gandolfi AJ. Pharmacokinetics of sufentanil and the total artificial heart. A four-compartment model. 41st Post Graduate Assembly, New York, 1987.

158. Lind RC and Gandolfi AJ. Effects of both nitrous oxide and animal weight on the guinea pig model of halothane associated hepatic necrosis. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.

159. Roth TP, Schuman S, Hubbard AK, and Gandolfi AJ. Localization of halothane-induced antigen by specific anti-halothane metabolite antibodies. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.

160. Schuman S, Roth TP, and Gandolfi AJ. Antigenic similarity of halothane induced antigens and synthetic trifluoroacetylated proteins. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.

161. Ruegg CE, Gandolfi AJ, and Brendel K. HgCl2 and K2Cr2O7 induced regioselective acute tubular necrosis in renal cortical slices: Localization and transport studies. Kidney International, 1987.

162. Wolfgang GHI, Gandolfi AJ, Krumdieck CL, and Brendel K. Evaluation of organic nephrotoxins using rabbit renal cortical slices. Johns Hopkins Center for Alternatives to Animal Testing Annual Meeting, "Progress in In Vitro Toxicology", 1987.

163. Roth TP, Hubbard AK, and Gandolfi AJ. Localization of halothane-induced antigen in situ by specific anti halothane metabolite antibodies. Toxicologist 8:11, 1988.

164. Hubbard AK, Roth TP, and Gandolfi AJ. Elicitation of a cell-mediated immune response to a reactive intermediate of halothane. Toxicologist 8:12, 1988.

165. Wolfgang GHI, Gandolfi AJ, Brendel K, and Nagle RB. Effect of transport and biotransformation on the renal site-specific toxicity of dichlorovinyl cysteine (DCVC). Toxicologist 8:1, 1988.

166. Lind RC and Gandolfi AJ. Effects of nitrous oxide and body weight on the guinea pig model of halothane hepatotoxicity. Toxicologist 8:65, 1988.

167. Connors MS, Bell MV, Gandolfi AJ, and Brendel K. Temporal separation of K+ and Ca++ movements in cultured rat livers treated with model hepatotoxicants. Toxicologist 8:66, 1988.

168. Fisher R, Gandolfi AJ, Nau H, and Brendel K. Valproic acid hepatotoxicity in rat, pig and human liver slices. Toxicologist 8:224, 1988.

169. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, and Brendel K. Partial retention of biotransformation in cryopreserved precision-cut liver slices. Toxicologist 8:203, 1988.

170. Wolfgang GHI, Gandolfi AJ, Nagle RB, and Brendel K. Progression of cellular injury induced by dichlorovinylcysteine (DCVC) in renal cortical slices. FASEB J 2:A794, 1988.

171. Vernetti LA, Gandolfi AJ, and Nagle RB. Effects of cyclosporins on intermediary filaments in DU­145 and PTK2 cells. FASEB J 2:A404, 1988.

172. Fisher R, Hanzlik RP, Gandolfi AJ, and Brendel K. Toxicity of ortho-substituted bromobenzenes to precision-cut rat liver slices. FASEB J 2:A1134, 1988.

173. Connors MS, Gandolfi AJ, and Brendel K. Enzyme leakage as an index of toxicity in incubating rat liver slices. Western Pharmacology Society, 1988.

174. Stefaniak MS, Gandolfi AJ, and Brendel K. Adult rat lung in dynamic organ culture. Western Pharmacology Society 1987.

175. Brendel K, Gandolfi AJ, Sipes IG, and Krumdieck CL. Xenobiotic metabolism in precision-cut human liver slices in organ culture. FASEB J 2:1988.

176. Connors MS, Gandolfi AJ, and Brendel K. Release of cellular enzymes from precision-cut rat liver slices in organ culture. FASEB J 2:A826, 1988.

177. Zaghloul HA, Gandolfi AJ, and Brendel K. In vitro nephrotoxicity of phenacetin in precision-cut rat kidney slices in dynamic organ culture. FASEB J 2:A803, 1988.

178. Stefaniak MS, Gandolfi AJ, and Brendel K. Agarose filled precision-cut rat lung slices in organ culture. FASEB J 2:A1606, 1988.

179. Brendel K, Gandolfi AJ, Sipes IG, and Krumdieck CL. Precision-cut liver slices in organ culture: A new tool in human drug metabolism and hepatotoxicity studies. American Assoc Pharmaceutical Scientists, 1988.

180. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Effect of body weight, sex, and nitrous oxide on halothane hepatotoxicity in the guinea pig. Anesthesiology 69:A442, 1988.

181. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity. Anesthesiology 69:A438, 1988.

182. Azri S, Gandolfi AJ, and Brendel K. Carbon tetrachloride toxicity in precision-cut rat liver slices. Pharmacologist 30:A58.3, 1988.

183. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. M.W. SOT, Salt Lake City, 1988.

184. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. M.W. SOT, Salt Lake City, 1988.

185. Limstrom SA, Connors S, Gandolfi AJ, and Brendel K. Gluconeogenesis as a viability parameter in precision-cut liver slices. American Federation for Clinical Research, 1988.

186. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. Toxicologist 9:26, 1989.

187. Fernando J, Ghantous HN, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. Toxicologist 9:283, 1989.

188. Hastings KL, Schuman S, Brown AP, Hubbard AK, and Gandolfi AJ. In situ detection of trifluoroacetylated antigens following in vivo exposure to halothane, enflurane, or isoflurane. Toxicologist 9:171, 1989.

189. Lind RC and Gandolfi AJ. Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. Toxicologist 9:147, 1989.

190. Vernetti LA, Gandolfi AJ, and Nagle RB. Cyclosporin A produces a selective rearrangement in cytokeratin intermediate filaments in PTK2 cell cultures. Toxicologist 9:159, 1989.

191. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. Toxicity, transport and metabolism of N-acetyl S-(1,2-dichlorovinyl)-L-cysteine (NAC-DCVC) in rabbit renal cortical slices. Toxicologist 9:80, 1989.

192. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. The effects of short term storage on xenobiotic metabolism of vitrified human liver slices. Toxicologist 9:283, 1989.

193. Connors S, Gandolfi AJ, Krumdieck CL, and Brendel K. Species comparison of cocaine hepatotoxicity in cultured rat liver slices. Toxicologist 9:69, 1989.

194. Klimecki WT, Wishnies SM, Gandolfi AJ, Krumdieck CL, and Brendel K. Xenobiotic metabolism in microslices from distinct regions of the liver. Toxicologist 9:283, 1989.

195. Fisher RL, Gandolfi AJ, Krumdieck CL, and Brendel K. The use of human cryopreserved precision-cut liver slices in hepatotoxicity studies. Toxicologist 9:282, 1989.

196. Connors S, Rankin DR, Gandolfi AJ, Krumdieck, and Brendel K. Effects of phenobarbital, ethanol and morphine on cocaine induced hepatotoxicity in precision-cut liver slices. Western Pharm Soc Meeting, February, 1989.

197. Gandolfi AJ and Brendel K. In vitro systems for nephrotoxicity studies. Practical In Vitro Toxicology, Nottingham, England, 1989.

198. Gandolfi AJ, Thomas CM, Azri S, and Brendel K. Histopathological evaluation of cultured precision-rat liver slices exposed to hepatotoxins. International Congress of Toxicology, Brighton, England, 1989.

199. Hastings KL, Schuman S, Hubbard AK, and Gandolfi AJ. Methods useful in diagnosis of the immunotoxic disease, halothane hepatitis. International Congress of Toxicology, Brighton, England, 1989.

200. Fisher R, Sipes IG, Gandolfi AJ, and Brendel K. Viability and toxicity assessment of cryopreserved human liver slices. Cryobiology Meetings, Charleston, S.C., June 15, 1989.

201. Hastings KL, Enriquez FJ, Bradley-Dunlop D, Schuman S, Thomas CM, Hubbard, AK, and Gandolfi AJ. Development of a monoclonal antibody reactive with halothane-associated neoantigens. Pharmacologist 31:193, 1989.

202. Lind RC, Ghantous HN, Gandolfi AJ, and Brown BR. Sevoflurane biotransformation and hepatotoxicity in the guinea pig. Anesthesiology 71:A310, 1989.

203. Lind RC, Black JB, Gandolfi AJ, and Brown BR. Covalent binding of biotransformation intermediates influences halothane-associated hepatotoxicity in guinea pigs. Anesthesiology 71:A242, 1989.

204. Stefaniak MS, Gandolfi AJ, and Brendel K. Lung explants: Characterization and intoxication. Mountain West Society of Toxicology, October, 1989.

205. Azri S, Mata HP, Gandolfi AJ, and Brendel K. Covalent binding of CCl4 to rat liver slices and conjugated diene formation. Mountain West Society of Toxicology, October, 1989.

206. Brown AP, Hastings KL, and Gandolfi AJ. In vitro covalent binding of halothane metabolites and neoantigen production in guinea pig liver slices. Mountain West Society of Toxicology, October, 1989.

207. Azri S, Gandolfi AJ, and Brendel K. Effects of biotransformation inducers and inhibitors on CCl4 toxicity in rat liver slices. Toxicologist 9:167, 1990.

208. Hastings KL, Schuman S, Thomas C, Brown AP, Hubbard AK, and Gandolfi AJ. Laboratory methods for the diagnosis of halothane hepatitis. Anesthesiology 71:A235, 1990.

209. Stefaniak MS, Pretlow TP, Krumdieck CL, Gandolfi AJ, and Brendel K. Agar-filled rat lung slices for use in toxicologic evaluations. Toxicologist 10:339, 1990.

210. Connors S, Rankin DR, Gandolfi AJ, Krumdieck CL, Eskelson C, and Brendel K. Liver slices from chronic ethanol treated rats are sensitized to cocaine hepatotoxicity. Toxicologist 10:332, 1990.

211. Parrish AR, Shipp NG, Dorr RT, Krumdieck CL, Pretlow TP, Gandolfi AJ, and Brendel K. Short term culture of adult rat heart slices. Toxicologist 10:34, 1990.

212. Fisher R, Sipes IG, Gandolfi AJ, and Brendel K. Toxicity assessment in cryopreserved human kidney and liver slices. Toxicologist 10:283, 1990.

213. Lohr CL, Gandolfi AJ, and Hubbard AK. Immunogenicity studies of a synthetic antigen of alpha-methyl dopa. Toxicologist 10:34, 1990.

214. Azri S, Mata HP, Gandolfi AJ, and Brendel K. CCl4 induced lipid peroxidation and enzyme loss in rat liver slices. Toxicologist 10:52, 1990.

215. Hastings KL, Schuman S, Brown AP, Thomas C, and Gandolfi AJ. Effect of S-ethylthiotrifluoroacetate pretreatment on the immune response to halothane in the guinea pig. Toxicologist 10:292, 1990.

216. Lind RC and Gandolfi AJ. Glutathione depletion potentiates a guinea pig model of halothane-associated hepatotoxicity. Toxicologist 10:66, 1990.

217. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of a halothane metabolite and neoantigen production in guinea pig liver slices in vitro. Toxicologist 10:331, 1990.

218. Gala K, Spaulding TC, Gandolfi AJ, and Waters SJ. Examination of the structural components responsible for the in vitro hepatotoxicity of M­741, an experimental neuromuscular blocking agent. Toxicologist 10:67, 1990.

219. Waters SJ, Spaulding TC, Brendel K and Gandolfi AJ. Hepatotoxicity of menadione in Sprague-Dawley rat liver slices. Toxicologist 10:66, 1990.

220. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Effect of volatile anesthetics on protein synthesis and secretion in guinea pig liver slices. Toxicologist 10:332, 1990.

221. Gandolfi AJ, Stefaniak MS, Eskelson CE, and Brendel K. Comparative toxicities of pulmonary toxins in agar-filled rat lung slices. Toxicologist 10:339, 1990.

222. Azri S, Mata HP, Gandolfi AJ, and Brendel K. CCl4 induced cytochrome P­450 loss and lipid peroxidation in rat liver slices. Biol React Intermediates IV, Tucson, January 1990.

223. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of halothane metabolite and neoantigen production in guinea pig liver slices. Biol React Intermediates IV, Tucson, January 1990.

224. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Inhibition of protein synthesis and secretion by volatile anesthetics in guinea pig liver slices. Biol React Intermediates IV, Tucson, January 1990.

225. Hastings KL, Schuman S, Brown AP, Thomas C, and Gandolfi AJ. S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Biol React Intermediates IV, Tucson, January 1990.

226. Lind RC and Gandolfi AJ. Covalent binding of oxidative biotransformation reactive intermediates to protein influences halothane-associated hepatotoxicity in guinea pigs. Biol React Intermediates IV, Tucson, January 1990.

227. Vernetti LA, Gandolfi AJ, and Nagle RB. Selective alteration of cytokeratin intermediate filament by cyclosporine A is a lethal toxicity in PtK2 cell cultures. Biol React Intermediates IV, Tucson, January 1990.

228. Wishnies SM, Gandolfi AJ, Sipes IG, and Brendel K. Biotransformation activity and chemical induced toxicity in vitrified human kidney cortical slices. Toxicologist 10:284, 1990.

229. Ghantous HN, Fernando J, Hastings K, Gandolfi AJ, and Brendel K. Volatile anesthetics effect on protein and albumin synthesis and secretion in guinea pig liver slices. FASEB J 4:A1140, 1990.

230. Lind RC and Gandolfi AJ. Glutathione depletion exacerbates halothane-associated hepatotoxicity in guinea pigs. Anesthesiology 73:A398, 1990.

231. Ghantous HN, Fernando J, Hastings KL, Gandolfi AJ, and Brendel K. The effect of volatile anesthetics on albumin synthesis and secretion in the guinea pig liver slices. Anesthesiology 73:A359, 1990.

232. Brown AP, Hastings KL, and Gandolfi AJ. Production and detection of volatile anesthetic-associated neoantigens in vitro. Anesthesiology 73:A350, 1990.

233. Brendel K, Fisher R, Gandolfi AJ, and Krumdieck C. Structure activity in organ cultured liver slices. CIBA-Geigy Workshop. "Structure Activity Relationships in Predictive Toxicology". June 21, 1990.

234. Azri S, Mata HP, Gandolfi AJ, and Brendel K. Loss of site-specific enzymes in precision-cut liver slices following intoxication with CCl4. ISSX, San Diego, October 1990.

235. Vernetti LA, Cress AE, Sarid D, Nagle RB, and Gandolfi AJ. Molecular interaction of cyclosporine A and mitoxantrone with cytokeratin protein. ISSX, San Diego, October 1990.

236. Fisher RL, Lofquist J, Bardsley BA, Paparo JJ, Cook DC, Gandolfi AJ, and Brendel K. Availability of human kidney, pancreas and liver slices for research. Amer Soc Cell Biol, 1990.

237. Vernetti AL, Gandolfi AJ, Nagle RB, and Cress AE. Cyclosporin A inhibition of cytokeratin intermediate filament phosphorylation shifts cytokeratin protein to a more insoluble form. Mountain West Society of Toxicology, Tucson, October 1990.

238. Fernando JL, Ghantous HN, Gandolfi AJ, and Brendel K. Comparative biotransformation and toxicity of desflurane and isoflurane in guinea pig liver slices. Mountain West Society of Toxicology, Tucson, October, 1990.

239. Thomas C, Hastings KL, Payne A, and Gandolfi AJ. Development of a murine model for halothane hepatitis: Preliminary investigations. Mountain West Society of Toxicology, Tucson, October, 1990.

240. Mata HP, Azri S, Gandolfi AJ, and Brendel K. Loss of site-specific enzymes in precision-cut rat liver slices following chloroform intoxication. Mountain West Society of Toxicology, Tucson, October, 1990.

241. Nowlin CLA, Howells S, Sarid D, and Gandolfi AJ. Preparation of mitochondria for scanning tunneling microscopy evaluation. Mountain West Society of Toxicology, Tucson, October, 1990.

242. Sanuik JT, Connors S, Gandolfi AJ, and Brendel K. Effect of trifluoroperazine (TFP) on allyl alcohol (AA) and acrolein (AC) toxicity in precision-cut rat liver slices in culture. Mountain West Society of Toxicology, Tucson, October, 1990.

243. Michaud JP, Gandolfi AJ, and Brendel K. The microtox system: A screening tool for interactive toxicity? Mountain West Society of Toxicology, Tucson, October, 1990.

244. Gandolfi AJ, Azri S, Mata HP, and Brendel K. The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slices. Toxicologist 11:A153, 1991.

245. Azri S, Mata HP, Gandolfi AJ, and Brendel K. The selective toxicity of CHCl3 in precision-cut rat liver slices. Toxicologist 11:A156, 1991.

246. Reid LL, Hastings KL, Gandolfi AJ, and Van Ert M. Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity. Toxicologist 11:A751, 1991.

247. Lind RC and Gandolfi AJ. Subanesthetic halothane is hepatotoxic in guinea pigs; plasma ICDH vs ALT as an index of injury. Toxicologist 11:A155, 1991.

248. Hastings KL, Thomas C, Brown AP, and Gandolfi AJ. A murine model for halothane hepatitis. Toxicologist 11:A609, 1991.

249. Vernetti LA, Nagle RB, and Gandolfi AJ. Inhibition of cytokeratin intermediate filament phosphorylation by cyclosporine A alters filament disassembly. Toxicologist 11:A312, 1991.

250. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Evaluation of two new anesthetics by precision-cut guinea pig liver slices. Toxicologist 11:A154, 1991.

251. Sheevers HV, Wunz TP, Wright SH, Brendel K, and Gandolfi AJ. Toxicity of organic cation compounds in precision-cut rabbit renal cortical slices. Toxicologist 11:A484, 1991.

252. Brown AP, Hastings KL, Cress AE, Gandolfi AJ, and Brendel K. Covalent binding of a halothane metabolite to a 30 kD protein in guinea pig liver slices. Toxicologist 11:A754, 1991.

253. Ellis JK, Spaulding TC, Gala K, Gandolfi AJ, and Waters SJ. Acute hepatotoxicity of M­741 in Sprague-Dawley rats. Toxicologist 11:A613, 1991.

254. Waters SJ, Spaulding TC, Brendel K, and Gandolfi AJ. Hepatotoxicity of benzyl viologen in Sprague-Dawley rat liver slices. Toxicologist 11:A782, 1991.

255. Stefaniak MS, Gandolfi AJ, and Brendel K. Toxicity of redox cycling compounds in rat lung slices. Toxicologist 11:A850, 1991.

256. Brendel K, Stefaniak MS, Spall RD, and Gandolfi AJ. Demonstration of cell-specific injury using rat lung slices. Toxicologist 11:A849, 1991.

257. Connors S, Sanuik JT, Gandolfi AJ, and Brendel K. Trifluoroperazine (TFP) protection against allyl alcohol (AA) toxicity in precision-cut rat liver slices. Toxicologist 11:160, 1991.

258. Krumdieck CL, Wishnies SM, Parrish AR, Gandolfi AJ, and Brendel K. Cold preservation of rat livers for use in biotransformation studies. Toxicologist 11:A158, 1991.

259. Fisher R, Gandolfi AJ, and Brendel K. Availability of human kidney slices for nephrotoxicity studies. Toxicologist 11:A464, 1991.

260. Carter SJ, Fisher RL, Gandolfi AJ, and Brendel K. Cold preservation of rat livers for in vitro toxicity assessment. Toxicologist 11:A157, 1991.

261. Parrish AR, Shipp NG, Dorr RT, Gandolfi AJ, and Brendel K. Comparative cardiotoxicity of allyamine (AA) and doxorubicin (DOX) in myocardial slices. Toxicologist 11:A1321, 1991.

262. Wishnies SM, Gandolfi AJ, and Brendel K. In vitro maintenance of phase I and II xenobiotic metabolism in rat liver slices. Toxicologist 11:A159, 1991.

263. Morgan S, Frink EJ, Ghantous H, Gandolfi AJ, and Brown BR. Inorganic fluoride production following sevoflurane in healthy surgical patients. Anesthesiology 75:A349, 1991.

264. McGuinness SJ, Ryan MP, Gandolfi AJ, and Brendel K. Comparison of renal tubules and slices for in vitro nephrotoxicity studies. International Society of Nephrology, Chatham, Massachusetts, October 1991.

265. Clarke JB, Hastings KL, and Gandolfi AJ. Effect of chloroquine on the formation of halothane-induced liver antigens. A tool to investigate drug hypersensitivity reactions. Foundation for Immunotoxicology, Sixth Annual Symposium, Virginia Beach, VA, October 1991.

266. Lind RC, Gandolfi AJ, and Hall PM. Glutathione depletion enhances covalent binding and hepatotoxicity of subanesthetic halothane in the guinea pig. Hepatology 14:A 451, 1991.

267. Brown AP, Hastings KL, and Gandolfi AJ. An in vitro model for hepatocyte secretion of halothane derived liver protein neoantigens. Foundation for Immunotoxicology, Sixth Annual Symposium, Virginia Beach, VA, October 1991.

268. Lerman J, Kleinman S, Yentis S, Sikich N, Ghantous H, and Gandolfi AJ. Plasma inorganic fluoride concentration in children anesthetized with sevoflurane. International Anes Research Society, 1991.

269. Sanuik JT, Fisher R, Carter SJ, Gandolfi AJ, and Brendel K. Cold- and cryo-preservation of dog liver and kidney slices. Toxicologist 12:A1433, 1992.

270. Carter SJ, Fisher RL, Sanuik JT, Hanzlik RP, Gandolfi AJ, and Brendel K. A comparison between rat liver slices, hepatocytes and the whole animal. Toxicologist 12:A1448, 1992.

271. Church LT, Wishnies SM, Gandolfi AJ, and Brendel K. Cold preservation of biotransformation activity in dog liver slices. Toxicologist 12:A1432, 1992.

272. Wishnies SM, Gandolfi AJ, and Brendel K. Co-culture of rabbit cortical kidney slices and liver slices: Phenacetin toxicity. Toxicologist 12:A287, 1992.

273. Parrish AR, Dorr RT, Gandolfi AJ, and Brendel K. The precision-cut adult human and rat heart slices: A model for doxorubicin and mitoxantrone cardiotoxicity. Toxicologist 12:A1507, 1992.

274. Hubbard AK and Gandolfi AJ. Reactivity of plasma from methyl dopa treated mice to liver proteins. Toxicologist 12:A642, 1992.

275. Waters SJ, McNeill J, Spaulding TC, Brendel K, and Gandolfi AJ. Rapid uptake and toxicity of M-741 in rat hepatic slices. Toxicologist 12:A1430, 1992.

276. Nowlin CLA, Howells S, Sarid D, and Gandolfi AJ. Examination of mitochondria exposed to 1,2-dimethylhydrazine using atomic force microscopy and other techniques. Toxicologist 12:A993, 1992.

277. Keith RL, Brendel K, Gandolfi AJ, Lowe TP, and Fernando Q. Utilization of precision-cut rabbit renal cortical slices to study the nephrotoxicity of metallic toxicants in chemical waste dumps. Toxicologist 12:A1457, 1992.

278. Lind RC and Gandolfi AJ. Concentration dependent inhibition of halothane biotransformation and covalent binding in the guinea pig. Toxicologist 12:A152, 1992.

279. Clarke JB, Chen ML, and Gandolfi AJ. Effect of chloroquine on the formation of halothane-induced liver antigens in guinea pigs. A tool to investigate immune-mediated toxicity. Toxicologist 12:A79, 1992.

280. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of a halothane biotransformation intermediate to a 27 kD cytosolic protein in guinea pig liver slices. Toxicologist 12:A80, 1992.

281. Hastings KL, Brown AP, Liebler DC, and Gandolfi AJ. Biotransformation of halothane to an oxidative intermediate that covalently binds cytosolic protein in an in vitro microsomal/cytosolic incubation system. Toxicologist 12:A963, 1992.

282. Sheevers HV, Wunz TM, Wunz TP, Wright SH, Brendel K, and Gandolfi AJ. Nephrotoxicity of quinolinium and pyridinium compounds in precision-cut rabbit renal cortical slices. Toxicologist 12:A286, 1992.

283. McGuinness SJ, Rankin DR, Gandolfi AJ, and Brendel K. Investigation of the nephrotoxicity of ellipticine and several derivatives in in vitro renal systems. Toxicologist 12:A288, 1992.

284. Mata E, Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Chronology of toxic events produced by halothane in guinea pig liver slices. Toxicologist 12:A1429, 1992.

285. Ghantous H, Mata E, Morgan S, Gandolfi AJ, and Brendel K. Effect of volatile anesthetics on guinea pig liver slices from livers preserved in University of Wisconsin solvent. Toxicologist 12:A1428, 1992.

286. Lind RC, Gandolfi AJ, and Hall PM. An animal model for fatal halothane hepatitis. VI International Congress of Toxicology, Rome, Italy, 1992.

287. Gandolfi AJ. In vitro approaches to nephrotoxicity studies. VI International Congress of Toxicology, Rome, Italy, 1992.

288. Lind RC, Gandolfi AJ, and Hall PM. A model for fatal halothane hepatitis in guinea pigs. Hepatology 16:161A, 1992.

289. Sheevers HV, Brendel K, and Gandolfi AJ. Transport of l-benzyl quinolinium in rabbit renal cortical slices and proximal tubule suspensions. MW SOT, Utah State University, Logan, Utah, September 1992.

290. Michaud JP, Gandolfi AJ, and Brendel K. Assessment of toxic interactions; Synergy of BrCCl3 and HCCl3 in rat liver slices. MWSOT, Utah State University, Logan, Utah, September 1992.

291. Clarke JB, Chen ML, Thomas C, and Gandolfi AJ. Enflurane produces cytosolic and microsomal liver adducts in the guinea pig crossreactive with halothane induced antibodies. Toxicologist 13:359, 1993.

292. Sheevers HV, Wright SH, Brendel K, and Gandolfi AJ. Toxicity and transport of l-benzyl quinolinium in rabbit renal cortical slices and proximal tubule suspensions. Toxicologist 13:207, 1993.

293. Keith RL, McGuinness SJ, Lowe TP, Chen Q, Fernando Q, and Gandolfi AJ. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Toxicologist 13:208, 1993.

294. Brown AP and Gandolfi AJ. Glutathione-S-transferase is covalently modified in the guinea pig liver following an in vivo exposure to halothane. Toxicologist 13:112, 1993.

295. McGuinness SJ, Rankin DR, Bezrutczyk P, Brendel K, and Gandolfi AJ. Nephrotoxicity and transport of celiptium in rabbit renal slices and isolated proximal tubules in suspension. Toxicologist 13:208, 1993.

296. Lind RC, Gandolfi AJ, and Hall PM. A guinea pig model for fatal halothane hepatitis. Toxicologist 13:31, 1993.

297. Gandolfi AJ, Ijomah P, and Brendel K. Microscopic evaluation of mercuric chloride nephrotoxicity in rabbit renal cortical slices. Toxicologist 13:208, 1993.

298. Burton C, Hatlelid K, Devine K, Fernando Q, Carter DE, Brendel K, and Gandolfi AJ. Effects of glutathione on HgCl2 and NaAsO2 toxicity and uptake in rabbit renal cortical slices. Toxicologist 13:190, 1993.

299. Hasal KS, Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Prolonged culture of liver slices. Toxicologist 13:137, 1993.

300. Hasal SJ, Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Rainbow trout liver slices: A tool for aquatic toxicology. Toxicologist 13:185, 1993.

301. Sanuik JT, Fisher RL, Hasal SJ, Gandolfi AJ, Krumdieck CL, and Brendel K. Roller culture conditions and slice diameter effect the viability of rat and mouse liver slices. Toxicologist 13:137, 1993.

302. Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Quality of human liver tissue effects cold- and cryo- preservation of slices. Toxicologist 13:130, 1993.

303. Brendel K, Fisher RL, Sanuik JT, Hasal SJ, Michaud JP, and Gandolfi AJ. Interactive hepatotoxicity in the binary system Hg++ - Halobenzenes using rat liver slices. Toxicologist 13:436, 1993.

304. Michaud JP, Gandolfi AJ, and Brendel K. Assessment of toxic interactions: Deviation from additivity by combinations of organohalides in rat liver slices. Toxicologist 13:339, 1993.

305. Ziegler TL, Winter SM, Sell R, Gandolfi AJ, and Sipes IG. Metabolism of acrylic acid in Sprague-Dawley rat liver and kidney slices. Toxicologist 13:138, 1993.

306. Burton C, Hatlelid K, Divine K, Fernando Q, Carter DE, Brendel K, and Gandolfi AJ. Glutathione effects on toxicity and uptake of HgCl2 and NaAsO2 in rabbit renal cortical slices. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

307. Keith RL, McGuinness SJ, Lowe TP, Chen Q, Fernando Q, and Gandolfi AJ. Uptake and accumulation of metals in rabbit renal cortical slices: Metal interaction studies. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

308. Hasal SJ, Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Trout liver slices as a tool for aquatic toxicology. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

309. Michaud JP, Gandolfi AJ, and Brendel K. Comparison of the microtox assay and rat liver slice culture for the study of interactive toxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

310. Michaud JP, Gandolfi AJ, and Brendel K. Validation of precision cut liver slice culture for the study of interactive hepatotoxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

311. Michaud JP, Gandolfi AJ, and Brendel K. Mathematical modeling and experimental designs for the study of interactive toxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

312. Fisher RL, Hasal SJ, Sanuik JT, Michaud JP, Gandolfi AJ, and Brendel K. Interactive hepatotoxicity in the binary system Hg++ - Halobenzenes using rat liver slices. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.

313. Payne AK, Morgan SE, and Gandolfi AJ. Biotransformation of sevoflurane in male Sprague Dawley rat liver slices. ISSX, Tucson, October, 1993.

314. Sell R and Gandolfi AJ. Use of precision cut rat liver slices for the biochemical assessment of liver preservation conditions. Hepatology, 18:322A, 1993.

315. Fisher RL, Hasal SJ, Gandolfi AJ, and Brendel K. Quality of human liver tissue affects the metabolism of isomeric dichlorobenzenes. ISSX, Tucson, October, 1993.

316. Fisher RL, Hasal SJ, Sipes IG, Gandolfi AJ, and Brendel K. Differences in dichlorobenzene metabolism and toxicity between Sprague-Dawley, Fischer 344 and human liver slices. ISSX, Tucson, October, 1993.

317. Keith RL, Ingersoll RT, Setiarahardjo I, Fernando Q, Aposhian VH, and Gandolfi AJ. Use of renal slices to evaluate chelators on the removal of Hg from the kidney. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.

318. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Induction of stress protein synthesis in precision-cut rat liver slices. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.

319. Sell R, Brendel K, and Gandolfi AJ. Precision cut rat liver slices: A model for the study of cold preservation injury. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.

320. Gandolfi AJ and Brendel K. Identification of cellular targets of toxicity in tissue slices using biochemical and microscopic techniques. World Congress on Alternatives, Baltimore, MD. In Vitro Tox 7:148, 1994.

321. Brendel K, Fisher RL, Hasal SJ, Sanuik JT, and Gandolfi AJ. Quality of human liver tissue affects scientific results. World Congress on Alternatives, Baltimore, MD, November, 1993.

322. Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, and Brendel K. Cold- and cryo- preservation of human liver and kidney slices. World Congress on Alternatives, Baltimore, MD, November, 1993.

323. Fisher RL, Hasal SJ, Jenkins PL, Shaughnessy RP, Roth GL, Gandolfi AJ, and Brendel K. Effect of cold- and cryo- preservation on warfarin metabolism in liver slices. Toxicologist 14:33, 1994.

324. Brendel K, Fisher RL, Hasal SJ, Shaughnessy RP, Roth GL, Jenkins PL, and Gandolfi AJ. Cold and cryopreservation sensitizes liver slices to chemical induced toxicity. Toxicologist 14:398, 1994.

325. Mata HP, Sameshima T, Gandolfi AJ, and Malan TP. Effect of P450 inducers on sevoflurane metabolism in rat liver slices. Toxicologist 14:190, 1994.

326. Lind RC, Gandolfi AJ, and Hall PM. HCFC-123 hepatotoxicity in guinea pigs; potentiation by glutathione depletion. Toxicologist 14:279, 1994.

327. Clarke JB, Chen M, and Gandolfi AJ. Characterization of the antibody response to halothane. Implication for animal models. Toxicologist 14:406, 1994.

328. Keith RL, Ingersoll RT, Setiarahardjo I, Fernando Q, Aposhian VH, and Gandolfi AJ. Evaluation of chelators for the removal of Hg from renal cortical slices. Toxicologist 14:69, 1994.

329. Payne AK, Morgan SE, Gandolfi AJ, and Brendel K. Biotransformation of sevoflurane by liver slices from Sprague Dawley neonates. Toxicologist 14:434, 1994.

330. Sheevers HV, Wright SH, Brendel K, and Gandolfi AJ. Nephrotoxicity and uptake of l-benzyl quinolinium in rabbit renal proximal tubule and mitochondrial suspensions. Toxicologist 14:70, 1994.

331. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Arsenite and heat-shock induce stress proteins in precision-cut rat liver slices. Toxicologist 14:32, 1994.

332. Waters SJ, McNeill J, Brendel K, and Gandolfi AJ. Prolonged in vivo liver retention and hepatocellular uptake of M-741 in rat hepatic slices. Toxicologist 14:32, 1994.

333. Sell R, Brendel K, and Gandolfi AJ. An in vitro model utilizing precision-cut rat liver slices for the study of cold preservation injury. XII International Congress of Pharmacology, Montreal, Canada, July, 1994.

334. Furst SM, Leudke D, and Gandolfi AJ. Sensitization of the immune system by trifluoroacetylated (TFA) proteins and Kupffer cells in halothane exposed guinea pigs. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.

335. Chen ML and Gandolfi AJ. Characterization of the humoral immune response and hepatotoxicity after multiple-halothane exposures at 40 day-interval in guinea pigs. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.

336. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Micro-proton induced x-ray emission (:-PIXE) methodology for metals analysis. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.

337. Hasal SJ, Aposhian VH, Gandolfi AJ, and Brendel K. Human and rabbit renal cortical slices as a model to evaluate heavy metal chelators. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.

338. Furst SM and Gandolfi AJ. Enhanced lymphocyte adhesion to Kupffer cells co-cultured with trifluoroacetylated (TFA) protein. Toxicologist 15:102, 1995.

339. Leudke DL, Furst SM, and Gandolfi AJ. Trifluoroacetylated (TFA) proteins and Kupffer cells sensitize the immune system in halothane exposed guinea pigs. Toxicologist 15:102, 1995.

340. Gandolfi AJ, Furst SM, and Leudke DL. Kupffer cells from halothane exposed guinea pigs carry trifluoroacetylated (TFA) protein adducts. Toxicologist 15:149, 1995.

341. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Use of micro-proton induced x-ray emission (:PiXE) for heavy metal analysis. Toxicologist 15:106, 1995.

342. Lind RC and Gandolfi AJ. Late protective effect of dimethyl sulfoxide in the guinea pig model of halothane hepatotoxicity. Toxicologist 15:218, 1995.

343. Wijeweera JB, Kies P, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A pretreatment potentiates vinylidene chloride-induced liver damage in precision-cut rat liver slices. Toxicologist 15:286, 1995.

344. Groves CE, Morales MN, Rankin DR, and Gandolfi AJ. Organic ion toxicants disrupt organic ion transport in rabbit renal proximal tubule (RPT) suspensions. Toxicologist 15:297, 1995.

345. Thomas CM, Wijeweera JB, Gandolfi AJ, and Brendel K. Carbon tetrachloride induces stress protein synthesis in precision-cut rat liver slices. Toxicologist 15:50, 1995.

346. Chen ML and Gandolfi AJ. Humoral immune response and hepatotoxicity after multiple-halothane exposures in guinea pigs. Toxicologist 15:102, 1995.

347. Leavitt JA, McIntyre, Jr. LC, Ashbaugh MD, Cox RP, Keith RL, Gandolfi AJ, and Fernando Q. The nuclear microprobe at the University of Arizona. 12th International Conference on Ion Beam Analysis, May 1995.

348. Furst SM, Leudke D, and Gandolfi AJ. Cellular immune system involvement in halothane 0induced hepatotoxicity. International Congress of Toxicology -VII, Seattle, July 2, 1995.

349. Jenkins PL, Fisher RL, Fisher Jr. FJ, Shaughnessy RP, Gandolfi AJ, and Brendel K. Long-term incubation of rat and human liver slices: A study with enalapril maleate. Toxicologist 15:286, 1995.

350. Fisher RL, Shaughnessy RP, Jenkins PL, Austin ML, and Roth GL. Dynamic organ culture is superior to multiwell plate culturing systems for maintaining liver slice viability. Toxicologist 15:108, 1995.

351. Hasal SJ, Aposhian VH, Gandolfi AJ, and Brendel K. Human and rabbit renal cortical slices in aerated submersion culture as a model to evaluate heavy metal chelators. Toxicologist 15:310, 1995.

352. Furst SM, Luedke D, and Gandolfi AJ. Halothane exposed guinea pigs exhibit a cellular immune response to trifluoroacetylated (TFA)-proteins and Kupffer cells. Anesthesiology 83:A341, 1995.

353. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late protective action in the guinea pig model of halothane hepatotoxicity. Anesthesiology 83:A346, 1995.

354. Gandolfi AJ. Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Society of Toxicologic Pathologist, 14th International Symposium, June 11, 1995.

355. Lind RC and Gandolfi AJ. Late protection against chemical induced liver injury with dimethyl sulfoxide. Hepatology 22:379A, 1995.

356. Hoivik DJ, Manautou JE, Khairallah EA, Fisher RL, Brendel K, Gandolfi AJ, and Cohen SD. Characterization of acetaminophen induced toxicity in mouse kidney slices. The International Toxicologist, 12-PD-3, July 2-6, 1995.

357. Chen ML and Gandolfi AJ. Effect of pre-existing anti-TFA antibodies on the humoral immune response and hepatotoxicity after subsequent halothane exposure. Toxicologist 30:293, 1996.

358. Furst SM and Gandolfi AJ. Cellular immune mediation of halothane induced hepatotoxicity. Toxicologist 30:63, 1996.

359. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Assessment of heavy metal accumulation in renal tissue using micro-proton induced x-ray emission (:-PIXE). Toxicologist 30:258, 1996.

360. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late hepatoprotective effect against chloroform and bromobenzene induced liver injury in the rat. Toxicologist 30:293, 1996.

361. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Toxicologist 30:126, 1996.

362. Wei H, Divine KK, and Gandolfi AJ. Uptake and toxicity of HgCl2 and synthesized Hg(SG)2 and Hg(CYS)2 in isolated rabbit renal proximal tubule suspensions. Toxicologist 30:129, 1996.

363. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A (VA) potentiation of vinylidene chloride (VDC) toxicity in precision-cut rat liver slices. Toxicologist 30:124, 1996.

364. Fisher RL, Hasal SJ, Ulreich JB, Nakazato PZ, Bhattacharyya AK, Le T, Gandolfi AJ, and Brendel K. Rat and dog liver slice viability in surface and submersion culture. Toxicologist 30:255, 1996.

365. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K. Liver/kidney slice co-incubation: A model for interactive organ toxicity. Toxicologist 30:307, 1996.

366. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Robert S. Flinn Foundation Biomedical Research Initiative Symposium, Scottsdale, AZ, May 3, 1996.

367. Keith RL, Gandolfi AJ, McIntyre, LC, Ashbaugh MD, Qiu L, Lott JR, and Fernando Q. Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue. Intern Conf Nuclear Microprobe Technology and Applications, Santa Fe, NM, Nov. 10-15, 1996.

368. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late hepatoprotective effect against chloroform and bromobenzene induced liver injury in the rat. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

369. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A (VA) potentiation of vinylidene chloride (VDC) toxicity in precision-cut liver slices. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

370. Chen ML and Gandolfi AJ. Effect of pre-existing anti-TFA antibodies on the humoral immune response and hepatotoxicity after subsequent halothane exposure. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

371. Duffy S, Lind RC, and Gandolfi AJ. Halothane liver protein adducts in responsive (halothane hepatitis) and non-responsive guinea pigs. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

372. Furst SM and Gandolfi AJ. Cellular immune mediation of halothane induced hepatotoxicity. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

373. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K. Liver/kidney slice co-incubation: A model for interactive organ toxicity. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

374. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Assessment of heavy metal accumulation in renal tissue using micro-proton induced x-ray emission (:-PIXE). Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

375. Morgan SE, Frink EJ, Nogami WM, Salmon RS, and Escobar C. Production of carbon monoxide and carboxyhemoglobin during desflurane, enflurane, isoflurane, and sevoflurane anesthesia. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

376. Wei HB, Divine KK, and Gandolfi AJ. Uptake and toxicity of HGCl2 and synthesized Hg(SG)2 and Hg(CYS) 2 in isolated rabbit renal proximal tubule suspensions. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

377. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.

378. Gandolfi AJ and Lind RC.  Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene.  Mountain West Society of Toxicology, Salt Lake City, October 2-4, 1996.

379.  Lind RC and Gandolfi AJ.  Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene.  NIEHS Center Director's meeting, Tucson, AZ, Dec. 9, 1996.

380.  Hasal SJ, Gandolfi AJ, Brendel K.  Sequential incubation of chlorotrifluoroethylene in rat liver and kidney slices.  NIEHS Center Director's meeting, Tucson, AZ, Dec. 9, 1996.

381.  Fisher RL, Hasal SJ, Gandolfi AJ, and Brendel K.  Importance of optimizing human and animal tissue slice culture for biotransformation and toxicity studies.  Toxicologist 36:55, 1997.

382.  Hasal SJ, Gandolfi AJ, and Brendel K.  Sequential incubation of chlorotrifluoroethylene in rat liver and kidney slices.  Toxicologist 36:56, 1997.

383.  Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, and Gandolfi AJ.  Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission (µ-PIXE).  Toxicologist 36:185, 1997.

384.  Lind RC and Gandolfi AJ.  Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene.  Toxicologist 36:319, 1997.

385.  Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K.  Localization of heat shock protein 70 in rat liver slices with fluorescence confocal microscopy.  Toxicologist 36:56, 1997.

386.  Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, and Gandolfi AJ.  Accumulation of HgCl2 and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions.  Toxicologist 36:185, 1997.
387.  Wijeweera JB, Zeng X-H, Gandolfi AJ, and Brendel K.  Stress protein expression by drinking water contaminants vinylidene chloride and chloroacetic acids in precision-cut rat liver.  Toxicologist 36:320, 1997.

388.  Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, and Gandolfi AJ.  Accumulation of HgCl2 and three synthesized Hg-S-conjugates in islolated rabbit renal proximal tubule suspensions.  NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.

389. Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, Gandolfi AJ.  Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission (µ-PIXE).  NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.

390. Qiu L, Lott JR, Fernando Q, Ashbaugh MD, McIntyre LC, Keith RL, Wei H, and Gandolfi AJ.  The PIXE and micro-PIXE facility at the University of Arizona.  NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.

391. Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, Gandolfi AJ.  Accumulation of HgCl2 and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions.  TCE-Mini Conference, University of Arizona, Superfund, Feb. 28, 1997.

392. Parrish AR, Bral CM, Ramos KS, Fisher RL, Brendel K, and Gandolfi AJ.  Alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices by benzo(A)pyrene.  Third Robert S. Flinn Foundation Biomedical Research Symposium, Tucson, AZ, May 9, 1997.

393. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K.  Localization of heat shock protein 70 in rat liver slices with fluorescence confocal microscopy.  Third Robert S. Flinn Foundation Biomedical Research Symposium, Tucson, AZ, May 9, 1997.

394. Wijeweera JB, Zheng XH, and Gandolfi AJ.  Interactive toxicity of MCA and VDC in precision-cut rat liver slices.  Current Issues in Chemical Mixtures Conference.  Colorado State University , Ft. Collins, CO, August 12, 1997.

395. Parrish AR, Ramos KS, Brendel K, and Gandolfi AJ.  Precision-cut liver slices: Investigation of the molecular response to toxicants. Society of Toxicology, March 1998.

396. Lind RC and Gandolfi AJ.  Dimethyl sulfoxide and diallyl sulfide are hepatoprotective when administered twenty-four hours after chloroform.  Hepatology 26:341A, 1997.

397. Parrish AR, Catania JM, Mason DE, and Gandolfi AJ.  Chemically-induced oxidative stress interferes with post-translational modification of the E-cadherin/catenin complex.  Toxicologist 31:1998.

398. Catania JM, Parrish AR, and Gandolfi AJ. Hypoxia causes a dissociation of cell adhesion proteins via an alteration in  -catenin phosphorylation.  Toxicologist 31:1998.

399. Turney KD, Parrish AR, and Gandolfi AJ.  Changes in AP-1 and c-jun expressoin in precision-cut rabbit renal cortical slices following exposure to Hg(II).  Toxicologist 31: 1998.

400. Zheng X-H, Younis H, Turney KD, Parrish AR, and Gandolfi AJ.  Molecular alterations in renal cortical slices following exposure to sub-toxic levels of arsenite.  Toxicologist 31: 1998.

401. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K.  The biosynthesis of S-(2-chloro-1,1,2-trifluoroethyl)glutathione in rat liver slices and its consecutive turnover in rat renal cortical slices.  Toxicologist 31: 1998.

402. Catania JM, Parrish AR, and Gandolfi AJ.  Hypoxia causes a dissociation of cell adhesion proteins via an alteration in protein phosphorylation.  Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.

403. Lind RC, Begay CK, and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide and diallyl sulfide when administered twenty-four hours after chloroform. Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.

404. Parrish AR, Zheng XH, Younis H, Turney KD, and Gandolfi AJ.  Alterations in c-jun gene expression following arsenite exposure in renal cortical slices.  Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.

405. Turney KD, Parrish AR, and Gandolfi AJ.  Changes in AP and c-jun expression in precision-cut rabbit renal cortical slices following exposure to Hg(II).  Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.

406. Wijeweera JB, Zheng XH, and Gandolfi AJ.  Stress protein expression by precision-cut rat liver slices exposed to non cytotoxic concentrations of MCA and DVC.  Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.

407. Turney KD, Parrish AR, and Gandolfi AJ.  Increased AP-1 and c-jun in renal slices following exposure to Hg(II).  Superfund Metals Symposium, Tucson, AZ, January 8-9, 1998.

408. Zheng X-H, Younis, H, Turney KD, Parrish AR, and Gandolfi AJ.  Molecular alterations in renal slices following arsenite exposure.  Superfund Metals Symposium, Tucson, AZ,  January 8-9, 1998.

409. Pena CE, Gandolfi AJ, and Carter DE.  Outreach to Mexico on environmental health issues.  1998 Superfund Basic Research Program Conference, Hitchhikers Guide to Outreach, Boston, MA, March 25, 1998.

410. Gandolfi AJ, Parrish AR, Turney KD, and Zheng XH.  Molecular alteration in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V).  1998 Superfund Basic Research Program Conference, Boston, MA, March 23-24, 1998.

411. Chitkara MK, Parrish AR, and Gandolfi AJ.  Generation and detection of apoptosis in rat liver slices.  MWSOT, Tucson, AZ, September 17-18, 1998.

412. Gandolfi AJ, Nagle RB, Cress A, Dalkin B, and Parrish AR.  Use of human prostate slices in toxicity studies.  MWSOT, Tucson, AZ, September 17-18, 1998.

413. Ito Y, Begay CK, Lind RC, Gandolfi AJ, and McCuskey RS.  Hepatoprotection by dimethyl sulfoxide: effects on hepatic microcirculation when administered 24 hours after chloroform.  MWSOT, Tucson, AZ, September 17-18, 1998.

414. Lind RC, Begay CK, and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide and aminobenzotriazole when administered 24 hr after chloroform: role of inhibition of ongoing bioactivation.  MWSOT, Tucson, AZ, September 17-18, 1998.

415. Parrish AR and Gandolfi AJ.  Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.  MWSOT, Tucson, AZ, September 17-18, 1998.

416. Turney KD, Parrish AR, and Gandolfi AJ.  Selective activation of the MAPK pathway in renal tissue by HG(II).  MWSOT, Tucson, AZ, September 17-18, 1998.

417. Zheng X-H, Turney KD, Younis H, Parrish AR, and Gandolfi AJ.  Arsenite [As(III)] and arsenate [As(V)] enhance DNA binding of the AP-1 and Elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices.  MWSOT, Tucson, AZ, September 17-18, 1998.

418.  Parrish AR and Gandolfi AJ. Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.  Tox Sci, 48:364, 1999.

419. Zheng XH, Parrish AR, Turney KD,Younis HS, and Gandolfi, AJ.  Arsenite [AS(III)] and arsenate [AS(V)] enhance DNA binding of the AP-1 and Elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices.  Tox Sci 48:351, 1999.

420.  Ito Y, Lind RC, Begay CK, Gandolfi AJ, and McCuskey RS.  Hepatoprotection by dimethylsulfoxide and aminobenzotriazole: comparison of effects on hepatic microcirculation when administered 24 hours after chloroform.  Tox Sci 48:191, 1999.

421. Lind RC, Begay CK, and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide and aminobenzotriazole when administered 24 hr after chloroform: role of inhibition of ongoing bioactivation.   Tox Sci 48: 191, 1999.

422. Catania JM, Parrish AR, and Gandolfi AJ.  Toxicity of a sevoflurane degradation product to rat liver and renal cortical slices.  Tox Sci 48:28, 1999.

423. Chitkara MK, Petrick JS, Parrish AR, and Gandolfi AJ.  Generation and detection of apoptosis in rat liver slices.  Tox Sci 48:90, 1999.

424. Nagle RB, Cress A, Dalkin B, Parrish AR, and Gandolfi AJ.  Establishment of precision-cut human prostate slices as an in vitro toxicology model.  Tox Sci 48:71, 1999.

425. Cromey D, Lantz RC, Rocha C, Parrish AR, and Gandolfi AJ.  Live time evaluation of cell toxicity in precision-cut tissue slices using confocal microscopy.  Tox Sci 48:71, 1999.

426. Begay CK, Lind RC, Zheng XH, and Gandolfi AJ.  Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure.   Tox Sci 48:316, 1999.

427. Turney KD, Parrish AR, and Gandolfi AJ.  Selective activation within the MAPK pathway by HG(II).  Tox Sci 48:331, 1999.

428. Parrish AR, Catania JM, and Gandolfi AJ.  Disruption of the E-cadherin/catenin complex by oxidative stress correlates with phosphorylation of tyrosine but not serine.  Tox Sci 48:162, 1999.

429. Catania JM, Parrish AR, and Gandolfi AJ. Toxicity of a sevoflurane degradation product to rat liver and renal cortical Slices.   First Annual College of Pharmacy Student Showcase, April 8, 1999.

430. Lantz RC, Orozco J, Cromey D, Rocha C, Parrish AR, and Gandolfi AJ.  Live-time evaluation of cell toxicity in precision-cut tissue slices using confocal microscopy.  NIH Biomedical Imaging Symposium, Bethesda, MD, June 26-26, 1999.

431.  Schmelz M, Sallam K, Parrish AR, Gandolfi AJ, Jones JCR, and Nagle RB.  Adhesion molecule rearrangement in human prostate organ culture.  ASCB, December 1999.

432.  Schmelz M, Barrera J, Sallam K, Weyer C, Clark V, McDaniel K, Gandolfi AJ, Parrish AR,Weinstein R, and Nagle RB.  Human prostate organ culture as a model of adhesion molecule rearrangement.  Arizona Cancer Center Science Fair, June 1999.

433.  Henriquez X, Wilson CL, Zheng X-H, Gandolfi AJ, and Parrish AR.  Differential gene expression in rabbit renal cortical slices exposed to sodium arsenite.  Gulf Coast Regional Chapter Meeting, November 20, 1999.

434. Orozco J, Parrish AR, Schmelz M, Nagle RB, and Gandolfi AJ. Optimization and characterization of precision-cut prostate slices as a tool for toxicological studies.  Tox Sci 54:A1768, 2000.

435. Kirkpatrick DS, Catania JM,  Bautista FM,  Parrish AR, and Gandolfi AJ. Alterations in the ubiquitin-dependent proteolytic pathway caused by low-level arsenite exposure in rabbit renal cortical slices.  Tox Sci 54:A1321, 2000.

436. Orozco J, Lantz RC , Cromey DE, and Gandolfi AJ.  Evaluation of live precision-cut tissue slices using multiple indicatiors of cellular injury via a confocal microscopic technique.  Tox Sci 54:A1767, 2000.

437. Zheng XH, Wilson CL, Parrish AR, and Gandolfi AJ. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds.  Tox Sci 54:A1832, 2000.

438. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.  Tox Sci 54:A1769, 2000.

439. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.  Western Pharmacology Society, January 2000, Tucson, AZ.

440. Kirkpatrick DS, Catania JM, and Gandolfi AJ. Increased ubiquitin-conjugated proteins following low-level arsenite exposure.  Fourth International Conference on Arsenic Exposure, San Diego, CA, June 2000.

441. Zheng XH, Gandolfi AJ, Wilson CL, and Parrish AR.  Analysis of differential expressed genes in rabbit renal cortical slices exposed to arsenic compounds.  Fourth International Conference on Arsenic Exposure, San Diego, CA, June 2000.

442. Kirkpatrick DS, Catania JM,  Bautista FM,  Parrish AR, and Gandolfi AJ. Alterations in the ubiquitin-dependent proteolytic pathway caused by low-level arsenite exposure in rabbit renal cortical slices.  Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.

443. Zheng XH, Wilson CL, Parrish AR, and Gandolfi AJ. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.

444. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.

445. Begay CK and Gandolfi AJ.  Eicosanoids Levels During Chloroform Induced Injury.  I.  Effects of Hepatoprotectants, DMSO and Aminobenzotriazole. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.

446. Begay CK and Gandolfi AJ.  The effects of hepatoprotectants, DMSO and aminobenzotriazole and cyclooxygenase and lipoxygenase inhibitors on eicosanoids levels during chloroform induced injury.  SACNAS, Atlanta, GA, October 10-15, 2000.

447.  Kirkpatrick DS, Catania JM, Dale KV, and Gandolfi AJ.  Low-level arsenite does not affect the ubiquitin conjugating activity of rabbit renal slices or human embryonic kidney cells.   Tox Sci 60:364, 2001.

448. Begay CK and Gandolfi AJ.  The effects of hepatoprotectants on eicosanoid levels during chloroform-induced hepatic injury.   Tox Sci 60:1664, 2001.

449. Carranza Rosales P, Kirkpatrick DS, Said Fernandez S,  and Gandolfi AJ. DMPS effect on cellular stress response in OK cells exposed to HgCl2 and NaAsO2.  Tox Sci 60:1490, 2001.

450. Zheng XH and Gandolfi AJ.  Up-regulation of P68 and GDI in rabbit renal cortical slices exposed to low level arsenic.  Tox Sci 60:1494, 2001.

451.  Kirkpatrick DS and Gandolfi AJ.  Low-level arsenite does not affect the ubiquitin conjugating activity of rabbit renal slices. Superfund Basic Research Program Annual Meeting, University of North Carolina, December 12-14, 2000.

 452. Gandolfi AJ.  Hazardous Waste Risk and Remediation in the Southwest.  Superfund Basic Research Program Annual Meeting, University of North Carolina, December 12-14, 2000.

453.  Begay CK and Gandolfi AJ. The effects of hepatoprotectants, DMSO and aminobenzotriazole and cyclooxygenase and lipoxygenase inhibitors on eicosanoids levels during chloroform induced injury.  MGE@MSA, Arizona State University, Tempe, AZ, January 12, 2001.

454. Gandolfi AJ and Brendel K.  Development of precision-cut tissueslices as an in vitro model for pharmacological, toxicological, and biotransformation studies.  J.H. CAAT 20th Anniversary Symposium, Baltimore, MD, September 10-12, 2001.

455. Kremer C, Thomas T, Dalkin B, Gandolfi AJ, and Nagle R.  Effects of androgen stimulation on organ cultures of human prostate.  AACR 2002 93rd Annual Meeting, San Francisco, CA, April 6-10, 2002.

456. Kirkpatrick DS, Dale KV, Liebler DC, and Gandolfi AJ.   Identification of ubiquitin-conjugated proteins using lc-ms techniques: potential molecular indicators of toxic insults. Symposium on Gene Expression,  Bethesda, MD, December 2-4, 2001.

457. Gandolfi AJ.  Hazardous Waste Risk and Remediation in the Southwest.  Superfund Basic    Research Program Annual Meeting,  Gainesville, FL, December 9-12, 2001.

458. Peraza MA, Kopplin MJ, Carter DE, and Gandolfi AJ. Inorganic arsenic biotransformation and  mitochondrial toxicity in HK-2 human proximal tubular cells.  Toxicologist 66: Abstract 403, 2002.

459. Kirkpatrick DS, Dale KV, Liebler DC, and Gandolfi AJ.   Identification of ubiquitin-conjugated proteins using lc-ms techniques: potential molecular indicators of toxic insults.  Toxicologist 66: Abstract 1083, 2002.

460. Dale KV, Kirkpatrick DS, and Gandolfi AJ.  Effects of low-level arsenic exposure in the cortex of rabbit kidney.  Fifteenth Annual Undergraduate Research Forum, University of Arizona, February 13, 2002.

461. Begay CK and Gandolfi AJ.  Late administration of Cox-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.  MGE@MSA, Phoenix, AZ, March, 2002.

462. Zheng XH, Watts G, Vaught S, and Gandolfi AJ.  Low-level exposure to arsenite alters gene expression in HEK 293 cells.  International Arsenic Meetings, San Diego, 2002.

463. Kirkpatrick DS, Weldon SF, and Gandolfi AJ.  Ni-NTA Purification of Ub-Modified Proteins from His(6X)-Ub-GFP Cells:  Implications for the Identification of Protein Targets of As (III).  Superfund Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.

464. Peraza MA, Carter DE, and Gandolfi AJ. Subcytotoxic inorganic arsenic affects mitochondria in HK-2 human proximal tubular cells: potential for apoptotic cell death.  Superfund  Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.

465. Zheng XH, Watts G, Vaught S, and Gandolfi AJ. Differential expressed of genes in HEK293 cells exposed to arsenite.  Superfund  Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.

466. Meza MM, Kopplin MJ, and Gandolfi AJ. Drinking water arsenic concentrations in Sonora, Mexico. Superfund  Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.

467. Begay CK and Gandolfi AJ.  Late administration of Cox-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.  NM-AGEP Conference, Albuquerque, NM, September 19-21, 2002.

468. Sierra-Alvarez R, Field JA, Cortinas I, Kopplin MJ, and Gandolfi AJ.  Microbial reduction and mobilization of arsenate under landfill conditions.  The Seventh International Symposium on In Situ and On-Site Bioremediation, Orlando, FL, June 2-5, 2003.

469. Begay CK and Gandolfi AJ.  Late administration of Cox-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury.  Tox Sci 72 (S1):964, 2003.

470. Kirkpatrick DS, Vaillancourt RR, Derbyshire ZE, and Gandolfi AJ.  Increased Ubiquination of the kindase TAK1 following as (III) exposure in HEK293 Cells. Tox Sci 72 (S1):1305, 2003.

471. Peraza MA, Carter DE, and Gandolfi AJ. Subcytotoxic inorganic arsenic affects mitochondria in HK-2 human proximal tubular cells: potential for apoptotic cell death. Tox Sci 72 (S1):1743, 2003.

472. Meza MM, Kopplin MJ, and Gandolfi AJ. Arsenic Drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico. Tox Sci 72 (S1):893, 2003.

473. Zheng XH, Watts GS, Vaught SE and Gandolfi AJ.  Toxicogenomic effects of low-level as (III) exposure to human kidney cells. Tox Sci 72 (S1):455, 2003.

474.  Catania JM, Fernandez A, and Gandolfi AJ.  Precision-Cut Tissue Chips: A New Toxicology Screen.  SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.

475. Bredfeldt T and Gandolfi AJ.  Effects of Arsenite on Human Urothelial Cells.  SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.

476. Cortinas I, Field, JA, Sierra-Alvarez R, Gandolfi AJ, and Kopplin M.  Anaerobic Microbial Activity Promotes the Desorption of Arsenate Sorbed onto Drinking Water Treatment Residuals.  SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.

477. Yenal U, Field JA, Sierra-Alvarez R, Kopplin M, Begay CK, and Gandolfi AJ.  Anaerobic Biodegradation of Organoarsenical Pesticides, Methylarsonic Acid (MMAV) and Dimethylarsinic Acid (DMAV).  SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.

478.  Catania JM, Fernandez A, and Gandolfi AJ.  Precision-Cut Tissue Chips: A New Toxicology Screen. MWSOT, Breckenridge, CO, September 18-19, 2003.

479.  Bredfeldt T, Kopplin MJ, and Gandolfi AJ.  Effects of Arsenite on UROtsa Cells: Low-Level Arsenite Causes Accumulation of Ubiuquitinated Proteins which is Perpetuated by Reduction in Cellular Glutathione Levels.  MWSOT, Breckenridge, CO, September 18-19, 2003.

480.  Cortinas I, Badilla C, Sierra-Alvarez R, Field JA, Kopplin M, Gandolfi AJ.  Microbial Mobilization of Arsenic Sorbed onto Activated Alumina and Granular Ferrihydrite.  Quad University Superfund Meeting, University of California, Berkelely, October 2003.

481.  Catania JM, Fernandez A, and Gandolfi AJ.  Precision-cut Tissue Chips as a Toxicological Tool.  SOT, Baltimore, MD, March 21-25, 2004.

482.  Peraza MA, Carter DE, and Gandolfi AJ.  Subcytotoxic inorganic arsenite targets mitochondria in HK-2 human proximal tubular cells: implications on mechanism of cell death.  SOT, Baltimore, MD, March 21-25, 2004.

483.  Bredfeldt TG, Kopplin M, Mash EA, and Gandolfi AJ.  Effects of Arsenite and Monomethyl Arsonous Acid on UROtsa Cells: Low-level Exposure Causes Accumulation of Ubiquitinated Proteins which is Enhanced by Reduction in Cellular Glutathione Levels.  SOT, Baltimore, MD, March 21-25, 2004

484. Zheng XH, Bredfeldt TG, Watts GS, Vaught SE, May AC, and Gandolfi AJ.  Arsenite Mediates Gene Expression in Human Bladder Epithelium.  SOT, Baltimore, MD, March 21-25, 2004.
 
485. 
Schmelz M, Moll R, Hesse U, Futscher B, Prasad-Ramarao A, Gandolfi AJ, Hasan SR, Bartholdi M, Cress AE. Identification of a New Epithelial Cell Subpopulation with Proliferation Capacity in the Normal Human Prostate Gland: A Stem Cell Candidate?  Prostate Cancer Meeting, Tucson, AZ, May 2004.

486.  McColl CM, Brusseau ML, and Gandolfi AJ.  The University of Arizona Superfund Basic Research Program (SBRP): An Interdisciplinary Approach to Environmental Research and Education.  Arizona Hydrological Society Annual Meeting, Tucson, AZ, August 2004.

487. Catania JM, Pershing AM, A. Fernandez A, and Gandolfi AJ.  Precision-Cut Tissue Chips as a Toxicological Tool.  AHSC Poster Forum, September 15, 2004.

488. Bredfeldt TG, Billings KE, Zheng XH, Mash EA and Gandolfi AJ. Mechanisms of arsenite and monomethyl arsonous acid-induced toxicity in human urothelial cells. MWSOT, Park City, UT, September 9-10, 2004.

489.  McColl CM, Brusseau ML, and Gandolfi AJ.  The University of Arizona Superfund Basic Research Program (SBRP): An Interdisciplinary Approach to Environmental Research and Education.  TRIF Hydrology Meeting, Tucson, AZ, September 16, 2004.

490. McColl CM, Brusseau ML, and Gandolfi AJ.  The University of Arizona Superfund Basic Research Program (SBRP): An Interdisciplinary Approach to Environmental Research and Education.  SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

491. Billings KE, Bredfeldt TG, Kopplin MJ, and Gandolfi AJ.  Effects of Arsenite and Monomethylarsonous Acid on Human Bladder Urothelial Cells Malignantly Transformed by Arsenite.  SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

492. Bredfeldt TG, Billings KE, Zheng XH, Jagadish B, Mash EA and Gandolfi AJ. Mechanisms of arsenite and monomethyl arsonous acid-induced toxicity in human urothelial cells.  SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

493. Catania JM, Pershing AM, Fernandez A, and Gandolfi AJ.  Precision-Cut Tissue Chips as a Toxicological Tool.  SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004. 

494. Meza-Montenegro, Kopplin MJ, and Gandolfi AJ.  MM, Determination of molecular biomarkers in people chronically exposed to low levels of arsenic by drinking water in Sonora, Mexico.  SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

495. Zheng XH, Bredfeldt TG, Watts GS, and Gandolfi AJ.  Gene Expression Induction in Human Bladder Epithelium Exposed to Low-level Arsenic. SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

496. Cortinas I, Camacho DA, Sierra-Alvarez R, Field JA, Kopplin MJ, and Gandolfi AJ.  Microbial Mobilization and Transformation of Arsenic Sorbed onto Granular Ferrihydrite  under Simulated Landfill Conditions. SBRP/SWEHSC Annual Science Fair, Tucson, AZ, September 29, 2004.

497. Billings KE, Bredfeldt TG, Zheng XH, Kopplin MJ, Watts GS, Sens DA, Mash EA, and Gandolfi AJ.  Characterization of Human Bladder Urothelial Cells Malignantly Transformed by Arsenite.  The Toxicologist 84 (S1) 31 (Abstract 146) 2005.

498.  Bredfeldt TG, Billings KE, Zheng XH, Mash EA, Domann FE, Lau SS, Sens DA, and Gandolfi AJ.  Arsenite and Monomethyl Arsonous Acid-Induced Toxicity ion Human Urothelial Cells.  The Toxicologist 84 (S1) 31 (Abstract 147) 2005.

499. Zheng XH, Bredfeldt TG, Watts GS, and Gandolfi AJ.  Toxicogenomical Study on Human Bladder Epithelium Exposed to Arsenic.  The Toxicologist 84 (S1) 238 (Abstract 1161) 2005.

500. Blomquist E, Pershing A, Catania J, and Gandolfi AJ.  Critical Evaluation of the Varying Incubation Environments on the Viability of Precision-Cut Liver Chips Post-Vitrification.  2004 Undergraduate Biology Research Program Conference. February 2005.

501. Bredfeldt TG, Zheng XH, Watts GS, Bhumasamudram J, Mash EA, and Gandolfi AJ. Monomethylarsonous acid induces transformation of human bladder cells.  MWSOT, Santa Fe, NM, September 15-16, 2005.

502. Moreno D, Field JA, and Gandolfi AJ.  The US-Mexico Binational Center for Environmental Sciences and Toxicology at the University of Arizona.  Border Health Information for Action VI Conference, Tucson, AZ, October 27-28, 2005.

503.  Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, and Klimecki WT.  Variability in the arsenic methylation: Polymorphisms associated with arsenic metabolism.  International Workshop on the Use of Biomarkers in Children.  Buenos Aires, Argentina, November 17-18, 2005.

504. Bredfeldt TG, Billings KE, Zheng XH, Mash EA, Domann FE, Lau SS, Sens DA, and Gandolfi, A.J. Arsenite and monomethyl arsonous acid-induced toxicity in human urothelial cells.  2005 AHSC Frontiers in Biomedical Research Poster Forum, October 28, 2005.

505. Gandolfi AJ and Colbert N.  Graduate programs in the College of Pharmacy.  2005 AHSC Frontiers in Biomedical Research Poster Forum, October 28, 2005.

506. Meza MM, Kopplin MJ, and Gandolfi AJ.  Arsenic drinking water exposure in children and adults from the Yaqui Valley, Sonora.  15th Annual International Society of Exposure Analysis, Tucson, AZ  November 1-3, 2005.

507. Moreno Ramírez D, Field JA, Gandolfi AJ. Centro Binacional Estados Unidos-Mexico de Ciencias Ambientales y Toxicología [abstract]. Environmental Fate, Remediation and Health Effects of Heavy Metals and Arsenic in the Sonora/Arizona Border Region; December 8-9, 2005; Hermosillo. Sonora (SON): University of Sonora.  Abstract 1.

508. Eblin KE,Cromey D, Bowen ME, Bredfeldt TG, Mash EA, and Gandolfi AJ.  Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture.  Society of Toxicology, San Diego, CA.  March 2006.

509. Begay CK, Yellowhair M, Neilson JW, Maier RM, and Gandolfi A J. An assay for toxic     evaluation of bioavailable toxicants (e.g. arsenic and uranium) using a luminescent     bacterial biosensor.  Society of Toxicology, San Diego, CA.  March 2006.

510. Bredfeldt TG, Salt SE, Lane NL, and Gandolfi, AJ.  Monomethylarsonous acid induces cox-2 in human bladder cells.  Society of Toxicology, San Diego, CA.  March 2006.

511. Bredfeldt TG, Zheng XH, Watts GS,  Mash EA, and Gandolfi, A.J. Monomethylarsonous acid transforms human bladder cells.  Society of Toxicology, San Diego, CA.  March 2006.

512.  Diaz R and Gandolfi AJ.  Real-time PCR analysis of glucose regulatory genes and diabetic indicators in lymphocytes.  2006 UBER Conference, Tucson, AZ.

513. Moreno Ramírez D, Field JA, Gandolfi AJ. Outreach to Southwestern Hispanic Communities and Neighboring Mexico [abstract].  Superfund Basic Research Program 2005 Annual Meeting; January 12-13, 2006; New York, NY; New York Academy of Medicine. Abstract 74.

514. Ramirez M, Brusseau ML, Gandolfi AJ.  The Role of the Research Translation Core [abstract].  Superfund Basic Research Program 2005 Annual Meeting; January 12-13, 2006; New York. NY; New York Academy of Medicine. Abstract 76.

515. Klimecki WT, Meza M, Yu L, Thompson D, Rodriguez Y, Gandolfi AJ.  Gene by Environment Effects in Arsenic Metabolism:  Genetic polymorphisms with differential effects in children.  EPA Science Forum, Washington DC.

516. Eblin KE, Bowen ME, Cromey D, Bredfeldt TG, Mash GA, Lau SS, Gandolfi AJ.  Arsenite and monomethlyarsonous acid generate oxidative stress response in human bladder cell culture.  Mountain West SOT Meeting, Phoenix, AZ, September 7-8, 2006.

517. Li Y, Sun Z, Gandolfi AJ, Zhang DD.  The molecular mechanism of Nrf2 activation by sodium arsenite and monomethyl arsonous acid.   SOT Annual Meeting, Charlotte, NC, 2007.

518. Eblin KE, Hau A, Gandolfi AJ.  Arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells via the production of reactive oxygen species.  SOT Annual Meeting, Charlotte, NC, 2007.

519. Ramirez M, Moreno D, Brusseau M, Field JA, Gandolfi AJ.  Dynamically defining research translation and outreach (RT/O): the impact of the University of Arizona Superfund Basic Research Program’s RT/O Cores.  SBRP Annual Meeting, San Diego, CA, December 11-12, 2006.

520.  Eblin KE, Hau A, Gandolfi AJ.  Arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells via the production of reactive oxygen species. US-Mexico Binational Meeting, Tucson, AZ, March 12-14, 2007.

521.  Cortinas I, Sierra R, Kopplin M, Gandolfi AJ, Field J.  Microbial mobilization of arsenic from water treatment residuals.  U.S.-Mexico Binational Meeting, Tucson, AZ, March 12-14, 2007.

522.  Cortinas I, Field J, Kopplin M, Gandolfi AJ.  Anaerobic biodegradation of organoarsenical pesticides.  U.S.-Mexico Binational Meeting, Tucson, AZ, March 12-14, 2007.

523.  Alegria-Torres JA, Gandolfi AJ, Diaz-Barriga F, Perez-Maldonado I.  DDT: Toxicological molecular mechanisms and apoptosis.  US-Mexico Binational Meeting, Tucson, AZ, March 12-14, 2007.

524.  Klimecki WT, Meza MM, Rodriguez YY, Gandolfi AJ.  Human genetic polymorphisms: Biomarkers of variability in arsenic metabolism.  SOT Annual Meeting, Charlotte NC, 2007.

525.  Buffington SE, Eblin KE, Zheng XH, Gandolfi AJ.  Chronic exposure to monomethylarsonous acid induces changes in human urotsa cells consistent with urothelial tumorigenesis.  LDS Life Science Research Symposium, August 17-18, 2007, Snowbird, Utah.

526.  Buffington SE, Eblin KE., Zheng XH, Gandolfi AJ. Chronic exposure to monomethylarsonous acid induces changes in human urotsa cells consistant with urothelial tumorigenesis.  25th Annual MWSOT, Breckenridge, CO, September 6-7, 2007.

527. Gandolfi AJ.  US-Mexico Binational Center for Environmental Science and Toxicology: Model for Binational Interactions.  ISEE Meeting Symposium 20 – Binational Interactions, Mexico City, September 6, 2007.

528.  Gandolfi AJ, Ramirez M, Palmer K.  Hazardous Waste Risk and Remediation in the Southwest.  20th Anniversary Superfund Basic Research Program Annual Meeting, Durham, NC, December 2-5, 2007.

529.  Moreno D, Maier, R, Field J, Gandolfi AJ.  US-Mexico Binational Center for Environmental Sciences and Toxicology.  20th Anniversary Superfund Basic Research Program Annual Meeting, Durham, NC, December 2-5, 2007.

530. Ramirez M, Moreno D, Estrella R, Brusseau JL, Field JA, Gandolfi AJ.  What Really Counts: Transferring Information to Stakeholders – The Impact of Research Translation and Community Outreach (RT/CO) Cores.  20th Anniversary Superfund Basic Research Program Annual Meeting, Durham, NC, December 2-5, 2007.

531. Eblin KE, Buffington SE, Gandolfi AJ.  Reactive oxygen scavengers reduce hyperproliferation and anchorage independent growth of UROtsa cells chronically exposed to monomethylarsonous acid.  20th Anniversary Superfund Basic Research Program Annual Meeting, Durham, NC, December 2-5, 2007.

532.  Buffington SE, Eblin KE, Zheng XH, Gandolfi AJ.  Chronic exposure to monomethylarsonous acid induces changes in human urotsa cells consistant with urothelial tumorigenesis.  SOT Seattle, WA, 2008.

533.  Wnek SM, Eblin KE, Cromey DW, Gandolfi AJ.  Long-term, low-level exposure of UROtsa cells to monomethylarsonous acid produces protein carbonyl modifications and oxidative damage to DNA.  SOT Seattle, WA, 2008.

534.  Eblin KE, Buffington SE, Gandolfi AJ.  Reactive oxygen species scavengers reduce hyperproliferations and anchorage independent growth of UROtsa cells chronically exposed to monomethylarsonous acid.  SOT Seattle, WA, 2008.

535.  Wnek SM, Eblin KE, Cromey DW, Gandolfi AJ.  Long-term, low-level exposure of urotsa cells to monomethylarsonous acid produces damage to DNA.  MWSOT, Salt Lake City, UT, October 2, 2008.

536.  Futscher BW,  Boitano S, Burgess J, Jensen TJ, Novak P, Eblin KE, Klimecki W, Meza M, Gandolfi AJ, Lantz RC.  Arsenic-induced biomarkers and epigenetic remodeling.  NIEHS Environmental Toxicology Center Directors Meeting, University of Pennsylvania, October 19-21, 2008.

537. Wang XJ, Villeneuve NF, Zheng YD, Gandolfi AJ, Zhang DD.  The Nrf2-dependent cellular defense mechanism in arsenic toxicity.  American College Toxicity, Tucson, AZ, November 13, 2008.

538.  Moreno DR, Ramirez M, Estrella R, Artiola J, Brusseau ML, Field JA, Maier RM, Gandolfi AJ.  Towards an informed Mexican and Mexican-American citizenry: bridging the gap to increase human capacity and information dissemination.   SBRP Annual Meeting, Pacific Grove, CA, December 8-9, 2008.

539.  Wnek SM, Jensen TJ, Medeiros MK, Gandolfi AJ.  Defining the duration of chronic, low-level monomethylarsonous acid exposure required to induce the cellular transformation of UROtsa cells.  SOT Baltimore, March 2009.

540.  Chou CL, Hao WD, Regan JW, Gandolfi AJ.  Epidermal growth factor receptor dependent hypoxia inducible factor-1α expression by monomethylarsonous acid (MMA III) in human bladder cells.  SOT Baltimore, March 2009.

541.  Escudero Lourdes C, Cardenas-Gonzalez MC, Wnek SM, Medeiros MK, Gandolfi AJ.  Low level exposure to MMAIII induced the over-production of cytokines associated ith tumor progression in human urothelium cell line.  SOT Baltimore, March 2009.

542  Yassine H, Kimzey M, Alvarez I, Stratton S, Gandolfi AJ, Stump C, Tsaprailis G, Galligan MA, Lau S.  Oxidative stress determined by plasma methylglyoxal using GC-MS, urinary arsenic, and correlation with severity of diabetic albuminuria.  57th ASMS Conference on Mass Spectrometry, Philadelphia, PA, May 31-June 2009.

543.  Chen Z, Thompson P, Klimecki W, Burgess J, Zhao Q, Wu G, Arendell L, Gandolfi AJ.  Association between urinary arsenic concentrations and health in women from Southern Arizona.  SWEHSC External Advisory Board, April 29, 2009.

544.  Zhao Q, Thompson P, Klimecki W, Burgess J, Gandolfi AJ, Grant A, Arendell L, Chen Z.  Association between urinary arsenic concentration and body lean mass measures - Womens Breast and Bone Density Study.  42nd Annual Society of Epidemeologic Research, Anaheim, CA , June 23-26, 2009.

545.  Wu G, Q. Zhao Q, Arendell L, Thompson P, Klimecki W, Gandolfi AJ, Burgess J, Chen Z.  A pilot study of the association between urinary arsenic concentrations and bone mineral density.  42nd Annual Society of Epidemeologic Research, Anaheim, CA , June 23-26, 2009.

546.  Wnek SM, Jensen TJ, Buffington SE, Medeiros MK, Futscher BW, Gandolfi AJ.  Chronic low-level arsenical exposure damages DNA, causes epigenetic alterations, and transforms human bladder cell line to malignant phenotype.  NIEHS Toxicology Centers, Milwaukee, WI, September 29-30, 2009.

547.  Gandolfi AJ, Wnek SM, Jensen TJ, Futscher BW.  Short-term, low-level exposure of a human bladder cell line to monomethylarsonous acid damages DNA and alters repair activity.  2010 SOT, Salt Lake City, UT.

548.  Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ.  Exposure of a human bladder cell line to short-term, low-level monomethylarsonous acid produces critical and irreversible events resulting in malignant transformation.  2010 SOT, Salt Lake City, UT.

549.  Escudero-Lourdes C, Gandolfi AJ.  Role of IL-8 in monomethyl arsenous acid (MMAIII)-induced human bladder cell malignant transformation.  2010 SOT, Salt Lake City, UT.

550.  Medeiros MK, Camarillo JM, Wnek SM, Escudero C, Zheng XH, Gandolfi AJ.  Cytotoxicity of arsenicals in primary human epithelial cell cultures.  2010 SOT, Salt Lake City, UT.

551.  Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi AJ.  Exposure of a human bladder cell line to short-term, low-level monomethylarsonous acid produces critical and irreversible events resulting in malignant transformation.  2009 Superfund Annual Meeting, November 2-5, New York, New York.

552.  Moreno DR, Meza-Figueroa DM, Maier RM, Field JA, Gandolfi AJ.  Stabilizing mine tailings:  multistakeholder outreach and science research in Mexico and the United States. 2009 Superfund Annual Meeting, November 2-5, New York, New York.

553.  Ramirez MD, Butler L, Maier RM, Betterton EA, Gandolfi AJ.  Creating partnerships with agencies to improve Superfund site clean up at Iron King Mine smelter site, Humboldt, Arizona.  2009 Superfund Annual Meeting, November 2-5, New York, New York.

554.  Zaslausky I, Witenack T, Pezzoli K, Sarabia H, Meza M, Gandolfi AJ, Tukey R.  Sharing Superfund Research Program water quality data using CUAHSIHIS cyberinfrastructure.  2009 Superfund Annual Meeting, November 2-5, New York, New York.




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Scholarly Presentations

Seminars:

Characterization and isolation of a soluble protein that stimulates microsomal dechlorination. Department of Biochemistry and Drug Metabolism, Hoffman-LaRouche, Inc., Nutley, NJ, November 26, 1974.

Biotransformation and toxicity of halogenated volatile anesthetics. Battelle Pacific Northwest Laboratories, Richland, WA, June 1975.

Pulmonary disposition and fibrogenic potential of oil shale dusts. Institute of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH, July 18, 1977.

Response of rats to intratracheally administered oil shale. Toxicology Program, University of Arizona, Tucson, AZ, December 13, 1977.

Halothane biotransformation: detection, significance, and clinical implications. Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, June 22, 1981.

Biotransformation and toxicity of halogenated vinyl cysteines. Department of Pharmacology, University of Arizona, Tucson, AZ, October 28, 1981.

Model systems to study cell specific toxicity of the kidney. Smith, Kline and French Laboratories, Philadelphia PA, November, 1986.

Use of cultured renal tissue explants in toxicology. Proctor and Gamble Company. Miami Valley Laboratories. May 21, 1987.

Model systems to study cell specific toxicity of the kidney. Warner Lambert - Parke/Davis, Ann Arbor, MI, November 16, 1987.

Use of cultured tissue explants in toxicology. Ortho Pharmaceutical Corp., Raritan, NJ, December 3, 1987.

Use of cultured tissue slices in toxicology. Sterling Winthrop Research Institute. Rensselaer, NY, December 15, 1987.

Use of culture tissue explant toxicity studies. University of Kansas, Kansas City, KS, September 15, 1988.

Halothane hepatitis: Clinical perspective. University of North Carolina, Department of Anesthesiology, Chapel Hill, NC, October 26, 1988.

Halothane hepatitis: Clinical correlation - Animal Models. University of North Carolina, Department of Anesthesiology, Chapel Hill, NC, October 27, 1988.

Biotransformation of inhalation anesthetics. Risk and Benefits of Inhalation Anesthetic Agents. Schliersee, Bavaria, November 7­9, 1988.

Dichlorovinyl cysteine induced cellular injury in rabbit renal cortical slices. Marshall University, Department of Pharmacology, Huntington, WV, November 21, 1988.

Anesthetic hepatotoxicity: Bioactivation or immune response. Rutgers University. Joint Program in Toxicology. March 15, 1989.

Anesthetic hepatotoxicity: Bioactivation or immune response. University of Connecticut, Toxicology Program. April 6, 1989.

Cultured organ slices in toxicology: An alternative to animal testing. University of Connecticut. School of Pharmacy. April 7, 1989

Biotransformation of inhalation anesthetics: Risks and benefits. Department of Anesthesiology, University of Trondheim, Norway, May 1989.

Cultured organ slices in toxicology. An alternative to animal testing. Department of Pharmacology and Toxicology, University of Trondheim, Norway, June 1989.

Biotransformation of inhalation anesthetics: Role in producing toxicity. Anaquest, Murray Hill, NJ, September 14, 1989.

Explaining the University of Arizona's IACUC. Arizona Branch AALAS Fall Symposium. October 13, 1989.

Role of Bioactivation in Chemical-Induced Toxicities. Department of Chemistry, Arizona State University, Tempe, AZ, October 23, 1989.

Role of Bioactivation in Chemical-Induced Toxicities. Department of Chemistry, Northern Arizona University, Flagstaff, AZ, November 3, 1989.

Role of the Immune System in Anesthetic-Induced Liver Injury. Duke University, Integrated Toxicology Program. Durham, NC, December 6, 1989.

Utilizing Precision-Cut Positional Renal Slices for Study of Site-Specific Toxicity. Medical College of Ohio, April 24, 1990.

Role of the immune system in anesthetic-induced liver injury, Eli Lilly, Indianapolis, IN, July 20, 1990.

Volatile anesthetic hepatotoxicity: Bioactivation or immune mediated? University of Mississippi, Jackson, MS, November 19, 1990.

In vivo and in vitro models of volatile anesthetic hepatotoxicity. Cancer Biology Series. Cancer Center, University of Arizona, March 30, 1992.

Precision-cut tissue slices as an in vitro toxicity tool. Environmental Toxicology Seminar. Universidad Nacional Autonoma de Mexico. Mexico City, April 22, 1992.

Volatile halogenated anesthetic hepatotoxicity. ManTech Environmental, Inc. Wright Patterson AFB, September 9, 1992.

Uptake of metals in renal slices. 1992 Superfund Fall Meeting, Tucson, AZ, September 26, 1992.

Halothane hepatotoxicity. Department of Pathology, University of Arizona, November 19, 1992.

Update on the use of tissue slices for in vitro toxicity studies. College of Pharmacy, University of New Mexico, Albuquerque, NM, March 3, 1993.

Biological fate and toxicity of fluorocarbons. 3M Specialty Chemicals Division. St. Paul, MN, July 20, 1994.

Examining idiosyncratic chemical reactions, Proctor & Gamble Co., Cincinnati, OH, November 1, 1994.

Use of renal slices in metal disposition and toxicity studies. Nyco Med, Collegeville, PA, July 14, 1995.

Role of the immune system in anesthetic induced liver injury. Department of Physiology, University of Arizona, Tucson, AZ, September 22, 1995.

Use of confocal microscopy to study toxic events in precision-cut tissue slices.  Procter & Gamble Co., Cincinnati, OH, March 27, 1997.

Use of precision-cut tissue slices in pharmacology and toxicology.  Colgate-Palmolive Visiting Professorship at Indiana University, March 18, 1998.

Et tu Sevo?  Department of Anesthesiology, Univeristy of Arizona, September 16, 1998.

Late DMSO administration provides a protective action against chemically-induced liver injury.  Department of Cellular Biology and Anatomy, University of Arizona, November 9, 1998.

Slicing and dicing: Making in vitro systems for biological studies.  Biological Chemistry Program.  University of Arizona, March 27, 2003.

Effect of in vitro exposure to arsenic on the ubiquitin pathway in human renal and bladder cells.  Chemistry Society, University of Nuevo Leon, Mexico, June 17, 2004.

Effects of Low Level Exposure to Arsenic on Human Bladder Cells, Biological Chemistry Program Seminar Series, February 24, 2005.

US-Mexico Binational Center for Environmental Sciences and Toxicology.  CONACyT – Desert Angels Conference, University of Arizona, May 11, 2005.

Effects of low-level arsenic exposure on human bladder cells and relationship to human population studies.  Sonora Institute of Technology, C. Obregon, Sonora, Mexico, May 16, 2005.

SBRP – Outreach to Mexico Overview.  Sonora Institute of Technology, C. Obregon, Sonora, Mexico, May 16, 2005.

US-Mexico Binational Center for Environmental Studies and Toxicology.  SEMARNAT. Mexico City, July 1, 2005.

New cryopreservation methods for tissue regeneration.  Prostate Cancer Research Program, Arizona Cancer Center, September 14, 2005.

Effects of low-level exposure to arsenic on human bladder cells.  Ohio Valley Society of Toxicology, September 26, 2005 (tele-seminar).

Arsenite and monomethylarsonous acid toxicity to human bladder cells.  Native American Cancer Research Partnership and Programs in Chemistry and Biology, Northern Arizona University, April 7, 2006.

University of Arizona’s Superfund Basic Research Program and US-Mexico Binational Center.  Department of Health Services, State of Arizona, Phoenix, April 12, 2006.

University of Arizona’s Superfund Basic Research Program and US-Mexico Binational Center, and Research Instrumentation at the Department of Health Services, State of Arizona.  SBRP Colloquium Presentation, May 11, 2006.

Arsenic: Is it Safe?  University of Arizona ACS Chemistry Club.  October 4, 2006.

Monomethylarsonous acid induces oxidative stress, mitogenic-signal transduction, and transformation in human bladder cells.  Frontiers in Medical Research, College of Medicine, May 1, 2007.

Symposium Presentations:

Water Users' Retreat, "Toxicity of TCE", Southwest Environmental Service, January 16, 1982.

Future research in anesthetic-induced toxicity. Society of Toxicology, Atlanta, GA, 1984.

Evidence for the role of the immune response in the pathogenesis of halothane hepatitis. Third International Conference on Anesthesia, Calgary, Alberta, Canada, 1984.

Use of isolated renal tubules for the detection and investigation of nephrotoxins. Johns Hopkins Center for Alternatives to Animal Testing, October 24, 1984.

Renal Toxicology: Possible Metabolic Mechanisms. Continuing Education Courses. Society of Toxicology, San Diego, CA,1985.

Alternatives to Animal Research. College of Medicine Forum, National Laboratory Annual Day, April 24, 1986.

In vitro and in vivo toxicology. Symposium IV. Genetic Toxicology: End of an era; Directions for the future. American College of Toxicology, Seventh Annual Meeting, Philadelphia, PA, November, 1986.

Evaluation of isolated rabbit renal tubules and precision-cut renal slices for the detection and investigation of nephrotoxins. Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, MD, March, 1987.

In Vitro Methodology Workshop. Preparation and utilization of positional renal slices. Third International Symposium on Nephrotoxicity. University of Surrey. Guildford, England, August 1987.

In Vitro Systems for Nephrotoxicity Studies. 2nd International Meeting of Practical In Vitro Toxicology, Nottingham, England, July 24, 1989.

Utilization of precision-cut liver slices to profile and rank-order potential hepatotoxins. Industrial In Vitro Toxicology Group. Role of hepatic culture in risk assessment. Bristol-Myers, Wallingford, CT, November 21, 1989.

Biotransformation of inhalation anesthetics. International Anesthesia Symposium Bochum. Inhalation anesthesia-position and trend. University of Bochum, Bochum, West Germany, August 24­25, 1990.

Volatile anesthetic hepatotoxicity. Role of the immune system. Mountain West Society of Toxicology, Boulder, CO, September 26, 1991.

In vitro and in vivo models for anesthetic-induced hepatotoxcity. Hepatotoxicity Symposium. Universidad Nacional Autonoma de Mexico. Mexico City, April 23, 1992.

In vitro systems for nephrotoxicity studies. VI International Congress of Toxicology. Rome, Italy, June 30, 1992.

Interactive toxicity of metals in the kidney. Fate, Transport, and Interactions of Metals. Joint USA-Mexico Conference. Tucson, AZ, April 13-16, 1993.

Novel mechanisms of chemically induced hepatotoxicity. Mechanisms of halothane hepatitis. American Society for Pharmacology and Experimental Therapeutics, San Francisco, CA, August, 1993.

Identification of cellular targets of toxicity in tissue slices using biochemical and microscopic techniques. World Congress on Alternatives and Animal Use in Life Sciences, Baltimore, MD, November, 1993.

Toxicity and metabolism of volatile anesthetics. Fluorine in Medicine in the 21st Century. The University of Manchester Institute of Science and Technology, Manchester, UK, April 18-21, 1994.

Metal uptake and toxicology studies in precision-cut renal cortical slices. Centro de Investigacion Biomedica del Noreste, Monterrey, Mexico, May 23-25, 1994.

Use of tissue slices in chemical mixture toxicity and interspecies investigations, Second Annual HERL Symposium, "Chemical Mixtures and Quantitative Risk Assessment", Research Triangle Park, NC, November 9, 1994.

The role of the immune system in halothane hepatotoxicity, immunotoxicity and carcinogenicity of pharmaceuticals, Drug Information Association, Arlington, VA, January 26-27, 1995.

Uptake and toxicity of metals in rabbit renal cortical slices. Second Symposium on the Use of Tissue Slices: In Vitro Models of Toxicity and Biotransformation. SOT Satellite Symposium. Baltimore, MD, March 4, 1995.

Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Society of Toxicological Pathologists, San Diego, CA, June 12, 1995.

Involvement of the immune system in anesthetic induced liver injury. Arkansas Toxicology Symposium, Honoring Gabriel L. Plaa, Ph.D., Little Rock, AR, October 19-20, 1995.

Hepatotoxicity of hydrochlorofluorocarbons. National Research Council, Committee on Toxicology. Workshop on toxicity of alternatives to chlorofluorocarbons. Beckman Center, Irvine, CA, March 7-8, 1996.

Toxic interactions of drinking water contaminants.  Third Superfund Sponsored TCE Symposium.  University of Arizona, February 28, 1997.

Molecular alterations in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V).  Risk considerations  for environmental health and safety.  Superfund Meeting, University of Arizona, January 9, 1998.

Use of human prostate slices in toxicity studies.  16th Annual Meeting, Mountain West SOT, Tucson, AZ, September 18, 1998.

A Slice of Life.  Founders Day, College of Medicine, University of Arizona, November 17, 1998.

Cytoprotective effects of DMSO against hepatotoxicants.  University of Texas Medical Branch at Galveston, February 17, 1999.

Molecular alterations in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V). Centro de Investigacion Biomedica del Noreste, Monterrey, Mexico, June 29, 1999.

Gene Screens as a Method to Evaluate Metal Toxicity.  25th Anniversary, Division de Investigacion Biomedica, IMSS, Monterrey, Mexico, June 28-29, 1999.

Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.   Pilot Projects Symposium.  Southwest Environmental Health Sciences Center, University of Arizona, December 3, 1999.

Drug-induced liver injury: Mechanisms and test systems.  Role of the immune system in producing volatile anesthetic hepatotoxicity in the guinea pig.  NIH Lister Hill Auditorium, Bethesda, MD, October 17-18, 2000.

University of Arizona Binational Center.  NIEHS Border Health Workshop, Albuquerque, NM, October 29-30, 2000.

Cooperative efforts between the University of Arizona and stakeholders addressing Hazardous Waste Problems in Arizona.  Superfund Directors Meeting.  University of North Carolina, December 12-14, 2000.

Precision-cut slices from transgenic mice as an in vitro toxicology system.  SWEHSC Pilot Projects, January 11, 2001, University of Arizona.

Molecular effects of low level arsenic.  University of Arizona Superfund Training Core Colloquium. October 11, 2001

Mechanism of arsenic transport in the kidney.  ADEQ-EPA Regional Meeting, October 29, 2001, Phoenix, AZ.

Effects of low-level arsenic exposure on human kidney cells. American/Japanese Conference on Arsenic in Medicine and Biology, December 11-15, 2002, Honolulu, Hawaii.

Effects of in vitro exposure to arsenic on the ubiquitin pathway in human renal and bladder cells. Symposium on:  Arsenic disruption of cell cycle.  Society of Toxicology Annual Meeting, Baltimore, MD, March 24, 2004.

Effects of low level exposure to arsenic on human bladder cells.  Biomedical Research Center of the Northeast (IMSS), Monterrey, Mexico, June 28, 2004.

Structure and function of liver.  USAID TIES Workshop, CINVESTAV, Mexico City, September 22, 2004.

Susceptibility of liver to toxicity. USAID TIES Workshop, CINVESTAV, Mexico City, September 22, 2004.

Arsenic toxicity to organs.  USAID TIES, “Shortcourse on Environmental Toxicology”.  CICESE, Ensendada, B.C., Mexico, March 17, 2005.

US-Mexico Outreach Programs.  USAID TIES.  Binational Programs at the University of Arizona. CICESE, Ensenada, B.C. Mexico, March 18, 2005.

US-Mexico Higher Education Partnership for Environmental Studies and Toxicology, USAID Conference.  United States-Mexico:  University Partnerships for Prosperity.  Guadalajara, Mexico, June 29 – July 1, 2005.

Evolution of the U.S.-Mexico Binational Center:  Support from Many Sources.  U.S.-Mexico Binational Center Meeting, Tucson, AZ, March 12-14, 2007.

Binational Environmental Health Studies – Bureaucracy and Benefits.  U.S.-Mexico Binational Center Meeting, Tucson, AZ, March 12-14, 2007.

Centro Binacional Estados Unidos-Mexico para Ciencias Ambientales y Toxicología: Apoyo de Muchas Fuentes.  University of San Luis Potosí, June 4, 2007.

Models for International Collaboration in Environmental Health.  ISEE Meeting, Mexico City, September 6, 2007.

Arsenic – A Centerpiece of Toxicity Studies at the University of Arizona.  American College of Toxicology, Tucson, AZ  November 12, 2008.

Presentations

Health Information about Arsenic and Lead.  Saginaw Hill Community Group.  Mission Branch Library, April 24, 2006.

COP Phoenix-based Pharmacogenomics Program, Phoenix City Council, June 13, 2006.

Toxicity of perchloroethylene.  Community meeting concerning Valle Verde Water Company. Nogales, AZ, June 20, 2007.

COP Research Studies – An Overview.  TGen, Inc. Phoenix, AZ, July 11, 2007.

CASA Project.  Promotora training. Environmental chemicals health effects, South Tucson, September 27, 2007.

North Indian Bend Superfund Site – Community Involvement Group.  Trichloroethylene health discussion, November 15, 2007. 

US Embassy – Academic Border Tour.  Status of US-Mexico Binational Center.  Swede Johnson Building.  University of Arizona, April 9, 2008.

CASA Project.  Promotora Training.  Principios de la Toxicologia, Drachman Hall, April 19, 2008.

Environmental Scientist Exchange Program.  Arizona-Mexico Commission – Summer Plenary Meeting.  Environment Committee.  Phoenix, AZ,  June 21, 2008.

Arsenic Toxicity:  It can make you sick!  Wildcat School, Junior High.  PULSE program, 42 students, August 13, 2008.

Role of the chemist in toxicology studies.  UA Chemistry Club, 40 students, December 3, 2008.

US-Mexico Binational Center – Update. CONACyT Director/UA President, February 2, 2009.

College of Pharmacy Research:  Now and Future.  ASU College of Nursing, February 9, 2009.



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