1974-1975 Mayo Research Fellow, Mayo Clinic, Anesthetic Metabolism by the Lung.
1975-1978 Battelle Pacific Northwest Laboratories. Senior Research Scientist.
1978-1983 University of Arizona. Research Assistant Professor of Toxicology and Research Associate in Anesthesiology.
1983-1985 University of Arizona. Assistant Professor of Anesthesiology and Pharmacology.
1985-1989 University of Arizona. Associate Professor of Anesthesiology and Pharmacology. Research Associate Professor of Pharmacology and Toxicology.
1989- University of Arizona. Professor of Anesthesiology, Pharmacology, and Toxicology.
1993-1996 University of Arizona, Chairman, Graduate Program in Pharmacology and Toxicology.
1999-2007 University of Arizona. Assistant Dean for Research and Graduate Studies, College of Pharmacy.
1999- University of Arizona. Professor, Department of Pharmacology and Toxicology, College of Pharmacy.
2000-2003 University of Arizona. Acting
Chair, Department of Pharmacology, Toxicology and Medicinal Chemistry,
College
of Pharmacy.
2003-
Chair, Department of Pharmaceutical Sciences, College of Pharmacy.
2007-
Associate Dean for Research and Graduate Studies, College of Pharmacy.
2009- Professor, Division of
Community, Environment, and Policy, Mel and Enid Zuckerman College of
Public Health
Anesthetic Metabolism and Toxicity Bloc: Lectures for Department of Anesthesiology; 1978, 1979, 1981, 1982, 1984, 1987, 1989, 1992, 1994, 1995, 35 Residents. Searle Life Support Systems; February 68, 1980. A short course in Anesthesiology/Neonatology.
Toxicology 454: Industrial Toxicology Lectures (Inhalation Toxicology, Biotransformation, Chemical Carcinogenesis); 1979, 1980.
Toxicology 596: Toxicology Seminar. Presented to the Toxicology and Industrial Hygiene Students. 1015 Students. 19781981.
Toxicology 601: (Spectral Techniques), 1982.
Biotoxicology 602: (Lecture and Laboratory): Lectures (Lung, Inhalation Toxicology, Renal Toxicology, In vitro toxicology, biochemical pathology, hematotoxicity, (Laboratory Experiments); Absorption, distribution, biotransformation, liver toxicity, cell injury; 1978present.
Pharmacology 550-Biochemical Pharmacology: Drug Metabolism and Disposition (Biotransformation Enzymes, Factors Affecting Biotransformation, Laboratory Experiments); 19781996, Special Topic 1997, Phase II, Special Topic 1998, 1999, Coordinator 2000-present.
Pharmacology 208: Drug Metabolism, University of California, Berkeley, Summer 19801994.
Environmental Toxicology 576: Instructor-Coordinator, 1980. Disposition of chemicals in environment, 1981. Inhalation Toxicology, 1982. Air Pollutants, 1983.
Pharmacology/Toxicology: Special Toxics, Independent Study. Environmental Toxicology, 1987.
Pharmacology 596: Student Seminar, Coordinator 19831989.
Immunotoxicology: Molecular mechanisms of metabolism. 1985. 30 Students.
Pharmacology 501/801: Medical Pharmacology, Drug Metabolism, 1987, 1994-1998, 2002, 80130 Students. POPS - 1994, 1995. 75 students.
Molecular Pharmacology 551: Microtubule assembly, 1989.
Toxicology Special Topics: Literature Review. 1990. 2 Students.
Vet Sciences 443/543: Experimental Animal Methods. 1991 (1 hr), Animal research methods and ethics, 1992 (2 hr).
Pharmacy 471a: Absorption, distribution, excretion, biotransformation lectures, 1992, 2002-present.
Short Course in Toxicology: National University, Mexico City, Pulmonary, Renal, and Cellular Toxicology, August 9-13, 1993.
CB10 597a: Mechanisms of Cancer Prevention. Chemoprotection against Cancer by Detoxification Enzymes, 1993.
Tox 610: In Vitro Toxicology, Use of renal slices, 1993.
Tox 195: Toxicology, The Poisons Around Us, 15 students-Spring, 1995; 18 students-Fall, 1995, 25 students-Fall, 1996, 20 students-Fall, 1997, 1998, 24 students, 1999, 25 students, 2000-present.
Tox 302: Undergraduate Environmental Toxicology, 50 students, 1995-2000.
Summer Minority Research Program: Applying for Graduate School, 1994, 1995, 1996; General principles of toxicology, 8 students.
Biochem 494: Independent Study, 1996.
Center for Toxicology: High School Teacher's Workshop,
Principles of Toxicology, June 1996, 8 teachers, (2 hr). 1998
Principles, Metal Toxicology, (3 hr). 1998 Insect Science Workshop -
Toxicology, Risk Assessment (3 hr), 10 teachers. 1999 Risk
Assessment, 12 teachers. 2000 Biotransformation. 2001 Basic Principles.
2002 Disinfectants. 2003 Teaching Environmental Toxicology.
2004 Teaching Basic Toxicology. 2004 PULSE Teachers: Superfund,
Authorization,
and Politics. 2006 Environmental Health and Toxicology Literacy.
Pharm 620: Principle of Pharmacology, Careers in Pharmacology/Toxicology, 18 students, 1996.
PCOL 420, 421: Case Studies in Biochem Pharmacology. 3 sections, 12 students, 1999, 2000; 4 sections, 12 students, 1999-present.
PCOL 610: Molecular and Cellular Toxicology (Immunotoxicology) 2000-2002. 2003 Low-level arsenic toxicity.
PHSC 596H: Special Topics in Pharmaceutical Sciences.
Journal Review, 2 sessions, 2002, 2004.-present
PCOL 474: Clinical Toxicology, 2 lectures - Role
Biotranformation in Clinical Toxicology, 70 students, 2003-present.
Metal Toxicology: Summer Minority Research Program, 10 students, 1999.
Colloquium: Superfund Basic Research Program. Coordinate 10-15 people, 2000-2003. Co-coordinate, 2003-present.
SWES 518: Introduction to Human Health Risk Assessment, Risk/Toxicity of Halo-Aliphatics, 30 students, 2002.
Chemistry 599: Northern Arizona University. Liver and Kidney Toxicity. 15 students, 2 hr, 2002.
PCOL 595b: Science Writing/Strategy/Skills. 15
students. Study Section Panel, 2002.
PCOL 573:
Experimental Models for In Vitro Toxicology. 8 students, 2004.
PCOL 630:
Proteosome Degradation/Signaling, 2 lectures, 20+ students,
2005-present.
Senior Research Projects
Dan Tinlin, 1990
Sheila Duffy, 1996
Vikas Patel, 1997
Jeffrey Catania, 1997-1998
Hugh Nguyen, 1997-1998
Ferleine Bautista, 1999
Kelly Dale, 2000-2001
Steve Weldon, 2002-2005
Sean McGinty, 2002-2003
Derek Dindal, 2003-2004
Erin Blomquist, 2004-2005
Nicole Lane, 2004-2005
Rachel Diaz, 2005-2007
Elyse Taylor, 2005
Andrew Hau, 2005-
Mahima Jain, 2006-2007
Michelle Wild, 2008-
Hio Lam Chao, 2008-
Thesis and Doctoral Committees:
M.S. in Physiology
Lynn Munoz – M.S. 2003. Characterization of rabbit OAT1
and OAT3.
M.S. in Pharmacology:
Graduate Committee Member
F. Margaret Dingmann - M.S. - Pharmacology 1997. Novel study of the effects of aprotinium on LLC PK cells.
Art Reigel - M.S. - Pharmacology, 1998. Effects of toluene on
dopamine neurons and its implication in inhalant abuse.
Masters
Degree – Applied Biosciences
Aaron M. Pershing, PSM, 2006. Cryopreservation techniques for
precision-cut tissue chip technology.
Elizabeth Arnold, PSM. Alternative ocular testing of personal
health care products.
M.S. in Toxicology:
Graduate Committee Member
Thomas Evans - M.S. - Toxicology 1979. Metabolism of melphlan.
Douglas Eisenstein - M.S. - Pharmacology 1979. Pyrrolizidine alkaloids: Extent of population exposure and prevention of toxic effects.
Barbara Larcom - M.S. - Toxicology 1979. Fate of nitrogen mustards, melphalan.
Mary Susan Connors - M.S. 1981. The isolated perfused rat liver - Viability and metabolism studies in an all-glass perfusion apparatus.
Dave Dutton - M.S. - Toxicology 1984. Mechanism of promotion in epidermal cells with TPA.
Debra Randall - M.S. - Toxicology 1984. Promotional effect of trichloroethylene on hepatocellular neoplasia.
Robert Nenad - Masters Candidate - Toxicology 1985. Effect of ranitidine and cimetidine on the disposition of fentanyl.
Laurie Goll - Masters Candidate - Toxicology - (Medical School). Acute renal failure: reversal with oxygen radical scavengers.
Kerry M. Barnhart - M.S. - Toxicology 1985. Activation of oncogenes by etiological agents.
Stephen Teo - M.S. - Toxicology 1985. Metabolism of chloramphenicol: Possible role in aplastic anemia and anemia and leukemia.
Lynnda Reid - M.S. - Toxicology 1990. Effect of benzene on IL2 production in mice. Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity.
Jefferey Burgess, M.D. - M.S. - Toxicology 1993. Evaluation of the safety of self-contained breathing apparatus at high exertion levels.
Karen Duncan - M.S. - Toxicology 1995. Mercury chloride induced apoptosis toxicity in renal cell lines.
Ira I. Chadnick - M.S. - Toxicology 1996. Assessment of carbon monoxide exposure for a newspaper vendor during work at a busy traffic intersection.
Sheila Healy - M.S. - Toxicology 1997. Arsenic methyl transferase enzymes in the guinea pig and rabbit.
Eric Wildfang - M.S. - Toxicology 1997. Characterization of the arsenic methyl transferase in hamster liver.
Latressa Billings - Masters Candidate - Toxicology. Metabolism of methyl styryl ketone.
Robert Kuester - M.S. - Toxicology 2001 - Strain specific hepatotoxicity of cadmium chloride.
Jacob Pritchett - M.S. - Toxicology 2001 - In vitro biotransformation of bisphenol A in human, mouse, and rat hepatocytes.
Hamid Badghisi - M.S.
- Toxicology 2001 - Identification of styrene
oxide aducts to hemoglobin using LCI MS/MS.
Laura
Tiscareno – M.S. – Toxicology 2004 – Analysis of pancreatic disease by
global proteomic profiling.
Advisor/Co-Advisor
Matthew Miller - M.S. - Toxicology (advisor) 1979. Disposition of enflurane in the obese.
Richard Jee - M.S. - Toxicology (co-advisor) 1979. Halothane hepatotoxicity.
Carl Potter - M.S. - Toxicology (co-advisor) 1980. Renal toxicity of volatile fluorocarbons.
Lorrene Buckley - M.S. - Toxicology (co-advisor) 1980. Evaluation of the nephrotoxic effects of inhaled chlorotrifluoroethylene in the rat: A subacute study.
John MacDonald - M.S. - Toxicology (co-advisor) 1981. Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.
Frank Plescia - M.S. - Toxicology (advisor) 1981. The disposition and hepatotoxicity of 1,2-dibromoethane.
Kathy Cater - M.S. - Toxicology (co-advisor) 1982. An evaluation of the newborn mouse as a potential method for the bioassay of liver carcinogenesis using histological and histochemical markers.
Debra Jaffe - M.S. - Toxicology (advisor) 1982. Genotoxicity of S-(trans-1,2-dichlorovinyl) -L-cysteine in renal tissue.
Ronald MacFarland - M.S. - Toxicology (co-advisor) 1982. Biotransformation of ethylene dibromide in extrahepatic tissues.
Richard Lind - M.S. - Toxicology (advisor) 1982. The role of endotoxin in halothane hepatotoxicity.
Janet Durham - M.S. - Toxicology (advisor) 1983. Hepatotoxicological evaluation of dantrolene sodium.
Stephen Glass - M.S. - Toxicology (advisor) 1983. Effect of cimetidine, ranitidine, and halothane on lidocaine pharmacokinetics.
Susan Meadows - M.S. - Toxicology (advisor) 1985. Persistent nephrotoxicity and renal tumor promotion in Swiss-Webster mice following exposure to dichlorovinylcysteine.
Betsy Corsino - M.S. - Toxicology (co-advisor) 1986. The pulmonary response induced by glass fibers.
Jennifer Phelps - M.S. - Toxicology (advisor) 1986. In vitro nephrotoxicity of cisplatin.
Majid Saidat Pajouh - M.S. - Microbiology and Immunology (co-advisor) 1986. Generation of halothane induced antibody in guinea pigs.
Leslie Pustilnik - M.S. - Toxicology (co-advisor) 1987. Pulmonary response to fibers in murine model of silicosis.
Lawrence Vernetti - M.S. - Toxicology (co-advisor) 1988. Effect of cyclosporin A on PtK2 cells and their cytoskeleton.
Cynthia Nowlin - M.S. - Toxicology 1992. Examination of mitochondria exposed to 1,2-dimethyl hydrazine using atomic force microscopy and other techniques.
Carmen Burton - M.S. - Toxicology 1994. Effect of glutathione on HgCl2 and NaAsO2 toxicity and uptake in rabbit renal cortical slices.
Andrea Payne - M.S. - Toxicology 1995. Biotransformation of sevoflurane by rat neonates liver slices.
Mingli Chen - M.S. - Toxicology 1996. Role of immune system in multiple halothane exposure induced liver injury.
Rainer Sell - M.S. - Toxicology 1996. Precision-cut rat liver slices: An in vitro model for the study of cold preservation injury.
Hong Bing Wei - M.S. Toxicology 1997. Effect of GSH conjugates on uptake and toxicity in rabbit renal tubules.
Rodney Keith - M.S. Toxicology 1997. Use of proton induced x-ray emission on uptake of metals in renal tissue.
Karen Turney - M.S. Toxicology 1999. Selective activation of
the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical
slices.
Sarah Buffington – M.S. Toxicology 2008. Chronic exposure to
monomethylarsonous acid induces changes in human UROtsa cells
consistent with urothelial tumorigenesis.
Ph.D. in Pharmacology and Toxicology:
Graduate Committee Member
Carl Potter - Ph.D. - Pharmacology 1982. Metabolic alterations of 1,2,7,8-tetrachlorodibenzo -p-dioxin to rats.
Mark Lafranconi - Ph.D. - Pharmacology 1983. Toxicology of the pulmonary epithelium.
Debra Jaffe - Ph.D. - Molecular Biology 1987. Mouse skin tumor initiation by ionizing radiation and the detection of dominant transforming genes.
Natalie Miller - Ph.D. - Pharmacology 1987. Mechanism-based inactivation of rat liver cytochromes P450 by analogues of chloramphenicol.
Eric Stine - Ph.D. - Pharmacology 1987. Hepatotoxicity of dichlorobenzene isomers.
Ala El-Sisi - Ph.D. - Pharmacology 1987. Elucidation of the mechanism of vitamin A potentiation of carbon tetrachloride - included liver injury.
William Bellamy - Ph.D. - Pharmacology 1988. Mechanisms of doxurubicin drug resistance.
Pam Shubat - Ph.D. - Pharmacology - 1988. Pulmonary vascular toxicity of monocrotaline.
Scott Mobley - Ph.D. - Pharmacology - 1991. Effect of vitamin A on Kupfer cell toxicity.
Janet Firrilo - Ph.D. - Pharmacology - 1992. Disposition and toxicity of cobalt naphthenate.
Stacie Wild - Ph.D. - Pharmacology - 1993. Detection of pyrrole in the biotransformation of pyrridizidine alkaloids.
Walter Klimecki - Ph.D. - Pharmacology - 1994. P-glycoprotein: Expression and function in normal circulating leukocytes.
Greg Bogdan - Ph.D. - Pharmacology - 1994. A 450K arsenite binding protein of the rabbit liver cytosol.
Amy Ham - Ph.D. - Pharmacology - 1995. Antioxidant reactions of vitamin E in rat liver.
Torka Poet - Ph.D. - Pharmacology - 1995. Cytochromes P450 involved in the bioactivation of cocaine in the rat.
John-Michael Sauer - Ph.D. - Pharmacology - 1996. All trans-retinal modulation of chemical-induced lung and liver toxicity.
Kristina Hatlelid - Ph.D. - Pharmacology - 1996. In vitro investigation of the toxic mechanism of action of arsine on the erythrocytes.
Stephanie Born - Ph.D. - Pharmacology - 1996. Characterization of canine cytochrome P450s 2B and 3A.
Steve Waters - Ph.D. - Pharmacology - 1996. Neuropeptidases as sites of peptide regulation by dopaminergic drugs.
Russell Ingersol - Ph.D. - Pharmacology - 1996. Central nervous system toxicity of manganese.
Edward Bilsky - Ph.D. - Pharmacology - 1996. Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence.
Shannon Winski - Ph.D. - Pharmacology - 1997. Metabolism and toxicity of sodium arsenite in human erythrocytes.
Kevin K. Divine - Ph.D. - Pharmacology - 1997. Modeled speciation of Hg and endogenous thiols. Their comparative toxicity in LLC-PK1 cells.
Maralee McVean - Ph.D. - Pharmacology - 1997 - Photoprotective activity of vitamin E in mouse skin.
Thomas Abbruscato - Ph.D. - Pharmacology - 1997. Opioid peptide permeation across the blood-brain barrier.
Raymond Robledo - Ph.D. - Pharmacology - 1998. Pulmonary toxicity of JP-8 jet fuel.
Karissa Adkins - Ph.D. - Pharmacology - 1998. Glucocorticoid regulation of GM-CSF in bronchial epithelial cells.
Robert Landsman - Ph.D. - Pharmacology - 1999. The human cannabinoid receptor expressed in CHO cells as a model to study cannabinoids.
Felix Ayala - Ph.D. - Pharmacology, 1999. Tissue specificity for metabolism and toxicity of arsine and arsenate.
Qingbo Tang - Ph.D. - Pharmacology, 2000. Nonopoid actions of dynorphin and neuropathic pain.
Di Bian - Ph.D. - Pharmacology, 2000. Peripheral and spinal mechanisms of neuropathis pain in the rat.
Marc Oshiro - Ph.D. - Pharmacology, 2000 - Role of IL-6 signaling via the Jak/Stat pathway in human myeloma.
Daniel Mason - Ph.D. - Pharmacology 2003. Mass spectral analysis of hydroquinone adducts.
Beau Hansen - Ph.D. - Pharmacology 2005. Proteomics methods
for detection of modified peptides.
Husam Younis - Ph.D. - Pharmacology, 2001. The molecular and cellular mechanisms of 1, 2-dichlorobenzene induced liver injury in F344 and S-D rats.
Jason Halliday - Ph.D. - Pharmacology 2002. Comparative
pharmacokinetic and disposition of a surrogate mineral hydrocarbon.
Jay
F. Petrick - Ph.D.- Pharmacology 2003. Arsenic:
Metabolism, cytotoxicity, and toxigenomic alterations in the developing
lung.
Shannon Conley –
Ph.D. – Pharmacology 2005. Selinium effects of on human
trabecular meshwork.
Linda Manza - Ph.D. - Pharmacology 2007. Characterization of protein sumoylation in response to alkylation stress.
Lisa Ahern – Ph.D. – Pharmacology 2008. Mechanism of hepatoprotectoin during hepatic cholestasis.
Taylor Jensen – Ph.D. - Pharmacology 2008. Epigenetic
remodeling during arsenical-induced malignant transformation.
Craig Fisher – Ph.D. – Pharmacology 2008. Non-alcoholic fatty
liver disease alters the three phases of hepatic drug metabolism.
Monica Yellowhair – Doctoral candidate. Depleted uranium
genotoxicity in human bronchial epithelial cells.
Matt Merrell – Doctoral Candidate – Induction of MRP2 in biliary
cells.
Alicia Bolt – Doctoral candidate. Genomic effect of inhaled
dust on lung performace.
Paulina Gomez Rubio – Doctoral candidate. Arsenic and lung
function.
Advisor/Co-Advisor
Russell White - Ph.D. - Pharmacology (advisor) 1981. Genotoxicity of 1,2-dibromoethane.
Christopher Hassal - Ph.D. - Pharmacology (co-advisor) 1983. Biotransformation and nephrotoxicity of halogenated ethylenes.
John MacDonald - Ph.D. - Pharmacology (co-advisor) 1984. Reversal of hepatotoxicity with free sulfhydryl compounds.
Peter Smith - Ph.D. - Pharmacology (co-advisor) 1985. A novel organ culture for the study of hepatotoxicity.
Leslie Rylander - Ph.D. - Pharmacology (advisor) 1985. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins.
Paul Silber - Ph.D. - Pharmacology (co-advisor) 1986. Early indicators of renal proximal tubular injury.
Charles Ruegg - Ph.D. - Pharmacology (advisor) 1987. Mechanisms underlying regioselective acute tubular necrosis of renal proximal tubular segments.
Grushenka Wolfgang - Ph.D. - Pharmacology (advisor) 1989. DCVC induced cellular injury in rabbit renal cortical slices.
Nancy Shipp - Ph.D. - Pharmacology (co-advisor) 1990. Cardiotoxicity of chemotherapeutic agents.
Mary Stefaniak - Ph.D. - Pharmacology (co-advisor) 1990. Precision-cut rat lung slices.
Lawrence Vernetti - Ph.D. - Pharmacology (co-advisor) 1991. The effect of cyclosporin on cytokeratin intermediate filament phosphorylation.
Alan Brown - Ph.D. - Pharmacology (advisor) 1992. Generation and expression of halothane derived protein adducts in the guinea pig liver.
Hilary Sheevers - Ph.D. - Pharmacology (advisor) 1993. Site-specific injury due to transport mechanisms.
Stephen Waters - Ph.D. - Pharmacology (advisor) - 1993. In vivo and in vitro hepatotoxicity of M741.
Jon-Pierre Michaud - Ph.D. - Pharmacology (co-advisor) 1994. Precision-cut rat liver slice culture: An in vitro tool for assessing hepatotoxic interactions of organohalides.
Steve Hasal - Ph.D. - Pharmacology (co-advisor) 1998. A model for the multistage metabolism and nephrotoxicity of chlorotrifluoroethylene.
Donald Kirkpatrick - Ph.D. - Pharmacology 2003. The effects of arsenic on the ubiquitin dependent proteolytic pathway.
Marjorie Peraza –
Ph.D. – Pharmacology 2003. Subcytotoxic
inorganic arsenic effects on mitochondria in a human proximal tubule
cell line.
Elizabeth Casarez –
Ph.D. – Pharmacology 2004. The influence of microorganisms on the
bioavailability and toxicity of arsenic in soils.
Jeffrey Catania – Ph.D. – Pharmacology 2006. Derivations of tissue slice technology as toxicological screening systems.
Ph.D./M.S. Committees - Other Disciplines
Janet Ludwig - Ph.D. - Agricultural Biochemistry and Nutrition 1981. Mechanism of the zinc protective effects against CCl4 hepatotoxicity.
Vikram Sinha - Doctoral candidate - Pharmaceutical Sciences - Pharmacokinetics of therapeutic agents.
Jeri Lott. Doctoral Candidate - Chemistry. An evaluation of biological markers for lead poisoning by proton induced x-ray emission.
Betsy C. Risendal - Ph.D. - Epidemiology 1998 - Cancer screening among urban Southwestern American Indian women.
Tarundeep Kakkar - Ph.D. - Pharmaceutical Sciences 1999 - Theoretical studies on enzyme inhibition kinetics.
Timothy Radabaugh - Doctoral Candidate - Genetics. Characterization
of the human liver cytosolic arsenic reductase.
Lynn Munoz – M.S. – Physiology 2003. Characterization of OAT1 and OAT3
transporters.
Huadong Tang – Ph.D. 2005 – Pharmaceutical Sciences.
Allometric
sealing for predicting human drug clearance.
Pilar
Carranza – Ph.D. – Biological Sciences 2004.
Characterization of the morphology and functionality of OK cell
model
for intoxication by mercury.
Roberta Bruhn – Ph.D.
– Epidemiology 2008. Relationship between glaucoma and selenium
levels in plasma and aqueous humor.
Zelieann Rivera-Craig
– Ph.D. – Physiological Sciences 2009. Characterization of
residual ovarian tissue in mice following 4-vinylcyclohexene-induced
ovarian failure.
Visiting Graduate Students:
Pilar Carranza (2000-2003) 2004, 2005 - Ph.D. - School of Medicine,
University
of Neuvo
Leon, Mexico. Effect of DMDS and DMSA on BSA transepithelial
transport by OK cells exposed to HgCl2.
Mercedes Meza (2001-2004) – Ph.D. - Sonora Institute of Technology,
Cuidad Obregon,
Sonora, Mexico. Arsenic drink water exposure and urinary
excretion in Yaqui Valley, Sonora, Mexico.
Laura Cruz (2005) – Relationship between arsenic exposure and
diabetes.
Andrea Diaz (2005) – Relationship between arsenic exposure and diabetes.
Jorge Alegria (2006) – Polymorphisms in apoptosis markers in
response to DDT.
Research Associates:
Andrea Hubbard (Callis), Ph.D., Immunology, 198385.
Gregory M. Becker, Ph.D., 1984.
Shana Azri, Ph.D. 1987-1990.
Hanan Ghantous, Ph.D., 1988-1991.
Ken Hastings, Dr. P.H., 1988-1991.
Sharon J. McGuinness, Ph.D., 1991-1992.
Janet B. Clarke, Ph.D., 1991-1993.
Patricia Ijomah, Ph.D. - 1991-1993.
Sylvia Furst, Ph.D. - 1994-1996.
Jayanthika Wijeweera, Ph.D. - 1992-1997.
Alan Parrish, Ph.D. - 1996 - 1999.
Artemio Fernandez, Ph.D. – 2003
Clinical Research Fellows:
John B. Bentley, M.D., 19801981.
James D. Borel, M.D., 19811982.
Karen Knieriem, M.D., Ph.D., 19841985.
Edward Frink, M.D., 19871988.
David Nyman, D.O., 2000-2004.
Foreign Research Fellows:
Gustavo Martinez Zedillo, Ph.D., 19801981.
Tetsuro Fukui, M.D., 19821983.
Ola Dale, M.D., Ph.D., Fogerty Fellowship. 19851986.
Bjorn Hagen, M.D., Ph.D., 1990.
Bupesh Kaul, M.D., 1990-1991.
Gerard Stinjtjes; Free University, The Netherlands, 1991.
Claudia Escudero, Mexico, 2008-
Graduate School Referee (Foreign University):
Kathie Knights - Doctoral Candidate. The Department of Pharmacology.
Flinders University, South Australia, 1984.
Soma Mitra – Doctoral Cadidate. Role Nutrition
in Clinical Expression Arsenic Toxicity. Jadavpur University,
India, 2003.
19681972 USPHS Trainee in Environmental Health and Science, Oregon State University.
19741975 Mayo Graduate School of Medicine Fellowship, Mayo Clinic.
1998
Founders Day Speaker, College of Medicine, University of Arizona,
November 17, 1998.
2004 Education
Award, Society of Toxicology.
2007
Findlay E. Russell MD, PhD, Distinguished Citizen Award, College of
Pharmacy
Research Grants:
1978-1979 American Cancer Society, Institutional Cancer Research Grant. Role of "C-S" Lyase in halogenated vinyl cysteine toxicity. $3,000. Completed.
1978-1980 National Cancer Institute, Organohalogen Carcinogenicity, Co-investigator. $189,410. Completed.
1979-1982 National Institutes of Health, NIAMD, Studies of Inhalation Anesthetic Hepatotoxicity, Co-investigator. $178,000. Completed.
1979-1980 Ohio Medical Products, Research Grant, Comparative Biotransformation of Ethane and Halothane in Obese Patients, Co-Investigator. $30,000. Completed.
1980 Biomedical Research Support Grant, College of Medicine, University of Arizona, Detection method for determination of fentanyl and its metabolites, Co-Investigator. $4,000. Completed.
1980 Biomedical Research Support Grant, College of Pharmacy, University of Arizona, Mechanism of sulfhydryl-type therapeutic agents in counteracting chemically induced liver toxicity, Co-Investigator. $6,000. Completed.
1980-1982 National Institute of Health, NIAMD, Supplemental Grant -Studies of Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $3,000. Completed.
1983 Norwich Eaton, Pilot Grant, Hepatotoxicity of Dantrolene Sodium, Co-Investigator. $1,000. Completed.
1983 Perkin Elmer, Pilot Grant, Utilization of Flame Photometry for Ca Analyses, Investigator. $1,500. Completed.
1981-1984 Janssen Pharmaceutica, Inc. Clinical evaluation and pharmacokinetics of sufentanil, Co-Investigator. $24,000. Completed.
1982-1987 National Institute of Health, NIAMD, Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $570,000. Completed.
1982-1984 Ohio Medical Products, Determination of the impurities in "yellow" Forane, Investigator. $25,000. Completed.
1984-1985 Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins. Investigator. $20,000.
1984 Biomedical Research Support Grant, College of Medicine, University of Arizona, Thin tissue slicer apparatus and studies. Co-Investigator. $8,000. Completed.
1984-1987 National Institutes of Health, NIEHS. Animal Models of Alcohol-Related Cancers, Co-Investigator. $300,000.
1983-1984 University of Arizona, Institutional Research Grant, American Chemical Society. Ethanol and Esophageal Carcinogenesis. Co-Investigator. $8,000.
1984 Deborah Heart and Lung Center. Metabolism of halothane in cyanotic and acyanotic pediatric cardiac patients. R.A. Moore (Investigator), Co-Investigator. $5,000. Completed.
1985-1986 Janssen Pharmaceutica, Inc. Evaluation and pharmacokinetics of sufentanil in renal failure patients. Co-Investigator. $20,000. Completed.
1985-1986 Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for nephrotoxicity. Investigator. $17,000. Completed.
1985-1988 NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $276,000. Completed.
1985-1989 NIEHS. Methods of development to assess human metabolism of chemical xenobiotics. Co-Investigator. $1.2 Million. Completed.
1985-1986 NIH. Fogarty International Research Fellowship. Volatile Anesthetics. Interaction with other drugs. Co-Investigator. $30,000. Completed.
1986-1987 University of Arizona. Small Grants Program. The cytoskeleton as a target for toxic agents. $5,000. Completed.
1986-1987 Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules and positional renal slices for nephrotoxicity. Investigator. $17,000. Completed.
1987-1988 Johns Hopkins Center For Alternatives to Animal Testing. Evaluation of precision-cut positional renal slices for nephrotoxicity studies. Investigator. $17,000. Completed.
1987-1990 NIH, NIDDK. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $367,000. Completed.
1987-1991 NIH, NIGMS. In Vitro Toxicology: Precision Tissue Slice Technology. Co-Principal Investigator. $528,000. Completed.
1988-1989 Maruishi Pharmaceutical Co., Japan. Disposition and toxicity of sevoflurane. Co-Investigator. $20,000. Completed.
1988-1989 Upjohn Company. Methods development towards establishment of an in vivo organ slice based tissue bank for the assessment of metabolism of chemical xenobiotics. Co-Investigator. $15,000. Completed.
1988-1992 NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $467,000.
1988-1989 Arizona Kidney Foundation. Toxic effects of cyclosporin on the cytoskeleton of renal cells. Co-Investigator. $6,570. Completed.
1989-1991 NATO (CRG). Drug Interactions/Anesthetics. Co-Investigator. $5,000. Completed.
1989-1994 NIH P01. Renal Handling of Organic Ions. In vitro renal toxicity: role of transport. Co-Investigator. $450,000.
1990-1992 NIEHS. Use of precision-cut tissue slices for interactive toxicity studies. Co-Investigator, $240,000. Completed.
1990-1993 NIH, NIGMS MARC Program. Society of Toxicology. Co-investigator 5%. $74,408. Completed.
1990-1993 NIH NIGMS. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $424,000.
1991-1996 NIEHS. Precision Tissue Slice Technology. Co-Principal Investigator. $540,000.
1991-1994 Arizona Disease Control Commission. Cultured Myocardial Slices as an Alternative In Vitro Tool for Toxicity Evaluation. Co-Investigator. $75,000.
1992-1995 NIEHS. Interactive toxicity studies of chemical waste dumps using renal cortical slices. Investigator. $300,000.
1992-1995 NIEHS. Xenobiotic metabolism in cryopreserved human liver slices. Co-Investigator. $362,000.
1993-1998 NIEHS. Studies of chemical disposition in mammals. Co-Investigator 5%, Year 1 - $314,824, total $1,734,000.
1994 Procter & Gamble. Examining idiosyncratic chemical reactions. Co-Investigator. $78,125.
1995-2000 NIEHS. Metal-metal interactions in the kidney. Investigator, $85,000/yr, $425,000 total.
1997 Colgate-Palmolive Visiting Professorship, Indiana University, $12,000.
1997-1999 Procter & Gamble. Use of confocal microscopy to study toxic events in precision-cut tissue slices. $82,000.
1997-2002 NIEHS. Hepatoprotective mechanisms of DMSO. Investigator, $107,000/yr, total $321,000.
1997-1998 Ohmeda, Inc. Hypersensitivity of compound A. $14,500.
1997-1998 Ohmeda, Inc. Sequential biotransformation and toxicity of compound A in tissue slices. $39,000.
2000-2005 Southwest Hazardous Waste NIEHS Superfund, Principal Investigator. $1.6 M/yr.
2000-2005 NIH Clinical Research Curriculum Award, Co-Director. $185,000/yr.
2001-2003 NIEHS. Development of toxicity screen from transgenic mice with fluorescent protein markers. Principal Investigator. $120,000.
2001-2005 Department of Defense (Algan-P.I.). Dynamic Tissue Culture System from Prostate Biopsy Specimens. Co-Investigator. $510,000.
2002-2003 NSF. Arsenic in Biology and Medicine. Principal Investigator. $17,250.
2002-2005 NCI. Tissue Chips for Toxicology Evaluation. Principal Investigator. $151,414/yr.
2002-2004 USGS/NIWR (Field-P.I.).
Agricultural Chemicals as a Major Non-Point Source of Arsenic:
Microbial Transformation of Organic Arsenicals. Co-Investigator.
$69,000/yr.
2003 NIEHS Southwest Environmental Health Sciences Center
(Interim Director) $870,000/yr (1999-2000).
2003-2006 NIH Optical Spectroscopy of Ovarian Cancer (Urs
Utzinger, PI). Co-Investigator. $250,000/yr.
2003-2008 Prostate Carcinoma: Invasion and Metastasis Factors
(Raymond Nagle, PI). Core Leader. $75,000/yr.
Training Grants
NIEHS. Training Program in Environmental Toxicology. Participant.
NIGMS. Clinical Pharmacology Research Training, Participant.
NIEHS. Toxicology Training Grant, Participant. $150,000/yr.
NIEHS. Training Grant for Environmental Science Graduate Students in Toxicology. $172,000.
Postdoctoral Grants
1989-1991 Azri, Shana. Carbon tetrachloride: In vitro slice toxicology. NIH National Research Science Award.
1997-1999 Parrish, Alan. Alterations in cadherin/catenin complexes by oxidative stress in precision-cut liver slices. $67,000.
Center Grants
1993- NIEHS, Southwest Environmental Health Sciences Center, Cell Injury Research Program Director, Year 1 $700,000.
1999-2004 NIEHS Southwest Environmental Health Science
Center, Research Program Director. $1 M/yr.
College of Medicine
College of Medicine, Administrative Review Committee, Department of Anesthesiology, 1979, 1985.
College of Medicine, Medical Student Interviewer, 1983-1987.
College of Medicine, DAR Review Committee, University of Arizona, 1985.
Biomedical Research Laboratories Management Committee, 1985-1999.International
EVCAM/CAAT Workshop Participant. Mechanisms of Toxicity, April 1996.
USAID TIES Meetings
Mexico City, 2004
Ensenada, Baja California, Mexico, 2005
Society of Toxicology
Appointed Positions
Program Committee, 1983-1986.
Public Relations Committee, Mechanisms of Specialty Section, 1981-1984.
Refresher Course on Endotoxins, Coordination Committee, 1984 Meetings.
Fluorinated Volatile Anesthetic Symposium Organizer, Coordinator, Chairman, 1984 Meetings.
Technical Committee, 1986-1988.
Tox 90's Education Issue Ad Hoc Committee, Chairman, 1988-1991.
Undergraduate Toxicology Ad hoc Committee, 1990-1994.
Nominating Committee, Mechanisms, Chair, 1991.
Toxicology Education Foundation, 2000-2002.
Board of Publications, 2005-2009; Chair 2008-2009.
Elected Positions
President, Mechanisms Specialty Section, 1989-1990.
Vice President, Mechanisms Specialty Section, 1988-1989.
Vice-President Elect, Mechanisms Specialty Section, 1987-1988.
Secretary-Treasurer, Mechanisms Specialty Section, 1984-1986.
Education Committee, SOT, 1988-1991.
Nominating Committee, SOT, 1992-1994.
Secretary, Society of Toxicology, 1997-2000.
Awards Committee, 2007-2009
3. Additional Professional Activities:
Professional Societies: (member since)
Society of Toxicology (1976)
American Society for Pharmacology and Experimental Therapeutics (1980)
Arizona Society of Anesthesiologists (1982)
American Society of Anesthesiologists (1982)
International Society for the Study of Xenobiotics (1982)
American Association for the Advancement of Science (1982)
American Association of Liver Diseases (1990)
Editor:
MECHANISMS Newsletter (Society of Toxicology), 1982-1985.
Associate Editor:
Toxicology Applied Pharmacology, 1986-1994.
In Vitro Toxicology, 1986-present
Area Editor:
Drug Chemical Toxicology, 1986-present.
Editorial Advisory Board:
Life Sciences, 1984-1993
In Vitro Toxicology, 1986-2001
Drug and Chemical Toxicology, 1983-1985
CRC Press. Molecular and In Vitro Toxicology, 1987-1996
Toxicology Applied Pharmacology, 1997-2000
Cell Biology and Toxicology, 1998-
Toxicology 2003-
Reviewer for following journals:
Life Sciences
J. Pharmacology and Experimental Therapeutics
Toxicology Applied Pharmacology
Drug Metabolism and Disposition
Chemical Biological Interactions
Biochemical Pharmacology
Molecular Pharmacology
Anesthesiology
Toxicology
Reviews of Contamination and Toxicology
Toxicologic Pathology
Environmenatl Health Perspectives
Sections Chaired National Meetings:
Organohalogen Section, Federation Meetings, Anaheim, California, 1980.
Renal Pharmacology and Toxicology, American Society Pharmacology and Experimental Therapeutics and Pharmacology Society of Canada, Calgary, Alberta Canada, 1981.
General Toxicology, Society of Toxicology, Las Vegas, Nevada, 1983.
Liver, Third International Congress on Toxicology, San Diego, 1983.
Fluorinated Volatile Anesthetic Symposium, 1984 Society of Toxicology Meetings.
Refresher Course on Endotoxins, Coordination Committee, Society of Toxicology 1984 Meetings.
Renal Toxicology, Society of Toxicology, 1985 Meetings, San Diego.
Mechanisms of Renal Toxicology, (Co-Chair), Society of Toxicology, 1989 Meetings, Atlanta.
Forum for New Investigators. NIH funding for new investigators. Society of Toxicology, February 27, 1991.
Mechanisms of Renal Toxicity, Society of Toxicology, 1992, Poster-Discussion Session, Co-Chair.
In Vitro Models: Liver, Society of Toxicology, 1993, Poster-Discussion Session, Co-Chair.
Toxicology Information via Use of Precision-Cut Tissue Slices, Society of Toxicology, 1994, Poster-Discussion Session, Co-Chair.
Modulation of Chemical Toxicity and Risk Assessment. Natural toxicants in foods, Tucson, AZ, June 1996.
Formation and Toxicities of Mono- and Diepoxides. Mountain West SOT, Salt Lake City, October 4, 1996.
International Consortium for the Environment. Water Quality
Session, San Antonio, TX, March 11-15, 2000.
In Vitro/Animal
Alternatives Model. Session Chair.
Society of Toxicology Annual Meeting,
Plenary Discussion
Session: “Integrating Research Approaches Across Disciplines”,
NIEHS Superfund Annual Meeting, University of Washington, November 2004.
Gene Regulations:
Metals. Session Chair. Society of Toxicology Annual
Meetings, New Orleans, LA. March 8, 2005.
SBRP Annual Meeting, Colloquium: Visions for the future. Durham,
NC, December 5, 2007.
Regional Issues in
Environmental Toxicology (organizer and chair) American College of
Toxicology, Tucson, AZ, November 9-12, 2008.
Commentator at National Meetings:
International Anesthesia Research Society, Reno, Nevada, March 913, 1980.
Renal Pharmacology and Toxicology, Round Table Discussion, Pharmacologist 23:189, 1981.
Gull Harbour Anesthesia Toxicity Symposium, June 2527, 1982. Gull Harbour, Manitoba, Canada.
Third International Conference on Molecular and Cellular Mechanisms of Anesthesia, Workshop on Metabolism and Toxicity of Anesthesia. University of Calgary, Calgary, Alberta, Canada, June 1315, 1984.
American Society of Anesthesiologist, Discussant, Drug Disposition
and Anesthetic Action, Atlanta, October 1996.
15th Annual International Society of Exposure Analysis.
“Exposure to Arsenic” session. Panelist. Tucson, AZ
November 1-3, 2005.
Consultantship:
Battelle, Pacific Northwest Laboratories, Consult in area of the biochemistry and biomedical pharmacology of fossil fuel pollutants. 1978-1979.
Gibson-Stephens Neuropharmaceuticals, Inc., Tucson, AZ, Toxicology- Biotransformation, 1982-present. 1978-1979.
Anaquest, BOC Technical Center. Toxicology. 1989-1996.
3M Company 1997-present. Halocarbon Toxicity.
Grant Reviewer:
Ad Hoc Reviewer. Clinical Sciences Study Section, National Institutes of Health. September 17, 1984.
Ad Hoc Reviewer. March of Dimes. Anesthetics and Birth defects. July 3, 1984.
National Science Foundation, 1988.
Arizona Kidney Foundation, 1989.
Ad Hoc Reviewer. Toxicology Study Section. National Institutes of Health. February 1990.
Johns Hopkins CAAT Awards, 1988, 1990, 1992, 1995-present.
Toxicology Study Section. National Institutes of Health. October 1990- 1994.
U. S. Department of Veterans Affairs, 1994.
John Sealy Memorial Endowment Fund, University of Texas at Galveston, 1991, 1993, 1994, 1995, 1996, 1997, 1998.
Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, February 1995.
External Reviewer, Toxicology Study Section, National Institutes of Health, June 1995.
Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, June 1996.
Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, March 1998, June 1998.
NSF Grant Reviewer, March 2001.
Ad Hoc Reviewer, NIEHS, K03 Awards, May 2001.
Ad Hoc Reviewer, Alcohol-Toxicology Study Section, February, October
2002.
NIH
Special Emphasis Panel, “High throughput molecular screening assay
development.”
August 5-6, 2004.
Colgate Palmolive
Alternative Animal Testing. Reviewer – Society of
Toxicology. September 2005.
1. Comprehensive Toxicology, Elsevier, AJ Gandolfi, CA McQueen, IG Sipes - Editors-in-Chief. 12 Volumes, 374 Chapters, 8000 pages, 1996-1997.
2. Comprehensive Toxicology, Elsevier-Academic Press, IG Sipes, CA McQueen, AJ Gandolfi. Volume 14. Cellular and Molecular Toxicology (Vanden, Heuvel, Greenlee, Perdew, Maltes) 644 pages, 2002.
B. Bookchapters
1. Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Third Edition, pp. 64-99, 1986.
2. Gandolfi AJ, Hubbard, AK, and Nunn JF. Hepatic and renal toxicity of inhalational anaesthetics: metabolic effects of nitrous oxide. In: General Anesthetics, 5th Edition, Nunn JF, Utting JE, Brown BR (editors) Butterworth, Publishers, Sonehan, MA, 1988, pp. 86-95.
3. Ruegg CE, Wolfgang GHI, Gandolfi AJ, Brendel K, and Krumdieck CL. Preparation and utilization of positional renal slices for In Vitro nephrotoxicity studies. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, 1988.
4. Smith PF, Fisher R, McKee R, Gandolfi AJ, Krumdieck CL, and Brendel K. Precision-cut liver slices: A new in vitro tool in toxicology. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, pp. 93-130, 1989.
5. Hubbard AK, Roth TP, and Gandolfi AJ. Immunological methods for investigating the mechanisms of halothane hepatotoxicity. In: Hepatotoxicity (Meeks, Bull, Editors) CRC Press, pp. 647-665, 1991.
6. Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Fourth Edition, 1990.
7. Clarke JB and Gandolfi AJ. Volatile anesthetics mechanisms of potential hepatotoxicity. Clinical Anesthesia Updates. Barash PG, Cullen BF, Stoelting RK, Editors), J.B. Lippincott Co, Philadelphia, Volume 3, pp. 1-10, 1992.
8. Clarke JB, Lind RC, and Gandolfi AJ. Mechanisms of Hepatotoxicity of Volatile Anesthetics. In: Advances in Anesthesia 10:219-246, 1992 (Stoelting RK, Barash PG, Gallagher TJ, editors).
9. Brendel K, Fisher RL, Krumdieck CL, and Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. In: In Vitro Biological Systems Volume 1, Tyson CA and Frazier JM (Editors), Academic Press, San Diego, pp 222-230, 1993.
10. Gandolfi AJ, Brendel K, and Fernando Q. Preparation and use of precision-cut renal cortical slices in renal toxicology. In: Methods in Renal Toxicology (RK Zalups and LH Lash, editors), CRC Press, Boca Raton, FL, pp. 109-122, 1996.
11. Clarke JB, Lind RC, and Gandolfi AJ. Biotransformation and hepatotoxicity of inhalation anesthetics. In: General Anesthesia (Brown BR, Prys-Roberts C, Editors), Butterworth-Heinemann, Oxford, Sixth Edition, 1995.
12. Furst SM and Gandolfi AJ. Immunologic mediation of chemical-induced hepatotoxicity. In: Toxicology of the Liver (William Hewitt and Gabriel Plaa, editors), Raven Press, pp.259-295 1995.
13. Kirkpatrick DS and Gandolfi AJ. In vitro techniques in screening and mechanistic studies: organ perfusion, slices, and nephron components. In: Toxicology and the Kidney - Third Edition (J.B. Tarloff and L.H. Lash, Editors) Chapter 4, 40 pages, 2004.
C. Refereed Journal Articles
1. Bottini AT, Dev V, Dowden BF, and Gandolfi AJ. Structure activity relationships of ethylenimines. VIII. Optically active methyl-substituted ethylenimines. J Med Chem 12:32-333, 1969.
2. Gandolfi AJ and Van Dyke RA. Dechlorination of chlorethane with a reconstituted liver microsomal system. Biochem Biophys Res Comm 53:687-692, 1973.
3. Gandolfi AJ, Nakaue HS, and Buhler DR. Effect of hexachlorophene on hepatic drug-metabolizing enzymes in the rat. Biochem Pharmacol 23:19972003, 1974.
4. Van Dyke RA and Gandolfi AJ. Studies on irreversible binding of radioactivity from (14C) halothane ro rat hepatic microsomal liids and protein. Drug Metab Disp 2:469-476, 1974.
5. Gandolfi AJ and Buhler DR. Biliary metabolites and enterohepatic circulation of hexachlorophene in the rat. Xenobiotica 4:693-704, 1974.
6. Van Dyke RA and Gandolfi AJ. Characteristics of a microsomal dechlorination system. Mol Pharmacol 11:809-817, 1975.
7. Van Dyke RA and Gandolfi AJ. Anaerobic release of fluoride from halothane: relationship to the binding of halothane metabolites to hepatic cellular constituents. Drug Metab Disp 4:4044, 1976.
8. Widger AL, Gandolfi AJ, and Van Dyke RA. Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anesthesiology 44:197-201, 1976.
9. Tinker JH, Gandolfi AJ, and Van Dyke RA. Evaluation of human plasma bromide levels in patients following halothane anesthesia: time correlation with total halothane dosage. Anesthesiology 44:194196, 1976.
10. Wood CL, Gandolfi AJ, and Van Dyke RA. Lipid binding of a halothane metabolite: in vitro comparison with lipid peroxidation. Drug Metab Disp 4:305313, 1976.
11. Gandolfi AJ and Buhler DR. Metabolism of hexachlorophene in the rabbit: excretion, tissue distribution and characterization of the urinary glucuronide conjugate. J Agricul Food Chem 25:2125, 1977.
12. Blitt CD, Brown BR Jr., Wright BJ, and Gandolfi AJ, Sipes IG. Pulmonary biotransformation of methoxyflurane: An in vitro study in the rabbit. Anesthesiology 51:528531, 1979.
13. Maiorino RM, Sipes IG, Gandolfi AJ, and Brown BR Jr. Quantitative determination of volatile halothane metabolites in biological tissues. J Chromatog 164:6372, 1979.
14. Miller MS and Gandolfi AJ. A rapid sensitive method for quantification of enflurane in blood. Anesthesiology 51:542544, 1979.
15. Bentley JB, Vaughan RW, Miller MS, Calkins JM, and Gandolfi AJ. Serum inorganic fluoride levels in obese patients during and after enflurane anesthesia. Anesth Analg 58:409412, 1979.
16. Renne RA, Smith LG, McDonald KE, Shields CA, Gandolfi AJ, and Lund JE. Morphologic and biochemical effects of intratracheally administered oil shale in rats. J Envir Path Tox 3:397406, 1980.
17. Soltis JJ and Gandolfi AJ. A simple method for the determination of organic fluoride using sodium fusion. Anesth Analg 59:6164, 1980.
18. Jee R, Gandolfi AJ, Sipes IG, and Brown BR Jr. Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol ApplPharm 52:267277, 1980.
19. Pelroy RA and Gandolfi, AJ. Use of a mixed function amine oxidase for metabolic activation in the Ames/Salmonella assay system. Mut Res 72:329334, 1980.
20. Sipes IG, Gandolfi AJ, Pohl LR, Krishna G., and Brown BR. Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharm Exp Therap 214:716720, 1980.
21. Gandolfi AJ, White RW, Sipes IG, and Pohl LR. Bioactivation and binding of halothane in vitro: Studies with 3H and 14C halothane. J Pharm Exp Therap 214:721725, 1980.
22. Vaughan RW, Gandolfi AJ, and Bentley JB. Biochemical considerations of morbid obesity. Life Sciences 26:22152221, 1980.
23. Miller MS, Gandolfi AJ, Vaughan RW, and Bentley JB. Disposition of enflurane in obese patients. J Pharm Exp Therap 215:292296, 1980.
24. Miller MS and Gandolfi AJ. Enflurane biotransformation in humans. Life Sciences 27:14651468, 1980.
25. Maiorino RM, Gandolfi AJ, Sipes IG, and Brown BR. Gas chromatographic method for the halothane metabolites, trifluoroacetic acid and bromide, in biological fluids. J Anal Tox 4:250254, 1980.
26. Maiorino RM, Sipes IG, Gandolfi AJ, Brown BR, and Lind RC. Factors affecting the formation of chlorotrifluoroethane and chlorodifluoro-ethylene from halothane. Anesthesiology 54:383389, 1981.
27. Blitt CD, Gandolfi AJ, Soltis JJ, and Brown BR. Extrahepatic biotransformation of halothane and enflurane. Anesth Analg 60:129132, 1981.
28. Potter CL, Gandolfi AJ, Nagle R, and Clayton JW. Renal toxicity of chlorotrifluoroethylene and hexafluoropropene in the rat. Toxicol ApplPharm 59:431440, 1981.
29. Gandolfi AJ, Sipes IG, and Brown BR. Detection of covalently bound halothane metabolites in the rat hypoxic model for halothane hepatotoxicity. Fund Appl Tox 1:255259, 1981.
30. Bentley JB, Vaughan RW, Cork RC, and Gandolfi AJ. Does evidence of reductive biotransformation correlate with hepatic binding of metabolites in obese patients. Anesth Analg 60:548551, 1981.
31. Gillespie TJ, Gandolfi AJ, Maiorino RM, and Vaughan RW. Gas chromatographic determination of fentanyl and its analogues in human plasma. J Anal Tox 5:133137, 1981.
32. White RD, Sipes IG, Gandolfi AJ, and Bowden GT. Characterization of hepatic DNA damage caused by exposure to 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis 2:839844, 1981.
33. Cunningham ML, Gandolfi AJ, Brendel K, and Sipes IG. Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes. Biochem Biophys Res Comm 29:12071212, 1981.
34. Gandolfi AJ, Nagle RB, Soltis JJ, and Plescia F. Nephrotoxicity of halogenated vinylcysteine compounds. Res Commun Chem Path Pharm 33:249261, 1981.
35. Bonhaus DW and Gandolfi AJ. Conjugation and bioactivation of chlorotrifluoroethylene. Life Sciences 29:23992405, 1981.
36. Maiorino RM, Gandolfi AJ, Brendel KB, MacDonald JR, and Sipes IG. Chromatographic resolution of amino acid adducts of aliphatic halides. Chem Biol Inter 38:175188, 1982.
37. DiRenzo AB, Gandolfi AJ, and Sipes IG. Microsomal bioactivation and covalent binding of aliphatic halides to DNA. Tox Letters 11:243252, 1982.
38. Bentley JB, Vaughan RV, Gandolfi AJ, and Cork RC. Halothane metabolism in obese versus nonobese patients. Anesthesiology 57:9497, 1982.
39. MacDonald JR, Gandolfi AJ, and Sipes IG. Potentiation of 1,12-trichloroethane hepatotoxicity by acetone pretreatment. Tox Letters 13:5769, 1982.
40. Bentley JB, Borel JD, Vaughan RV, and Gandolfi AJ. Weight: succinyl choline requirement and pseudocholinesterase activity. Anesthesiology 57:4849, 1982.
41. Gillespie TJ, Gandolfi AJ, Davis T, and Morano RA. Identification and quantification of methylfentanyl in postmortem samples. J Anal Tox 6:139142, 1982.
42. Borel JD, Bentley JB, Vaughan RV, and Gandolfi AJ. Enflurane blood-gas solubility: Influence of weight, hemoglobin and hematocrit. Anesth Analg 61:10061009, 1982.
43. Buckley LA, Gandolfi AJ, Nagle RB, and Clayton JW. Chlorotrifluoroethylene nephrotoxicity in the rat: A subacute study. Fund Appl Tox 2:181186, 1982.
44. DiRenzo AB, Gandolfi AJ, Sipes IG, and McDougal JN. Effect of senescence on the bioactivation of aliphatic halides. Res Comm Chem Path Pharmacol 36:493502, 1982.
45. MacDonald JR, Gandolfi AJ, and Sipes IG. Covalent binding of 14C1,1,2-trichloroethane to microsomal proteins and lipids following acetone pretreatment in vitro and in vivo. Drug Chem Tox 5:233247, 1982.
46. Hassall CD, Brendel K, and Gandolfi AJ. Effect of halogenated vinyl cysteine conjugates on renal tubular transport. Toxicology 26:285294, 1983.
47. Jaffe DR, Hassall CD, Brendel K, and Gandolfi AJ. In vivo and in vitro nephrotoxicity of the cysteine conjugates of hexachlorobutadiene. J Tox Env Health 11:857867, 1983.
48. Hassall CD, Gandolfi AJ, and Brendel K. Reversal of DCVC-induced inhibition of renal tubular transport by glutathione. J Appl Toxicol 3:321325, 1983.
49. Hassall CD, Gandolfi AJ, and Brendel K. Correlation of the in vivo and in vitro renal toxicity of S-(1,2-dichlorovinyl)-L-cysteine. Drug Chem Tox 6:507520, 1983.
50. MacDonald JR, Gandolfi AJ, and Sipes IG. Cysteine treatment of chemically induced liver injury. In: Developments in the Science and Practice of Toxicology, (Hayes, Schnell, Miya, eds.), Elsevier Science Publishers, pp 463466, 1983.
51. White RD, Gandolfi AJ, Bowden CT, and Sipes IG. The deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane. Toxicol ApplPharm 69:170178, 1983.
52. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. The involvement of endotoxin in halothane-associated liver injury. Anesthesiology 61:544550, 1984.
53. Hassall CD, Gandolfi AJ, and Brendel K. The formation and biotransformation of cysteine conjugates of halogenated ethylenes by rabbit renal tubules. Chem Biol Interact 49:283297, 1984.
54. Fukui T, Hameroff SR, and Gandolfi AJ. Alterations in plasma alpha1-acid glycoprotein and beta-endorphin in chronic pain patients. Anesthesiology 60:494496, 1984.
55. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of galactosamine-induced hepatotoxicity in rats. Toxicol ApplPharm 73:551558, 1984.
56. Durham JA, Gandolfi AJ, and Bentley JB. Hepatotoxicological evaluation of dantrolene sodium. Drug Chem Tox 7:2340, 1984.
57. Jaffe DR, Gandolfi AJ, and Nagle RB. Chronic toxicity of S-(trans1,2,-dichlorovinyl)-L-cysteine (DCVC) in mice. J Appl Toxicol 4:315319, 1984.
58. MacDonald JR, Lind RC, Sipes IG, and Gandolfi AJ. Determination of hepatic tissue calcium levels by flame emission spectrometry. J Anal Tox 8:155157, 1984.
59. DiRenzo AB, Gandolfi AJ, Sipes IG, Brendel K, and Byard JL. Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat hepatocyte cultures. Xenobiotica 14:521525, 1984.
60. MacFarland RT, Gandolfi AJ, and Sipes IG. Extrahepatic GSH-dependent metabolism of 1,2-dibromoethane and 1,2-dibromo3-chloropropane. Drug Chem Tox 7:213217, 1984.
61. Cater KC, Sipes IG, and Gandolfi AJ. A sequential quantitative study of dimethylnitrosamine (DMN) - induced hepatic hyperplastic nodules in the newborn mouse model using histochemical and histoenzymatic markers. J Toxicologic Path 13:39, 1985.
62. Jaffe DR, Hassall CS, Gandolfi AJ, and Brendel K. Production of DNA single strand breaks in rabbit renal tissue after exposure to 1,2-dichlorovinyl cysteine. Toxicology 35:2533, 1985.
63. Smith PF, Gandolfi AJ, Krumdieck CL, Putnam CW, Zukowski CF, Davis WM, and Brendel K. Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sciences 36:13671375, 1985.
64. Weldon ST, Gandolfi AJ, Williams-Van Alstyne SA, and Blitt CD. Characterization and quantitation of impurities in isoflurane vaporizers. Anesth Analg 64:634639, 1985.
65. Lind RC, Shivley JW, Sipes IG, Gandolfi AJ, and Brown BR. The rat model of halothane-associated hepatitis. Comparative Pathology Bulletin 17:34, 1985.
66. Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, and Perry DS. Post-operative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology 63:708710, 1985.
67. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Comparison of the requirements for hepatic injury with halothane and enflurane in rats. Anesth Analg 64:955963, 1985.
68. MacDonald JR, Gandolfi AJ, and Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol ApplPharm 81:1724, 1985.
69. Weldon ST, Perry DS, Cork RC, and Gandolfi AJ. Detection of picogram levels of sufentanil by capillary gas chromatography. Anesthesiology 63:684687, 1985.
70. DiRenzo AB, Gandolfi AJ, Brooks SD, and Brendel K. Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocytes. Drug Chem Tox 8:207218, 1985.
71. MacDonald JR, Gandolfi AJ, and Sipes IG. Hepatic cysteamine and nonprotein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. Drug Chem Tox 8:483494, 1985.
72. Jackson JE, Bentley JB, Glass SJ, Fukui T, Gandolfi AJ, and Plachetka JR. Effects of H2-Receptor blockade on lidocaine pharmacokinetics. Clin Pharmacol Therap 37:544548, 1985.
73. MacDonald JR, Gandolfi AJ, and Sipes IG. Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. Toxicology 39:135148, 1986.
74. Lind RC, Gandolfi AJ, Sipes IG, Brown BR, and Waters SJ. Oxygen requirements for the reductive defluorination of halothane by rat hepatic microsomes. Anesth Analg 65:835839, 1986.
75. Smith PF, Krack G, McKee RL, Johnson DG, Gandolfi AJ, Hruby VL, Krumdieck CL, and Brendel K. Maintenance of adult rat liver slices in dynamic organ culture. In Vitro Tox 22:706712, 1986.
76. Lind RC, Gandolfi AJ, and Brown BR. Are the requirements for hepatic injury with halothane and enflurane in rats really different? Anesth Analg 65:545547, 1986.
77. DiRenzo AB, Gandolfi AJ, Brendel K, and Krack G. Effect of volatile anesthetics on protein synthesis and secretion in rat hepatocyte suspensions. Drug Chem Tox 9:223237, 1986.
78. Silber PM, Gandolfi AJ, and Brendel K. Adaption of a gamma-glutamyl transpeptidase assay to microtiter plates. Anal Biochem 158:6871, 1986.
79. Silber PM, Gandolfi AJ, and Brendel K. Early biological indicators of S-(1,2-dichlorovinyl) cysteine nephrotoxicity in the rabbit. Drug Chem Tox 9:285303, 1986.
80. Moore RA, McNicholas KM, Gallagher JD, Gandolfi AJ, Sipes IG, Kerns D, and Clark DL. Halothane metabolism in acyanotic and cyanotic patients undergoing open heart surgery. Anesthesiology 65:12571262, 1986.
81. Ruegg CE, Gandolfi AJ, and Brendel K. Preparation and incubation of precision-cut, positional renal slices. Pharmacol Methods 17:111123, 1987.
82. Callis AH, Brooks SD, Roth TP, Gandolfi AJ, and Brown BR. Characterization of a halothane-induced humoral response in rabbits. Clin Exptl Immunol 67:343351, 1987.
83. Brown BR and Gandolfi AJ. Adverse effects of volatile anaesthetics. Br J Anaesth 59:1423, 1987.
84. Smith PF, Fisher R, Shubat PJ, Gandolfi AJ, Krumdieck CL, and Brendel K. In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system. Toxicol ApplPharm 87:509522, 1987.
85. Lind RC, Gandolfi AJ, Brown BR, and Hall PM. Halothane hepatotoxicity in guinea pigs. Anesth Analg 66:222228, 1987.
86. Sipes IG, Fisher RL, Smith PF, Gandolfi AJ, and Brendel K. A dynamic liver culture system: A tool for studying chemical biotransformation and toxicity. Arch Toxicol, Suppl 11, 2033, 1987.
87. Brendel K, Gandolfi AJ, Krumdieck CL, and Smith PF. Organ slices revisited. Trends Pharmacol Sci 8:1115, 1987.
88. Rylander LA, Phelps JS, Gandolfi AJ, and Brendel K. In vitro nephrotoxicity: Toxicity of cadmium chloride and dichlorovinyl cysteine to isolated renal tubules. In Vitro Tox 1:111127, 1987.
89. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or anoxic conditions. Toxicol ApplPharm 90:261273, 1987.
90. Becker GM, Gandolfi AJ, and Nagle RB. Effects of cyclosporin A and G on a kidney epithelial cell line (LLC-PK). Res Comm Chem Path Pharmacol 56:277286, 1987.
91. Phelps JS, Gandolfi AJ, Dohr R, and Brendel K. Cisplatin nephrotoxicity: In vitro studies with precision cut renal cortical slices. Toxicol ApplPharm 90:501512, 1987.
92. Siadat-Pajouh M, Callis AH, Roth TP, and Gandolfi AJ. Generation of halothane induced immune response in a guinea pig model for halothane hepatitis. Anesth Analg 66:2091214, 1987.
93. McKee RL, Hruby VJ, Trivedi DB, Johnson DG, Gandolfi AJ, Krumdieck CL, and Brendel K. A perifused precision-cut liver slice system for the study of hormone regulated hepatic glucose metabolism. J Pharmacol Methods 19:339-354, 1987.
94. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Chronology of halothane induced antigen expression in halothane-exposed rabbits. Clin Expt Immunol 72:330336, 1988.
95. Dale O, Gandolfi AJ, and Brendel K. Rat liver slices and diazepam metabolism: In vitro interaction with volatile anaesthetic drugs and albumin. Br J Anaesth 60:692696, 1988.
96. Meadows SD, Gandolfi AJ, and Nagle RB. Genotoxic effects of 1,2-dichlorovinyl cysteine: Initiation and promotion effects in Swiss-Webster Mice. Drug Chem Tox 11:307318, 1988.
97. Hubbard AK, Roth TP, Gandolfi AJ, and Brown BR. Halothane hepatitis patients generate an antibody response toward a metabolite of halothane. Anesthesiology 68:791796, 1988.
98. Lind RC and Gandolfi AJ. Hypoxia and anesthetic-associated liver injury in guinea pigs. Anesthesiology 68:974976, 1988.
99. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity. Anesthesiology 70:649653, 1988.
100. Hubbard AK, Roth TP, Schuman S, and Gandolfi AJ. Localization of halothane-induced antigen in situ by specific anti halothane metabolite antibodies. Clin Exp Immun 76:422427, 1989.
101. Hubbard AK, Gandolfi AJ, and Brown BR, Jr. Immunological basis of anesthetic-induced hepatotoxicity. Anesthesiology 69:814817, 1988.
102. Wolfgang GHI, Gandolfi AJ, and Brendel K. Evaluation of organic nephrotoxins in rabbit renal cortical slices. Tox In Vitro 3:341350, 1989.
103. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine. Toxicology 58:3342, 1989.
104. Lind RC, Gandolfi AJ, and Hall P. Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs. Anesthesiology 71:878884, 1989.
105. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. N-Acetyl S-(1,2-dichlorovinyl)-L-Cysteine produces a similar toxicity to S-(1,2- dichlorovinyl)-L-Cysteine in rabbit renal slices: Differential transport and metabolism. Toxicol ApplPharm 101:205219, 1989.
106. Fisher R, Smith PF, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. Toxicity of chlorobenzenes in cultured rat liver slices. In Vitro Tox 3:181194, 1990.
107. Lind RC, Gandolfi AJ, and Hall PM. Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. J Appl Toxicol 10:161-165, 1990.
108. Azri S, Gandolfi AJ, and Brendel K. Carbon tetrachloride toxicity in precision-cut rat liver slices. In Vitro Tox 3:127138, 1990.
109. Connors S, Rankin DR, Gandolfi AJ, Krumdieck CL, Koep LJ, and Brendel K. Cocaine hepatotoxicity in cultured liver slices: a species comparison. Toxicology 61:171183, 1990.
110. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. Drug Metab Disp 18:514518, 1990.
111. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. Toxicology 62:5969, 1990.
112. Hubbard AK, Levy JP, Roth TP, and Gandolfi AJ. Use of structural alterations in the synthesis of halothane metabolite antigens to mimic halothane-induced immunogens. Drug Chem Tox 13:93-112, 1990.
113. Wolfgang G, Gandolfi AJ, Nagle R, Brendel K, and Stevens J. Assessment of S-(1,2-Dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity. Chemico-Biological Interactions 75:153- 170, 1990.
114. Gandolfi AJ and Brendel K. In vitro systems for nephrotoxicity studies. Tox In Vitro 4:337345, 1990.
115. Lind RC, Gandolfi AJ, and Hall PM. Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. Anesthesiology 73:1208-1213, 1990.
116. Azri S, Gandolfi AJ, and Brendel K. Precision-cut liver slices: An in vitro system for profiling potential hepatotoxicants. In Vitro Tox 3:309-320, 1990.
117. Ghantous HN, Fernando J, Morgan SE, Gandolfi AJ, and Brendel K. Precision-cut guinea pig liver slices as a tool to study the toxicity of volatile anesthetics. ATLA 18:191-199, 1990.
118. Fisher R, Putnam CW, Koep LJ, Sipes IG, Gandolfi AJ, and Brendel K. Cryopreservation of pig and human liver slices. Cryobiology 28:131-142, 1991.
119. Brown AP, Hastings KL, and Gandolfi AJ. Generation and detection of neoantigens in guinea pig liver slices incubated with halothane. Int J Immunopharmac 13:429-435, 1991.
120. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Minimal biotransformation and toxicity of desflurane in guinea pig liver slices. Anesth Analg 72:796-800, 1991.
121. Vernetti LA, Nowlin CLA, Hameroff SR, Gandolfi AJ, Lee YC, and Sarid D. Scanning tunneling microscopy resolution of surface features on cytokeratin protein is enhanced by prolonged exposure of protein to cold temperatures. J Vacuum Sci Technol 9:1223-1226, 1991.
122. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Putnam CL, Krumdieck CL, and Brendel K. Biotransformation activity in vitrified human liver slices. Cryobiology 28:216-226, 1991.
123. Fisher R, Nau H, Gandolfi AJ, and Brendel K. Toxicity of valproic acid in liver slices from Sprague-Dawley rat and domestic pigs. Toxic In Vitro 5: 201-205, 1991.
124. Fisher R, Nau H, Gandolfi AJ, Putnam CW, and Brendel K. Valproic acid hepatotoxicity in human liver slices. Drug Chem Tox 14:375-394, 1991.
125. Hastings KL, Schuman S, Thomas C, Brown AP, Hubbard AK, and Gandolfi AJ. Screening for antibodies associated with halothane hepatitis. Br J Anaesth 67:722-728, 1991.
126. Fisher R, Barr J, Zukoski CF, Putnam CW, Sipes IG, Gandolfi AJ, and Brendel K. In vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices. Human Exptl Toxicol 10:357-363, 1991.
127. Stefaniak MS, Krumdieck CL, Spall RD, Gandolfi AJ, and Brendel K. Biochemical and histological characterization of Agar-filled precision cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Tox 5:7-19, 1992.
128. Frink EJ, Ghantous H, Malan TP, Morgan S, Fernando J, Gandolfi AJ, and Brown BR, Jr. Plasma inorganic fluoride with sevoflurane anesthesia: Correlation with indices of hepatic and renal function. Anesth Analg 74:231-235, 1992.
129. Ghantous HN, Fernando JL, Keith RL, Gandolfi AJ, and Brendel K. Effects of halothane and other volatile anaesthetics on protein synthesis and secretion in guinea pig liver slices. Br J Anaesth 68:172-177, 1992.
130. Azri S, Mata HP, Reid LL, Gandolfi AJ, and Brendel K. Further examination of the selective toxicity of CCl4 in rat liver slices. Toxicol ApplPharm 112:81-86, 1992.
131. Vernetti L, Sarid D, Gandolfi AJ, Nagle RB, Hameroff S, McCuskey R, and Cress AE. The topographical structure of cytokeratin intermediate filaments using scanning tunneling microscopy. Nanobiology 1:379-386, 1992.
132. Lind RC, Gandolfi AJ, and Hall PM. Subanesthetic halothane is hepatotoxic in the guinea pig. Anesth Analg 74:559-563, 1992.
133. Connors S, Gandolfi AJ, and Brendel K. Mini-review: Cocaine hepatotoxicity. In press, 1992.
134. Parrish AR, Shipp NG, Spall RD, Dorr RT, Krumdieck CL, Gandolfi AJ, and Brendel K. Organ culture of rat myocardial slices: An alternative in vitro tool in organ specific toxicology. Toxicology Methods 2:101-111, 1992.
135. Fisher R, Hanzlik RP, Gandolfi AJ, and Brendel K. Toxicity of ortho-substituted bromobenzenes in rat liver slices: A comparison to isolated hepatocytes and the whole animal. In Vitro Tox 4:173-186, 1991.
136. Brown AP, Hastings KL, Gandolfi AJ, Liebler DC, and Brendel K. Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane. Toxicology 73:281-195, 1992.
137. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicity. Anesth Analg 75:436-440, 1992.
138. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The hepatotoxicity of chloroform in precision-cut rat liver slices. Toxicology 73:239-250, 1992.
139. Lind RC, Gandolfi AJ, and Hall PM. Glutathione depletion enhances subanesthetic halothane hepatotoxicity in guinea pigs. Anesthesiology 77:721-727, 1992.
140. Ghantous H, Fernando J, Mata E, Gandolfi AJ, and Brendel K. Chronology of toxic events produced by halothane in guinea pig liver slices. In Vitro Tox 5:137-146, 1992.
141. Dale O, Frink EJ, Thommesen L, and Gandolfi AJ. Hepatic elimination of diazepam: Interactions with albumin, desflurane, and sevoflurane. Br J Anaesth 70:454-455, 1993.
142. Stinjntjes GJ, Commandeur JNM, te Koppele JM, McGuinness S, and Gandolfi AJ, Vermeulen NPE. Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices. Toxicology 79:67-79, 1993.
143. Lind RC and Gandolfi AJ. Concentration dependent inhibition of halothane biotransformation in the guinea pig. Drug Metab Disp 21:386-389, 1993.
144. McGuinness SG, Gandolfi AJ, and Brendel K. Use of renal slices and renal tubule suspensions for in vitro toxicity studies. In Vitro Toxicology 6:1-24, 1993.
145. Lowe T, Fernando Q, Keith R, and Gandolfi AJ. Elemental analysis of renal slices by proton induced x-ray emission. Env Health Perspectives 101:302-308, 1993.
146. Fisher RL, Hasal SJ, Sanuik JT, Scott KS, Gandolfi AJ, and Brendel K. Cold- and cryo-preservation of human liver and kidney slices. Cryobiology 30:250-261, 1993.
147. Hubbard AK, Lohr CL, Hastings K, Clarke J, and Gandolfi AJ. Immunogenicity studies of a synthetic antigen of alpha methyl dopa. International J Immunopharm Immunotox 15:621-637, 1993.
148. Lind RC, Gandolfi AJ, and Hall PM. A guinea pig model of halothane-associated hepatitis. Comparative Pathology Bulletin XXV (No. 3):3-4, 1993.
149. Fisher RL, Gandolfi AJ, Sipes IG, and Brendel K. Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver. Drug Chem Tox 16:321-339, 1993.
150. Reid LL, Hastings KL, Gandolfi AJ, and Van Ert M. Use of staphylococcal enterotoxin A - induced interleukin 2 production as an indicator of immunotoxicity. Drug Chem Tox 17:1-14, 1994.
151. Morgan SE, Frink EJ, and Gandolfi AJ. A simplified gas chromatographic method for quantifying the sevoflurane metabolite, hexafluoroisopropanol. Anesthesiology 80:201-205, 1994.
152. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slices. Fund Appl Toxicol 22:172-177, 1994.
153. Brown AP and Gandolfi AJ. Glutathione-S-transferase is a target for covalent modification by a halothane reactive intermediate in guinea pig liver. Toxicology 89:35-47, 1994.
154. Parrish AR, Wishnies SR, Dorr RT, Gandolfi AJ, and Brendel K. Coculture of rabbit liver and myocardial slices: Potentiation of the cardiotoxicity of allyl alcohol but not allylamine. In Vitro Toxicology 7:53-57, 1994.
155. Parrish AR, Dorr RT, Gandolfi AJ, and Brendel K. Adult rat myocardial slices: A tool for studies of comparative cardiotoxicity. Tox In Vitro 8:1233-1237, 1994.
156. Lind RC, Gandolfi AJ, and Hall P. A model for fatal halothane hepatitis in guinea pigs. Anesthesiology 81:478-487, 1994.
157. Christen U, Quinn J, Yeaman SJ, Kenna JG, Clarke JB, Gandolfi AJ, and Gut J. Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis: molecular mimicry of CF3CO-Lys by lipoic acid. Europ J Biochem 223:1035-1047, 1994.
158. Sheevers HV, Brendel K, Wright SH, Nagle RB, and Gandolfi AJ. Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices. Toxic In Vitro 8:1243-1251, 1994.
159. Michaud JP, Gandolfi AJ, and Brendel K. Toxic responses to defined chemical mixtures: Mathematical models and experimental designs. Life Sciences 55:635-651, 1994.
160. Fisher RL, Sanuik JT, Nau H, Gandolfi AJ, and Brendel K. Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humans. Toxic in Vitro 8:371-379, 1994.
161. Michaud JP, Gandolfi AJ, and Brendel K. Methods of assessing toxic interactions in vitro: Experimental design and data analysis. Toxicology Methods 5:21-40, 1995.
162. Fisher RL, Smith MS, Hasal SJ, Hasal KS, Gandolfi AJ, and Brendel K. The use of human lung slices in toxicology. Human Exp Tox 13:466-471, 1994.
163. Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Toxicity of cisplatin and mercuric chloride in human kidney cortical slices. Human Exp Tox 13:517-523, 1994.
164. Wysynski AM, Martinez-Zaguilan R, Alden C, Gandolfi AJ, and Gillies RJ. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicology Letters 74:157-166, 1994.
165. Hastings KL, Thomas C, Brown AP, and Gandolfi AJ. Trifluoroacetylation potentiates the humoral immune response to halothane in the guinea pig. Immunopharm Immunotox 17:201-213, 1995.
166. Fisher RL, Hasal SJ, Sipes IG, Gandolfi AJ, and Brendel K. Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fisher-344 and human liver slices. Human Exp Tox 14:414-421, 1995.
167. Lind RC, Gandolfi AJ, and Hall PM. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig. Potentiation of hepatic injury by prior glutathione depletion. Toxicol ApplPharm 134:175-181, 1995.
168. Payne AK, Morgan SE, Gandolfi AJ, and Brendel K. Biotransformation of sevoflurane by rat neonates liver slices. Drug Metab Disp 23:497-500, 1995.
169. Clarke JB, Chen M, Thomas C, Hubbard AH, Hastings KL, and Gandolfi AJ. Halogenated anesthetics form liver adducts and antigens that crossreact with halothane-induced antibodies. Intern Arch Allergy Immuno 108:24-32, 1995.
170. McGuinness SJ, Rankin DR, Bezruvczyk P, Brendel K, and Gandolfi AJ. Nephrotoxicity and transport of celiptium in rabbit renal proximal tubule suspensions. In Vitro Tox 8:169-175, 1995.
171. Frey N, Christen U, Jeno P, Yeaman SJ, Shimomura Y, Kenna JG, Gandolfi AJ, Ranek L, and Gut J. The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. Chem Res Toxicol 8:736-746, 1995.
172. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices. Toxicology 104:35-45, 1995.
173. Gunaratnum NT, Benson J, Gandolfi AJ, and Chen ML. Isoflurane hepatitis in an obese patient with a history of halothane hepatitis. Anesthesiology 83:1361-1364, 1995.
174. Groves CE, Morales MN, Gandolfi AJ, Dantzler WH, and Wright SH. Peritubular paraquat transport in isolated renal proximal tubules. J Pharm Exptl Therap, in revision, 1995.
175. Gandolfi AJ, Brendel K, Fisher RL, and Michaud JP. Use of tissue slices in chemical mixture toxicology and interspecies investigations. Toxicology 105:285-290, 1995.
176. Furst SM, Chen M, and Gandolfi AJ. Use of halothane as a model for investigating chemical-induced autoimmunity. Drug Information Journal 30:301-307, 1996.
177. Fisher RL, Shaughnessy RP, Jenkins PM, Austin ML, Roth GL, Gandolfi AJ, and Brendel K. Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: Optimization of tissue slice culture. Toxicology Methods 5:99-113, 1995.
178. Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices: Optimization of tissue slice culture, Part 2. Toxicology Methods 5:115-130, 1995.
179. Michaud JP, Gandolfi AJ, and Brendel K. Investigation of hepatotoxic interaction using precision-cut rat liver slice culture: Steps towards validation, and comparisons to in vivo findings. In Vitro Toxicology, in press, 1995.
180. Parrish AR, Gandolfi AJ, and Brendel K. Precision-cut tissue slices: Applications in pharmacology and toxicology. Life Sciences 57:1887-1901, 1995.
181. Gandolfi AJ, Wijeweera J, and Brendel K. Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Toxicol Pathology 24:58-61, 1996.
182. Fisher RL, Jenkins PM, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Rainbow trout liver slices: A tool for aquatic toxicology. Toxic Substances Mechanisms 15:13-26, 1996.
183. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices. Fund Appl Toxicol 34:73-83, 1996.
184. Hoivik DJ, Fisher RL, Brendel K, Gandolfi AJ, Khairallah EA, and Cohen SD. Protein arylation precedes acetaminophen toxicity in a dynamic organ culture of mouse kidney. Fund Appl Toxicol 34:99-104, 1996.
185. Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, and Brendel K. Cold- and cryopreservation of dog liver and kidney slices. Cryobiology 33:163-171, 1996.
186. Keith RL, Setiarahardjo I, Fernando Q, Aposhian HV, and Gandolfi AJ. Utilization of renal slices to evaluate the efficacy of chelators to remove mercury from the kidney. Toxicology 116:67-75, 1997.
187. Lind RC and Gandolfi AJ. Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and kidney. Toxicol Appl Pharmacol 142:201-207, 1997.
188. Chen M and Gandolfi AJ. Characterization of the humoral immune response and hepatotoxicity after multiple-halothane exposures in guinea pigs. Drug Metabolism Reviews 29:103-122, 1997.
189. Furst SM, Leudke D, Gaw H, Reich R, and Gandolfi AJ. Demonstration of a cellular immune response in halothane-exposed guinea pigs. Tox Appl Pharm 143:245-255, 1997.
190. Furst SM, Leudke D, and Gandolfi AJ. Kupffer cells from halothane exposed guinea pigs carry trifluoroacetylated protein adducts. Toxicology 120:119-132, 1997.
191. Furst SM, and Gandolfi AJ. Interaction of lymphocytes with Kupffer cells from halothane- exposed guinea pigs. Int Arch Allergy Immunol, 114:46-53, 1997.
192. Parrish AR, Fisher R, Bral C, Burghardt RC, Gandolfi AJ, Brendel K, and Ramos KS. Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut rat liver and kidney slices. Toxicol. Appl. Pharmacol, 152: 302-308, 1998.
193. Wijeweera J, Gandolfi AJ, and Zheng XH. Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slices. Env. Health Perspectives, 106 (Suppl 6) 1319-1323,1998.
194. Wei H, Qiu L, Divine KK, Fernando Q, and Gandolfi AJ. Toxicity and transport of three synthesized mercury-thiol-complexes in isolated rabbit renal proximal tubule suspensions. Drug Chem Tox, 22: 323-341, 1999.
195. Keith RL, Gandolfi AJ, McIntyre LC, Jr., Ashbaugh MD, and Fernando Q. Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE. Nuclear Instruments and Methods (B), 149: 167-176, 1999.
196. Lind RC and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide. I. Protection when given twenty-four hours after chloroform or bromobenzene. Tox Path, 27:342-347, 1999.
197. Lind RC and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide. II. Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury. Exp Toxicol Path, 51:537-543, 1999.
198. Parrish AR, Zheng XH, Turney KD, Younis HS, and Gandolfi AJ. Enhanced transcriptional factor DNA binding and gene expression induced by arsenite or arsenate in renal slices. Tox Sci, 50:98-105, 1999.
199. Parrish AR, Catania JM, Orozco J, and Gandolfi AJ. Chemically-induced oxidative stress disrupts the E-cadherin/catenin cell adhesion complex. Tox Sci, 51:80-86, 1999.
200. Turney KD, Parrish AR, Orozco J, and Gandolif AJ. Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices. Tox Appl Pharm, 160:262-270, 1999.
201. Lind RC, Begay CK, and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide III. Role of inhibition of the bioactivation and covalent binding of chloroform. Tox Appl Pharm, 166: 145-150, 2000.
202. Ito Y, Lind RC, Begay CK, Gandolfi AJ, McCuskey MK, and McCuskey RS. Late administration of dimethyl sulfoxide minimizes the hepatic microvascular inflammatory response to chloroform in rats. Hepatology Research, 18 (3):203-217 2000.
203. Wijeweera JB, Gandolfi AJ, Parrish A, and Lantz RC. Sodium arsenite enhances AP-1 and NFkB DNA binding and induces stress protein expression in precision-cut rat lung slices. Tox Sci, 61 283-294, 2001.
204. Catania JM, Parrish AR, and Gandolfi AJ. Toxicity of a sevoflurane degradation product incubated with liver and renal cortical slices. Drug Chem Tox, 24:347-357, 2001.
205. Zheng XH, Begay CK, Lind RC, and Gandolfi AJ. Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure. Drug Chem Tox, 24:339-346, 2001.
206. Fisher RL, Gandolfi AJ, and Brendel K. Human liver is a dominant factor in the outcome of in vitro studies. Cell Biol Tox, 17:179-189, 2001.
207. Parrish AR, Sallam K, Nyman DW, Orozco J, Cress AE, Dalkin BL, Nagle RB, and Gandolfi AJ. Culturing precision-cut human prostate slices as an in vitro model of prostate pathobiology. Cell Biol Tox, 18:205-219, 2002.
208. Fisher RL, Hasal SJ, Lipscomb JC, Gandolfi AJ, and Brendel K. Cold- and cryopreservation of monkey liver slices. Cryobiology, Toxicology Mechanisms Methods, 12:119-133, 2002.
209. Kirkpatrick DS, Dale KV, Catnaia JM, and Gandolfi AJ. Low-level arsenite causes accumulation of ubiquinated proteins in rabbit renal cortical slices and HEK 293 cells. Tox and App Pharm, 186:101-109, No. 2, January 2003.
210. Quanrud DM, Arnold RG, Lansey KE, Begay CK, Ela W, and Gandolfi AJ. Fate of effluent organic matter during soil aquifer treatment: biodegradability, chlorine reactivity, and genotoxicity. J. Water and Health, 1.1:33-44, 2003.
211. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M,
Bowden GT,
Henderson CJ, Wolf CR, Clark AJ, Brendel K, Fisher RL, and Gandolfi
AJ. Precision-cut tissue slices from transgenic mice as an in
vitro toxicology system. Toxicology In Vitro, 17:201-205, 2003.
212. Zheng XH, Watts G, Vaught S, and Gandolfi AJ.
Low-level arsenate induced gene expression in HEK293 cells.
Toxicology, 187:39-48, 2003.
213. Begay CK and Gandolfi AJ. Late administration of COX-2
inhibitors minimize hepatic necrosis in chloroform induced liver
injury. Tox 185: 79-87, 2003.
214. Peraza MA,
Carter DE, Gandolfi AJ. Toxicity and
metabolism of subcytotoxic inorganic arsenic in human renal
proximal tubule
epithelial cells (HK-2). Cell Biology Toxicology, 19:253-264, 2003.
220.
Sierra-Alvarez R, Field JA,
Cortinas I, Feijoo F,
Moreira MT, Kopplin M, Gandolfi AJ. Anaerobic
Microbial Mobilization and Biotransformation of Arsenate Adsorbed onto
Activated Alumina. Water Research, 39:199-209 (2005).
221. Kirkpatrick DS, Weldon SF, Tsaprailis G, Gygi SP, Liebler DC,
Gandolfi AJ. Proteomic identification of ubiquinated proteins
from human cells expressing His-tagged ubiquitin Proteomics,
5:2104-2111, 2005.
222. Schmelz M, Moll R, Hesse U, Prasad AR,
Gandolfi AJ, Hasan SR, Bartholdi M, Cress AE. Identification of a
Stem Candidate in the Normal Human Prostate Gland. European J
Cell Biology, 84:341-354, 2005.
223. Carranza Rosales P, Said-Fernandez S, Sepulveda-Saavedra
J, Cruz-Vega DE, Gandolfi AJ. Morphologic and functional
alterations induced by low doses of mercuric chloride in the kidney OK
cell line: ultrastructural evidence for an apoptotic mechanisms
of damage. Toxicology, 210:111-121, 2005.
224. Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D,
Gandolfi AJ, Klimecki WT. Developmentally restricted genetic
determinants of human arsenic metabolism: association between
urinary methylated arsenic and CYT19 polymorphisms in children.
Env Health Perspetive, 113:775-781, 2005.
225. Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ.
Monomethylarsenous acid induces transformation of human bladder
cells. Tox Appl Pharm, 216:69-79, 2006.
226. Cortinas I, Field JA, Sierra R, Kopplin M, Garbarino J,
Gandolfi AJ. Anaerobic biotransformation of roxarsone and related
N-substituted phenylarsonic acids. Env Sci Technol, 40:2951-2957,
2006.
227. Peraza MA, Carter DE, Gandolfi AJ. Morphological and
functional alterations in human proximal tubular cell line induced by
low-level inorganic arsenic: evidence for targeting mitochondria and
initiated apoptosis. J Appl Tox 26:356-367, 2006.
228. Conley SM, McKay BS, Gandolfi AJ, Stamer WD.
Alterations in human trabecular meshwork cell homeostasis by
selenium. Exp Eye Research, 82: 637-647, 2006.
229. Sierra R, Yenal U, Field JA, Kopplin M, Gandolfi
AJ, Garbarino JR. Anaerobic biotransformation of organoarsenical
pesticides, monomethylarsonic acid (MMAV) and dimethylarsinic acid
(DMAV). J. Ag Fd Chem, 54:3959-3966, 2006.
230. Eblin KE, Bowen ME, Cromey D, Bredfeldt TG,
Mash EA, Gandolfi AJ. Arsenite and monomethylarsonous acid
generate oxidative stress response in human bladder cell culture.
Tox Appl Pharm, 217:7-14, 2006.
231. Eblin KE, Bredfeldt TG, Buffington S, Gandolfi AJ.
Mitogenic, pro-inflammatory signal transduction caused by
monomethylarsonous acid in UROtsa cells. Tox Sci, 95(2): 321-330,
2007.
232. Carranza-Rosales P, Guzman-Delgado N, Cruz-Vega D,
Balderas-Renteria I, Gandolfi AJ. DMPS protective effect on
mitochondrial structure and function in OK cells exposed to toxic
concentrations of HgCl2. Cell Biol Toxicology, 23:163-176, 2007.
233. Meza M, Gandolfi AJ, Klimecki WT. Developmental and
genetic modulation of arsenic metabolism: a gene by environment
interaction? Tox Appl Pharm, 222:381-387, 2007.
234. Catania JM, Pershing AM, Gandolfi AJ. Precision-cut tissue
chips as an in vitro system. Tox In Vitro, 21:956-961,
2007.
235. Wang X, Sun Z, Chen W, Eblin KE, Gandolfi AJ, Zhang DD.
Nrf2 protects human bladder urothelial cells from arsenite and
monomethylarsonous acid toxicity. Tox Appl Pharm, 225: 206-213,
2007.
236. Meza MM, Kopplin MJ, Burgess JL, Gandolfi AJ.
Urinary arsenic methylation profile in children exposed to low arsenic
levels through drinking water. Toxicol Environ Chem, 90: 957-970, 2008.
237. Eblin KE, Bredfeldt TG, Gandolfi AJ. Immortalized
human urothelial cells as a model of arsenic-induced bladder cancer.
Toxicology, 248:67-76, 2008.
238. Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher
BW. Epigenetic Remodeling During Arsenical-Induced Malignant
Transformation. Carcinogenesis, 29:1500-8, 2008.
239. Eblin KE, Hau A, Jensen TJ, Buffington SE, Futscher BW,
Gandolfi AJ. The role of reactive oxygen species in arsenite and
monomethylarsonous acid-induced signal transduction in human bladder
cells: Acute studies. Toxicology, 250:47-54, 2008.
240. Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW,
Gandolif AJ. Reactive oxygen species regulate properties of
transformation in UROtsa cells exposed to monomethylarsonous acid by
modulating MAPK signaling. Toxicology, 255: 107-114, 2008.
241. Jensen TJ, Eblin KE, Wozniak RJ, Gandolfi AJ, Futscher
BW. Epigenetic mediated transcriptional activation of WNT5a
participates in arsenical-associated malignant transformation.
Toxicology and Applied Pharmacology, 235: 39-46, 2009.
D. Non-Refereed Journal Articles
1. Gandolfi AJ. Toxicity of TCE in Tucson well water. Southern Arizona Environmental Council Bulletin 11:23, 1982.
2. Gandolfi AJ, Blitt CD, and Weldon S. Discoloration and impurities in isoflurane vaporizer. Anesth Analg 62:366, 1983.
3. Gandolfi AJ and Brown BR. Hypoxia and halothane hepatotoxicity. Anesthesiology 62:859-861, 1983.
4. Gandolfi AJ, Cork RC, and Levy JP. Assay for serum sufentanil level not sensitive. Anesthesiology 65:112, 1986.
5. Gandolfi AJ. Book Review. Alternative to Animal Use in Research, Testing, and Education. American Scientist 74:674-675, 1986.
6. Brendel K, McKee RL, Hruby VJ, Johnson DG, Gandolfi AJ, and Krumdieck CL. Precision cut tissue slices in culture: A new tool in pharmacology. Proc West Pharmacol Soc 30:291-293, 1987.
7. Stefaniak MS, Gandolfi AJ, and Brendel K. Adult rat lung in dynamic organ culture: a new tool in pharmacology. Proc West Pharmacol Soc 31:149-151, 1988.
8. Connors MS, Gandolfi AJ, Krumdieck CL, and Brendel K. Lysosomal and cytosolic enzyme release as a measure of organelle-specific toxicity in cultured rat liver slices. Proc West Pharmacol Soc 31:143-147, 1988.
9. Brendel K and Gandolfi AJ. Predicting Toxicity. Arizona Medicine XLVI:4, 1990.
10. Gandolfi AJ. Guest authors discuss alternatives and challenges. Johns Hopkins Center for Alternatives to Animal Testing 9(1):9, 1991.
11. Kramer TH, Cork RC, and Gandolfi AJ. Pharmacokinetics of sufentanil. Can J Anaesth 36:485-486, 1989.
12. Gandolfi AJ, Brendel K, and Krumdieck CL. Tissue slicing and culturing revisited - An update. Alternatives (Bristol Myers Squibb Newsletter) 2, 1992.
13. Wijeweera JB, Gandolfi AJ, and Brendel K. Toxic interaction of drinking water contaminants. Vinylidene chloride and chloroacetic acid studies in precision-cut rat liver slices. SWEHSC Newletter, Winter 1995/1996.
14. Payne AK and Gandolfi AJ. Enzyme deficiency found in rat pup metabolism of new anesthetic intended for use with children. Southwest Association for Education in Biomedical Research, Newsletter, Volume 1, No. 2, 1994.
15. Furst SM and Gandolfi AJ. Adverse chemical reactions: Autoimmunity. SWEHSC Newsletter, Spring, 1995.
16. Gandolfi AJ and Lind RC. A sensitive animal model for testing the hepatotoxic potential of fluorocarbons. SWEHSC Newsletter, Summer, 1995.
17. Parrish AR, Nagle RB, Cass AE, Dalkin BL, and Gandolfi AJ. Development of precision-cut human prostate slices as an in vitro model for prostate pathobiology. SWEHSC Newsletter, Fall 1998.
18. Ito Y, Begay CK, Lind RC, Gandolfi AJ, and McCuskey RS. Utilization of in vitro microscopy to investigate the protective action of DMSO against chloroform-induced injury. SWEHSC Newsletter, Fall 1998.
19. Zheng XH, Parrish AR, and Gandolfi AJ. Analysis of differential expressed genes in rabbit renal cortical slices exposed to arsenic compounds. SWEHSC Newsletter, Winter 99-00.
9.
20. Efecto
de los niveles bajos de arsenico sobre los teijidos. Boletin
– Sociedad Quimica de Mexico, Section
Nuevo Leon, Mayo – Junio 2004.
E. Technical Manuals and Reports:
1. Gandolfi AJ, Hodgson WH, and Chandon JG. Design and performance of aerosol exposure system. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp 189191, (1977).
2. Gandolfi AJ and Shields CA. Effect of intratracheally administered oil shale and spent shale on pulmonary biotransformation enzyme activity. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp. 169-171, (1977).
3. Gandolfi AJ and Shields CA. Absorption of benzo-a-pyrene from intratracheally administered spent shale. Pacific Northwest Labs Ann Report to ERDA, Part 1, pp. 171-173, (1977).
4. Gandolfi AJ and Shields CA. Response of lungs to intratracheally administered oil shale dusts. Pacific Northwest Labs Ann Report to DOE, pp. 5.11-5.14, (1978).
5. Gandolfi AJ. Toxicity of TEE in Tucson well water. Southern Arizona Environmental Coundil Bulletin 11:2-3, 1982.
F. Conference Proceedings - Book Articles
1. Sipes IG and Gandolfi AJ. In vitro comparative bioactivatioin of aliphatic halogenated hydrocarbons. In: Mechanisms of Toxicity and Hazard Evaluation, (Holmstedt, Lauwerys, Mercier, Roberfroid, eds.), Elsevier-North Holland, pp. 501-506, 1980.
2. Sipes IG, Gandolfi AJ, and Brown BR. Halothane-associated hepatitis: Evidence for a direct toxicity. In: Drug Reactions in the Liver, (M Davis, JM Tredger, R Williams, eds), Pitman Medical Limited, London, pp. 219-231, 1981.
3. Sipes IG and Gandolfi AJ. Bioactivation of aliphatic organohalogens: formation, detection, and relevance in Toxicology of the Liver. G. Plaa and R. Leibel (editors) Raven Press, pp. 181-212, 1982.
4. Sipes IG and Gandolfi AJ. Role of reactive intermediates in halothane associated liver injury. In: Reactive Intermediates (R. Snyder et al, editor's) Plenum Press, New York, pp. 603618, 1982.
5. Weldon ST, Gillespie TJ, and Gandolfi AJ. Gas chromatographic analysis for fentanyl. Methodology in Analytical Toxicology, Vol. 3, (I. Sunshine, Editor) CRC Press, Inc., Boca Raton, FL, pp. 8993, 1985.
6. Callis AH, Brooks SD, Waters SJ, Gandolfi AJ, Lucas DO, Pohl LR, Satoh H, and Sipes IG. Evidence for a role of the immune response in the pathogenesis of halothane hepatitis. Molecular Mechanisms of Anesthesia, Progress in Anesthesiology, Vol. 3 (S. Roth, editor). Raven Press, pp. 441451, 1985.
7. Meadows SD, Gandolfi AJ, Nagle RB, and Brendel K. Persistent, progressive renal toxicity in male Swiss-Webster mice following subchronic exposure to 1,2-dichlorovinyl cysteine (DCVC). Renal Heterogeneity and Target Cell Toxicity (P.H. Bach, E.A. Lock, editors) John Wiley & Sons, New York, 1985, pp. 157160.
8. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Renal Heterogeneity and Target Organ Toxicity (P.H. Bach, E.A. Lock, editors), John Wiley & Sons, New York, 1985, pp. 531534.
9. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Inhibition of organic acid/base transport in isolated rabbit renal tubules by nephrotoxins. In: In Vitro Toxicology Volume D3 (A.M. Goldberg, editor). Mary Ann Liebert, Inc., New York, pp. 235247, 1985.
10. Phelps JS, Gandolfi AJ, Brendel K. Cisplatinum toxicity in rabbit renal proximal tubule suspensions and precision-cut renal cortical slices. In Vitro Toxicology, Vol. 4 (Goldberg AM, editor), pp. 441420, 1987.
11. Wolfgang GHI, Gandolfi AJ, Brendel K. Regioselective toxicity by dichlorovinyl cysteine in rabbit renal cortical slices. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. (P.H. Bach and E.A. Lock, editors), Guildford, England, pp. 583589, 1989.
12. Ruegg CE, Gandolfi AJ, Brendel K. Regioselective acute tubular necrosis in renal cortical slices following HgCl2 and K2Cr2O7: Localization and transport studies. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. Guildford, England, pp. 107112, 1989.
13. Wolfgang GHI, Gandolfi AJ, Krumdieck CL, Brendel K. Evaluation of organic nephrotoxins using rabbit renal cortical slices. In: Progress in In Vitro Toxicology Vol. 6 (AM Goldberg, Editor). Mary Ann Leibert, Inc. pp. 291301, 1988.
14. Azri S, Mata HP, Gandolfi AJ, Brendel K. CCl4-induced cytochrome P450 loss and lipid peroxidation in rat liver slices. Adv. Exp. Med. Biol. 283:669-674, 1991.
15. Brown AP, Hastings KL, Gandolfi AJ, Brendel K. Covalent binding of a halothane metabolite and neoantigen production in guinea pig liver slices. Adv. Exp. Med. Biol. 283:693-697, 1991.
16. Ghantous H, Fernando J, Gandolfi AJ, Brendel K. Inhibition of protein synthesis and secretion by volatile anesthetics in guinea pig liver slices. Adv. Exp. Med. Biol. 283:725-730, 1991.
17. Hastings KL, Schuman S, Brown AP, Thomas C, Gandolfi AJ. S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Adv. Exp. Med. Biol. 283:739-744, 1991.
18. Lind RC and Gandolfi AJ. Covalent binding of oxidative biotransformation reactive intermediates to protein influences halothane-associated hepatotoxicity in guinea pigs. Adv. Exp. Med. Biol. 283:763-766, 1991.
19. Vernetti LA, Gandolfi AJ, Nagle RB. Selective alteration of cytokeratin intermediate filament by cyclosporine A is a lethal toxicity in PtK2 cell cultures. Adv. Exp. Med. Biol. 283:847-851, 1991.
20. Brendel K, Fisher RL, Krumdieck CL, Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. J Amer Col Tox 9:621-627, 1990.
21. Vernetti LA, Sarid D, Gandolfi AJ, Cress AE, Nagle RB, McCuskey R, Hameroff SR. STM images of cytokeratin and binding IgG antibody. In: Scanned Probe Microscopy, AIP Conference Proceedings, Santa Barbara, CA, (H K Wickramasinghe, ed.), American Institute of Physics, New York, pp. 232-234, 1991.
22. Gandolfi AJ. Biotransformation of inhalation anesthetics: Role in producing toxicity. In: Inhalationsanasthesie - eine Standortbestimmung (H Laubenthal, C Puchstein, C Sirtl, eds.), Wissenschaftliche Verlagsabteilung Abbott GmbH, Wiesbaden, Germany, pp. 9-19, 1992.
23. Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ, Curtis LR. Novel mechanisms in chemically-induced hepatotoxicity. FASEB Journal 8:1285-1295, 1994.
24. Gandolfi AJ. Inhalation Anaesthetics: Toxicity and Metabolism. In: Fluorine in Medicine in the 21st Century. (Conference Proceedings) RAPRA (publishers), Paper number 17, pages 1-10, 1994.
25. Burton CA, Hatlelid K, Divine K, Carter DE, Fernando Q, Brendel K, Gandolfi AJ. Glutathione effects on toxicity and uptake of HgCl2 and NaAsO2 in rabbit renal cortical slices. Environ Health Perspect 103:81-84, 1995.
26. Keith RL, McGuinness SJ, Gandolfi AJ, Lowe TP, Chen Q, Fernando Q. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Environ Health Perspect 103:77-80, 1995.
27. McIntyre CC, Leavitt JA, Ashbaugh, MD, Borgardt J, Keith RL, Gandolfi AJ, Qiu L, Lott JR, Fernando Q. The nuclear microprobe at the University of Arizona, Nuclear Instruments and Methods, 130:45-50, 1997.
28. Keith RL, Gandolfi AJ, McIntyre LC., Jr., Ashbaugh MD, Fernando Q. Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue. Nuclear Instruments and Methods, 130:358-361, 1997.
29. Gandolfi AJ. Hepatotoxicity of hydrofluorocarbons. In: Abstracts of the Workshop on Toxicity of Alternatives to Chlorofluorocarbons. (R. Snyder, K. Bakshi, B. Wagner, editors.) Inhalation Toxicology 9:775-810, 1997.
G. Unpublished Work
Work in Progress
2.
Escudero Lourdes C, Medeiros MK, Wnek SM, Gandolfi
AJ. The role of IL-8 on the MMAIII-induced malignant
transformation of UROtsa cells. Tox Sci, in preparation, 2009.
3. Moreno DM, Ramirez MD, Estrella R, Maier RM, Gandolfi
AJ, Brusseau ML, Field JA. Community outreach and research
translation efforts of the U.S.-Mexico border region. Env Health
Perspectives, submitted, 2009.
4.
Meza M, Meza D, Klimecki W, Gandolfi AJ. Arsenic content in
water, dust, urban and agricultural soils and their relation with
biomarkers in exposed populations, from Sonora, Mexico. Env Res,
in preparation 2009.
5. Wnek SM, Jensen TJ, Severson PL, Futscher BW, Gandolfi
AJ. Short-term, low-level exposure of a human bladder cell line
to monomethylarsonous acid produces critical and irreversible events
resulting in malignant transformation. Tox Sci, in preparation,
2009.
2. Gandolfi AJ. Hexachlorophene: its absorption, distribution, excretion, and biotransformation in the rat and rabbit and in vitro interaction with rat liver microsomes. Dis Abst Inter 33:4106-B, 1973.
3. Gandolfi AJ, Van Dyke RA. Effects of anesthetics, aniline, aminopyrine and other compounds on the reduction and reoxidation of cytochrome P450 in reconstituted microsomal systems. Pharmacologist 15:156, 1973.
4. Van Dyke RA, Gandolfi AJ, Wood CL. Evidence for the binding of halothane metabolites to microsomal lipids, page 13. In: Abstracts of Scientific Papers 1973 Annual Meeting, ASA, San Francisco, CA., 1973.
5. Gandolfi AJ, Van Dyke RA. Characterization and isolation of a soluble protein that stimulates microsomal dechlorination. Pharmacol 16:261, 1974.
6. Zujko KE, Gandolfi AJ, Van Dyke RA. Solubilization and partial purification of human cytochrome P450. Pharmacol 16:321, 1974.
7. Gandolfi AJ, Van Dyke RA. Effect of animal pretreatment on the in vivo covalent binding of halothane metabolites in rat hepatic lipids and protein, No. 72. In: Society of Toxicology, 15th Annual Meeting, Williamsburg, VA., 1975.
8. Gandolfi AJ, Southorn PA, Van Dyke RA. Effect of ketamine on the isolated perfused rat lung. Fed Proc 34:750, 1975.
9. Tinker JH, Gandolfi AJ, Van Dyke RA. Elevation of human plasma bromide levels after halothane anesthesia: correlation with total halothane dosage, p 387. In: Abstracts of Scientific Papers, 1975 Annual Meeting, ASA, Chicago, Ill., 1975.
10. Gandolfi AJ, Lund JE, Renne RA et al. Response of rat to intratracheally administered oil shale dusts. No. 26. In: Society of Toxicology, 17th Annual Meeting, San Francisco, 1978
11. Andrew FD, Gandolfi AJ, Mahlum DD. Developmental effects of synthetic fuel related materials in rats. In: The Teratology Society, 18th Annual Meeting, 1978.
12. Gandolfi AJ, Pelroy RA. Utilization of isolated hepatic biotransformation enzymes in assessing the mutagenic activity of compounds in the salmonella mutagenicity assay. Pharmacologist 20:252, 1978.
13. Jee R, Maiorino R, Gandolfi AJ, Sipes IG, Brown BR. Investigations of hypoxic model for halothane hepatitis. Pharmacologist 20:258, 1978.
14. Cunningham ML, Gandolfi AJ, Brendel K, Sipes IG. Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes. No. 179, Society of Toxicology, 18th Annual Meeting, New Orleans, 1979.
15. Bentley JB, Vaughan RS, Gandolfi AJ, et al. Serum inorganic fluoride levels in obese patients during and after enflurane anesthesia. International Anesthesia Research Society, 53rd Congress, Miami, 1979.
16. Blitt CD, Gandolfi AJ, Soltis JJ, et al. Biotransformation of halothane and enflurane by the lung. International Anesthesia Research Society, 53rd Congress, Miami, 1979.
17. Gandolfi AJ, Sipes IG, White RW. Bioactivation and binding of 3H/14C halothane to microsomal lipids and protein. Fed Proceed 38:684, 1979.
18. Sipes IG, Gandolfi AJ, White RW. Metabolism and toxicity of deuterated halothane. Fed Proceed 38:684, 1979.
19. Jee R, Sipes IG, Gandolfi AJ. Propagation and inhibition of halothane hypoxia hepatotoxicity. Fed Proceed 38:916, 1979.
20. Blitt CD, Soltis JJ, Gandolfi AJ. A simple method for the determination of organic fluoride using sodium fusion. Assoc University Anesthesiologists, Annual Meeting, 1979.
21. Brown BR, Sipes IG, Gandolfi AJ. Characterization of hypoxic model for halothane hepatotoxicity. Anesthesiology 51:5239, 1979.
22. Sipes IG and Gandolfi AJ. Bioactivation and hepatotoxicity of 2H/3H halothane. Anesthesiology 51:5242, 1979.
23. Potter C, Gandolfi AJ, Clayton JW, Nagle R. Renal toxicity of inhaled chlorotrifluoroethylene in male Fischer rats. Pharmacologist 21:185, 1979.
24. Gandolfi AJ, MacDonald JR, Sipes IG. Comparative microsomal bioactivation of organohalogens. Pharmacologist 21:194, 1979.
25. Maiorino RM, Gandolfi AJ, Brendel K, Sipes IG. Resolution of organohalogens adducts to protein. Pharmacologist 21:195, 1979.
26. Miller M, Vaughan RW, Gandolfi AJ. The disposition of enflurane in obese and non-obese humans. Pharmacologist 21:262, 1979.
27. Vaughan RW, Miller MS, Gandolfi AJ, Bentley JB, Paplanus SH. Factors influencing enflurane disposition in the obese. International Anesthesia Research Society, 54th Congress, Reno, 1980.
28. Gandolfi AJ, Nagle RB, Soltis JJ, Plescia F. Nephrotoxicity of halogenated vinyl cysteine compounds. Fed Proc 39:546, 1980.
29. MacDonald JR, Gandolfi AJ, Sipes IG. Potentiation of 1,1,2-trichloroethane hepatotoxicity by acetone pretreatment. Fed Proceed 39:999, 1980.
30. White RD, Sipes IG, Gandolfi AJ. Determination of ethylene bromide induced DNA injury by alkaline elution. Fed Proceed 39:1022, 1980.
31. Sipes IG, Gandolfi AJ. In vitro comparative bioactivation of aliphatic halogenated hydrocarbons. Second International Congress Toxicology, Tox. Letters, Special Issue 1:33, 1980.
32. Gandolfi AJ, Sipes IG, DiRenzo AB. Comparative microsomal bioactivation and covalent binding of organohalogens to DNA. Pharmacologists 22:247, 1980.
33. Sipes IG, Maiorino RM, Gandolfi AJ, Brendel K. Characterization of the organohalogen adducts to protein. Pharmacologist 22:391, 1980.
34. Sipes IG, Gandolfi AJ, Maiorino RM, Brown BR. Rapid analysis of trifluoroacetic acid and bromide. Anesthesiology 53:5257, 1980.
35. Bentley JB, Gandolfi AJ, Vaughan RW. Hepatorenal indices among general anesthetics in obesity. Anesthesiology 53:5259, 1980.
36. Gandolfi AJ, Sipes IG, Brown BR. Non-radiometric detection of covalent binding of halothane. Anesthesiology 53:5236, 1980.
37. Vaughan RV, Bentley JB, Cork RC, Gandolfi AJ. Does evidence of reductive halothane biotransformation correlate with hepatic binding of metabolites in obese patients. International Anesthesia Research Society, 55th Congress, Atlanta, 1980.
38. White RD, Sipes IG, Gandolfi AJ, Bowden GT. Evidence for microsomal bioactivation of 1,2-dibromoethane resulting in mammalian DNA injury. Toxicologist 1:99, 1981.
39. Bonhaus DW, Gandolfi AJ. Conjugation and bioactivation of chlorotrifluoroethylene and trichloroethylene. Toxicologist 1:100, 1981.
40. Buckley LA, Gandolfi AJ, Clayton JW, Nagle RB. A subacute study of the renal toxicity of inhaled chlorotrifluoroethylene in rats. Toxicologist 1:82, 1981.
41. Gandolfi AJ, Lind RC, Sipes IG, Brown BR, and Pohl LR. Profile in urinary radioactivity following exposure to 3H/14C halothane in the hypoxic model. Toxicologist 1:101, 1981.
42. MacDonald JR, Gandolfi AJ, and Sipes IG. Bioactivation and covalent binding of 14C-1,1,2-trichloroethane in acetone treated rats. Toxicologist 1:100, 1981.
43. Maiorino RM, Gandolfi AJ, and Sipes IG. Comparison of chloroform and 1,2-dibromoethane adducts to protein. Toxicologist 1:67, 1981.
44. Borel JD, Bentley JB, Vaughan RW, and Gandolfi AJ. Enflurane blood-gas solubility: Influence of weight, hemoglobin, and hematocrit. Anesthesiology 55:A195, 1981.
45. Bentley JB, Borel JD, Vaughan RW, and Gandolfi AJ. Weight: Succinylcholine requirement and pseudocholinesterase activity? Anesthesiology 55:A213, 1981.
46. Bentley JB, Vaughan RW, Gandolfi AJ, and Cork RC. Altered halothane metabolism: Obese vs. nonobese subjects. Anesthesiology 55:A179, 1981.
47. Bentley JB, Borel JD, Gillespie TJ, Vaughan RW, Gandolfi AJ. Fentanyl pharmacokinetics in obese and nonobese patients. Anesthesiology 55:A177, 1981.
48. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown Jr, BR. Pharmacokinetics of high and low dose alfentanil. Anesthesiology 55:A256, 1981.
49. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown Jr, BR. Pharmacokinetics of intravenous sufentanil. Anesthesiology 55:A251, 1981.
50. Borel JD, Bentley JB, Gillespie TJ, Gandolfi AJ, Brown BR. Sufentanil, alfentanil, and fentanyl kinetics in dogs. Pharmacologist 23:469, 1981.
51. Bentley JB, Borel JD, Gillespie TJ, Vaughan RW, and Gandolfi AJ. Fentanyl pharmacokinetics: obese vs. nonobese patients. Pharmacologist 23:468, 1981.
52. Gandolfi AJ, Plescia FH, White RD, MacFarland RT, and Sipes IG. Disposition and hepatotoxicity of 1,2-dibromoethane. Pharmacologist 23:300, 1981.
53. Cater KC, Gandolfi AJ, and Sipes IG. A sequential quantitative study of dimethylnitrosamine (DMN) - induced hepatic hyperplastic nodules in the newborn mouse model. Pharmacologist 23:337, 1981.
54. Hassall C, Gandolfi AJ, and Brendel K. Depression of tubular active transport by halogenated hydrocarbons and their metabolites. Pharmacologist 23:411, 1981.
55. Gandolfi AJ, DiRenzo AB, McDougal JN, and Sipes IG. Effect of senescence on the bioactivation of aliphatic halides. Toxicologist 2:21, 1982.
56. Cater KC, Gandolfi AJ, and Sipes IG. An evaluation of dimethylnitrosamine (DMN) induced hepatocellular alterations in the newborn mouse model using histochemical and histoenzymatic markers. Toxicologist 2:99, 1982.
57. Vaughan RW, Bentley JB, Gandolfi AJ, and Cork RC. Comparative halothane metabolism in obese vs. nonobese patients. Sixth Asian Australian Congress of Anaesthesiologists, Auckland, New Zealand, 1982.
58. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of carbon tetrachloride induced hepatic damage. Fed Proc 41:1582, 1982.
59. Jaffe DR, Gandolfi AJ, Hassal CD, Bonhaus DB, and Brendel K. Production of DNA single strand breaks in kidney by 1,2-dichlorovinylcysteine (DCVC). Fed Proceed 41:1581, 1982.
60. Hassall CD, Jaffe D, Gandolfi AJ, and Brendel K. Renal toxicity of halogenated vinyl cysteine adducts in the rabbit in vivo and in vitro. Fed Proceed 41:1311, 1982.
61. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Role of endotoxin in the halothane hepatitis model in rats. Anesthesiology 57:A220, 1982.
62. Jaffe D, Hassall CD, Brendel K, and Gandolfi AJ. In vivo and in vitro nephrotoxicity of the cysteine conjugate of hexachlorobutadiene. Pharmacologist 24:A82, 1982.
63. Hassall CD, Gandolfi AJ, and Brendel K. Reversal of DCVC-induced inhibition of renal tubular active transport by glutathione. Pharmacologist 24:175, 1982.
64. MacFarland RT, Gandolfi AJ, and Sipes IG. Extrahepatic GSH-dependent metabolism of 1,2-dibromoethane (DBE) and 1,2-dibromo3-chloropropane (DBCP) in the rat and mouse. Pharmacologist 24:136, 1982.
65. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Role of endotoxin in halothane hepatitis. Pharmacologist 24:193, 1982.
66. Lee HR, Gandolfi AJ, Sipes IG, and Bentley J. Effect of histamine H-receptors antagonists on fentanyl metabolism. Pharmacologist 24:145, 1982.
67. Bentley JB, Finley JH, Humphrey LR, Gandolfi AJ, and Brown BR. Obesity and alfentanyl pharmacokinetics. Anesth Analg 62:245, 1982.
68. Hassall CD, Gandolfi AJ, and Brendel K. Regulation of DCVC-induced renal tubular toxicity by glutathione. Toxicologist 3:71, 1983.
69. Glass SJ, Bentley JB, Jackson JE, Banner W, Gandolfi AJ, and Plachetka JR. The effect of cimetidine and ranitidine on lidocaine pharmacokinetics. Toxicologist 3:158, 1983.
70. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Endotoxin mediated mechanisms of halothane hepatitis. Toxicologist 3:116, 1983.
71. Jaffe DR, Gandolfi AJ, and Nagle RB. Chronic toxicity of S-(trans1,2-dichlorovinyl)-L-cysteine (DCVC) in mice. Toxicologist 3:72, 1983.
72. Durham JA, Gandolfi AJ, and Bentley JB. Hepatotoxicological evaluation of dantrolene sodium. Toxicologist 3:130, 1983.
73. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of chemically induced hepatototoxicity. Toxicologist 3:97, 1983.
74. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Mediation of halothane hepatitis by endotoxin. Tox Letters 18:67, 1983.
75. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of chemically induced liver injury. Tox Letters 18:66, 1983.
76. Gandolfi AJ, Hassall CD, Jaffe DR, Brendel K, and Nagle RB. Nephrotoxicity of cysteine conjugates of halogenated alkenes. Tox Letters 18:66:1983.
77. Hassall CD, Gandolfi AJ, and Brendel K. Renal toxicity of dichlorovinyl glutathione in the rabbit. Fed Proceed 42:354, 1983.
78. MacDonald JR, Gandolfi AJ, and Sipes IG. Hepatic Ca++ levels following cystamine treatment of chemically-induced hepatotoxicity. Fed Proceed 42:356, 1983.
79. MacDonald JM, Lind RC, Gandolfi AJ, and Sipes IG. Analysis of hepatic calcium content by flame emission spectrometry. Fed Proceed 42:2068, 1983.
80. Gandolfi AJ, Weldon ST, and Blitt CD. Production and characterization of impurities in isoflurane vaporizers. Anesthesiology 59:A159, 1983.
81. Fukui T, Hameroff SR, and Gandolfi AJ. Alpha1-acid glycoprotein plasma levels are elevated in chronic pain. Anesthesiology 59:A203, 1983.
82. Bentley JB, Glass SJ, and Gandolfi AJ. The influence of halothane on lidocaine pharmacokinetics in man. Anesthesiology 59:A246, 1983.
83. DiRenzo AB, Gandolfi AJ, Brendel K, Byard JL, and Sipes IG. Effect of hypoxia on the bioactivation and toxicity of CCl4 and halothane in primary rat hepatocyte cultures. Pharmacologist 25:170, 1983.
84. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Comparison of models for halothane and enflurane induced hepatotoxicity. Pharmacologist 25:231, 1983.
85. Sipes IG, DiRenzo AB, Gandolfi AJ, Brendel K, and Byard JL. Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat hepatocyte cultures. lst International Society for the Study of Xenobiotics Meeting, West Palm Beach, Florida, 1983.
86. Blitt CD, Weldon ST, Williams-Van Alstyne SI, and Gandolfi AJ. Survey of impurities in isoflurane and enflurane vaporizers. International Anesthesia Research Society, Reno, Nevada, 1984.
87. Lind RC, Gandolfi AJ, and Sipes IG. Comparison of the protective action of immunopotentiators to CCl4 hepatic injury. Toxicologist 4:78, 1984.
88. MacDonald JR, Gandolfi AJ, and Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicologist 4:78, 1984.
89. Lind RC, Gandolfi AJ, and Sipes IG. Role of induction and normothermia in two models of volatile anesthetic hepatotoxicity. Toxicologist 4:43, 1984.
90. Waters SJ, Gandolfi AJ, and Sipes IG. Reductive metabolism and hepatotoxicity of halothane in Arocolor 1254 pretreated rats. Toxicologist 4:93, 1984.
91. Gandolfi AJ, DiRenzo AB, Lind RC, and Waters SJ. Comparison of the in vivo and in vitro hepatotoxicity of enflurane and halothane. IUPHAR 9th International Congress, London, 1984
92. Brown BR, Gandolfi AJ, Lind RC, and Sipes IG. Conflicting mechanisms of hepatic injury with halothane and enflurane. Anesthesiology 64:A270, 1984.
93. Sipes IG, Gandolfi AJ, Lind RC, and Brown BR. Comparison of the mechanisms of hepatic injury with halothane and enflurane. Third International Conference on Anesthesia, Calgary, 1984.
94. Callis AH, Waters SJ, Gandolfi AJ, Pohl LR, Satoh H, and Sipes IG. Evidence for a role of the immune response in the pathogenesis of halothane hepatitis. Third International Conference on Anesthesia, Calgary, 1984.
95. Meadows SD, Gandolfi AJ, Nagle RB, and Brendel K. Persistent, progressive renal toxicity in male Swiss-Webster mice following subchronic exposure to 1,2-dichlorovinyl cysteine (DCVC). Second International Symposium on Nephrotoxicity, University Surrey, England, 1984.
96. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Second International Symposium on Nephrotoxicity, University of Surrey, England, 1984.
97. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. Preparation of precision liver slices for in vitro toxicology. Pharmacologist 26:194, 1984.
98. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Inhibition of organic acid/base transport in isolated rabbit renal tubules by nephrotoxins. Pharmacologist 26:193, 1984.
99. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. A unique organ culture system for in vitro studies of hepatotoxicity. Johns Hopkins Center for Alternatives to Animal Testing, Third Annual Meeting, Baltimore. October, 1984.
100. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Organic acid/base transport in rabbit proximal tubule suspensions. Effects of halogenated hydrocarbons. Johns Hopkins Center for Alternatives to Animal Testing, Third Annual Meeting, Baltimore. October, 1984.
101. Lind RC, DiRenzo AB, Gandolfi AJ, Sipes IG, and Brendel K. Oxygen requirements for the reductive biotransformation of halothane. Toxicologist 5:244, 1985.
102. DiRenzo AB, Gandolfi AJ, Brooks SD, and Brendel K. Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocyte suspensions. Toxicologist 5:148, 1985.
103. Rylander-Yueh LA, Brendel K, and Gandolfi AJ. Effect of hydrocarbons on renal tubular organic acid/base transport. Toxicologist 5:55, 1985.
104. Lind RC, Gandolfi AJ, and Sipes IG. Halothane hepatotoxicity in several strains of guinea pig. Toxicologist 5:75, 1985.
105. Silber PM, Gandolfi AJ, and Brendel K. Acute nephrotoxicity of 1,2-dichlorovinyl cysteine in New Zealand white rabbits. Toxicologist 5:55, 1985.
106. Smith PF, Shubat PJ, Gandolfi AJ, Krumdieck CL, and Brendel K. Novel dynamic organ culture system for hepatotoxicity studies. Toxicologist 5:151, 1985.
107. Brooks SK, Callis AH, Gandolfi AJ, Sipes IG, and Pohl LR. Induction of an immune response following halothane exposure. Toxicologist 5:42, 1985.
108. Callis AH, Brooks SD, Gandolfi AJ, Sipes IG, and Pohl LR. Specificity of the antibodies induced by halothane exposure. Toxicologist 5:42, 1985.
109. Ruegg CE, Gandolfi AJ, Brendel K, and Krumdieck CL. Positional renal slices for study of site specific toxicity. Toxicologist 5:57, 1985.
110. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of galactosamine-induced hepatic damage. Hepatic non-protein sulfhydryl levels. Toxicologist 5:153, 1985.
111. Smith PF, Gandolfi AJ, Krumdieck CL, and Brendel K. A novel organ culture system for the maintenance of adult rat liver. Fed Proceed 44:627, 1985.
112. Moore RA, Gallagher JD, Gandolfi AJ, Sipes IG, Kerns D, McNicholas KW, and Clark DL. Halothane metabolism in acyanotic and cyanotic congenital heart patients undergoing cardiac surgery. Anesthesiology 65:A539, 1985.
113. Lind RC, Gandolfi AJ, and Brown BR. Halothane hepatotoxicity in both sexes of four strains of guinea pigs. Anesthesiology 65:A541, 1985.
114. Callis AH, Gandolfi AJ, Brooks SD, and Brown BR. Changing specificities in halothane-induced antibody as a pathogenic factor in halothane hepatitis. Anesthesiology 65:A548, 1985.
115. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. In vitro site specific toxicity of mercuric chloride in rabbit renal cortical slices. Pharmacologist 27:130, 1985.
116. Becker GM, Gandolfi AJ, and Nagle RB. Cyclosporine nephrotoxicity in the rat. Society of Toxicology, Mountain States Chapter Meeting, October, 1985.
117. Smith PF, Fisher R, Krack G, Gandolfi AJ, and Brendel K. Bromobenzene and allyl alcohol hepatotoxicity in cultured rat liver slices: II. Inhibition of toxicity by selective enzyme inhibitors. Toxicologist 6:118, 1986.
118. Rylander LA, Phelps JS, Brendel K, and Gandolfi AJ. Rabbit proximal tubule suspensions for the study of early nephrotoxic events. Toxicologist 6:174, 1986.
119. Roth TP, Callis AH, and Gandolfi AJ. Detection of halothane induced antigen using specific anti-halothane metabolite antibodies. Toxicologist 6:66, 1986.
120. Silber PM, Gandolfi AJ, and Brendel K. Glutathionuria induced by mercuric chloride and hexachlorobutadiene. Toxicologist 6:176, 1986.
121. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Differential toxicity of ischemia and HgCl2 in rabbit renal cortical slices. Toxicologist 6:174, 1986.
122. DiRenzo AB, Gandolfi AJ, Brendel K, and Krack G. Effect of volatile anesthetics on protein synthesis and secretion in rat hepatocyte suspensions. Toxicologist 6:116, 1986.
123. Fisher R, Smith PF, Gandolfi AJ, Sipes, and Brendel K. Hepatotoxicity of dichlorobenzene isomers in Sprague Dawley rat liver organ explants. Toxicologist 6:119, 1986.
124. Fisher R, Barr J, Zukoski CF, Putnam CW, Gandolfi AJ, Sipes IG, and Brendel K. Hepatotoxicity of three dichlorobenzene isomers in human liver organ culture. Toxicologist 6:118, 1986.
125. Gandolfi AJ, Rylander LA, Phelps JS, and Brendel K. Utilization of rabbit renal proximal tubules to examine the chronology of injury by nephrotoxic agents. Johns Hopkins Center for Alternatives to Animal Testing. In Vitro Toxicology Symposium. Baltimore, April, 1986.
126. Phelps JS, Gandolfi AJ, and Brendel K. Cisplatin toxicity in rabbit renal proximal tubule suspensions and precision-cut renal cortical slices. Johns Hopkins Center for Alternatives to Animal Testing. In Vitro Toxicology Symposium, Baltimore, April, 1986.
127. Callis AH, Gandolfi AJ, Roth TP, and Brown BR. Circulating anti-halothane antibodies in patients with unexplained hepatitis following halothane exposure. Anesthesiology 65:A235, 1986.
128. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Circulating immune complexes in halothane hepatitis patients correlate with anti-halothane antibody levels. Pharmacologist 28:194, 1986.
129. Dale O, Gandolfi AJ, and Brendel K. Liver slices: In vitro pharmacokinetic drug interaction studies. Pharmacologist 28:205, 1986.
130. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Circulating immune complexes in halothane hepatitis patients correlate with anti-halothane antibody levels. Mountain West Chapter Society of Toxicology 4th Annual Meeting, Tucson, October 1986.
131. Lind RC and Gandolfi AJ. Effect of phenobarbital pretreatment on the guinea pig model of halothane-associated hepatic necrosis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
132. Schuman S, Roth TP, and Gandolfi AJ. Generation of an immune response in the guinea pigs to trifluoroethanol. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
133. Levy JP, Hubbard AK, and Gandolfi AJ. Characterization of antibodies produced in human halothane hepatitis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
134. Adamson CR, Gandolfi AJ, and Brendel K. Biotransformation and toxicity of volatile anesthetics in rat liver slices. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
135. Wolfgang GHI, Ruegg CR, Brendel K, and Gandolfi AJ. Comparison of renal cortical slices incubated in two in vitro systems. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October 1986.
136. Osman K, Roth TP, and Gandolfi AJ. Circulating immune-complexes in halothane-induced hepatic injury in rabbits. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
137. Siadat-Pajouh M, Hubbard AK, and Gandolfi AJ. Halothane induced immune response in a guinea pig model of halothane hepatitis. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
138. Fisher R, Wishnies S, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. The effect of different culture media on the toxicity of monochlorobenzene and dichlorobenzenes. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
139. Becker G, Fisher R, Krumdieck CL, Gandolfi AJ, and Brendel K. Valproic acid toxicity in precision-cut liver slices. Mountain West Chapter/Society of Toxicology 4th Annual Meeting, Tucson, October, 1986.
140. Dale O, Gandolfi AJ, and Brendel K. Volatile anesthetics and diazepam metabolism: Interaction studies with rat liver slices. Fed Proceed 46:866, 1987.
141. Levy JP, Hubbard AK, and Gandolfi AJ. Characterization of antibodies produced in human halothane hepatitis. Toxicologist 7:231, 1987.
142. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Selective in vitro necrosis of proximal tubular segments in renal cortical slices. Toxicologist 7:88, 1987.
143. Roth TP, Osman K, Schuman S, Hubbard AK, and Gandolfi AJ. Chronology of halothane-induced antigen expression in halothane exposed rabbits. Toxicologist 7:232, 1987.
144. Lind RC, Gandolfi AJ, and Brown BR. Effect of phenobarbital pretreatment on the guinea pig model of halothane-associated hepatic necrosis. Toxicologist 7:55, 1987.
145. Wolfgang GHI, Gandolfi AJ, and Brendel K. In vitro toxicity of cephaloridine and hexachlorobutadiene in rabbit cortical slices. Toxicologist 7:90, 1987.
146. Siadat-Pajouh M, Roth TP, Hubbard AK, and Gandolfi AJ. Halothane induced immune response in a guinea pig model of halothane hepatitis. Toxicologist 7:231, 1987.
147. Adamson CR, Gandolfi AJ, and Brendel K. Toxicity of volatile anesthetics in rat liver slices. Toxicologist 7:60, 1987.
148. Fisher RL, Wishnies SM, Sipes IG, Gandolfi AJ, and Krumdieck CL. The effect of different culture media on the toxicity of monochlorobenzine and the dichlorobenzenes. Toxicologist 7:60, 1987.
149. Brendel K, Becker GM, Fisher RL, Smith PF, Gandolfi AJ, and Krumdieck CL. Organ slice technology: A tool to evaluate regioselective toxicity. Toxicologist 7:59, 1987.
150. Brendel K, Krumdieck CL, Gandolfi AJ, and McKee RM. Precision cut tissue slices in culture: A new tool in pharmacology. Western Pharmacology Society Meetings, Hawaii, 1987.
151. Dale O, Gandolfi AJ, and Brendel K. Rat liver slices and diazepam metabolism: In vitro interactions with volatile anesthetics and albumin. Norwegian Society of Pharmacology and Toxicology. Beito, Norway, 1987.
152. Dale O, Gandolfi AJ, and Brendel K. Elimination of diazepam in rat liver slices: Interactions with albumin and volatile anesthetics. The 19th Scandinavian Congress of Anesthesiologists, Sweden, 1987.
153. Wolfgang GHI, Gandolfi AJ, and Brendel K. In vitro toxicity of dichlorovinyl cysteine in rabbit renal cortical slices. Pharmacologist 29:A540, 1987.
154. Wolfgang GHI, Gandolfi AJ, and Brendel K. Regioselective toxicity by dichlorovinyl cysteine in rabbit renal cortical slices. Third International Symposium on Nephrotoxicity, University of Surrey, Guildford, England, 1987.
155. Ruegg CE, Gandolfi AJ, and Brendel K. Regioselective acute tubular necrosis in renal cortical slices following HgCl2 and K2Cr2O7: Localization and transport studies. Third International Symposium on Nephrotoxicity, University of Surrey, Guildford, England, 1987.
156. Cork RC, Gallo JA, Weiss LB, Plezia P, Kramer T, Levy JP, and Gandolfi AJ. Sufentanil infusion: Pharmacokinetics compared to bolus. IARS 62nd Congress, 1988.
157. Cork RC, Gallo JA, Smith R, Copeland J, Kramer T, Plezia P, Levy J, and Gandolfi AJ. Pharmacokinetics of sufentanil and the total artificial heart. A four-compartment model. 41st Post Graduate Assembly, New York, 1987.
158. Lind RC and Gandolfi AJ. Effects of both nitrous oxide and animal weight on the guinea pig model of halothane associated hepatic necrosis. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.
159. Roth TP, Schuman S, Hubbard AK, and Gandolfi AJ. Localization of halothane-induced antigen by specific anti-halothane metabolite antibodies. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.
160. Schuman S, Roth TP, and Gandolfi AJ. Antigenic similarity of halothane induced antigens and synthetic trifluoroacetylated proteins. Mountain West Society of Toxicology, Univ. Colorado, Boulder, CO, 1987.
161. Ruegg CE, Gandolfi AJ, and Brendel K. HgCl2 and K2Cr2O7 induced regioselective acute tubular necrosis in renal cortical slices: Localization and transport studies. Kidney International, 1987.
162. Wolfgang GHI, Gandolfi AJ, Krumdieck CL, and Brendel K. Evaluation of organic nephrotoxins using rabbit renal cortical slices. Johns Hopkins Center for Alternatives to Animal Testing Annual Meeting, "Progress in In Vitro Toxicology", 1987.
163. Roth TP, Hubbard AK, and Gandolfi AJ. Localization of halothane-induced antigen in situ by specific anti halothane metabolite antibodies. Toxicologist 8:11, 1988.
164. Hubbard AK, Roth TP, and Gandolfi AJ. Elicitation of a cell-mediated immune response to a reactive intermediate of halothane. Toxicologist 8:12, 1988.
165. Wolfgang GHI, Gandolfi AJ, Brendel K, and Nagle RB. Effect of transport and biotransformation on the renal site-specific toxicity of dichlorovinyl cysteine (DCVC). Toxicologist 8:1, 1988.
166. Lind RC and Gandolfi AJ. Effects of nitrous oxide and body weight on the guinea pig model of halothane hepatotoxicity. Toxicologist 8:65, 1988.
167. Connors MS, Bell MV, Gandolfi AJ, and Brendel K. Temporal separation of K+ and Ca++ movements in cultured rat livers treated with model hepatotoxicants. Toxicologist 8:66, 1988.
168. Fisher R, Gandolfi AJ, Nau H, and Brendel K. Valproic acid hepatotoxicity in rat, pig and human liver slices. Toxicologist 8:224, 1988.
169. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, and Brendel K. Partial retention of biotransformation in cryopreserved precision-cut liver slices. Toxicologist 8:203, 1988.
170. Wolfgang GHI, Gandolfi AJ, Nagle RB, and Brendel K. Progression of cellular injury induced by dichlorovinylcysteine (DCVC) in renal cortical slices. FASEB J 2:A794, 1988.
171. Vernetti LA, Gandolfi AJ, and Nagle RB. Effects of cyclosporins on intermediary filaments in DU145 and PTK2 cells. FASEB J 2:A404, 1988.
172. Fisher R, Hanzlik RP, Gandolfi AJ, and Brendel K. Toxicity of ortho-substituted bromobenzenes to precision-cut rat liver slices. FASEB J 2:A1134, 1988.
173. Connors MS, Gandolfi AJ, and Brendel K. Enzyme leakage as an index of toxicity in incubating rat liver slices. Western Pharmacology Society, 1988.
174. Stefaniak MS, Gandolfi AJ, and Brendel K. Adult rat lung in dynamic organ culture. Western Pharmacology Society 1987.
175. Brendel K, Gandolfi AJ, Sipes IG, and Krumdieck CL. Xenobiotic metabolism in precision-cut human liver slices in organ culture. FASEB J 2:1988.
176. Connors MS, Gandolfi AJ, and Brendel K. Release of cellular enzymes from precision-cut rat liver slices in organ culture. FASEB J 2:A826, 1988.
177. Zaghloul HA, Gandolfi AJ, and Brendel K. In vitro nephrotoxicity of phenacetin in precision-cut rat kidney slices in dynamic organ culture. FASEB J 2:A803, 1988.
178. Stefaniak MS, Gandolfi AJ, and Brendel K. Agarose filled precision-cut rat lung slices in organ culture. FASEB J 2:A1606, 1988.
179. Brendel K, Gandolfi AJ, Sipes IG, and Krumdieck CL. Precision-cut liver slices in organ culture: A new tool in human drug metabolism and hepatotoxicity studies. American Assoc Pharmaceutical Scientists, 1988.
180. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Effect of body weight, sex, and nitrous oxide on halothane hepatotoxicity in the guinea pig. Anesthesiology 69:A442, 1988.
181. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity. Anesthesiology 69:A438, 1988.
182. Azri S, Gandolfi AJ, and Brendel K. Carbon tetrachloride toxicity in precision-cut rat liver slices. Pharmacologist 30:A58.3, 1988.
183. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. M.W. SOT, Salt Lake City, 1988.
184. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. M.W. SOT, Salt Lake City, 1988.
185. Limstrom SA, Connors S, Gandolfi AJ, and Brendel K. Gluconeogenesis as a viability parameter in precision-cut liver slices. American Federation for Clinical Research, 1988.
186. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. Toxicologist 9:26, 1989.
187. Fernando J, Ghantous HN, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. Toxicologist 9:283, 1989.
188. Hastings KL, Schuman S, Brown AP, Hubbard AK, and Gandolfi AJ. In situ detection of trifluoroacetylated antigens following in vivo exposure to halothane, enflurane, or isoflurane. Toxicologist 9:171, 1989.
189. Lind RC and Gandolfi AJ. Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. Toxicologist 9:147, 1989.
190. Vernetti LA, Gandolfi AJ, and Nagle RB. Cyclosporin A produces a selective rearrangement in cytokeratin intermediate filaments in PTK2 cell cultures. Toxicologist 9:159, 1989.
191. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. Toxicity, transport and metabolism of N-acetyl S-(1,2-dichlorovinyl)-L-cysteine (NAC-DCVC) in rabbit renal cortical slices. Toxicologist 9:80, 1989.
192. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. The effects of short term storage on xenobiotic metabolism of vitrified human liver slices. Toxicologist 9:283, 1989.
193. Connors S, Gandolfi AJ, Krumdieck CL, and Brendel K. Species comparison of cocaine hepatotoxicity in cultured rat liver slices. Toxicologist 9:69, 1989.
194. Klimecki WT, Wishnies SM, Gandolfi AJ, Krumdieck CL, and Brendel K. Xenobiotic metabolism in microslices from distinct regions of the liver. Toxicologist 9:283, 1989.
195. Fisher RL, Gandolfi AJ, Krumdieck CL, and Brendel K. The use of human cryopreserved precision-cut liver slices in hepatotoxicity studies. Toxicologist 9:282, 1989.
196. Connors S, Rankin DR, Gandolfi AJ, Krumdieck, and Brendel K. Effects of phenobarbital, ethanol and morphine on cocaine induced hepatotoxicity in precision-cut liver slices. Western Pharm Soc Meeting, February, 1989.
197. Gandolfi AJ and Brendel K. In vitro systems for nephrotoxicity studies. Practical In Vitro Toxicology, Nottingham, England, 1989.
198. Gandolfi AJ, Thomas CM, Azri S, and Brendel K. Histopathological evaluation of cultured precision-rat liver slices exposed to hepatotoxins. International Congress of Toxicology, Brighton, England, 1989.
199. Hastings KL, Schuman S, Hubbard AK, and Gandolfi AJ. Methods useful in diagnosis of the immunotoxic disease, halothane hepatitis. International Congress of Toxicology, Brighton, England, 1989.
200. Fisher R, Sipes IG, Gandolfi AJ, and Brendel K. Viability and toxicity assessment of cryopreserved human liver slices. Cryobiology Meetings, Charleston, S.C., June 15, 1989.
201. Hastings KL, Enriquez FJ, Bradley-Dunlop D, Schuman S, Thomas CM, Hubbard, AK, and Gandolfi AJ. Development of a monoclonal antibody reactive with halothane-associated neoantigens. Pharmacologist 31:193, 1989.
202. Lind RC, Ghantous HN, Gandolfi AJ, and Brown BR. Sevoflurane biotransformation and hepatotoxicity in the guinea pig. Anesthesiology 71:A310, 1989.
203. Lind RC, Black JB, Gandolfi AJ, and Brown BR. Covalent binding of biotransformation intermediates influences halothane-associated hepatotoxicity in guinea pigs. Anesthesiology 71:A242, 1989.
204. Stefaniak MS, Gandolfi AJ, and Brendel K. Lung explants: Characterization and intoxication. Mountain West Society of Toxicology, October, 1989.
205. Azri S, Mata HP, Gandolfi AJ, and Brendel K. Covalent binding of CCl4 to rat liver slices and conjugated diene formation. Mountain West Society of Toxicology, October, 1989.
206. Brown AP, Hastings KL, and Gandolfi AJ. In vitro covalent binding of halothane metabolites and neoantigen production in guinea pig liver slices. Mountain West Society of Toxicology, October, 1989.
207. Azri S, Gandolfi AJ, and Brendel K. Effects of biotransformation inducers and inhibitors on CCl4 toxicity in rat liver slices. Toxicologist 9:167, 1990.
208. Hastings KL, Schuman S, Thomas C, Brown AP, Hubbard AK, and Gandolfi AJ. Laboratory methods for the diagnosis of halothane hepatitis. Anesthesiology 71:A235, 1990.
209. Stefaniak MS, Pretlow TP, Krumdieck CL, Gandolfi AJ, and Brendel K. Agar-filled rat lung slices for use in toxicologic evaluations. Toxicologist 10:339, 1990.
210. Connors S, Rankin DR, Gandolfi AJ, Krumdieck CL, Eskelson C, and Brendel K. Liver slices from chronic ethanol treated rats are sensitized to cocaine hepatotoxicity. Toxicologist 10:332, 1990.
211. Parrish AR, Shipp NG, Dorr RT, Krumdieck CL, Pretlow TP, Gandolfi AJ, and Brendel K. Short term culture of adult rat heart slices. Toxicologist 10:34, 1990.
212. Fisher R, Sipes IG, Gandolfi AJ, and Brendel K. Toxicity assessment in cryopreserved human kidney and liver slices. Toxicologist 10:283, 1990.
213. Lohr CL, Gandolfi AJ, and Hubbard AK. Immunogenicity studies of a synthetic antigen of alpha-methyl dopa. Toxicologist 10:34, 1990.
214. Azri S, Mata HP, Gandolfi AJ, and Brendel K. CCl4 induced lipid peroxidation and enzyme loss in rat liver slices. Toxicologist 10:52, 1990.
215. Hastings KL, Schuman S, Brown AP, Thomas C, and Gandolfi AJ. Effect of S-ethylthiotrifluoroacetate pretreatment on the immune response to halothane in the guinea pig. Toxicologist 10:292, 1990.
216. Lind RC and Gandolfi AJ. Glutathione depletion potentiates a guinea pig model of halothane-associated hepatotoxicity. Toxicologist 10:66, 1990.
217. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of a halothane metabolite and neoantigen production in guinea pig liver slices in vitro. Toxicologist 10:331, 1990.
218. Gala K, Spaulding TC, Gandolfi AJ, and Waters SJ. Examination of the structural components responsible for the in vitro hepatotoxicity of M741, an experimental neuromuscular blocking agent. Toxicologist 10:67, 1990.
219. Waters SJ, Spaulding TC, Brendel K and Gandolfi AJ. Hepatotoxicity of menadione in Sprague-Dawley rat liver slices. Toxicologist 10:66, 1990.
220. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Effect of volatile anesthetics on protein synthesis and secretion in guinea pig liver slices. Toxicologist 10:332, 1990.
221. Gandolfi AJ, Stefaniak MS, Eskelson CE, and Brendel K. Comparative toxicities of pulmonary toxins in agar-filled rat lung slices. Toxicologist 10:339, 1990.
222. Azri S, Mata HP, Gandolfi AJ, and Brendel K. CCl4 induced cytochrome P450 loss and lipid peroxidation in rat liver slices. Biol React Intermediates IV, Tucson, January 1990.
223. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of halothane metabolite and neoantigen production in guinea pig liver slices. Biol React Intermediates IV, Tucson, January 1990.
224. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Inhibition of protein synthesis and secretion by volatile anesthetics in guinea pig liver slices. Biol React Intermediates IV, Tucson, January 1990.
225. Hastings KL, Schuman S, Brown AP, Thomas C, and Gandolfi AJ. S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Biol React Intermediates IV, Tucson, January 1990.
226. Lind RC and Gandolfi AJ. Covalent binding of oxidative biotransformation reactive intermediates to protein influences halothane-associated hepatotoxicity in guinea pigs. Biol React Intermediates IV, Tucson, January 1990.
227. Vernetti LA, Gandolfi AJ, and Nagle RB. Selective alteration of cytokeratin intermediate filament by cyclosporine A is a lethal toxicity in PtK2 cell cultures. Biol React Intermediates IV, Tucson, January 1990.
228. Wishnies SM, Gandolfi AJ, Sipes IG, and Brendel K. Biotransformation activity and chemical induced toxicity in vitrified human kidney cortical slices. Toxicologist 10:284, 1990.
229. Ghantous HN, Fernando J, Hastings K, Gandolfi AJ, and Brendel K. Volatile anesthetics effect on protein and albumin synthesis and secretion in guinea pig liver slices. FASEB J 4:A1140, 1990.
230. Lind RC and Gandolfi AJ. Glutathione depletion exacerbates halothane-associated hepatotoxicity in guinea pigs. Anesthesiology 73:A398, 1990.
231. Ghantous HN, Fernando J, Hastings KL, Gandolfi AJ, and Brendel K. The effect of volatile anesthetics on albumin synthesis and secretion in the guinea pig liver slices. Anesthesiology 73:A359, 1990.
232. Brown AP, Hastings KL, and Gandolfi AJ. Production and detection of volatile anesthetic-associated neoantigens in vitro. Anesthesiology 73:A350, 1990.
233. Brendel K, Fisher R, Gandolfi AJ, and Krumdieck C. Structure activity in organ cultured liver slices. CIBA-Geigy Workshop. "Structure Activity Relationships in Predictive Toxicology". June 21, 1990.
234. Azri S, Mata HP, Gandolfi AJ, and Brendel K. Loss of site-specific enzymes in precision-cut liver slices following intoxication with CCl4. ISSX, San Diego, October 1990.
235. Vernetti LA, Cress AE, Sarid D, Nagle RB, and Gandolfi AJ. Molecular interaction of cyclosporine A and mitoxantrone with cytokeratin protein. ISSX, San Diego, October 1990.
236. Fisher RL, Lofquist J, Bardsley BA, Paparo JJ, Cook DC, Gandolfi AJ, and Brendel K. Availability of human kidney, pancreas and liver slices for research. Amer Soc Cell Biol, 1990.
237. Vernetti AL, Gandolfi AJ, Nagle RB, and Cress AE. Cyclosporin A inhibition of cytokeratin intermediate filament phosphorylation shifts cytokeratin protein to a more insoluble form. Mountain West Society of Toxicology, Tucson, October 1990.
238. Fernando JL, Ghantous HN, Gandolfi AJ, and Brendel K. Comparative biotransformation and toxicity of desflurane and isoflurane in guinea pig liver slices. Mountain West Society of Toxicology, Tucson, October, 1990.
239. Thomas C, Hastings KL, Payne A, and Gandolfi AJ. Development of a murine model for halothane hepatitis: Preliminary investigations. Mountain West Society of Toxicology, Tucson, October, 1990.
240. Mata HP, Azri S, Gandolfi AJ, and Brendel K. Loss of site-specific enzymes in precision-cut rat liver slices following chloroform intoxication. Mountain West Society of Toxicology, Tucson, October, 1990.
241. Nowlin CLA, Howells S, Sarid D, and Gandolfi AJ. Preparation of mitochondria for scanning tunneling microscopy evaluation. Mountain West Society of Toxicology, Tucson, October, 1990.
242. Sanuik JT, Connors S, Gandolfi AJ, and Brendel K. Effect of trifluoroperazine (TFP) on allyl alcohol (AA) and acrolein (AC) toxicity in precision-cut rat liver slices in culture. Mountain West Society of Toxicology, Tucson, October, 1990.
243. Michaud JP, Gandolfi AJ, and Brendel K. The microtox system: A screening tool for interactive toxicity? Mountain West Society of Toxicology, Tucson, October, 1990.
244. Gandolfi AJ, Azri S, Mata HP, and Brendel K. The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slices. Toxicologist 11:A153, 1991.
245. Azri S, Mata HP, Gandolfi AJ, and Brendel K. The selective toxicity of CHCl3 in precision-cut rat liver slices. Toxicologist 11:A156, 1991.
246. Reid LL, Hastings KL, Gandolfi AJ, and Van Ert M. Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity. Toxicologist 11:A751, 1991.
247. Lind RC and Gandolfi AJ. Subanesthetic halothane is hepatotoxic in guinea pigs; plasma ICDH vs ALT as an index of injury. Toxicologist 11:A155, 1991.
248. Hastings KL, Thomas C, Brown AP, and Gandolfi AJ. A murine model for halothane hepatitis. Toxicologist 11:A609, 1991.
249. Vernetti LA, Nagle RB, and Gandolfi AJ. Inhibition of cytokeratin intermediate filament phosphorylation by cyclosporine A alters filament disassembly. Toxicologist 11:A312, 1991.
250. Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Evaluation of two new anesthetics by precision-cut guinea pig liver slices. Toxicologist 11:A154, 1991.
251. Sheevers HV, Wunz TP, Wright SH, Brendel K, and Gandolfi AJ. Toxicity of organic cation compounds in precision-cut rabbit renal cortical slices. Toxicologist 11:A484, 1991.
252. Brown AP, Hastings KL, Cress AE, Gandolfi AJ, and Brendel K. Covalent binding of a halothane metabolite to a 30 kD protein in guinea pig liver slices. Toxicologist 11:A754, 1991.
253. Ellis JK, Spaulding TC, Gala K, Gandolfi AJ, and Waters SJ. Acute hepatotoxicity of M741 in Sprague-Dawley rats. Toxicologist 11:A613, 1991.
254. Waters SJ, Spaulding TC, Brendel K, and Gandolfi AJ. Hepatotoxicity of benzyl viologen in Sprague-Dawley rat liver slices. Toxicologist 11:A782, 1991.
255. Stefaniak MS, Gandolfi AJ, and Brendel K. Toxicity of redox cycling compounds in rat lung slices. Toxicologist 11:A850, 1991.
256. Brendel K, Stefaniak MS, Spall RD, and Gandolfi AJ. Demonstration of cell-specific injury using rat lung slices. Toxicologist 11:A849, 1991.
257. Connors S, Sanuik JT, Gandolfi AJ, and Brendel K. Trifluoroperazine (TFP) protection against allyl alcohol (AA) toxicity in precision-cut rat liver slices. Toxicologist 11:160, 1991.
258. Krumdieck CL, Wishnies SM, Parrish AR, Gandolfi AJ, and Brendel K. Cold preservation of rat livers for use in biotransformation studies. Toxicologist 11:A158, 1991.
259. Fisher R, Gandolfi AJ, and Brendel K. Availability of human kidney slices for nephrotoxicity studies. Toxicologist 11:A464, 1991.
260. Carter SJ, Fisher RL, Gandolfi AJ, and Brendel K. Cold preservation of rat livers for in vitro toxicity assessment. Toxicologist 11:A157, 1991.
261. Parrish AR, Shipp NG, Dorr RT, Gandolfi AJ, and Brendel K. Comparative cardiotoxicity of allyamine (AA) and doxorubicin (DOX) in myocardial slices. Toxicologist 11:A1321, 1991.
262. Wishnies SM, Gandolfi AJ, and Brendel K. In vitro maintenance of phase I and II xenobiotic metabolism in rat liver slices. Toxicologist 11:A159, 1991.
263. Morgan S, Frink EJ, Ghantous H, Gandolfi AJ, and Brown BR. Inorganic fluoride production following sevoflurane in healthy surgical patients. Anesthesiology 75:A349, 1991.
264. McGuinness SJ, Ryan MP, Gandolfi AJ, and Brendel K. Comparison of renal tubules and slices for in vitro nephrotoxicity studies. International Society of Nephrology, Chatham, Massachusetts, October 1991.
265. Clarke JB, Hastings KL, and Gandolfi AJ. Effect of chloroquine on the formation of halothane-induced liver antigens. A tool to investigate drug hypersensitivity reactions. Foundation for Immunotoxicology, Sixth Annual Symposium, Virginia Beach, VA, October 1991.
266. Lind RC, Gandolfi AJ, and Hall PM. Glutathione depletion enhances covalent binding and hepatotoxicity of subanesthetic halothane in the guinea pig. Hepatology 14:A 451, 1991.
267. Brown AP, Hastings KL, and Gandolfi AJ. An in vitro model for hepatocyte secretion of halothane derived liver protein neoantigens. Foundation for Immunotoxicology, Sixth Annual Symposium, Virginia Beach, VA, October 1991.
268. Lerman J, Kleinman S, Yentis S, Sikich N, Ghantous H, and Gandolfi AJ. Plasma inorganic fluoride concentration in children anesthetized with sevoflurane. International Anes Research Society, 1991.
269. Sanuik JT, Fisher R, Carter SJ, Gandolfi AJ, and Brendel K. Cold- and cryo-preservation of dog liver and kidney slices. Toxicologist 12:A1433, 1992.
270. Carter SJ, Fisher RL, Sanuik JT, Hanzlik RP, Gandolfi AJ, and Brendel K. A comparison between rat liver slices, hepatocytes and the whole animal. Toxicologist 12:A1448, 1992.
271. Church LT, Wishnies SM, Gandolfi AJ, and Brendel K. Cold preservation of biotransformation activity in dog liver slices. Toxicologist 12:A1432, 1992.
272. Wishnies SM, Gandolfi AJ, and Brendel K. Co-culture of rabbit cortical kidney slices and liver slices: Phenacetin toxicity. Toxicologist 12:A287, 1992.
273. Parrish AR, Dorr RT, Gandolfi AJ, and Brendel K. The precision-cut adult human and rat heart slices: A model for doxorubicin and mitoxantrone cardiotoxicity. Toxicologist 12:A1507, 1992.
274. Hubbard AK and Gandolfi AJ. Reactivity of plasma from methyl dopa treated mice to liver proteins. Toxicologist 12:A642, 1992.
275. Waters SJ, McNeill J, Spaulding TC, Brendel K, and Gandolfi AJ. Rapid uptake and toxicity of M-741 in rat hepatic slices. Toxicologist 12:A1430, 1992.
276. Nowlin CLA, Howells S, Sarid D, and Gandolfi AJ. Examination of mitochondria exposed to 1,2-dimethylhydrazine using atomic force microscopy and other techniques. Toxicologist 12:A993, 1992.
277. Keith RL, Brendel K, Gandolfi AJ, Lowe TP, and Fernando Q. Utilization of precision-cut rabbit renal cortical slices to study the nephrotoxicity of metallic toxicants in chemical waste dumps. Toxicologist 12:A1457, 1992.
278. Lind RC and Gandolfi AJ. Concentration dependent inhibition of halothane biotransformation and covalent binding in the guinea pig. Toxicologist 12:A152, 1992.
279. Clarke JB, Chen ML, and Gandolfi AJ. Effect of chloroquine on the formation of halothane-induced liver antigens in guinea pigs. A tool to investigate immune-mediated toxicity. Toxicologist 12:A79, 1992.
280. Brown AP, Hastings KL, Gandolfi AJ, and Brendel K. Covalent binding of a halothane biotransformation intermediate to a 27 kD cytosolic protein in guinea pig liver slices. Toxicologist 12:A80, 1992.
281. Hastings KL, Brown AP, Liebler DC, and Gandolfi AJ. Biotransformation of halothane to an oxidative intermediate that covalently binds cytosolic protein in an in vitro microsomal/cytosolic incubation system. Toxicologist 12:A963, 1992.
282. Sheevers HV, Wunz TM, Wunz TP, Wright SH, Brendel K, and Gandolfi AJ. Nephrotoxicity of quinolinium and pyridinium compounds in precision-cut rabbit renal cortical slices. Toxicologist 12:A286, 1992.
283. McGuinness SJ, Rankin DR, Gandolfi AJ, and Brendel K. Investigation of the nephrotoxicity of ellipticine and several derivatives in in vitro renal systems. Toxicologist 12:A288, 1992.
284. Mata E, Ghantous H, Fernando J, Gandolfi AJ, and Brendel K. Chronology of toxic events produced by halothane in guinea pig liver slices. Toxicologist 12:A1429, 1992.
285. Ghantous H, Mata E, Morgan S, Gandolfi AJ, and Brendel K. Effect of volatile anesthetics on guinea pig liver slices from livers preserved in University of Wisconsin solvent. Toxicologist 12:A1428, 1992.
286. Lind RC, Gandolfi AJ, and Hall PM. An animal model for fatal halothane hepatitis. VI International Congress of Toxicology, Rome, Italy, 1992.
287. Gandolfi AJ. In vitro approaches to nephrotoxicity studies. VI International Congress of Toxicology, Rome, Italy, 1992.
288. Lind RC, Gandolfi AJ, and Hall PM. A model for fatal halothane hepatitis in guinea pigs. Hepatology 16:161A, 1992.
289. Sheevers HV, Brendel K, and Gandolfi AJ. Transport of l-benzyl quinolinium in rabbit renal cortical slices and proximal tubule suspensions. MW SOT, Utah State University, Logan, Utah, September 1992.
290. Michaud JP, Gandolfi AJ, and Brendel K. Assessment of toxic interactions; Synergy of BrCCl3 and HCCl3 in rat liver slices. MWSOT, Utah State University, Logan, Utah, September 1992.
291. Clarke JB, Chen ML, Thomas C, and Gandolfi AJ. Enflurane produces cytosolic and microsomal liver adducts in the guinea pig crossreactive with halothane induced antibodies. Toxicologist 13:359, 1993.
292. Sheevers HV, Wright SH, Brendel K, and Gandolfi AJ. Toxicity and transport of l-benzyl quinolinium in rabbit renal cortical slices and proximal tubule suspensions. Toxicologist 13:207, 1993.
293. Keith RL, McGuinness SJ, Lowe TP, Chen Q, Fernando Q, and Gandolfi AJ. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Toxicologist 13:208, 1993.
294. Brown AP and Gandolfi AJ. Glutathione-S-transferase is covalently modified in the guinea pig liver following an in vivo exposure to halothane. Toxicologist 13:112, 1993.
295. McGuinness SJ, Rankin DR, Bezrutczyk P, Brendel K, and Gandolfi AJ. Nephrotoxicity and transport of celiptium in rabbit renal slices and isolated proximal tubules in suspension. Toxicologist 13:208, 1993.
296. Lind RC, Gandolfi AJ, and Hall PM. A guinea pig model for fatal halothane hepatitis. Toxicologist 13:31, 1993.
297. Gandolfi AJ, Ijomah P, and Brendel K. Microscopic evaluation of mercuric chloride nephrotoxicity in rabbit renal cortical slices. Toxicologist 13:208, 1993.
298. Burton C, Hatlelid K, Devine K, Fernando Q, Carter DE, Brendel K, and Gandolfi AJ. Effects of glutathione on HgCl2 and NaAsO2 toxicity and uptake in rabbit renal cortical slices. Toxicologist 13:190, 1993.
299. Hasal KS, Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Prolonged culture of liver slices. Toxicologist 13:137, 1993.
300. Hasal SJ, Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Rainbow trout liver slices: A tool for aquatic toxicology. Toxicologist 13:185, 1993.
301. Sanuik JT, Fisher RL, Hasal SJ, Gandolfi AJ, Krumdieck CL, and Brendel K. Roller culture conditions and slice diameter effect the viability of rat and mouse liver slices. Toxicologist 13:137, 1993.
302. Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Quality of human liver tissue effects cold- and cryo- preservation of slices. Toxicologist 13:130, 1993.
303. Brendel K, Fisher RL, Sanuik JT, Hasal SJ, Michaud JP, and Gandolfi AJ. Interactive hepatotoxicity in the binary system Hg++ - Halobenzenes using rat liver slices. Toxicologist 13:436, 1993.
304. Michaud JP, Gandolfi AJ, and Brendel K. Assessment of toxic interactions: Deviation from additivity by combinations of organohalides in rat liver slices. Toxicologist 13:339, 1993.
305. Ziegler TL, Winter SM, Sell R, Gandolfi AJ, and Sipes IG. Metabolism of acrylic acid in Sprague-Dawley rat liver and kidney slices. Toxicologist 13:138, 1993.
306. Burton C, Hatlelid K, Divine K, Fernando Q, Carter DE, Brendel K, and Gandolfi AJ. Glutathione effects on toxicity and uptake of HgCl2 and NaAsO2 in rabbit renal cortical slices. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
307. Keith RL, McGuinness SJ, Lowe TP, Chen Q, Fernando Q, and Gandolfi AJ. Uptake and accumulation of metals in rabbit renal cortical slices: Metal interaction studies. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
308. Hasal SJ, Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Trout liver slices as a tool for aquatic toxicology. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
309. Michaud JP, Gandolfi AJ, and Brendel K. Comparison of the microtox assay and rat liver slice culture for the study of interactive toxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
310. Michaud JP, Gandolfi AJ, and Brendel K. Validation of precision cut liver slice culture for the study of interactive hepatotoxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
311. Michaud JP, Gandolfi AJ, and Brendel K. Mathematical modeling and experimental designs for the study of interactive toxicity. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
312. Fisher RL, Hasal SJ, Sanuik JT, Michaud JP, Gandolfi AJ, and Brendel K. Interactive hepatotoxicity in the binary system Hg++ - Halobenzenes using rat liver slices. Joint U.S.-Mexico Conference, "Fate, Transport, and Interactions of Metals", Tucson, Arizona, April 13-16, 1993.
313. Payne AK, Morgan SE, and Gandolfi AJ. Biotransformation of sevoflurane in male Sprague Dawley rat liver slices. ISSX, Tucson, October, 1993.
314. Sell R and Gandolfi AJ. Use of precision cut rat liver slices for the biochemical assessment of liver preservation conditions. Hepatology, 18:322A, 1993.
315. Fisher RL, Hasal SJ, Gandolfi AJ, and Brendel K. Quality of human liver tissue affects the metabolism of isomeric dichlorobenzenes. ISSX, Tucson, October, 1993.
316. Fisher RL, Hasal SJ, Sipes IG, Gandolfi AJ, and Brendel K. Differences in dichlorobenzene metabolism and toxicity between Sprague-Dawley, Fischer 344 and human liver slices. ISSX, Tucson, October, 1993.
317. Keith RL, Ingersoll RT, Setiarahardjo I, Fernando Q, Aposhian VH, and Gandolfi AJ. Use of renal slices to evaluate chelators on the removal of Hg from the kidney. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.
318. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Induction of stress protein synthesis in precision-cut rat liver slices. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.
319. Sell R, Brendel K, and Gandolfi AJ. Precision cut rat liver slices: A model for the study of cold preservation injury. Mountain West Society of Toxicology, University of Arizona, Tucson, October, 1993.
320. Gandolfi AJ and Brendel K. Identification of cellular targets of toxicity in tissue slices using biochemical and microscopic techniques. World Congress on Alternatives, Baltimore, MD. In Vitro Tox 7:148, 1994.
321. Brendel K, Fisher RL, Hasal SJ, Sanuik JT, and Gandolfi AJ. Quality of human liver tissue affects scientific results. World Congress on Alternatives, Baltimore, MD, November, 1993.
322. Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, and Brendel K. Cold- and cryo- preservation of human liver and kidney slices. World Congress on Alternatives, Baltimore, MD, November, 1993.
323. Fisher RL, Hasal SJ, Jenkins PL, Shaughnessy RP, Roth GL, Gandolfi AJ, and Brendel K. Effect of cold- and cryo- preservation on warfarin metabolism in liver slices. Toxicologist 14:33, 1994.
324. Brendel K, Fisher RL, Hasal SJ, Shaughnessy RP, Roth GL, Jenkins PL, and Gandolfi AJ. Cold and cryopreservation sensitizes liver slices to chemical induced toxicity. Toxicologist 14:398, 1994.
325. Mata HP, Sameshima T, Gandolfi AJ, and Malan TP. Effect of P450 inducers on sevoflurane metabolism in rat liver slices. Toxicologist 14:190, 1994.
326. Lind RC, Gandolfi AJ, and Hall PM. HCFC-123 hepatotoxicity in guinea pigs; potentiation by glutathione depletion. Toxicologist 14:279, 1994.
327. Clarke JB, Chen M, and Gandolfi AJ. Characterization of the antibody response to halothane. Implication for animal models. Toxicologist 14:406, 1994.
328. Keith RL, Ingersoll RT, Setiarahardjo I, Fernando Q, Aposhian VH, and Gandolfi AJ. Evaluation of chelators for the removal of Hg from renal cortical slices. Toxicologist 14:69, 1994.
329. Payne AK, Morgan SE, Gandolfi AJ, and Brendel K. Biotransformation of sevoflurane by liver slices from Sprague Dawley neonates. Toxicologist 14:434, 1994.
330. Sheevers HV, Wright SH, Brendel K, and Gandolfi AJ. Nephrotoxicity and uptake of l-benzyl quinolinium in rabbit renal proximal tubule and mitochondrial suspensions. Toxicologist 14:70, 1994.
331. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Arsenite and heat-shock induce stress proteins in precision-cut rat liver slices. Toxicologist 14:32, 1994.
332. Waters SJ, McNeill J, Brendel K, and Gandolfi AJ. Prolonged in vivo liver retention and hepatocellular uptake of M-741 in rat hepatic slices. Toxicologist 14:32, 1994.
333. Sell R, Brendel K, and Gandolfi AJ. An in vitro model utilizing precision-cut rat liver slices for the study of cold preservation injury. XII International Congress of Pharmacology, Montreal, Canada, July, 1994.
334. Furst SM, Leudke D, and Gandolfi AJ. Sensitization of the immune system by trifluoroacetylated (TFA) proteins and Kupffer cells in halothane exposed guinea pigs. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.
335. Chen ML and Gandolfi AJ. Characterization of the humoral immune response and hepatotoxicity after multiple-halothane exposures at 40 day-interval in guinea pigs. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.
336. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Micro-proton induced x-ray emission (:-PIXE) methodology for metals analysis. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.
337. Hasal SJ, Aposhian VH, Gandolfi AJ, and Brendel K. Human and rabbit renal cortical slices as a model to evaluate heavy metal chelators. Mountain West Society of Toxicology, Inhalation Toxicology Research Institute, Kirkland Air Force Base, Albuquerque, NM, September, 1994.
338. Furst SM and Gandolfi AJ. Enhanced lymphocyte adhesion to Kupffer cells co-cultured with trifluoroacetylated (TFA) protein. Toxicologist 15:102, 1995.
339. Leudke DL, Furst SM, and Gandolfi AJ. Trifluoroacetylated (TFA) proteins and Kupffer cells sensitize the immune system in halothane exposed guinea pigs. Toxicologist 15:102, 1995.
340. Gandolfi AJ, Furst SM, and Leudke DL. Kupffer cells from halothane exposed guinea pigs carry trifluoroacetylated (TFA) protein adducts. Toxicologist 15:149, 1995.
341. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Use of micro-proton induced x-ray emission (:PiXE) for heavy metal analysis. Toxicologist 15:106, 1995.
342. Lind RC and Gandolfi AJ. Late protective effect of dimethyl sulfoxide in the guinea pig model of halothane hepatotoxicity. Toxicologist 15:218, 1995.
343. Wijeweera JB, Kies P, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A pretreatment potentiates vinylidene chloride-induced liver damage in precision-cut rat liver slices. Toxicologist 15:286, 1995.
344. Groves CE, Morales MN, Rankin DR, and Gandolfi AJ. Organic ion toxicants disrupt organic ion transport in rabbit renal proximal tubule (RPT) suspensions. Toxicologist 15:297, 1995.
345. Thomas CM, Wijeweera JB, Gandolfi AJ, and Brendel K. Carbon tetrachloride induces stress protein synthesis in precision-cut rat liver slices. Toxicologist 15:50, 1995.
346. Chen ML and Gandolfi AJ. Humoral immune response and hepatotoxicity after multiple-halothane exposures in guinea pigs. Toxicologist 15:102, 1995.
347. Leavitt JA, McIntyre, Jr. LC, Ashbaugh MD, Cox RP, Keith RL, Gandolfi AJ, and Fernando Q. The nuclear microprobe at the University of Arizona. 12th International Conference on Ion Beam Analysis, May 1995.
348. Furst SM, Leudke D, and Gandolfi AJ. Cellular immune system involvement in halothane 0induced hepatotoxicity. International Congress of Toxicology -VII, Seattle, July 2, 1995.
349. Jenkins PL, Fisher RL, Fisher Jr. FJ, Shaughnessy RP, Gandolfi AJ, and Brendel K. Long-term incubation of rat and human liver slices: A study with enalapril maleate. Toxicologist 15:286, 1995.
350. Fisher RL, Shaughnessy RP, Jenkins PL, Austin ML, and Roth GL. Dynamic organ culture is superior to multiwell plate culturing systems for maintaining liver slice viability. Toxicologist 15:108, 1995.
351. Hasal SJ, Aposhian VH, Gandolfi AJ, and Brendel K. Human and rabbit renal cortical slices in aerated submersion culture as a model to evaluate heavy metal chelators. Toxicologist 15:310, 1995.
352. Furst SM, Luedke D, and Gandolfi AJ. Halothane exposed guinea pigs exhibit a cellular immune response to trifluoroacetylated (TFA)-proteins and Kupffer cells. Anesthesiology 83:A341, 1995.
353. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late protective action in the guinea pig model of halothane hepatotoxicity. Anesthesiology 83:A346, 1995.
354. Gandolfi AJ. Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Society of Toxicologic Pathologist, 14th International Symposium, June 11, 1995.
355. Lind RC and Gandolfi AJ. Late protection against chemical induced liver injury with dimethyl sulfoxide. Hepatology 22:379A, 1995.
356. Hoivik DJ, Manautou JE, Khairallah EA, Fisher RL, Brendel K, Gandolfi AJ, and Cohen SD. Characterization of acetaminophen induced toxicity in mouse kidney slices. The International Toxicologist, 12-PD-3, July 2-6, 1995.
357. Chen ML and Gandolfi AJ. Effect of pre-existing anti-TFA antibodies on the humoral immune response and hepatotoxicity after subsequent halothane exposure. Toxicologist 30:293, 1996.
358. Furst SM and Gandolfi AJ. Cellular immune mediation of halothane induced hepatotoxicity. Toxicologist 30:63, 1996.
359. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Assessment of heavy metal accumulation in renal tissue using micro-proton induced x-ray emission (:-PIXE). Toxicologist 30:258, 1996.
360. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late hepatoprotective effect against chloroform and bromobenzene induced liver injury in the rat. Toxicologist 30:293, 1996.
361. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Toxicologist 30:126, 1996.
362. Wei H, Divine KK, and Gandolfi AJ. Uptake and toxicity of HgCl2 and synthesized Hg(SG)2 and Hg(CYS)2 in isolated rabbit renal proximal tubule suspensions. Toxicologist 30:129, 1996.
363. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A (VA) potentiation of vinylidene chloride (VDC) toxicity in precision-cut rat liver slices. Toxicologist 30:124, 1996.
364. Fisher RL, Hasal SJ, Ulreich JB, Nakazato PZ, Bhattacharyya AK, Le T, Gandolfi AJ, and Brendel K. Rat and dog liver slice viability in surface and submersion culture. Toxicologist 30:255, 1996.
365. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K. Liver/kidney slice co-incubation: A model for interactive organ toxicity. Toxicologist 30:307, 1996.
366. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Robert S. Flinn Foundation Biomedical Research Initiative Symposium, Scottsdale, AZ, May 3, 1996.
367. Keith RL, Gandolfi AJ, McIntyre, LC, Ashbaugh MD, Qiu L, Lott JR, and Fernando Q. Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue. Intern Conf Nuclear Microprobe Technology and Applications, Santa Fe, NM, Nov. 10-15, 1996.
368. Lind RC and Gandolfi AJ. Dimethyl sulfoxide has a late hepatoprotective effect against chloroform and bromobenzene induced liver injury in the rat. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
369. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K. Vitamin A (VA) potentiation of vinylidene chloride (VDC) toxicity in precision-cut liver slices. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
370. Chen ML and Gandolfi AJ. Effect of pre-existing anti-TFA antibodies on the humoral immune response and hepatotoxicity after subsequent halothane exposure. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
371. Duffy S, Lind RC, and Gandolfi AJ. Halothane liver protein adducts in responsive (halothane hepatitis) and non-responsive guinea pigs. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
372. Furst SM and Gandolfi AJ. Cellular immune mediation of halothane induced hepatotoxicity. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
373. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K. Liver/kidney slice co-incubation: A model for interactive organ toxicity. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
374. Keith RL, Leavitt JA, McIntyre LC, Fernando Q, and Gandolfi AJ. Assessment of heavy metal accumulation in renal tissue using micro-proton induced x-ray emission (:-PIXE). Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
375. Morgan SE, Frink EJ, Nogami WM, Salmon RS, and Escobar C. Production of carbon monoxide and carboxyhemoglobin during desflurane, enflurane, isoflurane, and sevoflurane anesthesia. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
376. Wei HB, Divine KK, and Gandolfi AJ. Uptake and toxicity of HGCl2 and synthesized Hg(SG)2 and Hg(CYS) 2 in isolated rabbit renal proximal tubule suspensions. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
377. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Evaluation of rat liver slices with fluorescence confocal microscopy. Second Annual Science Fair, Center for Toxicology, University of Arizona, May 13, 1996.
378. Gandolfi AJ and Lind RC. Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene. Mountain West Society of Toxicology, Salt Lake City, October 2-4, 1996.
379. Lind RC and Gandolfi AJ. Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene. NIEHS Center Director's meeting, Tucson, AZ, Dec. 9, 1996.
380. Hasal SJ, Gandolfi AJ, Brendel K. Sequential incubation of chlorotrifluoroethylene in rat liver and kidney slices. NIEHS Center Director's meeting, Tucson, AZ, Dec. 9, 1996.
381. Fisher RL, Hasal SJ, Gandolfi AJ, and Brendel K. Importance of optimizing human and animal tissue slice culture for biotransformation and toxicity studies. Toxicologist 36:55, 1997.
382. Hasal SJ, Gandolfi AJ, and Brendel K. Sequential incubation of chlorotrifluoroethylene in rat liver and kidney slices. Toxicologist 36:56, 1997.
383. Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, and Gandolfi AJ. Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission (µ-PIXE). Toxicologist 36:185, 1997.
384. Lind RC and Gandolfi AJ. Hepatoprotection resulting from administration of dimethyl sulfoxide twenty-four hours after chloroform or bromobenzene. Toxicologist 36:319, 1997.
385. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Localization of heat shock protein 70 in rat liver slices with fluorescence confocal microscopy. Toxicologist 36:56, 1997.
386. Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC,
Fernando Q, and Gandolfi AJ. Accumulation of HgCl2 and three
synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule
suspensions. Toxicologist 36:185, 1997.
387. Wijeweera JB, Zeng X-H, Gandolfi AJ, and Brendel K.
Stress protein expression by drinking water contaminants vinylidene
chloride and chloroacetic acids in precision-cut rat liver.
Toxicologist 36:320, 1997.
388. Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, and Gandolfi AJ. Accumulation of HgCl2 and three synthesized Hg-S-conjugates in islolated rabbit renal proximal tubule suspensions. NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.
389. Keith RL, McIntyre LC, Ashbaugh MD, Fernando Q, Gandolfi AJ. Characterization of heavy metal deposition in rabbit renal tissue using micro-proton induced x-ray emission (µ-PIXE). NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.
390. Qiu L, Lott JR, Fernando Q, Ashbaugh MD, McIntyre LC, Keith RL, Wei H, and Gandolfi AJ. The PIXE and micro-PIXE facility at the University of Arizona. NIEHS Superfund 10th Anniversary Meeting, Feb. 23-26, 1997, North Carolina.
391. Wei H, Qiu L, Divine KK, Ashbaugh MD, McIntyre LC, Fernando Q, Gandolfi AJ. Accumulation of HgCl2 and three synthesized Hg-S-conjugates in isolated rabbit renal proximal tubule suspensions. TCE-Mini Conference, University of Arizona, Superfund, Feb. 28, 1997.
392. Parrish AR, Bral CM, Ramos KS, Fisher RL, Brendel K, and Gandolfi AJ. Alterations in growth-related gene expression and signaling in precision-cut adult rat liver slices by benzo(A)pyrene. Third Robert S. Flinn Foundation Biomedical Research Symposium, Tucson, AZ, May 9, 1997.
393. Payne AK, Cromey DW, Lantz RC, Gandolfi AJ, and Brendel K. Localization of heat shock protein 70 in rat liver slices with fluorescence confocal microscopy. Third Robert S. Flinn Foundation Biomedical Research Symposium, Tucson, AZ, May 9, 1997.
394. Wijeweera JB, Zheng XH, and Gandolfi AJ. Interactive toxicity of MCA and VDC in precision-cut rat liver slices. Current Issues in Chemical Mixtures Conference. Colorado State University , Ft. Collins, CO, August 12, 1997.
395. Parrish AR, Ramos KS, Brendel K, and Gandolfi AJ. Precision-cut liver slices: Investigation of the molecular response to toxicants. Society of Toxicology, March 1998.
396. Lind RC and Gandolfi AJ. Dimethyl sulfoxide and diallyl sulfide are hepatoprotective when administered twenty-four hours after chloroform. Hepatology 26:341A, 1997.
397. Parrish AR, Catania JM, Mason DE, and Gandolfi AJ. Chemically-induced oxidative stress interferes with post-translational modification of the E-cadherin/catenin complex. Toxicologist 31:1998.
398. Catania JM, Parrish AR, and Gandolfi AJ. Hypoxia causes a dissociation of cell adhesion proteins via an alteration in -catenin phosphorylation. Toxicologist 31:1998.
399. Turney KD, Parrish AR, and Gandolfi AJ. Changes in AP-1 and c-jun expressoin in precision-cut rabbit renal cortical slices following exposure to Hg(II). Toxicologist 31: 1998.
400. Zheng X-H, Younis H, Turney KD, Parrish AR, and Gandolfi AJ. Molecular alterations in renal cortical slices following exposure to sub-toxic levels of arsenite. Toxicologist 31: 1998.
401. Hasal SJ, Fisher RL, Gandolfi AJ, and Brendel K. The biosynthesis of S-(2-chloro-1,1,2-trifluoroethyl)glutathione in rat liver slices and its consecutive turnover in rat renal cortical slices. Toxicologist 31: 1998.
402. Catania JM, Parrish AR, and Gandolfi AJ. Hypoxia causes a dissociation of cell adhesion proteins via an alteration in protein phosphorylation. Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.
403. Lind RC, Begay CK, and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide and diallyl sulfide when administered twenty-four hours after chloroform. Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.
404. Parrish AR, Zheng XH, Younis H, Turney KD, and Gandolfi AJ. Alterations in c-jun gene expression following arsenite exposure in renal cortical slices. Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.
405. Turney KD, Parrish AR, and Gandolfi AJ. Changes in AP and c-jun expression in precision-cut rabbit renal cortical slices following exposure to Hg(II). Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.
406. Wijeweera JB, Zheng XH, and Gandolfi AJ. Stress protein expression by precision-cut rat liver slices exposed to non cytotoxic concentrations of MCA and DVC. Third Annual Science Fair, Center For Toxicology, University of Arizona, October 13, 1997.
407. Turney KD, Parrish AR, and Gandolfi AJ. Increased AP-1 and c-jun in renal slices following exposure to Hg(II). Superfund Metals Symposium, Tucson, AZ, January 8-9, 1998.
408. Zheng X-H, Younis, H, Turney KD, Parrish AR, and Gandolfi AJ. Molecular alterations in renal slices following arsenite exposure. Superfund Metals Symposium, Tucson, AZ, January 8-9, 1998.
409. Pena CE, Gandolfi AJ, and Carter DE. Outreach to Mexico on environmental health issues. 1998 Superfund Basic Research Program Conference, Hitchhikers Guide to Outreach, Boston, MA, March 25, 1998.
410. Gandolfi AJ, Parrish AR, Turney KD, and Zheng XH. Molecular alteration in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V). 1998 Superfund Basic Research Program Conference, Boston, MA, March 23-24, 1998.
411. Chitkara MK, Parrish AR, and Gandolfi AJ. Generation and detection of apoptosis in rat liver slices. MWSOT, Tucson, AZ, September 17-18, 1998.
412. Gandolfi AJ, Nagle RB, Cress A, Dalkin B, and Parrish AR. Use of human prostate slices in toxicity studies. MWSOT, Tucson, AZ, September 17-18, 1998.
413. Ito Y, Begay CK, Lind RC, Gandolfi AJ, and McCuskey RS. Hepatoprotection by dimethyl sulfoxide: effects on hepatic microcirculation when administered 24 hours after chloroform. MWSOT, Tucson, AZ, September 17-18, 1998.
414. Lind RC, Begay CK, and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide and aminobenzotriazole when administered 24 hr after chloroform: role of inhibition of ongoing bioactivation. MWSOT, Tucson, AZ, September 17-18, 1998.
415. Parrish AR and Gandolfi AJ. Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex. MWSOT, Tucson, AZ, September 17-18, 1998.
416. Turney KD, Parrish AR, and Gandolfi AJ. Selective activation of the MAPK pathway in renal tissue by HG(II). MWSOT, Tucson, AZ, September 17-18, 1998.
417. Zheng X-H, Turney KD, Younis H, Parrish AR, and Gandolfi AJ. Arsenite [As(III)] and arsenate [As(V)] enhance DNA binding of the AP-1 and Elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices. MWSOT, Tucson, AZ, September 17-18, 1998.
418. Parrish AR and Gandolfi AJ. Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex. Tox Sci, 48:364, 1999.
419. Zheng XH, Parrish AR, Turney KD,Younis HS, and Gandolfi, AJ. Arsenite [AS(III)] and arsenate [AS(V)] enhance DNA binding of the AP-1 and Elk-1 transcription factors and c-jun and c-fos gene expression in precision-cut renal slices. Tox Sci 48:351, 1999.
420. Ito Y, Lind RC, Begay CK, Gandolfi AJ, and McCuskey RS. Hepatoprotection by dimethylsulfoxide and aminobenzotriazole: comparison of effects on hepatic microcirculation when administered 24 hours after chloroform. Tox Sci 48:191, 1999.
421. Lind RC, Begay CK, and Gandolfi AJ. Hepatoprotection by dimethyl sulfoxide and aminobenzotriazole when administered 24 hr after chloroform: role of inhibition of ongoing bioactivation. Tox Sci 48: 191, 1999.
422. Catania JM, Parrish AR, and Gandolfi AJ. Toxicity of a sevoflurane degradation product to rat liver and renal cortical slices. Tox Sci 48:28, 1999.
423. Chitkara MK, Petrick JS, Parrish AR, and Gandolfi AJ. Generation and detection of apoptosis in rat liver slices. Tox Sci 48:90, 1999.
424. Nagle RB, Cress A, Dalkin B, Parrish AR, and Gandolfi AJ. Establishment of precision-cut human prostate slices as an in vitro toxicology model. Tox Sci 48:71, 1999.
425. Cromey D, Lantz RC, Rocha C, Parrish AR, and Gandolfi AJ. Live time evaluation of cell toxicity in precision-cut tissue slices using confocal microscopy. Tox Sci 48:71, 1999.
426. Begay CK, Lind RC, Zheng XH, and Gandolfi AJ. Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure. Tox Sci 48:316, 1999.
427. Turney KD, Parrish AR, and Gandolfi AJ. Selective activation within the MAPK pathway by HG(II). Tox Sci 48:331, 1999.
428. Parrish AR, Catania JM, and Gandolfi AJ. Disruption of the E-cadherin/catenin complex by oxidative stress correlates with phosphorylation of tyrosine but not serine. Tox Sci 48:162, 1999.
429. Catania JM, Parrish AR, and Gandolfi AJ. Toxicity of a sevoflurane degradation product to rat liver and renal cortical Slices. First Annual College of Pharmacy Student Showcase, April 8, 1999.
430. Lantz RC, Orozco J, Cromey D, Rocha C, Parrish AR, and Gandolfi AJ. Live-time evaluation of cell toxicity in precision-cut tissue slices using confocal microscopy. NIH Biomedical Imaging Symposium, Bethesda, MD, June 26-26, 1999.
431. Schmelz M, Sallam K, Parrish AR, Gandolfi AJ, Jones JCR, and Nagle RB. Adhesion molecule rearrangement in human prostate organ culture. ASCB, December 1999.
432. Schmelz M, Barrera J, Sallam K, Weyer C, Clark V, McDaniel K, Gandolfi AJ, Parrish AR,Weinstein R, and Nagle RB. Human prostate organ culture as a model of adhesion molecule rearrangement. Arizona Cancer Center Science Fair, June 1999.
433. Henriquez X, Wilson CL, Zheng X-H, Gandolfi AJ, and Parrish AR. Differential gene expression in rabbit renal cortical slices exposed to sodium arsenite. Gulf Coast Regional Chapter Meeting, November 20, 1999.
434. Orozco J, Parrish AR, Schmelz M, Nagle RB, and Gandolfi AJ. Optimization and characterization of precision-cut prostate slices as a tool for toxicological studies. Tox Sci 54:A1768, 2000.
435. Kirkpatrick DS, Catania JM, Bautista FM, Parrish AR, and Gandolfi AJ. Alterations in the ubiquitin-dependent proteolytic pathway caused by low-level arsenite exposure in rabbit renal cortical slices. Tox Sci 54:A1321, 2000.
436. Orozco J, Lantz RC , Cromey DE, and Gandolfi AJ. Evaluation of live precision-cut tissue slices using multiple indicatiors of cellular injury via a confocal microscopic technique. Tox Sci 54:A1767, 2000.
437. Zheng XH, Wilson CL, Parrish AR, and Gandolfi AJ. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds. Tox Sci 54:A1832, 2000.
438. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Tox Sci 54:A1769, 2000.
439. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Western Pharmacology Society, January 2000, Tucson, AZ.
440. Kirkpatrick DS, Catania JM, and Gandolfi AJ. Increased ubiquitin-conjugated proteins following low-level arsenite exposure. Fourth International Conference on Arsenic Exposure, San Diego, CA, June 2000.
441. Zheng XH, Gandolfi AJ, Wilson CL, and Parrish AR. Analysis of differential expressed genes in rabbit renal cortical slices exposed to arsenic compounds. Fourth International Conference on Arsenic Exposure, San Diego, CA, June 2000.
442. Kirkpatrick DS, Catania JM, Bautista FM, Parrish AR, and Gandolfi AJ. Alterations in the ubiquitin-dependent proteolytic pathway caused by low-level arsenite exposure in rabbit renal cortical slices. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.
443. Zheng XH, Wilson CL, Parrish AR, and Gandolfi AJ. Differential gene expression in rabbit renal cortical slices exposed to arsenic compounds. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.
444. Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Rincon M, Henderson CJ, Brendel K, and Gandolfi AJ. Precision-cut tissue slices from transgenic mice as an in vitro toxicology system. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.
445. Begay CK and Gandolfi AJ. Eicosanoids Levels During Chloroform Induced Injury. I. Effects of Hepatoprotectants, DMSO and Aminobenzotriazole. Annual Science Fair, Center For Toxicology, University of Arizona, May 2000.
446. Begay CK and Gandolfi AJ. The effects of hepatoprotectants, DMSO and aminobenzotriazole and cyclooxygenase and lipoxygenase inhibitors on eicosanoids levels during chloroform induced injury. SACNAS, Atlanta, GA, October 10-15, 2000.
447. Kirkpatrick DS, Catania JM, Dale KV, and Gandolfi AJ. Low-level arsenite does not affect the ubiquitin conjugating activity of rabbit renal slices or human embryonic kidney cells. Tox Sci 60:364, 2001.
448. Begay CK and Gandolfi AJ. The effects of hepatoprotectants on eicosanoid levels during chloroform-induced hepatic injury. Tox Sci 60:1664, 2001.
449. Carranza Rosales P, Kirkpatrick DS, Said Fernandez S, and Gandolfi AJ. DMPS effect on cellular stress response in OK cells exposed to HgCl2 and NaAsO2. Tox Sci 60:1490, 2001.
450. Zheng XH and Gandolfi AJ. Up-regulation of P68 and GDI in rabbit renal cortical slices exposed to low level arsenic. Tox Sci 60:1494, 2001.
451. Kirkpatrick DS and Gandolfi AJ. Low-level arsenite does not affect the ubiquitin conjugating activity of rabbit renal slices. Superfund Basic Research Program Annual Meeting, University of North Carolina, December 12-14, 2000.
452. Gandolfi AJ. Hazardous Waste Risk and Remediation in the Southwest. Superfund Basic Research Program Annual Meeting, University of North Carolina, December 12-14, 2000.
453. Begay CK and Gandolfi AJ. The effects of hepatoprotectants, DMSO and aminobenzotriazole and cyclooxygenase and lipoxygenase inhibitors on eicosanoids levels during chloroform induced injury. MGE@MSA, Arizona State University, Tempe, AZ, January 12, 2001.
454. Gandolfi AJ and Brendel K. Development of precision-cut tissueslices as an in vitro model for pharmacological, toxicological, and biotransformation studies. J.H. CAAT 20th Anniversary Symposium, Baltimore, MD, September 10-12, 2001.
455. Kremer C, Thomas T, Dalkin B, Gandolfi AJ, and Nagle R. Effects of androgen stimulation on organ cultures of human prostate. AACR 2002 93rd Annual Meeting, San Francisco, CA, April 6-10, 2002.
456. Kirkpatrick DS, Dale KV, Liebler DC, and Gandolfi AJ. Identification of ubiquitin-conjugated proteins using lc-ms techniques: potential molecular indicators of toxic insults. Symposium on Gene Expression, Bethesda, MD, December 2-4, 2001.
457. Gandolfi AJ. Hazardous Waste Risk and Remediation in the Southwest. Superfund Basic Research Program Annual Meeting, Gainesville, FL, December 9-12, 2001.
458. Peraza MA, Kopplin MJ, Carter DE, and Gandolfi AJ. Inorganic arsenic biotransformation and mitochondrial toxicity in HK-2 human proximal tubular cells. Toxicologist 66: Abstract 403, 2002.
459. Kirkpatrick DS, Dale KV, Liebler DC, and Gandolfi AJ. Identification of ubiquitin-conjugated proteins using lc-ms techniques: potential molecular indicators of toxic insults. Toxicologist 66: Abstract 1083, 2002.
460. Dale KV, Kirkpatrick DS, and Gandolfi AJ. Effects of low-level arsenic exposure in the cortex of rabbit kidney. Fifteenth Annual Undergraduate Research Forum, University of Arizona, February 13, 2002.
461. Begay CK and Gandolfi AJ. Late administration of Cox-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. MGE@MSA, Phoenix, AZ, March, 2002.
462. Zheng XH, Watts G, Vaught S, and Gandolfi AJ. Low-level exposure to arsenite alters gene expression in HEK 293 cells. International Arsenic Meetings, San Diego, 2002.
463. Kirkpatrick DS, Weldon SF, and Gandolfi AJ. Ni-NTA Purification of Ub-Modified Proteins from His(6X)-Ub-GFP Cells: Implications for the Identification of Protein Targets of As (III). Superfund Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.
464. Peraza MA, Carter DE, and Gandolfi AJ. Subcytotoxic inorganic arsenic affects mitochondria in HK-2 human proximal tubular cells: potential for apoptotic cell death. Superfund Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.
465. Zheng XH, Watts G, Vaught S, and Gandolfi AJ. Differential expressed of genes in HEK293 cells exposed to arsenite. Superfund Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.
466. Meza MM, Kopplin MJ, and Gandolfi AJ. Drinking water arsenic concentrations in Sonora, Mexico. Superfund Basic Research Program Annual Meeting, Tucson, AZ, November 3-6, 2002.
467. Begay CK and Gandolfi AJ. Late administration of Cox-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. NM-AGEP Conference, Albuquerque, NM, September 19-21, 2002.
468. Sierra-Alvarez R, Field JA, Cortinas I, Kopplin MJ, and Gandolfi AJ. Microbial reduction and mobilization of arsenate under landfill conditions. The Seventh International Symposium on In Situ and On-Site Bioremediation, Orlando, FL, June 2-5, 2003.
469. Begay CK and Gandolfi AJ. Late administration of Cox-2
inhibitors minimize hepatic necrosis in chloroform induced liver
injury. Tox Sci 72 (S1):964, 2003.
470. Kirkpatrick DS, Vaillancourt RR, Derbyshire ZE, and Gandolfi
AJ. Increased Ubiquination of the kindase TAK1 following as (III)
exposure in HEK293 Cells. Tox Sci 72 (S1):1305, 2003.
471. Peraza MA, Carter DE, and Gandolfi AJ. Subcytotoxic inorganic
arsenic affects mitochondria in HK-2 human proximal tubular cells:
potential for apoptotic cell death. Tox Sci 72 (S1):1743, 2003.
472. Meza MM, Kopplin MJ, and Gandolfi AJ. Arsenic Drinking water
exposure and urinary excretion among adults in the Yaqui Valley,
Sonora, Mexico. Tox Sci 72 (S1):893, 2003.
473. Zheng XH, Watts GS, Vaught SE and Gandolfi AJ. Toxicogenomic
effects of low-level as (III) exposure to human kidney cells. Tox Sci
72 (S1):455, 2003.
474. Catania JM, Fernandez A, and Gandolfi AJ.
Precision-Cut Tissue Chips: A New Toxicology Screen.
SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.
475. Bredfeldt T and Gandolfi AJ. Effects of Arsenite
on Human Urothelial Cells. SWEHSC/Superfund Science Fair, Tucson,
AZ, May 20, 2003.
476. Cortinas I, Field, JA, Sierra-Alvarez R, Gandolfi AJ, and Kopplin
M. Anaerobic Microbial Activity Promotes the Desorption of
Arsenate Sorbed onto Drinking Water Treatment Residuals.
SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.
477. Yenal U, Field JA, Sierra-Alvarez R, Kopplin M, Begay CK, and
Gandolfi AJ. Anaerobic Biodegradation of Organoarsenical
Pesticides, Methylarsonic Acid (MMAV) and Dimethylarsinic Acid
(DMAV). SWEHSC/Superfund Science Fair, Tucson, AZ, May 20, 2003.
478. Catania JM, Fernandez A, and Gandolfi AJ.
Precision-Cut Tissue Chips: A New Toxicology Screen. MWSOT,
Breckenridge, CO, September 18-19, 2003.
479. Bredfeldt T, Kopplin MJ, and Gandolfi AJ. Effects of Arsenite on UROtsa Cells: Low-Level Arsenite Causes Accumulation of Ubiuquitinated Proteins which is Perpetuated by Reduction in Cellular Glutathione Levels. MWSOT, Breckenridge, CO, September 18-19, 2003.
480. Cortinas I, Badilla C, Sierra-Alvarez R, Field JA, Kopplin M, Gandolfi AJ. Microbial Mobilization of Arsenic Sorbed onto Activated Alumina and Granular Ferrihydrite. Quad University Superfund Meeting, University of California, Berkelely, October 2003.524.
Klimecki WT, Meza MM,
Rodriguez YY, Gandolfi AJ. Human genetic polymorphisms:
Biomarkers
of variability in arsenic metabolism. SOT
Annual Meeting, Charlotte NC, 2007.
526. Buffington SE, Eblin KE., Zheng XH, Gandolfi AJ. Chronic exposure to monomethylarsonous acid induces changes in human urotsa cells consistant with urothelial tumorigenesis. 25th Annual MWSOT, Breckenridge, CO, September 6-7, 2007.
Characterization and isolation of a soluble protein that stimulates microsomal dechlorination. Department of Biochemistry and Drug Metabolism, Hoffman-LaRouche, Inc., Nutley, NJ, November 26, 1974.
Biotransformation and toxicity of halogenated volatile anesthetics. Battelle Pacific Northwest Laboratories, Richland, WA, June 1975.
Pulmonary disposition and fibrogenic potential of oil shale dusts. Institute of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH, July 18, 1977.
Response of rats to intratracheally administered oil shale. Toxicology Program, University of Arizona, Tucson, AZ, December 13, 1977.
Halothane biotransformation: detection, significance, and clinical implications. Department of Anesthesia, Stanford University School of Medicine, Stanford, CA, June 22, 1981.
Biotransformation and toxicity of halogenated vinyl cysteines. Department of Pharmacology, University of Arizona, Tucson, AZ, October 28, 1981.
Model systems to study cell specific toxicity of the kidney. Smith, Kline and French Laboratories, Philadelphia PA, November, 1986.
Use of cultured renal tissue explants in toxicology. Proctor and Gamble Company. Miami Valley Laboratories. May 21, 1987.
Model systems to study cell specific toxicity of the kidney. Warner Lambert - Parke/Davis, Ann Arbor, MI, November 16, 1987.
Use of cultured tissue explants in toxicology. Ortho Pharmaceutical Corp., Raritan, NJ, December 3, 1987.
Use of cultured tissue slices in toxicology. Sterling Winthrop Research Institute. Rensselaer, NY, December 15, 1987.
Use of culture tissue explant toxicity studies. University of Kansas, Kansas City, KS, September 15, 1988.
Halothane hepatitis: Clinical perspective. University of North Carolina, Department of Anesthesiology, Chapel Hill, NC, October 26, 1988.
Halothane hepatitis: Clinical correlation - Animal Models. University of North Carolina, Department of Anesthesiology, Chapel Hill, NC, October 27, 1988.
Biotransformation of inhalation anesthetics. Risk and Benefits of Inhalation Anesthetic Agents. Schliersee, Bavaria, November 79, 1988.
Dichlorovinyl cysteine induced cellular injury in rabbit renal cortical slices. Marshall University, Department of Pharmacology, Huntington, WV, November 21, 1988.
Anesthetic hepatotoxicity: Bioactivation or immune response. Rutgers University. Joint Program in Toxicology. March 15, 1989.
Anesthetic hepatotoxicity: Bioactivation or immune response. University of Connecticut, Toxicology Program. April 6, 1989.
Cultured organ slices in toxicology: An alternative to animal testing. University of Connecticut. School of Pharmacy. April 7, 1989
Biotransformation of inhalation anesthetics: Risks and benefits. Department of Anesthesiology, University of Trondheim, Norway, May 1989.
Cultured organ slices in toxicology. An alternative to animal testing. Department of Pharmacology and Toxicology, University of Trondheim, Norway, June 1989.
Biotransformation of inhalation anesthetics: Role in producing toxicity. Anaquest, Murray Hill, NJ, September 14, 1989.
Explaining the University of Arizona's IACUC. Arizona Branch AALAS Fall Symposium. October 13, 1989.
Role of Bioactivation in Chemical-Induced Toxicities. Department of Chemistry, Arizona State University, Tempe, AZ, October 23, 1989.
Role of Bioactivation in Chemical-Induced Toxicities. Department of Chemistry, Northern Arizona University, Flagstaff, AZ, November 3, 1989.
Role of the Immune System in Anesthetic-Induced Liver Injury. Duke University, Integrated Toxicology Program. Durham, NC, December 6, 1989.
Utilizing Precision-Cut Positional Renal Slices for Study of Site-Specific Toxicity. Medical College of Ohio, April 24, 1990.
Role of the immune system in anesthetic-induced liver injury, Eli Lilly, Indianapolis, IN, July 20, 1990.
Volatile anesthetic hepatotoxicity: Bioactivation or immune mediated? University of Mississippi, Jackson, MS, November 19, 1990.
In vivo and in vitro models of volatile anesthetic hepatotoxicity. Cancer Biology Series. Cancer Center, University of Arizona, March 30, 1992.
Precision-cut tissue slices as an in vitro toxicity tool. Environmental Toxicology Seminar. Universidad Nacional Autonoma de Mexico. Mexico City, April 22, 1992.
Volatile halogenated anesthetic hepatotoxicity. ManTech Environmental, Inc. Wright Patterson AFB, September 9, 1992.
Uptake of metals in renal slices. 1992 Superfund Fall Meeting, Tucson, AZ, September 26, 1992.
Halothane hepatotoxicity. Department of Pathology, University of Arizona, November 19, 1992.
Update on the use of tissue slices for in vitro toxicity studies. College of Pharmacy, University of New Mexico, Albuquerque, NM, March 3, 1993.
Biological fate and toxicity of fluorocarbons. 3M Specialty Chemicals Division. St. Paul, MN, July 20, 1994.
Examining idiosyncratic chemical reactions, Proctor & Gamble Co., Cincinnati, OH, November 1, 1994.
Use of renal slices in metal disposition and toxicity studies. Nyco Med, Collegeville, PA, July 14, 1995.
Role of the immune system in anesthetic induced liver injury. Department of Physiology, University of Arizona, Tucson, AZ, September 22, 1995.
Use of confocal microscopy to study toxic events in precision-cut tissue slices. Procter & Gamble Co., Cincinnati, OH, March 27, 1997.
Use of precision-cut tissue slices in pharmacology and toxicology. Colgate-Palmolive Visiting Professorship at Indiana University, March 18, 1998.
Et tu Sevo? Department of Anesthesiology, Univeristy of Arizona, September 16, 1998.
Late DMSO administration provides a protective action against
chemically-induced liver injury. Department of Cellular Biology
and Anatomy, University of Arizona, November 9, 1998.
Slicing and dicing: Making in vitro systems for
biological studies. Biological Chemistry Program.
University of Arizona, March 27, 2003.
Effects of Low Level Exposure to Arsenic on Human Bladder Cells,
Biological Chemistry Program Seminar Series, February 24, 2005.
US-Mexico Binational Center for Environmental Sciences and
Toxicology. CONACyT – Desert Angels Conference, University of
Arizona, May 11, 2005.
Effects of low-level arsenic exposure on human bladder cells and
relationship to human population studies. Sonora Institute of
Technology, C. Obregon, Sonora, Mexico, May 16, 2005.
SBRP – Outreach to Mexico Overview. Sonora Institute of
Technology, C. Obregon, Sonora, Mexico, May 16, 2005.
US-Mexico Binational Center for Environmental Studies and Toxicology. SEMARNAT. Mexico City, July 1, 2005.
New cryopreservation methods for tissue regeneration. Prostate
Cancer Research Program, Arizona Cancer Center, September 14, 2005.
Effects of low-level exposure to arsenic on human bladder
cells. Ohio Valley Society of Toxicology, September 26, 2005
(tele-seminar).
Arsenite and monomethylarsonous acid toxicity to human bladder
cells. Native American Cancer Research Partnership and Programs
in Chemistry and Biology, Northern Arizona University, April 7, 2006.
University of Arizona’s Superfund Basic Research Program and
US-Mexico Binational Center. Department of Health Services, State
of Arizona, Phoenix, April 12, 2006.
University of Arizona’s Superfund Basic Research Program and US-Mexico Binational Center, and Research Instrumentation at the Department of Health Services, State of Arizona. SBRP Colloquium Presentation, May 11, 2006.
Arsenic: Is it Safe? University of Arizona ACS Chemistry Club. October 4, 2006.
Monomethylarsonous acid induces oxidative stress, mitogenic-signal
transduction, and transformation in human bladder cells.
Frontiers in Medical Research, College of Medicine, May 1, 2007.
Symposium Presentations:
Water Users' Retreat, "Toxicity of TCE", Southwest Environmental Service, January 16, 1982.
Future research in anesthetic-induced toxicity. Society of Toxicology, Atlanta, GA, 1984.
Evidence for the role of the immune response in the pathogenesis of halothane hepatitis. Third International Conference on Anesthesia, Calgary, Alberta, Canada, 1984.
Use of isolated renal tubules for the detection and investigation of nephrotoxins. Johns Hopkins Center for Alternatives to Animal Testing, October 24, 1984.
Renal Toxicology: Possible Metabolic Mechanisms. Continuing Education Courses. Society of Toxicology, San Diego, CA,1985.
Alternatives to Animal Research. College of Medicine Forum, National Laboratory Annual Day, April 24, 1986.
In vitro and in vivo toxicology. Symposium IV. Genetic Toxicology: End of an era; Directions for the future. American College of Toxicology, Seventh Annual Meeting, Philadelphia, PA, November, 1986.
Evaluation of isolated rabbit renal tubules and precision-cut renal slices for the detection and investigation of nephrotoxins. Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, MD, March, 1987.
In Vitro Methodology Workshop. Preparation and utilization of positional renal slices. Third International Symposium on Nephrotoxicity. University of Surrey. Guildford, England, August 1987.
In Vitro Systems for Nephrotoxicity Studies. 2nd International Meeting of Practical In Vitro Toxicology, Nottingham, England, July 24, 1989.
Utilization of precision-cut liver slices to profile and rank-order potential hepatotoxins. Industrial In Vitro Toxicology Group. Role of hepatic culture in risk assessment. Bristol-Myers, Wallingford, CT, November 21, 1989.
Biotransformation of inhalation anesthetics. International Anesthesia Symposium Bochum. Inhalation anesthesia-position and trend. University of Bochum, Bochum, West Germany, August 2425, 1990.
Volatile anesthetic hepatotoxicity. Role of the immune system. Mountain West Society of Toxicology, Boulder, CO, September 26, 1991.
In vitro and in vivo models for anesthetic-induced hepatotoxcity. Hepatotoxicity Symposium. Universidad Nacional Autonoma de Mexico. Mexico City, April 23, 1992.
In vitro systems for nephrotoxicity studies. VI International Congress of Toxicology. Rome, Italy, June 30, 1992.
Interactive toxicity of metals in the kidney. Fate, Transport, and Interactions of Metals. Joint USA-Mexico Conference. Tucson, AZ, April 13-16, 1993.
Novel mechanisms of chemically induced hepatotoxicity. Mechanisms of halothane hepatitis. American Society for Pharmacology and Experimental Therapeutics, San Francisco, CA, August, 1993.
Identification of cellular targets of toxicity in tissue slices using biochemical and microscopic techniques. World Congress on Alternatives and Animal Use in Life Sciences, Baltimore, MD, November, 1993.
Toxicity and metabolism of volatile anesthetics. Fluorine in Medicine in the 21st Century. The University of Manchester Institute of Science and Technology, Manchester, UK, April 18-21, 1994.
Metal uptake and toxicology studies in precision-cut renal cortical slices. Centro de Investigacion Biomedica del Noreste, Monterrey, Mexico, May 23-25, 1994.
Use of tissue slices in chemical mixture toxicity and interspecies investigations, Second Annual HERL Symposium, "Chemical Mixtures and Quantitative Risk Assessment", Research Triangle Park, NC, November 9, 1994.
The role of the immune system in halothane hepatotoxicity, immunotoxicity and carcinogenicity of pharmaceuticals, Drug Information Association, Arlington, VA, January 26-27, 1995.
Uptake and toxicity of metals in rabbit renal cortical slices. Second Symposium on the Use of Tissue Slices: In Vitro Models of Toxicity and Biotransformation. SOT Satellite Symposium. Baltimore, MD, March 4, 1995.
Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Society of Toxicological Pathologists, San Diego, CA, June 12, 1995.
Involvement of the immune system in anesthetic induced liver injury. Arkansas Toxicology Symposium, Honoring Gabriel L. Plaa, Ph.D., Little Rock, AR, October 19-20, 1995.
Hepatotoxicity of hydrochlorofluorocarbons. National Research Council, Committee on Toxicology. Workshop on toxicity of alternatives to chlorofluorocarbons. Beckman Center, Irvine, CA, March 7-8, 1996.
Toxic interactions of drinking water contaminants. Third Superfund Sponsored TCE Symposium. University of Arizona, February 28, 1997.
Molecular alterations in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V). Risk considerations for environmental health and safety. Superfund Meeting, University of Arizona, January 9, 1998.
Use of human prostate slices in toxicity studies. 16th Annual Meeting, Mountain West SOT, Tucson, AZ, September 18, 1998.
A Slice of Life. Founders Day, College of Medicine, University of Arizona, November 17, 1998.
Cytoprotective effects of DMSO against hepatotoxicants. University of Texas Medical Branch at Galveston, February 17, 1999.
Molecular alterations in renal tissue following in vitro exposure to nanomolar levels of Hg(II), As(III), or As(V). Centro de Investigacion Biomedica del Noreste, Monterrey, Mexico, June 29, 1999.
Gene Screens as a Method to Evaluate Metal Toxicity. 25th Anniversary, Division de Investigacion Biomedica, IMSS, Monterrey, Mexico, June 28-29, 1999.
Oxidative stress disrupts the E-cadherin/catenin cell adhesion complex. Pilot Projects Symposium. Southwest Environmental Health Sciences Center, University of Arizona, December 3, 1999.
Drug-induced liver injury: Mechanisms and test systems. Role of the immune system in producing volatile anesthetic hepatotoxicity in the guinea pig. NIH Lister Hill Auditorium, Bethesda, MD, October 17-18, 2000.
University of Arizona Binational Center. NIEHS Border Health Workshop, Albuquerque, NM, October 29-30, 2000.
Cooperative efforts between the University of Arizona and stakeholders addressing Hazardous Waste Problems in Arizona. Superfund Directors Meeting. University of North Carolina, December 12-14, 2000.
Precision-cut slices from transgenic mice as an in vitro toxicology system. SWEHSC Pilot Projects, January 11, 2001, University of Arizona.
Molecular effects of low level arsenic. University of Arizona Superfund Training Core Colloquium. October 11, 2001
Mechanism of arsenic transport in the kidney. ADEQ-EPA Regional Meeting, October 29, 2001, Phoenix, AZ.
Effects of
low-level arsenic exposure on human kidney cells.
American/Japanese Conference on Arsenic in Medicine and Biology,
December 11-15, 2002, Honolulu, Hawaii.
Effects
of in vitro exposure
to arsenic on the
ubiquitin pathway in human renal and bladder cells. Symposium on:
Arsenic disruption of cell cycle.
Society of Toxicology Annual Meeting,
Effects
of low level
exposure to arsenic on human bladder cells.
Biomedical
Structure
and function of
liver. USAID TIES Workshop, CINVESTAV, Mexico City, September 22,
2004.
Susceptibility
of liver to toxicity. USAID TIES Workshop, CINVESTAV,
Mexico City, September 22, 2004.
Arsenic
toxicity to
organs. USAID TIES, “Shortcourse on
Environmental Toxicology”. CICESE,
Ensendada, B.C.,
US-Mexico Outreach
Programs. USAID TIES. Binational Programs at the
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