A. Jay Gandolfi, Ph.D.

Curriculum Vitae
Table of Contents

[ Education] [ Major Field ] [ Academic & Professional Appointments ] [ Teaching ]
[ Honors, Awards, Prizes, Fellowships, Research Grants, etc. ] [ Service Activities ]
[ Publications ] [ Abstracts ] [ Scholarly Presentations ]

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September 2008

A. Jay Gandolfi, Ph.D.

Curriculum Vitae
             Birthplace: San Mateo, California
Birthdate:  December 11, 1946

A. Education:

1964-1966 College of San Mateo, San Mateo, California; Premedical

1966-1968 University of California, Davis, California; B.A., Chemistry

1968-1972 Oregon State University, Corvallis, Oregon; Ph.D., Biochemistry and Biophysics Minor - Toxicology and Pharmacology Doctoral Dissertation: Hexachlorophene: Its Absorption Distribution, Excretion, and Biotransformation in the Rat and Rabbit and In VitroInteraction with Rat Liver Microsomes. D.R. Buhler, Ph.D. - Major Advisor.
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B. Major Field:

Major effort is in research and teaching in the areas of biochemical pharmacology and toxicology with special emphasis on the mechanism(s) of toxicity.

Specific Areas:

1. Anesthesiology

Disposition of anesthetics
Organ-specific toxicity of anesthetics

2. Biotransformations

Dehalogenation mechanisms
Isolated cell and enzyme systems

3. Organ Specific Toxicity

Inhalation/Lung
Hepatic

Renal

4. Mechanisms of Toxicology

Mechanisms of cellular injury
Antidotes to chemical insults

5. In Vitro Toxicity

Systems Development
Extrapolation to whole animals
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C. Academic & Professional Appointments:

1968              University of California. Senior Research Project. Synthesis and purification of nitrogen mustard derivatives for cancer chemotherapy.
1968-1972    Oregon State University. USPHS trainee in the Environmental Health Sciences Center.
1972-1975    Mayo Clinic. Residency-postdoctoral position in the Department of Anesthesiology.

1974-1975     Mayo Research Fellow, Mayo Clinic, Anesthetic Metabolism by the Lung.

1975-1978     Battelle Pacific Northwest Laboratories. Senior Research Scientist.

1978-1983     University of Arizona. Research Assistant Professor of Toxicology and Research Associate in Anesthesiology.

1983-1985     University of Arizona. Assistant Professor of Anesthesiology and Pharmacology.

1985-1989     University of Arizona. Associate Professor of Anesthesiology and Pharmacology. Research Associate Professor of Pharmacology and Toxicology.

1989-             University of Arizona. Professor of Anesthesiology, Pharmacology, and Toxicology.

1993-1996     University of Arizona, Chairman, Graduate Program in Pharmacology and Toxicology.

1999-             University of Arizona.  Assistant Dean for Research and Graduate Affairs, College of Pharmacy.

1999-             University of Arizona.  Professor, Department of Pharmacology and Toxicology, College of Pharmacy.

2000-2003     University of Arizona.  Acting Chair, Department of Pharmacology, Toxicology and Medicinal Chemistry, College of Pharmacy.

2003-             Chair, Department of Pharmaceutical Sciences, College of Pharmacy.

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D. Teaching

Courses:

Anesthetic Metabolism and Toxicity Bloc: Lectures for Department of Anesthesiology; 1978, 1979, 1981, 1982, 1984, 1987, 1989, 1992, 1994, 1995, 35 Residents. Searle Life Support Systems; February 6­8, 1980. A short course in Anesthesiology/Neonatology.

Toxicology 454: Industrial Toxicology Lectures (Inhalation Toxicology, Biotransformation, Chemical Carcinogenesis); 1979, 1980.

Toxicology 596: Toxicology Seminar. Presented to the Toxicology and Industrial Hygiene Students. 10­15 Students. 1978­1981.

Toxicology 601: (Spectral Techniques), 1982.

Biotoxicology 602: (Lecture and Laboratory): Lectures (Lung, Inhalation Toxicology, Renal Toxicology, In vitro toxicology, biochemical pathology, hematotoxicity, (Laboratory Experiments); Absorption, distribution, biotransformation, liver toxicity, cell injury; 1978­present.

Pharmacology 550-Biochemical Pharmacology: Drug Metabolism and Disposition (Biotransformation Enzymes, Factors Affecting Biotransformation, Laboratory Experiments); 1978­1996, Special Topic 1997, Phase II, Special Topic 1998, 1999, Coordinator 2000-present.

Pharmacology 208: Drug Metabolism, University of California, Berkeley, Summer 1980­1994.

Environmental Toxicology 576: Instructor-Coordinator, 1980. Disposition of chemicals in environment, 1981. Inhalation Toxicology, 1982. Air Pollutants, 1983.

Pharmacology/Toxicology: Special Toxics, Independent Study. Environmental Toxicology, 1987.

Pharmacology 596: Student Seminar, Coordinator 1983­1989.

Immunotoxicology: Molecular mechanisms of metabolism. 1985. 30 Students.

Pharmacology 501/801: Medical Pharmacology, Drug Metabolism, 1987, 1994-1998, 2002, 80­130 Students. POPS - 1994, 1995. 75 students.

Molecular Pharmacology 551: Microtubule assembly, 1989.

Toxicology Special Topics: Literature Review. 1990. 2 Students.

Vet Sciences 443/543: Experimental Animal Methods. 1991 (1 hr), Animal research methods and ethics, 1992 (2 hr).

Pharmacy 471a: Absorption, distribution, excretion, biotransformation lectures, 1992, 2002-present.

Short Course in Toxicology:  National University, Mexico City, Pulmonary, Renal, and Cellular Toxicology, August 9-13, 1993.

CB10 597a: Mechanisms of Cancer Prevention. Chemoprotection against Cancer by Detoxification Enzymes, 1993.

Tox 610: In Vitro Toxicology, Use of renal slices, 1993.

Tox 195: Toxicology, The Poisons Around Us, 15 students-Spring, 1995; 18 students-Fall, 1995, 25 students-Fall, 1996, 20 students-Fall, 1997, 1998, 24 students, 1999, 25 students, 2000-present.

Tox 302: Undergraduate Environmental Toxicology, 50 students, 1995-2000.

Summer Minority Research Program:  Applying for Graduate School, 1994, 1995, 1996; General principles of toxicology, 8 students.

Biochem 494: Independent Study, 1996.

Center for Toxicology: High School Teacher's Workshop, Principles of Toxicology, June 1996, 8 teachers, (2 hr). 1998 Principles, Metal Toxicology, (3 hr). 1998 Insect Science Workshop - Toxicology, Risk Assessment (3 hr), 10 teachers.  1999 Risk Assessment, 12 teachers. 2000 Biotransformation. 2001 Basic Principles. 2002 Disinfectants.  2003 Teaching Environmental Toxicology.  2004 Teaching Basic Toxicology.  2004 PULSE Teachers: Superfund, Authorization, and Politics.  2006 Environmental Health and Toxicology Literacy.

Pharm 620:  Principle of Pharmacology, Careers in Pharmacology/Toxicology, 18 students, 1996.

PCOL 420, 421: Case Studies in Biochem Pharmacology.  3 sections, 12 students, 1999, 2000; 4 sections, 12 students, 1999-present.

PCOL 610: Molecular and Cellular Toxicology (Immunotoxicology) 2000-2002.  2003 Low-level arsenic toxicity.

PHSC 596H: Special Topics in Pharmaceutical Sciences.  Journal Review, 2 sessions, 2002, 2004.-present

PCOL 474:  Clinical Toxicology, 2 lectures - Role Biotranformation in Clinical Toxicology, 70 students, 2003-present.

Metal Toxicology:  Summer Minority Research Program, 10 students, 1999.

Colloquium:  Superfund Basic Research Program.  Coordinate 10-15 people, 2000-2003.  Co-coordinate, 2003-present.

SWES 518:  Introduction to Human Health Risk Assessment, Risk/Toxicity of Halo-Aliphatics, 30 students, 2002.

Chemistry 599:  Northern Arizona University.  Liver and Kidney Toxicity.  15 students, 2 hr, 2002.

PCOL 595b:  Science Writing/Strategy/Skills. 15 students.  Study Section Panel, 2002.

PCOL 573:  Experimental Models for In Vitro Toxicology.  8 students, 2004.

PCOL 630:  Proteosome Degradation/Signaling, 2 lectures, 20+ students, 2005-present.

Senior Research Projects

Dan Tinlin, 1990

Sheila Duffy, 1996

Vikas Patel, 1997

Jeffrey Catania, 1997-1998

Hugh Nguyen, 1997-1998

Ferleine Bautista, 1999

Kelly Dale, 2000-2001

Steve Weldon, 2002-2005

Sean McGinty, 2002-2003

Derek Dindal, 2003-2004

Erin Blomquist, 2004-2005

Nicole Lane, 2004-2005

Rachel Diaz, 2005-2007

Elyse Taylor, 2005

Andrew Hau, 2005-

Mahima Jain, 2006-2007

Thesis and Doctoral Committees:

M.S. in Physiology

Lynn Munoz – M.S. 2003.  Characterization of rabbit OAT1 and OAT3.

M.S. in Pharmacology:

Graduate Committee Member

F. Margaret Dingmann - M.S. - Pharmacology 1997.  Novel study of the effects of aprotinium on LLC PK cells.

Art Reigel - M.S. - Pharmacology, 1998. Effects of toluene on dopamine neurons and its implication in inhalant abuse.

Masters Degree – Applied Biosciences

Aaron M. Pershing, PSM, 2006.  Cryopreservation techniques for precision-cut tissue chip technology.

Elizabeth Arnold, PSM.  Alternative ocular testing of personal health care products.

M.S. in Toxicology:

Graduate Committee Member

Thomas Evans - M.S. - Toxicology 1979. Metabolism of melphlan.

Douglas Eisenstein - M.S. - Pharmacology 1979. Pyrrolizidine alkaloids: Extent of population exposure and prevention of toxic effects.

Barbara Larcom - M.S. - Toxicology 1979. Fate of nitrogen mustards, melphalan.

Mary Susan Connors - M.S. 1981. The isolated perfused rat liver - Viability and metabolism studies in an all-glass perfusion apparatus.

Dave Dutton - M.S. - Toxicology 1984. Mechanism of promotion in epidermal cells with TPA.

Debra Randall - M.S. - Toxicology 1984. Promotional effect of trichloroethylene on hepatocellular neoplasia.

Robert Nenad - Masters Candidate - Toxicology 1985. Effect of ranitidine and cimetidine on the disposition of fentanyl.

Laurie Goll - Masters Candidate - Toxicology - (Medical School). Acute renal failure: reversal with oxygen radical scavengers.

Kerry M. Barnhart - M.S. - Toxicology 1985. Activation of oncogenes by etiological agents.

Stephen Teo - M.S. - Toxicology 1985. Metabolism of chloramphenicol: Possible role in aplastic anemia and anemia and leukemia.

Lynnda Reid - M.S. - Toxicology 1990. Effect of benzene on IL­2 production in mice. Use of staphylococcal enterotoxin A-induced interleukin 2 production as an indicator of immunotoxicity.

Jefferey Burgess, M.D. - M.S. - Toxicology 1993. Evaluation of the safety of self-contained breathing apparatus at high exertion levels.

Karen Duncan - M.S. - Toxicology 1995.  Mercury chloride induced apoptosis toxicity in renal cell lines.

Ira I. Chadnick - M.S. - Toxicology 1996.  Assessment of carbon monoxide exposure for a newspaper vendor during work at a busy traffic intersection.

Sheila Healy - M.S. - Toxicology 1997.  Arsenic methyl transferase enzymes in the guinea pig and rabbit.

Eric Wildfang - M.S. - Toxicology 1997.  Characterization of the arsenic methyl transferase in hamster liver.

Latressa Billings - Masters Candidate - Toxicology.  Metabolism of methyl styryl ketone.

Robert Kuester - M.S. - Toxicology 2001 - Strain specific hepatotoxicity of cadmium chloride.

Jacob Pritchett - M.S. - Toxicology 2001 - In vitro biotransformation of bisphenol A in human, mouse, and rat hepatocytes.

Hamid Badghisi - M.S. - Toxicology 2001 - Identification of styrene oxide aducts to hemoglobin using LCI MS/MS.

Laura Tiscareno – M.S. – Toxicology 2004 – Analysis of pancreatic disease by global  proteomic profiling.

Advisor/Co-Advisor

Matthew Miller - M.S. - Toxicology (advisor) 1979. Disposition of enflurane in the obese.

Richard Jee - M.S. - Toxicology (co-advisor) 1979. Halothane hepatotoxicity.

Carl Potter - M.S. - Toxicology (co-advisor) 1980. Renal toxicity of volatile fluorocarbons.

Lorrene Buckley - M.S. - Toxicology (co-advisor) 1980. Evaluation of the nephrotoxic effects of inhaled chlorotrifluoroethylene in the rat: A subacute study.

John MacDonald - M.S. - Toxicology (co-advisor) 1981. Acetone potentiation of 1,1,2-trichloroethane hepatotoxicity.

Frank Plescia - M.S. - Toxicology (advisor) 1981. The disposition and hepatotoxicity of 1,2-dibromoethane.

Kathy Cater - M.S. - Toxicology (co-advisor) 1982. An evaluation of the newborn mouse as a potential method for the bioassay of liver carcinogenesis using histological and histochemical markers.

Debra Jaffe - M.S. - Toxicology (advisor) 1982.  Genotoxicity of S-(trans-1,2-dichlorovinyl) -L-cysteine in renal tissue.

Ronald MacFarland - M.S. - Toxicology (co-advisor) 1982. Biotransformation of ethylene dibromide in extrahepatic tissues.

Richard Lind - M.S. - Toxicology (advisor) 1982. The role of endotoxin in halothane hepatotoxicity.

Janet Durham - M.S. - Toxicology (advisor) 1983. Hepatotoxicological evaluation of dantrolene sodium.

Stephen Glass - M.S. - Toxicology (advisor) 1983. Effect of cimetidine, ranitidine, and halothane on lidocaine pharmacokinetics.

Susan Meadows - M.S. - Toxicology (advisor) 1985. Persistent nephrotoxicity and renal tumor promotion in Swiss-Webster mice following exposure to dichlorovinylcysteine.

Betsy Corsino - M.S. - Toxicology (co-advisor) 1986. The pulmonary response induced by glass fibers.

Jennifer Phelps - M.S. - Toxicology (advisor) 1986. In vitro nephrotoxicity of cisplatin.

Majid Saidat Pajouh - M.S. - Microbiology and Immunology (co-advisor) 1986. Generation of halothane induced antibody in guinea pigs.

Leslie Pustilnik - M.S. - Toxicology (co-advisor) 1987. Pulmonary response to fibers in murine model of silicosis.

Lawrence Vernetti - M.S. - Toxicology (co-advisor) 1988. Effect of cyclosporin A on PtK2 cells and their cytoskeleton.

Cynthia Nowlin - M.S. - Toxicology 1992. Examination of mitochondria exposed to 1,2-dimethyl hydrazine using atomic force microscopy and other techniques.

Carmen Burton - M.S. - Toxicology 1994. Effect of glutathione on HgCl2 and NaAsO2 toxicity and uptake in rabbit renal cortical slices.

Andrea Payne - M.S. - Toxicology 1995.  Biotransformation of sevoflurane by rat neonates liver slices.

Mingli Chen - M.S. - Toxicology 1996.  Role of immune system in multiple halothane exposure induced liver injury.

Rainer Sell - M.S.  - Toxicology 1996.  Precision-cut rat liver slices: An in vitro model for the study of cold preservation injury.

Hong Bing Wei - M.S. Toxicology 1997.  Effect of GSH conjugates on uptake and toxicity in rabbit renal tubules.

Rodney Keith - M.S. Toxicology 1997.  Use of proton induced x-ray emission on uptake of metals in renal tissue.

Karen Turney - M.S. Toxicology 1999.  Selective activation of the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices.

Sarah Buffington – M.S. Toxicology 2008. Chronic exposure to monomethylarsonous acid induces changes in human UROtsa cells consistent with urothelial tumorigenesis.

Ph.D. in Pharmacology and Toxicology:

Graduate Committee Member

Carl Potter - Ph.D. - Pharmacology 1982.  Metabolic alterations of 1,2,7,8-tetrachlorodibenzo -p-dioxin to rats.

Mark Lafranconi - Ph.D. - Pharmacology 1983. Toxicology of the pulmonary epithelium.

Debra Jaffe - Ph.D. - Molecular Biology 1987. Mouse skin tumor initiation by ionizing radiation and the detection of dominant transforming genes.

Natalie Miller - Ph.D. - Pharmacology 1987. Mechanism-based inactivation of rat liver cytochromes P­450 by analogues of chloramphenicol.

Eric Stine - Ph.D. - Pharmacology 1987. Hepatotoxicity of dichlorobenzene isomers.

Ala El-Sisi - Ph.D. - Pharmacology 1987. Elucidation of the mechanism of vitamin A potentiation of carbon tetrachloride - included liver injury.

William Bellamy - Ph.D. - Pharmacology 1988. Mechanisms of doxurubicin drug resistance.

Pam Shubat - Ph.D. - Pharmacology - 1988. Pulmonary vascular toxicity of monocrotaline.

Scott Mobley - Ph.D. - Pharmacology - 1991. Effect of vitamin A on Kupfer cell toxicity.

Janet Firrilo - Ph.D. - Pharmacology - 1992. Disposition and toxicity of cobalt naphthenate.

Stacie Wild - Ph.D. - Pharmacology - 1993. Detection of pyrrole in the biotransformation of pyrridizidine alkaloids.

Walter Klimecki - Ph.D. - Pharmacology - 1994. P-glycoprotein: Expression and function in normal circulating leukocytes.

Greg Bogdan - Ph.D. - Pharmacology - 1994. A 450K arsenite binding protein of the rabbit liver cytosol.

Amy Ham - Ph.D. - Pharmacology - 1995. Antioxidant reactions of vitamin E in rat liver.

Torka Poet - Ph.D. - Pharmacology - 1995. Cytochromes P450 involved in the bioactivation of cocaine in the rat.

John-Michael Sauer - Ph.D. - Pharmacology - 1996. All trans-retinal modulation of chemical-induced lung and liver toxicity.

Kristina Hatlelid - Ph.D. - Pharmacology - 1996. In vitro investigation of the toxic mechanism of action of arsine on the erythrocytes.

Stephanie Born - Ph.D. - Pharmacology - 1996.  Characterization of canine cytochrome P450s 2B and 3A.

Steve Waters - Ph.D. - Pharmacology - 1996.  Neuropeptidases as sites of peptide regulation by dopaminergic drugs.

Russell Ingersol - Ph.D. - Pharmacology - 1996.  Central nervous system toxicity of manganese.

Edward Bilsky - Ph.D. - Pharmacology - 1996.  Studies on opioid delta receptor mediated antinociception, opioid antinociceptive tolerance and physical dependence.

Shannon Winski - Ph.D. - Pharmacology - 1997.  Metabolism and toxicity of sodium arsenite in human erythrocytes.

Kevin K. Divine - Ph.D. - Pharmacology - 1997.  Modeled speciation of Hg and endogenous thiols.  Their comparative toxicity in LLC-PK1 cells.

Maralee McVean - Ph.D. - Pharmacology - 1997 - Photoprotective activity of vitamin E in mouse skin.

Thomas Abbruscato - Ph.D. - Pharmacology - 1997.  Opioid peptide permeation across the blood-brain barrier.

Raymond Robledo - Ph.D. - Pharmacology - 1998.   Pulmonary toxicity of JP-8 jet fuel.

Karissa Adkins - Ph.D. - Pharmacology - 1998.  Glucocorticoid regulation of GM-CSF in bronchial epithelial cells.

Robert Landsman - Ph.D. - Pharmacology - 1999.  The human cannabinoid receptor expressed in CHO cells as a model to study cannabinoids.

Felix Ayala - Ph.D. - Pharmacology, 1999.  Tissue specificity for metabolism and toxicity of arsine and arsenate.

Qingbo Tang - Ph.D. - Pharmacology, 2000.  Nonopoid actions of dynorphin and neuropathic pain.

Di Bian - Ph.D. - Pharmacology, 2000.  Peripheral and spinal mechanisms of neuropathis pain in the rat.

Marc Oshiro - Ph.D. - Pharmacology, 2000 - Role of IL-6 signaling via the Jak/Stat pathway in human myeloma.

Daniel Mason - Ph.D.  - Pharmacology 2003.  Mass spectral analysis of hydroquinone adducts.

Beau Hansen - Ph.D. - Pharmacology 2005.  Proteomics methods for detection of modified peptides.

Husam Younis - Ph.D. - Pharmacology, 2001.  The molecular and cellular mechanisms of 1, 2-dichlorobenzene induced liver injury in F344 and S-D rats.

Jason Halliday - Ph.D. - Pharmacology 2002.  Comparative pharmacokinetic and disposition of a surrogate mineral hydrocarbon.

Jay F. Petrick - Ph.D.- Pharmacology 2003.  Arsenic: Metabolism, cytotoxicity, and toxigenomic alterations in the developing lung.

Shannon Conley – Ph.D. – Pharmacology 2005.  Selinium effects of on human trabecular meshwork.

Linda Manza - Ph.D.  - Pharmacology 2007.  Characterization of protein sumoylation in response to alkylation stress.

Lisa Ahern – Ph.D. – Pharmacology 2008.  Mechanism of hepatoprotectoin during hepatic cholestasis.

Taylor Jensen – Doctoral candidate.  HOX-1 expression in breast tumor.

Craig Fisher – Doctoral candidate.  DAS effects on choleastasis.

Monica Yellowhair – Doctoral candidate.  Depleted uranium genotoxicity in human bronchial epithelial cells.

Matt Merrell – Doctoral Candidate – Induction of MRP2 in biliary cells.

Alicia Bolt – Doctoral candidate.  Genomic effect of inhaled dust on lung performace.

Paulina Gomez Rubio – Doctoral candidate.  Arsenic and lung function.

Advisor/Co-Advisor

Russell White - Ph.D. - Pharmacology (advisor) 1981. Genotoxicity of 1,2-dibromoethane.

Christopher Hassal - Ph.D. - Pharmacology (co-advisor) 1983. Biotransformation and nephrotoxicity of halogenated ethylenes.

John MacDonald - Ph.D. - Pharmacology (co-advisor) 1984. Reversal of hepatotoxicity with free sulfhydryl compounds.

Peter Smith - Ph.D. - Pharmacology (co-advisor) 1985. A novel organ culture for the study of hepatotoxicity.

Leslie Rylander - Ph.D. - Pharmacology (advisor) 1985. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins.

Paul Silber - Ph.D. - Pharmacology (co-advisor) 1986. Early indicators of renal proximal tubular injury.

Charles Ruegg - Ph.D. - Pharmacology (advisor) 1987. Mechanisms underlying regioselective acute tubular necrosis of renal proximal tubular segments.

Grushenka Wolfgang - Ph.D. - Pharmacology (advisor) 1989. DCVC induced cellular injury in rabbit renal cortical slices.

Nancy Shipp - Ph.D. - Pharmacology (co-advisor) 1990. Cardiotoxicity of chemotherapeutic agents.

Mary Stefaniak - Ph.D. - Pharmacology (co-advisor) 1990. Precision-cut rat lung slices.

Lawrence Vernetti - Ph.D. - Pharmacology (co-advisor) 1991. The effect of cyclosporin on cytokeratin intermediate filament phosphorylation.

Alan Brown - Ph.D. - Pharmacology (advisor) 1992. Generation and expression of halothane derived protein adducts in the guinea pig liver.

Hilary Sheevers - Ph.D. - Pharmacology (advisor) 1993. Site-specific injury due to transport mechanisms.

Stephen Waters - Ph.D. - Pharmacology (advisor) - 1993. In vivo and in vitro hepatotoxicity of M741.

Jon-Pierre Michaud - Ph.D. - Pharmacology (co-advisor) 1994. Precision-cut rat liver slice culture: An in vitro tool for assessing hepatotoxic interactions of organohalides.

Steve Hasal - Ph.D. - Pharmacology (co-advisor) 1998. A model for the multistage metabolism and nephrotoxicity of chlorotrifluoroethylene.

Donald Kirkpatrick - Ph.D. - Pharmacology 2003.  The effects of arsenic on the ubiquitin dependent proteolytic pathway.

Marjorie Peraza – Ph.D. – Pharmacology 2003.  Subcytotoxic inorganic arsenic effects on mitochondria in a human proximal tubule cell line.

Elizabeth Casarez – Ph.D. – Pharmacology 2004.  The influence of microorganisms on the bioavailability and toxicity of arsenic in soils.

Jeffrey Catania – Ph.D. – Pharmacology 2006.  Derivations of tissue slice technology as toxicological screening systems.

Tiffany Bredfeldt – Ph.D. – Pharmacology 2006.  Low-level arsenic toxicity in human bladder cells.

Kylee Eblin – Ph.D. – Pharmacology 2008. The effects of arsenical-induced reactive oxygen species on human bladder cells.

Ph.D./M.S. Committees - Other Disciplines

Janet Ludwig - Ph.D. - Agricultural Biochemistry and Nutrition 1981. Mechanism of the zinc protective effects against CCl4 hepatotoxicity.

Vikram Sinha - Doctoral candidate - Pharmaceutical Sciences - Pharmacokinetics of therapeutic agents.

Jeri Lott. Doctoral Candidate - Chemistry. An evaluation of biological markers for lead poisoning by proton induced x-ray emission.

Betsy C. Risendal - Ph.D. - Epidemiology 1998 - Cancer screening among urban Southwestern American Indian women.

Tarundeep Kakkar - Ph.D. - Pharmaceutical Sciences 1999 - Theoretical studies on enzyme inhibition kinetics.

Timothy Radabaugh - Doctoral Candidate - Genetics. Characterization of the human liver cytosolic arsenic reductase.

Lynn Munoz – M.S. – Physiology 2003. Characterization of OAT1 and OAT3 transporters.

Roberta Bruhn – Ph.D. – Epidemiology 2008.  Relationship between glaucoma and selenium levels in plasma and aqueous humor. 

Huadong Tang – Ph.D. 2005 – Pharmaceutical Sciences.  Allometric sealing for predicting human drug clearance.

Pilar Carranza – Ph.D. – Biological Sciences 2004.  Characterization of the morphology and functionality of OK cell model for intoxication by mercury. University of Nuevo Leon.

Zelieann Rivera – Doctoral Candidate – Physiological Sciences.  Ovarian toxicity induced by chemicals.

Visiting Graduate Students:

Pilar Carranza (2000-2003) 2004, 2005 - Ph.D. - School of Medicine, University of Neuvo Leon, Mexico.  Effect of DMDS and DMSA on BSA transepithelial transport by OK cells exposed to HgCl2.

Mercedes Meza (2001-2004) – Ph.D. - Sonora Institute of Technology, Cuidad Obregon, Sonora, Mexico.  Arsenic drink water exposure and urinary excretion in Yaqui Valley, Sonora, Mexico.

Laura Cruz (2005) – Relationship between arsenic exposure and diabetes.

Andrea Diaz (2005) – Relationship between arsenic exposure and diabetes.

Jorge Alegria (2006) – Polymorphisms in apoptosis markers in response to DDT.

Research Associates:

Andrea Hubbard (Callis), Ph.D., Immunology, 1983­85.

Gregory M. Becker, Ph.D., 1984.

Shana Azri, Ph.D. 1987-1990.

Hanan Ghantous, Ph.D., 1988-1991.

Ken Hastings, Dr. P.H., 1988-1991.

Sharon J. McGuinness, Ph.D., 1991-1992.

Janet B. Clarke, Ph.D., 1991-1993.

Patricia Ijomah, Ph.D. - 1991-1993.

Sylvia Furst, Ph.D. - 1994-1996.

Jayanthika Wijeweera, Ph.D. - 1992-1997.

Alan Parrish, Ph.D. - 1996 - 1999.

Artemio Fernandez, Ph.D. – 2003

Clinical Research Fellows:

John B. Bentley, M.D., 1980­1981.

James D. Borel, M.D., 1981­1982.

Karen Knieriem, M.D., Ph.D., 1984­1985.

Edward Frink, M.D., 1987­1988.

David Nyman, D.O., 2000-2004.

Foreign Research Fellows:

Gustavo Martinez Zedillo, Ph.D., 1980­1981.

Tetsuro Fukui, M.D., 1982­1983.

Ola Dale, M.D., Ph.D., Fogerty Fellowship. 1985­1986.

Bjorn Hagen, M.D., Ph.D., 1990.

Bupesh Kaul, M.D., 1990-1991.

Gerard Stinjtjes; Free University, The Netherlands, 1991.

Graduate School Referee (Foreign University):

Kathie Knights - Doctoral Candidate. The Department of Pharmacology. Flinders University, South Australia, 1984.

Soma Mitra – Doctoral Cadidate.  Role Nutrition in Clinical Expression Arsenic Toxicity.  Jadavpur University, India, 2003.

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E. Honors, Awards, Prizes, Fellowships, Research Grants, etc.:

Honors:

1968­1972   USPHS Trainee in Environmental Health and Science, Oregon State University.

1974­1975   Mayo Graduate School of Medicine Fellowship, Mayo Clinic.

1998           Founders Day Speaker, College of Medicine, University of Arizona, November 17, 1998.

2004           Education Award, Society of Toxicology.

 2007          Findlay E. Russell MD, PhD, Distinguished Citizen Award, College of Pharmacy

Research Grants:

1978-­1979   American Cancer Society, Institutional Cancer Research Grant. Role of "C-S" Lyase in halogenated vinyl cysteine toxicity. $3,000. Completed.

1978-­1980   National Cancer Institute, Organohalogen Carcinogenicity, Co-investigator. $189,410. Completed.

1979-­1982   National Institutes of Health, NIAMD, Studies of Inhalation Anesthetic Hepatotoxicity, Co-investigator. $178,000. Completed.

1979-­1980   Ohio Medical Products, Research Grant, Comparative Biotransformation of Ethane and Halothane in Obese Patients, Co-Investigator. $30,000. Completed.

1980           Biomedical Research Support Grant, College of Medicine, University of Arizona, Detection method for determination of fentanyl and its metabolites, Co-Investigator. $4,000. Completed.

1980            Biomedical Research Support Grant, College of Pharmacy, University of Arizona, Mechanism of sulfhydryl-type therapeutic agents in counteracting chemically induced liver toxicity, Co-Investigator. $6,000. Completed.

1980-­1982   National Institute of Health, NIAMD, Supplemental Grant -Studies of Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $3,000. Completed.

1983             Norwich Eaton, Pilot Grant, Hepatotoxicity of Dantrolene Sodium, Co-Investigator. $1,000. Completed.

1983             Perkin Elmer, Pilot Grant, Utilization of Flame Photometry for Ca Analyses, Investigator. $1,500. Completed.

1981-­1984   Janssen Pharmaceutica, Inc. Clinical evaluation and pharmacokinetics of sufentanil, Co-Investigator. $24,000. Completed.

1982-­1987   National Institute of Health, NIAMD, Inhalation Anesthetic Hepatotoxicity, Co-Investigator. $570,000. Completed.

1982-­1984   Ohio Medical Products, Determination of the impurities in "yellow" Forane, Investigator. $25,000. Completed.

1984-­1985   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for the detection and investigation of nephrotoxins. Investigator. $20,000.

1984            Biomedical Research Support Grant, College of Medicine, University of Arizona, Thin tissue slicer apparatus and studies. Co-Investigator. $8,000. Completed.

1984-­1987   National Institutes of Health, NIEHS. Animal Models of Alcohol-Related Cancers, Co-Investigator. $300,000.

1983-­1984   University of Arizona, Institutional Research Grant, American Chemical Society. Ethanol and Esophageal Carcinogenesis. Co-Investigator. $8,000.

1984             Deborah Heart and Lung Center. Metabolism of halothane in cyanotic and acyanotic pediatric cardiac patients. R.A. Moore (Investigator), Co-Investigator. $5,000. Completed.

1985-­1986   Janssen Pharmaceutica, Inc. Evaluation and pharmacokinetics of sufentanil in renal failure patients. Co-Investigator. $20,000. Completed.

1985-­1986   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules for nephrotoxicity. Investigator. $17,000. Completed.

1985-­1988   NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $276,000. Completed.

1985-­1989   NIEHS. Methods of development to assess human metabolism of chemical xenobiotics. Co-Investigator. $1.2 Million. Completed.

1985-­1986   NIH. Fogarty International Research Fellowship. Volatile Anesthetics. Interaction with other drugs. Co-Investigator. $30,000. Completed.

1986-­1987   University of Arizona. Small Grants Program. The cytoskeleton as a target for toxic agents. $5,000. Completed.

1986-­1987   Johns Hopkins Center for Alternatives to Animal Testing. Use of isolated rabbit renal tubules and positional renal slices for nephrotoxicity. Investigator. $17,000. Completed.

1987-­1988   Johns Hopkins Center For Alternatives to Animal Testing. Evaluation of precision-cut positional renal slices for nephrotoxicity studies. Investigator. $17,000. Completed.

1987-­1990   NIH, NIDDK. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $367,000. Completed.

1987-­1991   NIH, NIGMS. In Vitro Toxicology: Precision Tissue Slice Technology. Co-Principal Investigator. $528,000. Completed.

1988-­1989   Maruishi Pharmaceutical Co., Japan. Disposition and toxicity of sevoflurane. Co-Investigator. $20,000. Completed.

1988-­1989   Upjohn Company. Methods development towards establishment of an in vivo organ slice based tissue bank for the assessment of metabolism of chemical xenobiotics. Co-Investigator. $15,000. Completed.

1988-­1992   NIH, NIGMS. Immune mechanisms of halothane hepatitis. Principal Investigator. $467,000.

1988-­1989   Arizona Kidney Foundation. Toxic effects of cyclosporin on the cytoskeleton of renal cells. Co-Investigator. $6,570. Completed.

1989-­1991   NATO (CRG). Drug Interactions/Anesthetics. Co-Investigator. $5,000. Completed.

1989-­1994   NIH P01. Renal Handling of Organic Ions. In vitro renal toxicity: role of transport. Co-Investigator. $450,000.

1990-1992   NIEHS. Use of precision-cut tissue slices for interactive toxicity studies. Co-Investigator, $240,000. Completed.

1990-­1993   NIH, NIGMS MARC Program. Society of Toxicology. Co-investigator 5%. $74,408. Completed.

1990-1993   NIH NIGMS. Studies of Inhalation Anesthetic Hepatotoxicity. Co-Investigator. $424,000.

1991-1996   NIEHS. Precision Tissue Slice Technology. Co-Principal Investigator. $540,000.

1991-1994   Arizona Disease Control Commission. Cultured Myocardial Slices as an Alternative In Vitro Tool for Toxicity Evaluation. Co-Investigator. $75,000.

1992-1995   NIEHS. Interactive toxicity studies of chemical waste dumps using renal cortical slices. Investigator. $300,000.

1992-1995   NIEHS. Xenobiotic metabolism in cryopreserved human liver slices. Co-Investigator. $362,000.

1993-1998   NIEHS.  Studies of chemical disposition in mammals.  Co-Investigator 5%, Year 1 - $314,824, total $1,734,000.

1994            Procter & Gamble. Examining idiosyncratic chemical reactions.  Co-Investigator.  $78,125.

1995-2000   NIEHS.  Metal-metal interactions in the kidney.  Investigator, $85,000/yr, $425,000 total.

1997             Colgate-Palmolive Visiting Professorship, Indiana University, $12,000.

1997-1999   Procter & Gamble.  Use of confocal microscopy to study toxic events in precision-cut tissue slices. $82,000.

1997-2002   NIEHS.  Hepatoprotective mechanisms of DMSO.  Investigator, $107,000/yr, total $321,000.

1997-1998   Ohmeda, Inc.  Hypersensitivity of compound A.  $14,500.

1997-1998   Ohmeda, Inc.  Sequential biotransformation and toxicity of compound A in tissue slices.  $39,000.

2000-2005    Southwest Hazardous Waste NIEHS Superfund, Principal Investigator.  $1.6 M/yr.

2000-2005    NIH Clinical Research Curriculum Award, Co-Director. $185,000/yr.

 2001-2003   NIEHS.  Development of toxicity screen from transgenic mice with fluorescent protein markers.   Principal Investigator. $120,000.

 2001-2005   Department of Defense (Algan-P.I.).  Dynamic Tissue Culture System from Prostate Biopsy Specimens.  Co-Investigator. $510,000.

 2002-2003   NSF.  Arsenic in Biology and Medicine.  Principal Investigator. $17,250.

 2002-2005   NCI.  Tissue Chips for Toxicology Evaluation.  Principal Investigator. $151,414/yr.

 2002-2004   USGS/NIWR (Field-P.I.).  Agricultural Chemicals as a Major Non-Point Source of Arsenic: Microbial Transformation of Organic Arsenicals.  Co-Investigator. $69,000/yr.

2003  NIEHS Southwest Environmental Health Sciences Center (Interim Director) $870,000/yr (1999-2000).

2003-2006  NIH Optical Spectroscopy of Ovarian Cancer (Urs Utzinger, PI).  Co-Investigator.  $250,000/yr.

2003-2008  Prostate Carcinoma: Invasion and Metastasis Factors (Raymond Nagle, PI).  Core Leader.  $75,000/yr.

Training Grants

NIEHS.  Training Program in Environmental Toxicology. Participant.

NIGMS. Clinical Pharmacology Research Training, Participant.

NIEHS.  Toxicology Training Grant, Participant. $150,000/yr.

NIEHS.  Training Grant for Environmental Science Graduate Students in Toxicology.  $172,000.

Postdoctoral Grants

1989-­1991  Azri, Shana. Carbon tetrachloride: In vitro slice toxicology. NIH National Research Science Award.

1997-1999  Parrish, Alan.  Alterations in cadherin/catenin complexes by oxidative stress in precision-cut liver slices. $67,000.

Center Grants

1993-           NIEHS, Southwest Environmental Health Sciences Center, Cell Injury Research Program Director, Year 1 $700,000.

1999-2004   NIEHS Southwest Environmental Health Science Center, Research Program Director. $1 M/yr.

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F. Service Activities

1. University and College Committees:

College of Medicine

College of Medicine, Administrative Review Committee, Department of Anesthesiology, 1979,  1985.

College of Medicine, Medical Student Interviewer, 1983-1987.

College of Medicine, DAR Review Committee, University of Arizona, 1985.

Biomedical Research Laboratories Management Committee, 1985-1995.

College of Medicine, Student Progress Committee, 1987-1988.

Dean's Research Council, College of Medicine, 1991-1995, Ad Hoc 1995-1996, 1996-2001.

Committee of Nine, 1993-1995.

Search Committee, Chair, Department of Anesthesiology, 1994-1995.

Promotion and Tenure Committee, 1996-1999.

Advisory Board, Circulatory Science Program, 1995-1997.

LCME Accreditation, Research/Graduate Education Subcommittee, 1996-1997.

Architect Selection Committee, Life Sciences North Shell Space, 1996.

Life Science North Construction Committee, 1997-.

Chair, BRL Space Committee 1996-1997.

Advisory Board, University of Arizona Pain Institute, 1996-present.

Chair, COM/DRC Space Committee 1997-.

Long Range Planning/Dean's Research Council Sub-Committee for College of Medicine
Strategic Plan, 1997-1999.

Chair, Promotion and Tenure Committee, 1998-1999.

Donald Shear Memorial Student Award Committee, 1999-present.

College of Medicine, Department of Pharmacology

Graduate Program in Pharmacology and Toxicology, Review Committee, 1987­1988.

Department of Pharmacology, Research Review Committee - Chairman, 1987.

Academic Program Review Self Study Committee, 1998

College of Medicine, Department of Anesthesiology

Department of Anesthesiology, Tenure and Promotion Committee, 1986-2000.

Chair, Promotion and Tenure Committee, 1994.

Director, Anesthesiology Research Laboratories, 1985-1998.

Executive Committee, 1996-1998.

Graduate Program in Pharmacology and Toxicology

Coordinate Recruiting in State and Recruiting Information, 1989-1990.

Chair, Graduate Program in Pharmacology and Toxicology, 1993-1996.

Graduate Program Executive Committee, 1993-2000.

Self Study Committee for Pharmacology and Toxicology IDP and Academic Program Review, 1997-1998.

Academic Program Review Self Study Committee, 1997-1998.

College of Pharmacy

College of Pharmacy, Masters of Toxicology Admissions Committee, 1984-1999.

College of Pharmacy, Department of Pharmacology/Toxicology, Committee for Reorganization of Toxicology Courses Content, 1984.

Chair, Re-Organization Committee for College Departments and Graduate Programs, 2000.

Department Chair (Pharmacy Practice and Science) Search Committee, 2003-

Center for Toxicology/Superfund Research Program

Organizing Committee, Fourth International Meeting, Biological Reactive Intermediates, Tucson, Arizona, 1990.

Organizational Committee 1991.

National Advisory Board Meeting, "In vitro toxicology studies", April 8, 1991.

Organizing Committee, A Joint United States/Mexico Conference, Fate, Transport, and Interactions of Metals, Tucson, AZ, 1993.

Organizing Committee, 5th International Society for the Study of Xenobiotics, Tucson, AZ, 1993.

Organizing Committee. Modulation of Chemical Toxicity and Risk Assessment. Meeting in Tucson, AZ, June 1996.

Organizing Committee.  Metals-Risk considerations for environmental health and safety.  Meeting in Tucson, AZ, January 8-9, 1998.

Steering Committee, United States/Mexico Conference on hazardous waste management and technologies, Tucson, AZ, August 9-11, 1998.

Program Committee, EPA/Tri-University Superfund Research Programs.  University of California, Berkeley, CA, October 26-27, 1998.

Organize and host 2002 Superfund Basic Research Program Annual Meeting, University Marriott Hotel, Tucson, AZ  November 3-6, 2002.

Program Committee.  Superfund Basic Research Program Annual Meeting, Dartmouth College, November 2003.

Program Committee.  Superfund Basic Research Program Annual Meeting, University of Washington, November 2004.

Arizona Health Sciences Center

Bobbi Olson Building - Research Themes Committee, 2001-2002.

University

Selection Committee UA/VA Veterinarian 1989.

University Animal Care Committee, 1987­1989. Chairman 1989-1991.

DAR Expansion and Facilities Committee, 1987-1991.

Earth Day 20th Anniversary. Chemicals in the Environment. Presented "Why We Need Chemicals". April 25, 1990.

Academic Review Committee of Department of Anatomy, Co-Chair, 1991-1992.

Tucson Veterans Administration, Research and Development Committee, 1993-1995.

Graduate Program in Pharmacology and Toxicology, Chairman, 1993-1996.

Associate Director, University of Arizona Superfund Program, 1994-1999.

Academic Program Review. Physiological Sciences Interdisciplinary Graduate Program, May 1996.

Tri-College Promotion and Tenure Committee, Chair, 1996-1997.

Academic Program Review Self Study Committee, Graduate Program in Pharmacology and Toxicology, 1997-1998.

NCA 2000 University Accreditation Steering Committee, 1998-2000.

Search Committee, College of Sciences Dean, 1999.

Search Committee, Vice President for Health/Dean-College of Medicine, 2000-2001.

Special Committee for Defining Vice President for Health Goals, October-December, 2000.

Proposition 301 Subcommittees for Water and Biotechnology, November-present, 2000.

Associate Dean’s Advisory Group (to VP Research), 2002-

IBSB Director Oversight Committee, 2003-

IBSB Director Search Committee, 2003-2004.

Undergraduate Biology Research Program (UBRP), Selection Committee, 2004-

Committee on Soft Money for Faculty Salaries, 2004-

University Compensation Advisory Committee, 2003-2004.

University of Arizona, Honorary Degrees Committee, 2006-2007

U.S. Mexico Binational Center

Director, 2005-

Organizing Committee, Inaugural Binational Meeting, March 12-14, 2007.

International

Co-Chaired/Coordinated American/Japanese Conference on Arsenic in Medicine and Biology, December 11-15, 2002, Honolulu, Hawaii.

2. National Committees

Member Delphi Group, Metabolism and Toxicity, Scientific Advisory Board to the Association of University Anesthetists, 1980.

NIEHS. Site Review Member. Environmental Health Science Centers Grants, Nashville, February, 1984.

Biological Sciences Section Committee. American Association for the Advancement of Science (SCIENCE), 1985­1987.

American Society for Pharmacology and Experimental Therapeutics. Committee on Core and Use of Research Animals, 1991-1994.

Organizing Committee, Fifth Northern American ISSX Meeting, Tucson, AZ, Oct. 17-21, 1993.

Johns Hopkins Center for Alternatives to Animal Testing, Advisory Board, 1995-.

University of California, Berkeley Superfund Program.  External Advisory Board, 1996-1998.

International

EVCAM/CAAT Workshop Participant. Mechanisms of Toxicity, April 1996.

USAID TIES Meetings
    Mexico City, 2004
    Ensenada, Baja California, Mexico, 2005

Society of Toxicology

Appointed Positions

Program Committee, 1983-­1986.

Public Relations Committee, Mechanisms of Specialty Section, 1981-­1984.

Refresher Course on Endotoxins, Coordination Committee, 1984 Meetings.

Fluorinated Volatile Anesthetic Symposium Organizer, Coordinator, Chairman, 1984 Meetings.

Technical Committee, 1986-­1988.

Tox 90's Education Issue Ad Hoc Committee, Chairman, 1988-1991.

Undergraduate Toxicology Ad hoc Committee, 1990-1994.

Nominating Committee, Mechanisms, Chair, 1991.

Toxicology Education Foundation, 2000-2002.

Board of Publications, 2005-2009; Chair 2008-2009.

Elected Positions

President, Mechanisms Specialty Section, 1989-­1990.

Vice President, Mechanisms Specialty Section, 1988-­1989.

Vice-President Elect, Mechanisms Specialty Section, 1987-­1988.

Secretary-Treasurer, Mechanisms Specialty Section, 1984-­1986.

Education Committee, SOT, 1988-­1991.

Nominating Committee, SOT, 1992-1994.

Secretary, Society of Toxicology, 1997-2000.

Awards Committee, 2007-2009

3. Additional Professional Activities:

Professional Societies: (member since)

Society of Toxicology (1976)

American Society for Pharmacology and Experimental Therapeutics (1980)

Arizona Society of Anesthesiologists (1982)

American Society of Anesthesiologists (1982)

International Society for the Study of Xenobiotics (1982)

American Association for the Advancement of Science (1982)

American Association of Liver Diseases (1990)

Editor:

MECHANISMS Newsletter (Society of Toxicology), 1982-­1985.

Associate Editor:

Toxicology Applied Pharmacology, 1986-1994.

In Vitro Toxicology, 1986-present

Area Editor:

Drug Chemical Toxicology, 1986-present.

Editorial Advisory Board:

Life Sciences, 1984-1993

In Vitro Toxicology, 1986-2001

Drug and Chemical Toxicology, 1983-­1985

CRC Press. Molecular and In Vitro Toxicology, 1987-1996

Toxicology Applied Pharmacology, 1997-2000

Cell Biology and Toxicology, 1998-

Toxicology 2003-

Reviewer for following journals:

Life Sciences

J. Pharmacology and Experimental Therapeutics

Toxicology Applied Pharmacology

Drug Metabolism and Disposition

Chemical Biological Interactions

Biochemical Pharmacology

Molecular Pharmacology

Anesthesiology

Toxicology

Reviews of Contamination and Toxicology

Toxicologic Pathology

Environmenatl Health Perspectives

Sections Chaired National Meetings:

Organohalogen Section, Federation Meetings, Anaheim, California, 1980.

Renal Pharmacology and Toxicology, American Society Pharmacology and Experimental Therapeutics and Pharmacology Society of Canada, Calgary, Alberta Canada, 1981.

General Toxicology, Society of Toxicology, Las Vegas, Nevada, 1983.

Liver, Third International Congress on Toxicology, San Diego, 1983.

Fluorinated Volatile Anesthetic Symposium, 1984 Society of Toxicology Meetings.

Refresher Course on Endotoxins, Coordination Committee, Society of Toxicology 1984 Meetings.

Renal Toxicology, Society of Toxicology, 1985 Meetings, San Diego.

Mechanisms of Renal Toxicology, (Co-Chair), Society of Toxicology, 1989 Meetings, Atlanta.

Forum for New Investigators. NIH funding for new investigators. Society of Toxicology, February 27, 1991.

Mechanisms of Renal Toxicity, Society of Toxicology, 1992, Poster-Discussion Session, Co-Chair.

In Vitro Models: Liver, Society of Toxicology, 1993, Poster-Discussion Session, Co-Chair.

Toxicology Information via Use of Precision-Cut Tissue Slices, Society of Toxicology, 1994, Poster-Discussion Session, Co-Chair.

Modulation of Chemical Toxicity and Risk Assessment. Natural toxicants in foods, Tucson, AZ, June 1996.

Formation and Toxicities of Mono- and Diepoxides.  Mountain West SOT, Salt Lake City, October 4, 1996.

International Consortium for the Environment.  Water Quality Session, San Antonio, TX, March 11-15, 2000.

In Vitro/Animal Alternatives Model.  Session Chair.  Society of Toxicology Annual Meeting, Baltimore, MD.  March 22, 2004.

Plenary Discussion Session:  “Integrating Research Approaches Across Disciplines”, NIEHS Superfund Annual Meeting, University of Washington, November 2004.

Gene Regulations: Metals.  Session Chair.  Society of Toxicology Annual Meetings, New Orleans, LA.  March 8, 2005.

SBRP Annual Meeting, Colloquium: Visions for the future.  Durham, NC, December 5, 2007.

Commentator at National Meetings:

International Anesthesia Research Society, Reno, Nevada, March 9­13, 1980.

Renal Pharmacology and Toxicology, Round Table Discussion, Pharmacologist 23:189, 1981.

Gull Harbour Anesthesia Toxicity Symposium, June 25­27, 1982. Gull Harbour, Manitoba, Canada.

Third International Conference on Molecular and Cellular Mechanisms of Anesthesia, Workshop on Metabolism and Toxicity of Anesthesia. University of Calgary, Calgary, Alberta, Canada, June 13­15, 1984.

American Society of Anesthesiologist, Discussant, Drug Disposition and Anesthetic Action, Atlanta, October 1996.

15th Annual International Society of Exposure Analysis.  “Exposure to Arsenic” session.  Panelist.  Tucson, AZ  November 1-3, 2005.

Consultantship:

Battelle, Pacific Northwest Laboratories, Consult in area of the biochemistry and biomedical pharmacology of fossil fuel pollutants. 1978-­1979.

Gibson-Stephens Neuropharmaceuticals, Inc., Tucson, AZ, Toxicology- Biotransformation, 1982-present. 1978-­1979.

Anaquest, BOC Technical Center. Toxicology. 1989-1996.

3M Company 1997-present.  Halocarbon Toxicity.

Grant Reviewer:

Ad Hoc Reviewer. Clinical Sciences Study Section, National Institutes of Health. September 17, 1984.

Ad Hoc Reviewer. March of Dimes. Anesthetics and Birth defects. July 3, 1984.

National Science Foundation, 1988.

Arizona Kidney Foundation, 1989.

Ad Hoc Reviewer. Toxicology Study Section. National Institutes of Health. February 1990.

Johns Hopkins CAAT Awards, 1988, 1990, 1992, 1995-present.

Toxicology Study Section. National Institutes of Health. October 1990- 1994.

U. S. Department of Veterans Affairs, 1994.

John Sealy Memorial Endowment Fund, University of Texas at Galveston, 1991, 1993, 1994, 1995, 1996, 1997, 1998.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, February 1995.

External Reviewer, Toxicology Study Section, National Institutes of Health, June 1995.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, June 1996.

Ad Hoc Reviewer, Toxicology Study Section, National Institutes of Health, March 1998, June 1998.

NSF Grant Reviewer, March 2001.

Ad Hoc Reviewer, NIEHS, K03 Awards, May 2001.

Ad Hoc Reviewer, Alcohol-Toxicology Study Section, February, October 2002.

NIH Special Emphasis Panel, “High throughput molecular screening assay development.” August 5-6, 2004.

Colgate Palmolive Alternative Animal Testing.  Reviewer – Society of Toxicology.  September 2005.

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G. Publications:

A. Books

1. Comprehensive Toxicology, Elsevier, AJ Gandolfi, CA McQueen, IG Sipes - Editors-in-Chief. 12 Volumes, 374 Chapters, 8000 pages, 1996-1997.

2.  Comprehensive Toxicology, Elsevier-Academic Press, IG Sipes, CA McQueen, AJ Gandolfi.  Volume 14.  Cellular and Molecular Toxicology (Vanden, Heuvel, Greenlee, Perdew, Maltes) 644 pages, 2002.

B. Bookchapters

1.  Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Third Edition, pp. 64-99, 1986.

2.  Gandolfi AJ, Hubbard, AK, and Nunn JF. Hepatic and renal toxicity of inhalational anaesthetics: metabolic effects of nitrous oxide. In: General Anesthetics, 5th Edition, Nunn JF, Utting JE, Brown BR (editors) Butterworth, Publishers, Sonehan, MA, 1988, pp. 86-95.

3.  Ruegg CE, Wolfgang GHI, Gandolfi AJ, Brendel K, and Krumdieck CL. Preparation and utilization of positional renal slices for In Vitro nephrotoxicity studies. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, 1988.

4.  Smith PF, Fisher R, McKee R, Gandolfi AJ, Krumdieck CL, and Brendel K. Precision-cut liver slices: A new in vitro tool in toxicology. In: In Vitro Models in Toxicology (C.A. McQueen, editor) Telford Press, pp. 93-130, 1989.

5.  Hubbard AK, Roth TP, and Gandolfi AJ. Immunological methods for investigating the mechanisms of halothane hepatotoxicity. In: Hepatotoxicity (Meeks, Bull, Editors) CRC Press, pp. 647-665, 1991.

6.  Sipes IG and Gandolfi AJ. Biotransformation of Toxic Substances. In: Casarett and Doull=s Toxicology: The Basic Science of Poisons (Doull, Klaassen, Amdur, Editors), Fourth Edition, 1990.

7.  Clarke JB and Gandolfi AJ. Volatile anesthetics mechanisms of potential hepatotoxicity. Clinical Anesthesia Updates. Barash PG, Cullen BF, Stoelting RK, Editors), J.B. Lippincott Co, Philadelphia, Volume 3, pp. 1-10, 1992.

8.  Clarke JB, Lind RC, and Gandolfi AJ. Mechanisms of Hepatotoxicity of Volatile Anesthetics. In: Advances in Anesthesia 10:219-246, 1992 (Stoelting RK, Barash PG, Gallagher TJ, editors).

9.  Brendel K, Fisher RL, Krumdieck CL, and Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. In: In Vitro Biological Systems Volume 1, Tyson CA and Frazier JM (Editors), Academic Press, San Diego, pp 222-230, 1993.

10. Gandolfi AJ, Brendel K, and Fernando Q. Preparation and use of precision-cut renal cortical slices in renal toxicology. In: Methods in Renal Toxicology (RK Zalups and LH Lash, editors), CRC Press, Boca Raton, FL, pp. 109-122, 1996.

11. Clarke JB, Lind RC, and Gandolfi AJ. Biotransformation and hepatotoxicity of inhalation anesthetics. In: General Anesthesia (Brown BR, Prys-Roberts C, Editors), Butterworth-Heinemann, Oxford, Sixth Edition, 1995.

12. Furst SM and Gandolfi AJ. Immunologic mediation of chemical-induced hepatotoxicity. In: Toxicology of the Liver (William Hewitt and Gabriel Plaa, editors), Raven Press, pp.259-295 1995.

13. Kirkpatrick DS and Gandolfi AJ.  In vitro techniques in screening and mechanistic studies: organ perfusion, slices, and nephron components.  In: Toxicology and the Kidney - Third Edition (J.B. Tarloff and L.H. Lash, Editors) Chapter 4, 40 pages, 2004.

C. Refereed Journal Articles

1.  Bottini AT, Dev V, Dowden BF, and Gandolfi AJ. Structure activity relationships of ethylenimines. VIII. Optically active methyl-substituted ethylenimines. J Med Chem 12:32-333, 1969.

2.  Gandolfi AJ and Van Dyke RA. Dechlorination of chlorethane with a reconstituted liver microsomal system. Biochem Biophys Res Comm 53:687-692, 1973.

3.  Gandolfi AJ, Nakaue HS, and Buhler DR. Effect of hexachlorophene on hepatic drug-metabolizing enzymes in the rat. Biochem Pharmacol 23:1997­2003, 1974.

4.  Van Dyke RA and Gandolfi AJ. Studies on irreversible binding of radioactivity from (14C) halothane ro rat hepatic microsomal liids and protein. Drug Metab Disp 2:469-476, 1974.

5.  Gandolfi AJ and Buhler DR. Biliary metabolites and enterohepatic circulation of hexachlorophene in the rat. Xenobiotica 4:693-704, 1974.

6.  Van Dyke RA and Gandolfi AJ. Characteristics of a microsomal dechlorination system. Mol Pharmacol 11:809-817, 1975.

7.  Van Dyke RA and Gandolfi AJ. Anaerobic release of fluoride from halothane: relationship to the binding of halothane metabolites to hepatic cellular constituents. Drug Metab Disp 4:40­44, 1976.

8.  Widger AL, Gandolfi AJ, and Van Dyke RA. Hypoxia and halothane metabolism in vivo: release of inorganic fluoride and halothane metabolite binding to cellular constituents. Anesthesiology 44:197-201, 1976.

9.  Tinker JH, Gandolfi AJ, and Van Dyke RA. Evaluation of human plasma bromide levels in patients following halothane anesthesia: time correlation with total halothane dosage. Anesthesiology 44:194­196, 1976.

10. Wood CL, Gandolfi AJ, and Van Dyke RA. Lipid binding of a halothane metabolite: in vitro comparison with lipid peroxidation. Drug Metab Disp 4:305­313, 1976.

11. Gandolfi AJ and Buhler DR. Metabolism of hexachlorophene in the rabbit: excretion, tissue distribution and characterization of the urinary glucuronide conjugate. J Agricul Food Chem 25:21­25, 1977.

12. Blitt CD, Brown BR Jr., Wright BJ, and Gandolfi AJ, Sipes IG. Pulmonary biotransformation of methoxyflurane: An in vitro study in the rabbit. Anesthesiology 51:528­531, 1979.

13. Maiorino RM, Sipes IG, Gandolfi AJ, and Brown BR Jr. Quantitative determination of volatile halothane metabolites in biological tissues. J Chromatog 164:63­72, 1979.

14. Miller MS and Gandolfi AJ. A rapid sensitive method for quantification of enflurane in blood. Anesthesiology 51:542­544, 1979.

15. Bentley JB, Vaughan RW, Miller MS, Calkins JM, and Gandolfi AJ. Serum inorganic fluoride levels in obese patients during and after enflurane anesthesia. Anesth Analg 58:409­412, 1979.

16. Renne RA, Smith LG, McDonald KE, Shields CA, Gandolfi AJ, and Lund JE. Morphologic and biochemical effects of intratracheally administered oil shale in rats. J Envir Path Tox 3:397­406, 1980.

17. Soltis JJ and Gandolfi AJ. A simple method for the determination of organic fluoride using sodium fusion. Anesth Analg 59:61­64, 1980.

18. Jee R, Gandolfi AJ, Sipes IG, and Brown BR Jr. Factors influencing halothane hepatotoxicity in the rat hypoxic model. Toxicol ApplPharm 52:267­277, 1980.

19. Pelroy RA and Gandolfi, AJ. Use of a mixed function amine oxidase for metabolic activation in the Ames/Salmonella assay system. Mut Res 72:329­334, 1980.

20. Sipes IG, Gandolfi AJ, Pohl LR, Krishna G., and Brown BR. Comparison of the biotransformation and hepatotoxicity of halothane and deuterated halothane. J Pharm Exp Therap 214:716­720, 1980.

21. Gandolfi AJ, White RW, Sipes IG, and Pohl LR. Bioactivation and binding of halothane in vitro: Studies with 3H and 14C halothane. J Pharm Exp Therap 214:721­725, 1980.

22. Vaughan RW, Gandolfi AJ, and Bentley JB. Biochemical considerations of morbid obesity. Life Sciences 26:2215­2221, 1980.

23. Miller MS, Gandolfi AJ, Vaughan RW, and Bentley JB. Disposition of enflurane in obese patients. J Pharm Exp Therap 215:292­296, 1980.

24. Miller MS and Gandolfi AJ. Enflurane biotransformation in humans. Life Sciences 27:1465­1468, 1980.

25. Maiorino RM, Gandolfi AJ, Sipes IG, and Brown BR. Gas chromatographic method for the halothane metabolites, trifluoroacetic acid and bromide, in biological fluids. J Anal Tox 4:250­254, 1980.

26. Maiorino RM, Sipes IG, Gandolfi AJ, Brown BR, and Lind RC. Factors affecting the formation of chlorotrifluoroethane and chlorodifluoro-ethylene from halothane. Anesthesiology 54:383­389, 1981.

27. Blitt CD, Gandolfi AJ, Soltis JJ, and Brown BR. Extrahepatic biotransformation of halothane and enflurane. Anesth Analg 60:129­132, 1981.

28. Potter CL, Gandolfi AJ, Nagle R, and Clayton JW. Renal toxicity of chlorotrifluoroethylene and hexafluoropropene in the rat. Toxicol ApplPharm 59:431­440, 1981.

29. Gandolfi AJ, Sipes IG, and Brown BR. Detection of covalently bound halothane metabolites in the rat hypoxic model for halothane hepatotoxicity. Fund Appl Tox 1:255­259, 1981.

30. Bentley JB, Vaughan RW, Cork RC, and Gandolfi AJ. Does evidence of reductive biotransformation correlate with hepatic binding of metabolites in obese patients. Anesth Analg 60:548­551, 1981.

31. Gillespie TJ, Gandolfi AJ, Maiorino RM, and Vaughan RW. Gas chromatographic determination of fentanyl and its analogues in human plasma. J Anal Tox 5:133­137, 1981.

32. White RD, Sipes IG, Gandolfi AJ, and Bowden GT. Characterization of hepatic DNA damage caused by exposure to 1,2-dibromoethane using the alkaline elution technique. Carcinogenesis 2:839­844, 1981.

33. Cunningham ML, Gandolfi AJ, Brendel K, and Sipes IG. Covalent binding of halogenated volatile solvents to subcellular macromolecules in hepatocytes. Biochem Biophys Res Comm 29:1207­1212, 1981.

34. Gandolfi AJ, Nagle RB, Soltis JJ, and Plescia F. Nephrotoxicity of halogenated vinylcysteine compounds. Res Commun Chem Path Pharm 33:249­261, 1981.

35. Bonhaus DW and Gandolfi AJ. Conjugation and bioactivation of chlorotrifluoroethylene. Life Sciences 29:2399­2405, 1981.

36. Maiorino RM, Gandolfi AJ, Brendel KB, MacDonald JR, and Sipes IG. Chromatographic resolution of amino acid adducts of aliphatic halides. Chem Biol Inter 38:175­188, 1982.

37. DiRenzo AB, Gandolfi AJ, and Sipes IG. Microsomal bioactivation and covalent binding of aliphatic halides to DNA. Tox Letters 11:243­252, 1982.

38. Bentley JB, Vaughan RV, Gandolfi AJ, and Cork RC. Halothane metabolism in obese versus nonobese patients. Anesthesiology 57:94­97, 1982.

39. MacDonald JR, Gandolfi AJ, and Sipes IG. Potentiation of 1,1­2-trichloroethane hepatotoxicity by acetone pretreatment. Tox Letters 13:57­69, 1982.

40. Bentley JB, Borel JD, Vaughan RV, and Gandolfi AJ. Weight: succinyl choline requirement and pseudocholinesterase activity. Anesthesiology 57:48­49, 1982.

41. Gillespie TJ, Gandolfi AJ, Davis T, and Morano RA. Identification and quantification of methylfentanyl in postmortem samples. J Anal Tox 6:139­142, 1982.

42. Borel JD, Bentley JB, Vaughan RV, and Gandolfi AJ. Enflurane blood-gas solubility: Influence of weight, hemoglobin and hematocrit. Anesth Analg 61:1006­1009, 1982.

43. Buckley LA, Gandolfi AJ, Nagle RB, and Clayton JW. Chlorotrifluoroethylene nephrotoxicity in the rat: A subacute study. Fund Appl Tox 2:181­186, 1982.

44. DiRenzo AB, Gandolfi AJ, Sipes IG, and McDougal JN. Effect of senescence on the bioactivation of aliphatic halides. Res Comm Chem Path Pharmacol 36:493­502, 1982.

45. MacDonald JR, Gandolfi AJ, and Sipes IG. Covalent binding of 14C­1,1,2-trichloroethane to microsomal proteins and lipids following acetone pretreatment in vitro and in vivo. Drug Chem Tox 5:233­247, 1982.

46. Hassall CD, Brendel K, and Gandolfi AJ. Effect of halogenated vinyl cysteine conjugates on renal tubular transport. Toxicology 26:285­294, 1983.

47. Jaffe DR, Hassall CD, Brendel K, and Gandolfi AJ. In vivo and in vitro nephrotoxicity of the cysteine conjugates of hexachlorobutadiene. J Tox Env Health 11:857­867, 1983.

48. Hassall CD, Gandolfi AJ, and Brendel K. Reversal of DCVC-induced inhibition of renal tubular transport by glutathione. J Appl Toxicol 3:321­325, 1983.

49. Hassall CD, Gandolfi AJ, and Brendel K. Correlation of the in vivo and in vitro renal toxicity of S-(1,2-dichlorovinyl)-L-cysteine. Drug Chem Tox 6:507­520, 1983.

50. MacDonald JR, Gandolfi AJ, and Sipes IG. Cysteine treatment of chemically induced liver injury. In: Developments in the Science and Practice of Toxicology, (Hayes, Schnell, Miya, eds.), Elsevier Science Publishers, pp 463­466, 1983.

51. White RD, Gandolfi AJ, Bowden CT, and Sipes IG. The deuterium isotope effect on the metabolism and toxicity of 1,2-dibromoethane. Toxicol ApplPharm 69:170­178, 1983.

52. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. The involvement of endotoxin in halothane-associated liver injury. Anesthesiology 61:544­550, 1984.

53. Hassall CD, Gandolfi AJ, and Brendel K. The formation and biotransformation of cysteine conjugates of halogenated ethylenes by rabbit renal tubules. Chem Biol Interact 49:283­297, 1984.

54. Fukui T, Hameroff SR, and Gandolfi AJ. Alterations in plasma alpha­1-acid glycoprotein and beta-endorphin in chronic pain patients. Anesthesiology 60:494­496, 1984.

55. MacDonald JR, Gandolfi AJ, and Sipes IG. Cystamine treatment of galactosamine-induced hepatotoxicity in rats. Toxicol ApplPharm 73:551­558, 1984.

56. Durham JA, Gandolfi AJ, and Bentley JB. Hepatotoxicological evaluation of dantrolene sodium. Drug Chem Tox 7:23­40, 1984.

57. Jaffe DR, Gandolfi AJ, and Nagle RB. Chronic toxicity of S-(trans­1,2,-dichlorovinyl)-L-cysteine (DCVC) in mice. J Appl Toxicol 4:315­319, 1984.

58. MacDonald JR, Lind RC, Sipes IG, and Gandolfi AJ. Determination of hepatic tissue calcium levels by flame emission spectrometry. J Anal Tox 8:155­157, 1984.

59. DiRenzo AB, Gandolfi AJ, Sipes IG, Brendel K, and Byard JL. Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat hepatocyte cultures. Xenobiotica 14:521­525, 1984.

60. MacFarland RT, Gandolfi AJ, and Sipes IG. Extrahepatic GSH-dependent metabolism of 1,2-dibromoethane and 1,2-dibromo­3-chloropropane. Drug Chem Tox 7:213­217, 1984.

61. Cater KC, Sipes IG, and Gandolfi AJ. A sequential quantitative study of dimethylnitrosamine (DMN) - induced hepatic hyperplastic nodules in the newborn mouse model using histochemical and histoenzymatic markers. J Toxicologic Path 13:3­9, 1985.

62. Jaffe DR, Hassall CS, Gandolfi AJ, and Brendel K. Production of DNA single strand breaks in rabbit renal tissue after exposure to 1,2-dichlorovinyl cysteine. Toxicology 35:25­33, 1985.

63. Smith PF, Gandolfi AJ, Krumdieck CL, Putnam CW, Zukowski CF, Davis WM, and Brendel K. Dynamic organ culture of precision liver slices for in vitro toxicology. Life Sciences 36:1367­1375, 1985.

64. Weldon ST, Gandolfi AJ, Williams-Van Alstyne SA, and Blitt CD. Characterization and quantitation of impurities in isoflurane vaporizers. Anesth Analg 64:634­639, 1985.

65. Lind RC, Shivley JW, Sipes IG, Gandolfi AJ, and Brown BR. The rat model of halothane-associated hepatitis. Comparative Pathology Bulletin 17:3­4, 1985.

66. Wiggum DC, Cork RC, Weldon ST, Gandolfi AJ, and Perry DS. Post-operative respiratory depression and elevated sufentanil levels in a patient with chronic renal failure. Anesthesiology 63:708­710, 1985.

67. Lind RC, Gandolfi AJ, Sipes IG, and Brown BR. Comparison of the requirements for hepatic injury with halothane and enflurane in rats. Anesth Analg 64:955­963, 1985.

68. MacDonald JR, Gandolfi AJ, and Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol ApplPharm 81:17­24, 1985.

69. Weldon ST, Perry DS, Cork RC, and Gandolfi AJ. Detection of picogram levels of sufentanil by capillary gas chromatography. Anesthesiology 63:684­687, 1985.

70. DiRenzo AB, Gandolfi AJ, Brooks SD, and Brendel K. Toxicity and biotransformation of volatile halogenated anesthetics in rat hepatocytes. Drug Chem Tox 8:207­218, 1985.

71. MacDonald JR, Gandolfi AJ, and Sipes IG. Hepatic cysteamine and nonprotein sulfhydryl levels following cystamine or cysteamine treatment of galactosamine-poisoned rats. Drug Chem Tox 8:483­494, 1985.

72. Jackson JE, Bentley JB, Glass SJ, Fukui T, Gandolfi AJ, and Plachetka JR. Effects of H2-Receptor blockade on lidocaine pharmacokinetics. Clin Pharmacol Therap 37:544­548, 1985.

73. MacDonald JR, Gandolfi AJ, and Sipes IG. Amelioration of carbon tetrachloride-induced hepatic necrosis by post-toxicant treatment with cystamine. Toxicology 39:135­148, 1986.

74. Lind RC, Gandolfi AJ, Sipes IG, Brown BR, and Waters SJ. Oxygen requirements for the reductive defluorination of halothane by rat hepatic microsomes. Anesth Analg 65:835­839, 1986.

75. Smith PF, Krack G, McKee RL, Johnson DG, Gandolfi AJ, Hruby VL, Krumdieck CL, and Brendel K. Maintenance of adult rat liver slices in dynamic organ culture. In Vitro Tox 22:706­712, 1986.

76. Lind RC, Gandolfi AJ, and Brown BR. Are the requirements for hepatic injury with halothane and enflurane in rats really different? Anesth Analg 65:545­547, 1986.

77. DiRenzo AB, Gandolfi AJ, Brendel K, and Krack G. Effect of volatile anesthetics on protein synthesis and secretion in rat hepatocyte suspensions. Drug Chem Tox 9:223­237, 1986.

78. Silber PM, Gandolfi AJ, and Brendel K. Adaption of a gamma-glutamyl transpeptidase assay to microtiter plates. Anal Biochem 158:68­71, 1986.

79. Silber PM, Gandolfi AJ, and Brendel K. Early biological indicators of S-(1,2-dichlorovinyl) cysteine nephrotoxicity in the rabbit. Drug Chem Tox 9:285­303, 1986.

80. Moore RA, McNicholas KM, Gallagher JD, Gandolfi AJ, Sipes IG, Kerns D, and Clark DL. Halothane metabolism in acyanotic and cyanotic patients undergoing open heart surgery. Anesthesiology 65:1257­1262, 1986.

81. Ruegg CE, Gandolfi AJ, and Brendel K. Preparation and incubation of precision-cut, positional renal slices. Pharmacol Methods 17:111­123, 1987.

82. Callis AH, Brooks SD, Roth TP, Gandolfi AJ, and Brown BR. Characterization of a halothane-induced humoral response in rabbits. Clin Exptl Immunol 67:343­351, 1987.

83. Brown BR and Gandolfi AJ. Adverse effects of volatile anaesthetics. Br J Anaesth 59:14­23, 1987.

84. Smith PF, Fisher R, Shubat PJ, Gandolfi AJ, Krumdieck CL, and Brendel K. In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system. Toxicol ApplPharm 87:509­522, 1987.

85. Lind RC, Gandolfi AJ, Brown BR, and Hall PM. Halothane hepatotoxicity in guinea pigs. Anesth Analg 66:222­228, 1987.

86. Sipes IG, Fisher RL, Smith PF, Gandolfi AJ, and Brendel K. A dynamic liver culture system: A tool for studying chemical biotransformation and toxicity. Arch Toxicol, Suppl 11, 20­33, 1987.

87. Brendel K, Gandolfi AJ, Krumdieck CL, and Smith PF. Organ slices revisited. Trends Pharmacol Sci 8:11­15, 1987.

88. Rylander LA, Phelps JS, Gandolfi AJ, and Brendel K. In vitro nephrotoxicity: Toxicity of cadmium chloride and dichlorovinyl cysteine to isolated renal tubules. In Vitro Tox 1:111­127, 1987.

89. Ruegg CE, Gandolfi AJ, Brendel K, and Nagle RB. Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or anoxic conditions. Toxicol ApplPharm 90:261­273, 1987.

90. Becker GM, Gandolfi AJ, and Nagle RB. Effects of cyclosporin A and G on a kidney epithelial cell line (LLC-PK). Res Comm Chem Path Pharmacol 56:277­286, 1987.

91. Phelps JS, Gandolfi AJ, Dohr R, and Brendel K. Cisplatin nephrotoxicity: In vitro studies with precision cut renal cortical slices. Toxicol ApplPharm 90:501­512, 1987.

92. Siadat-Pajouh M, Callis AH, Roth TP, and Gandolfi AJ. Generation of halothane induced immune response in a guinea pig model for halothane hepatitis. Anesth Analg 66:209­1214, 1987.

93. McKee RL, Hruby VJ, Trivedi DB, Johnson DG, Gandolfi AJ, Krumdieck CL, and Brendel K. A perifused precision-cut liver slice system for the study of hormone regulated hepatic glucose metabolism. J Pharmacol Methods 19:339-354, 1987.

94. Roth TP, Callis AH, Gandolfi AJ, and Brown BR. Chronology of halothane induced antigen expression in halothane-exposed rabbits. Clin Expt Immunol 72:330­336, 1988.

95. Dale O, Gandolfi AJ, and Brendel K. Rat liver slices and diazepam metabolism: In vitro interaction with volatile anaesthetic drugs and albumin. Br J Anaesth 60:692­696, 1988.

96. Meadows SD, Gandolfi AJ, and Nagle RB. Genotoxic effects of 1,2-dichlorovinyl cysteine: Initiation and promotion effects in Swiss-Webster Mice. Drug Chem Tox 11:307­318, 1988.

97. Hubbard AK, Roth TP, Gandolfi AJ, and Brown BR. Halothane hepatitis patients generate an antibody response toward a metabolite of halothane. Anesthesiology 68:791­796, 1988.

98. Lind RC and Gandolfi AJ. Hypoxia and anesthetic-associated liver injury in guinea pigs. Anesthesiology 68:974­976, 1988.

99. Lind RC, Gandolfi AJ, Hall PM, and Brown BR. Role of oxidative biotransformation of halothane in the guinea pig model of halothane-associated hepatotoxicity. Anesthesiology 70:649­653, 1988.

100. Hubbard AK, Roth TP, Schuman S, and Gandolfi AJ. Localization of halothane-induced antigen in situ by specific anti halothane metabolite antibodies. Clin Exp Immun 76:422­427, 1989.

101. Hubbard AK, Gandolfi AJ, and Brown BR, Jr. Immunological basis of anesthetic-induced hepatotoxicity. Anesthesiology 69:814­817, 1988.

102. Wolfgang GHI, Gandolfi AJ, and Brendel K. Evaluation of organic nephrotoxins in rabbit renal cortical slices. Tox In Vitro 3:341­350, 1989.

103. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. In vitro and in vivo nephrotoxicity of the L and D isomers of S-(1,2-dichlorovinyl)-cysteine. Toxicology 58:33­42, 1989.

104. Lind RC, Gandolfi AJ, and Hall P. Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs. Anesthesiology 71:878­884, 1989.

105. Wolfgang GHI, Gandolfi AJ, Stevens JL, and Brendel K. N-Acetyl S-(1,2-dichlorovinyl)-L-Cysteine produces a similar toxicity to S-(1,2- dichlorovinyl)-L-Cysteine in rabbit renal slices: Differential transport and metabolism. Toxicol ApplPharm 101:205­219, 1989.

106. Fisher R, Smith PF, Sipes IG, Gandolfi AJ, Krumdieck CL, and Brendel K. Toxicity of chlorobenzenes in cultured rat liver slices. In Vitro Tox 3:181­194, 1990.

107. Lind RC, Gandolfi AJ, and Hall PM. Isoniazid potentiation of a guinea pig model of halothane-associated hepatotoxicity. J Appl Toxicol 10:161-165, 1990.

108. Azri S, Gandolfi AJ, and Brendel K. Carbon tetrachloride toxicity in precision-cut rat liver slices. In Vitro Tox 3:127­138, 1990.

109. Connors S, Rankin DR, Gandolfi AJ, Krumdieck CL, Koep LJ, and Brendel K. Cocaine hepatotoxicity in cultured liver slices: a species comparison. Toxicology 61:171­183, 1990.

110. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Biotransformation of halothane in guinea pig liver slices. Drug Metab Disp 18:514­518, 1990.

111. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Toxicity of halothane in guinea pig liver slices. Toxicology 62:59­69, 1990.

112. Hubbard AK, Levy JP, Roth TP, and Gandolfi AJ. Use of structural alterations in the synthesis of halothane metabolite antigens to mimic halothane-induced immunogens. Drug Chem Tox 13:93-112, 1990.

113. Wolfgang G, Gandolfi AJ, Nagle R, Brendel K, and Stevens J. Assessment of S-(1,2-Dichlorovinyl)-L-cysteine induced toxic events in rabbit renal cortical slices. Biochemical and histological evaluation of uptake, covalent binding, and toxicity. Chemico-Biological Interactions 75:153- 170, 1990.

114. Gandolfi AJ and Brendel K. In vitro systems for nephrotoxicity studies. Tox In Vitro 4:337­345, 1990.

115. Lind RC, Gandolfi AJ, and Hall PM. Covalent binding of oxidative biotransformation intermediates is associated with halothane hepatotoxicity in guinea pigs. Anesthesiology 73:1208-1213, 1990.

116. Azri S, Gandolfi AJ, and Brendel K. Precision-cut liver slices: An in vitro system for profiling potential hepatotoxicants. In Vitro Tox 3:309-320, 1990.

117. Ghantous HN, Fernando J, Morgan SE, Gandolfi AJ, and Brendel K. Precision-cut guinea pig liver slices as a tool to study the toxicity of volatile anesthetics. ATLA 18:191-199, 1990.

118. Fisher R, Putnam CW, Koep LJ, Sipes IG, Gandolfi AJ, and Brendel K. Cryopreservation of pig and human liver slices. Cryobiology 28:131-142, 1991.

119. Brown AP, Hastings KL, and Gandolfi AJ. Generation and detection of neoantigens in guinea pig liver slices incubated with halothane. Int J Immunopharmac 13:429-435, 1991.

120. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Minimal biotransformation and toxicity of desflurane in guinea pig liver slices. Anesth Analg 72:796-800, 1991.

121. Vernetti LA, Nowlin CLA, Hameroff SR, Gandolfi AJ, Lee YC, and Sarid D. Scanning tunneling microscopy resolution of surface features on cytokeratin protein is enhanced by prolonged exposure of protein to cold temperatures. J Vacuum Sci Technol 9:1223-1226, 1991.

122. Wishnies SM, Parrish AR, Sipes IG, Gandolfi AJ, Putnam CL, Krumdieck CL, and Brendel K. Biotransformation activity in vitrified human liver slices. Cryobiology 28:216-226, 1991.

123. Fisher R, Nau H, Gandolfi AJ, and Brendel K. Toxicity of valproic acid in liver slices from Sprague-Dawley rat and domestic pigs. Toxic In Vitro 5: 201-205, 1991.

124. Fisher R, Nau H, Gandolfi AJ, Putnam CW, and Brendel K. Valproic acid hepatotoxicity in human liver slices. Drug Chem Tox 14:375-394, 1991.

125. Hastings KL, Schuman S, Thomas C, Brown AP, Hubbard AK, and Gandolfi AJ. Screening for antibodies associated with halothane hepatitis. Br J Anaesth 67:722-728, 1991.

126. Fisher R, Barr J, Zukoski CF, Putnam CW, Sipes IG, Gandolfi AJ, and Brendel K. In vitro hepatotoxicity of three dichlorobenzene isomers in human liver slices. Human Exptl Toxicol 10:357-363, 1991.

127. Stefaniak MS, Krumdieck CL, Spall RD, Gandolfi AJ, and Brendel K. Biochemical and histological characterization of Agar-filled precision cut rat lung slices in dynamic organ culture as an in vitro tool. In Vitro Tox 5:7-19, 1992.

128. Frink EJ, Ghantous H, Malan TP, Morgan S, Fernando J, Gandolfi AJ, and Brown BR, Jr. Plasma inorganic fluoride with sevoflurane anesthesia: Correlation with indices of hepatic and renal function. Anesth Analg 74:231-235, 1992.

129. Ghantous HN, Fernando JL, Keith RL, Gandolfi AJ, and Brendel K. Effects of halothane and other volatile anaesthetics on protein synthesis and secretion in guinea pig liver slices. Br J Anaesth 68:172-177, 1992.

130. Azri S, Mata HP, Reid LL, Gandolfi AJ, and Brendel K. Further examination of the selective toxicity of CCl4 in rat liver slices. Toxicol ApplPharm 112:81-86, 1992.

131. Vernetti L, Sarid D, Gandolfi AJ, Nagle RB, Hameroff S, McCuskey R, and Cress AE. The topographical structure of cytokeratin intermediate filaments using scanning tunneling microscopy. Nanobiology 1:379-386, 1992.

132. Lind RC, Gandolfi AJ, and Hall PM. Subanesthetic halothane is hepatotoxic in the guinea pig. Anesth Analg 74:559-563, 1992.

133. Connors S, Gandolfi AJ, and Brendel K. Mini-review: Cocaine hepatotoxicity. In press, 1992.

134. Parrish AR, Shipp NG, Spall RD, Dorr RT, Krumdieck CL, Gandolfi AJ, and Brendel K. Organ culture of rat myocardial slices: An alternative in vitro tool in organ specific toxicology. Toxicology Methods 2:101-111, 1992.

135. Fisher R, Hanzlik RP, Gandolfi AJ, and Brendel K. Toxicity of ortho-substituted bromobenzenes in rat liver slices: A comparison to isolated hepatocytes and the whole animal. In Vitro Tox 4:173-186, 1991.

136. Brown AP, Hastings KL, Gandolfi AJ, Liebler DC, and Brendel K. Formation and identification of protein adducts to cytosolic proteins in guinea pig liver slices exposed to halothane. Toxicology 73:281-195, 1992.

137. Ghantous HN, Fernando J, Gandolfi AJ, and Brendel K. Sevoflurane is biotransformed by guinea pig liver slices but causes minimal cytotoxicity. Anesth Analg 75:436-440, 1992.

138. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The hepatotoxicity of chloroform in precision-cut rat liver slices. Toxicology 73:239-250, 1992.

139. Lind RC, Gandolfi AJ, and Hall PM. Glutathione depletion enhances subanesthetic halothane hepatotoxicity in guinea pigs. Anesthesiology 77:721-727, 1992.

140. Ghantous H, Fernando J, Mata E, Gandolfi AJ, and Brendel K. Chronology of toxic events produced by halothane in guinea pig liver slices. In Vitro Tox 5:137-146, 1992.

141. Dale O, Frink EJ, Thommesen L, and Gandolfi AJ. Hepatic elimination of diazepam: Interactions with albumin, desflurane, and sevoflurane. Br J Anaesth 70:454-455, 1993.

142. Stinjntjes GJ, Commandeur JNM, te Koppele JM, McGuinness S, and Gandolfi AJ, Vermeulen NPE. Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue      slices. Toxicology 79:67-79, 1993.

143. Lind RC and Gandolfi AJ. Concentration dependent inhibition of halothane biotransformation in the guinea pig. Drug Metab Disp 21:386-389, 1993.

144. McGuinness SG, Gandolfi AJ, and Brendel K. Use of renal slices and renal tubule suspensions for in vitro toxicity studies. In Vitro Toxicology 6:1-24, 1993.

145. Lowe T, Fernando Q, Keith R, and Gandolfi AJ. Elemental analysis of renal slices by proton induced x-ray emission. Env Health Perspectives 101:302-308, 1993.

146. Fisher RL, Hasal SJ, Sanuik JT, Scott KS, Gandolfi AJ, and Brendel K. Cold- and cryo-preservation of human liver and kidney slices. Cryobiology 30:250-261, 1993.

147. Hubbard AK, Lohr CL, Hastings K, Clarke J, and Gandolfi AJ. Immunogenicity studies of a synthetic antigen of alpha methyl dopa. International J Immunopharm Immunotox 15:621-637, 1993.

148. Lind RC, Gandolfi AJ, and Hall PM. A guinea pig model of halothane-associated hepatitis. Comparative Pathology Bulletin XXV (No. 3):3-4, 1993.

149. Fisher RL, Gandolfi AJ, Sipes IG, and Brendel K. Culture medium composition affects the relative toxicities of chlorobenzenes in rat liver slices and the isolated perfused liver. Drug Chem Tox 16:321-339, 1993.

150. Reid LL, Hastings KL, Gandolfi AJ, and Van Ert M. Use of staphylococcal enterotoxin A - induced interleukin 2 production as an indicator of immunotoxicity. Drug Chem Tox 17:1-14, 1994.

151. Morgan SE, Frink EJ, and Gandolfi AJ. A simplified gas chromatographic method for quantifying the sevoflurane metabolite, hexafluoroisopropanol. Anesthesiology 80:201-205, 1994.

152. Azri-Meehan S, Mata HP, Gandolfi AJ, and Brendel K. The interactive toxicity of CHCl3 and BrCCl3 in precision-cut rat liver slices. Fund Appl Toxicol 22:172-177, 1994.

153. Brown AP and Gandolfi AJ. Glutathione-S-transferase is a target for covalent modification by a halothane reactive intermediate in guinea pig liver. Toxicology 89:35-47, 1994.

154. Parrish AR, Wishnies SR, Dorr RT, Gandolfi AJ, and Brendel K. Coculture of rabbit liver and myocardial slices: Potentiation of the cardiotoxicity of allyl alcohol but not allylamine. In Vitro Toxicology 7:53-57, 1994.

155. Parrish AR, Dorr RT, Gandolfi AJ, and Brendel K. Adult rat myocardial slices: A tool for studies of comparative cardiotoxicity. Tox In Vitro 8:1233-1237, 1994.

156. Lind RC, Gandolfi AJ, and Hall P. A model for fatal halothane hepatitis in guinea pigs. Anesthesiology 81:478-487, 1994.

157. Christen U, Quinn J, Yeaman SJ, Kenna JG, Clarke JB, Gandolfi AJ, and Gut J. Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis: molecular mimicry of CF3CO-Lys by lipoic acid. Europ J Biochem 223:1035-1047, 1994.

158. Sheevers HV, Brendel K, Wright SH, Nagle RB, and Gandolfi AJ. Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices. Toxic In Vitro 8:1243-1251, 1994.

159. Michaud JP, Gandolfi AJ, and Brendel K. Toxic responses to defined chemical mixtures: Mathematical models and experimental designs. Life Sciences 55:635-651, 1994.

160. Fisher RL, Sanuik JT, Nau H, Gandolfi AJ, and Brendel K. Comparative toxicity of valproic acid and its metabolites in liver slices from adult rats, weanling rats and humans. Toxic in Vitro 8:371-379, 1994.

161. Michaud JP, Gandolfi AJ, and Brendel K. Methods of assessing toxic interactions in vitro: Experimental design and data analysis. Toxicology Methods 5:21-40, 1995.

162. Fisher RL, Smith MS, Hasal SJ, Hasal KS, Gandolfi AJ, and Brendel K. The use of human lung slices in toxicology. Human Exp Tox 13:466-471, 1994.

163. Fisher RL, Sanuik JT, Gandolfi AJ, and Brendel K. Toxicity of cisplatin and mercuric chloride in human kidney cortical slices. Human Exp Tox 13:517-523, 1994.

164. Wysynski AM, Martinez-Zaguilan R, Alden C, Gandolfi AJ, and Gillies RJ. Phenobarbital induces cytosolic acidification in an established liver epithelial cell line. Toxicology Letters 74:157-166, 1994.

165. Hastings KL, Thomas C, Brown AP, and Gandolfi AJ. Trifluoroacetylation potentiates the humoral immune response to halothane in the guinea pig. Immunopharm Immunotox 17:201-213, 1995.

166. Fisher RL, Hasal SJ, Sipes IG, Gandolfi AJ, and Brendel K. Comparative metabolism and toxicity of dichlorobenzenes in Sprague-Dawley, Fisher-344 and human liver slices. Human Exp Tox 14:414-421, 1995.

167. Lind RC, Gandolfi AJ, and Hall PM. Biotransformation and hepatotoxicity of HCFC-123 in the guinea pig. Potentiation of hepatic injury by prior glutathione depletion. Toxicol ApplPharm 134:175-181, 1995.

168. Payne AK, Morgan SE, Gandolfi AJ, and Brendel K. Biotransformation of sevoflurane by rat neonates liver slices. Drug Metab Disp 23:497-500, 1995.

169. Clarke JB, Chen M, Thomas C, Hubbard AH, Hastings KL, and Gandolfi AJ. Halogenated anesthetics form liver adducts and antigens that crossreact with halothane-induced antibodies. Intern Arch Allergy Immuno 108:24-32, 1995.

170. McGuinness SJ, Rankin DR, Bezruvczyk P, Brendel K, and Gandolfi AJ. Nephrotoxicity and transport of celiptium in rabbit renal proximal tubule suspensions. In Vitro Tox 8:169-175, 1995.

171. Frey N, Christen U, Jeno P, Yeaman SJ, Shimomura Y, Kenna JG, Gandolfi AJ, Ranek L, and Gut J. The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. Chem Res Toxicol 8:736-746, 1995.

172. Wijeweera JB, Thomas CM, Gandolfi AJ, and Brendel K. Sodium arsenite and heat shock induce stress proteins in precision-cut rat liver slices. Toxicology 104:35-45, 1995.

173. Gunaratnum NT, Benson J, Gandolfi AJ, and Chen ML. Isoflurane hepatitis in an obese patient with a history of halothane hepatitis. Anesthesiology 83:1361-1364, 1995.

174. Groves CE, Morales MN, Gandolfi AJ, Dantzler WH, and Wright SH. Peritubular paraquat transport in isolated renal proximal tubules. J Pharm Exptl Therap, in revision, 1995.

175. Gandolfi AJ, Brendel K, Fisher RL, and Michaud JP. Use of tissue slices in chemical mixture toxicology and interspecies investigations. Toxicology 105:285-290, 1995.

176. Furst SM, Chen M, and Gandolfi AJ. Use of halothane as a model for investigating chemical-induced autoimmunity. Drug Information Journal 30:301-307, 1996.

177. Fisher RL, Shaughnessy RP, Jenkins PM, Austin ML, Roth GL, Gandolfi AJ, and Brendel K. Dynamic organ culture is superior to multiwell plate culture for maintaining precision-cut tissue slices: Optimization of tissue slice culture. Toxicology Methods 5:99-113, 1995.

178. Fisher RL, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Determination of optimal incubation media and suitable slice diameters in precision-cut liver slices: Optimization of tissue slice culture, Part 2. Toxicology Methods 5:115-130, 1995.

179. Michaud JP, Gandolfi AJ, and Brendel K. Investigation of hepatotoxic interaction using precision-cut rat liver slice culture: Steps towards validation, and comparisons to in vivo findings. In Vitro Toxicology, in press, 1995.

180. Parrish AR, Gandolfi AJ, and Brendel K. Precision-cut tissue slices: Applications in pharmacology and toxicology. Life Sciences 57:1887-1901, 1995.

181. Gandolfi AJ, Wijeweera J, and Brendel K. Use of precision-cut liver slices as an in vitro tool for evaluating liver function. Toxicol Pathology 24:58-61, 1996.

182. Fisher RL, Jenkins PM, Hasal SJ, Sanuik JT, Gandolfi AJ, and Brendel K. Rainbow trout liver slices: A tool for aquatic toxicology. Toxic Substances Mechanisms 15:13-26, 1996.

183. Wijeweera JB, Gandolfi AJ, Badger DA, Sipes IG, and Brendel K.  Vitamin A potentiation of vinylidene chloride hepatotoxicity in rats and precision-cut rat liver slices.  Fund Appl Toxicol 34:73-83, 1996.

184. Hoivik DJ, Fisher RL, Brendel K, Gandolfi AJ, Khairallah EA, and Cohen SD.  Protein arylation precedes acetaminophen toxicity in a dynamic organ culture of mouse kidney.  Fund Appl Toxicol 34:99-104, 1996.

185. Fisher RL, Hasal SJ, Sanuik JT, Hasal KS, Gandolfi AJ, and  Brendel K.  Cold- and cryopreservation of dog liver and kidney slices.  Cryobiology 33:163-171, 1996.

186. Keith RL, Setiarahardjo I, Fernando Q, Aposhian HV, and Gandolfi AJ.  Utilization of renal slices to evaluate the efficacy of chelators to remove mercury from the kidney.  Toxicology 116:67-75, 1997.

187. Lind RC and Gandolfi AJ.  Late dimethyl sulfoxide administration provides a protective action against chemically induced injury in both the liver and kidney.  Toxicol Appl Pharmacol 142:201-207, 1997.

188. Chen M and Gandolfi AJ.  Characterization of the humoral immune response and hepatotoxicity after multiple-halothane exposures in guinea pigs.  Drug Metabolism Reviews 29:103-122, 1997.

189. Furst SM, Leudke D, Gaw H, Reich R, and Gandolfi AJ.  Demonstration of a cellular immune response in halothane-exposed guinea pigs.  Tox Appl Pharm 143:245-255, 1997.

190. Furst SM, Leudke D, and Gandolfi AJ.  Kupffer cells from halothane exposed guinea pigs carry trifluoroacetylated protein adducts.  Toxicology 120:119-132, 1997.

191. Furst SM, and Gandolfi AJ.  Interaction of lymphocytes with Kupffer cells from halothane- exposed guinea pigs.  Int Arch Allergy Immunol, 114:46-53, 1997.

192. Parrish AR, Fisher R, Bral C, Burghardt RC, Gandolfi AJ, Brendel K, and Ramos KS.  Benzo(a)pyrene-induced alterations in growth-related gene expression and signaling in precision-cut rat liver and kidney slices.  Toxicol. Appl. Pharmacol, 152: 302-308, 1998.

193. Wijeweera J, Gandolfi AJ, and Zheng XH.  Interactive toxicity and stress protein expression by vinylidene chloride and monochloroacetate in precision-cut rat liver slices.  Env. Health Perspectives, 106 (Suppl 6) 1319-1323,1998.

194.  Wei H, Qiu L, Divine KK, Fernando Q, and Gandolfi AJ.  Toxicity and transport of three synthesized mercury-thiol-complexes in isolated rabbit renal proximal tubule suspensions.  Drug Chem Tox, 22: 323-341, 1999.

195. Keith RL, Gandolfi AJ, McIntyre LC, Jr., Ashbaugh MD, and Fernando Q.  Analysis of heavy metal deposition in renal tissue by sectional mapping using PIXE.  Nuclear Instruments and Methods (B), 149: 167-176, 1999.

196. Lind RC and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide.  I.  Protection when given twenty-four hours after chloroform or bromobenzene.  Tox Path, 27:342-347, 1999.

197. Lind RC and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide.  II.  Characterization of optimal dose and the latest time of administration for effective protection against chloroform and bromobenzene induced injury.  Exp Toxicol Path, 51:537-543, 1999.

198. Parrish AR, Zheng XH, Turney KD, Younis HS, and Gandolfi AJ.  Enhanced transcriptional factor DNA binding and  gene expression induced by arsenite or arsenate in renal slices.  Tox Sci, 50:98-105, 1999.

199. Parrish AR, Catania JM, Orozco J, and Gandolfi AJ.  Chemically-induced oxidative stress disrupts the E-cadherin/catenin cell adhesion complex.  Tox Sci, 51:80-86, 1999.

200.  Turney KD, Parrish AR, Orozco J, and Gandolif AJ.  Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices.  Tox Appl Pharm, 160:262-270, 1999.

201.   Lind RC, Begay CK, and Gandolfi AJ.  Hepatoprotection by dimethyl sulfoxide III.  Role of inhibition of the bioactivation and covalent binding of chloroform.  Tox Appl Pharm, 166: 145-150, 2000.

202.   Ito Y, Lind RC, Begay CK, Gandolfi AJ, McCuskey MK, and McCuskey RS.  Late administration of dimethyl sulfoxide minimizes the hepatic microvascular inflammatory response to chloroform in rats.  Hepatology Research, 18 (3):203-217 2000.

203.  Wijeweera JB, Gandolfi AJ, Parrish A, and Lantz RC.  Sodium arsenite enhances AP-1 and NFkB DNA binding and induces stress protein expression in precision-cut rat lung slices.  Tox Sci, 61 283-294, 2001.

204.  Catania JM, Parrish AR, and Gandolfi AJ.  Toxicity of a sevoflurane degradation product incubated with liver and renal cortical slices.  Drug Chem Tox, 24:347-357, 2001.

205.  Zheng XH, Begay CK, Lind RC, and Gandolfi AJ.  Humoral immune response to a sevoflurane degradation product in the guinea pig following inhalation exposure.   Drug Chem Tox, 24:339-346, 2001.

206. Fisher RL, Gandolfi AJ, and Brendel K.  Human liver is a dominant factor in the outcome of in vitro studies.  Cell Biol Tox, 17:179-189, 2001.

207. Parrish AR, Sallam K, Nyman DW, Orozco J, Cress AE, Dalkin BL, Nagle RB, and Gandolfi AJ.  Culturing precision-cut human prostate slices as an in vitro model of prostate pathobiology.  Cell Biol Tox, 18:205-219, 2002.

208. Fisher RL, Hasal SJ, Lipscomb JC, Gandolfi AJ, and Brendel K.  Cold- and cryopreservation of monkey liver slices.  Cryobiology, Toxicology Mechanisms Methods, 12:119-133, 2002.

209. Kirkpatrick DS, Dale KV, Catnaia JM, and Gandolfi AJ.  Low-level arsenite causes accumulation of ubiquinated proteins in rabbit renal cortical slices and HEK 293 cells. Tox and App Pharm, 186:101-109, No. 2, January 2003.

210. Quanrud DM, Arnold RG, Lansey KE, Begay CK, Ela W, and Gandolfi AJ.  Fate of effluent organic matter during soil aquifer treatment: biodegradability, chlorine reactivity, and genotoxicity. J. Water and Health, 1.1:33-44, 2003. 

211.  Catania JM, Parrish AR, Kirkpatrick DS, Chitkara M, Bowden GT, Henderson CJ, Wolf CR, Clark AJ, Brendel K, Fisher RL, and Gandolfi AJ.  Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.  Toxicology In Vitro, 17:201-205, 2003.

212.  Zheng XH, Watts G, Vaught S, and Gandolfi AJ.  Low-level arsenate induced gene expression in HEK293 cells.  Toxicology, 187:39-48, 2003.

213.  Begay CK and Gandolfi AJ. Late administration of COX-2 inhibitors minimize hepatic necrosis in chloroform induced liver injury. Tox 185: 79-87, 2003.

214.  Peraza MA, Carter DE, Gandolfi AJ.  Toxicity and metabolism of  subcytotoxic inorganic arsenic in human renal proximal tubule epithelial cells (HK-2). Cell Biology Toxicology, 19:253-264, 2003.

215. Carter DE, Aposhian HV, Gandolfi AJ.  The metabolism of inorganic arsenic, gallium arsenide, and arsine: a toxicochemical review.  Tox Appl Pharm, 193:309-334, 2003.

216. Meza M, Kopplin M, Gandolfi AJ.  Arsenic drinking water exposure and unirnary excretion among adults in the Yaqui Vally, Sonora, Mexico.  Environ Res, 96:119-126, 2004.

217.  Bredfeldt TG,  Kopplin M, Gandolfi AJ.  Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Tox Appl Pharm, 198:412-418, 2004.

218.  Nyman DW, Stratton MS, Kopplin MJ, Dalkin BL, Nagle RB, Gandolfi AJ.  Selenium and selenomethionine levels in prostate cancer patients.  Cancer Detection and Prevention, 28:8-16, 2004.

219.  Field JA, Sierra-Alvarez R, Cortinas I, Feijool G, Moreira MT, Kopplin M, Gandolfi AJ. Facile reduction of arsenate in methanogenic sludge.  Biodegradation, 15:185-196, 2004.

220. Sierra-Alvarez R, Field JA, Cortinas I, Feijoo F, Moreira MT, Kopplin M, Gandolfi AJ. Anaerobic Microbial Mobilization and Biotransformation of Arsenate Adsorbed onto Activated Alumina. Water Research, 39:199-209 (2005).

221. Kirkpatrick DS, Weldon SF, Tsaprailis G, Gygi SP, Liebler DC, Gandolfi AJ.  Proteomic identification of ubiquinated proteins from human cells expressing His-tagged ubiquitin  Proteomics, 5:2104-2111, 2005.     

222.  Schmelz M, Moll R, Hesse U, Prasad AR, Gandolfi AJ, Hasan SR, Bartholdi M, Cress AE.  Identification of a Stem Candidate in the Normal Human Prostate Gland.  European J Cell Biology, 84:341-354, 2005.

223.  Carranza Rosales P, Said-Fernandez S, Sepulveda-Saavedra J, Cruz-Vega DE, Gandolfi AJ.  Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line:  ultrastructural evidence for an apoptotic mechanisms of damage.  Toxicology, 210:111-121, 2005.

224.  Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT.  Developmentally restricted genetic determinants of human arsenic metabolism:  association between urinary methylated arsenic and CYT19 polymorphisms in children.  Env Health Perspetive, 113:775-781, 2005.

225. Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ.  Monomethylarsenous acid induces transformation of human bladder cells.  Tox Appl Pharm, 216:69-79, 2006.

226. Cortinas I, Field JA, Sierra R, Kopplin M, Garbarino J, Gandolfi AJ.  Anaerobic biotransformation of roxarsone and related N-substituted phenylarsonic acids.  Env Sci Technol, 40:2951-2957, 2006.

227. Peraza MA, Carter DE, Gandolfi AJ.  Morphological and functional alterations in human proximal tubular cell line induced by low-level inorganic arsenic: evidence for targeting mitochondria and initiated apoptosis.  J Appl Tox 26:356-367, 2006.

228. Conley SM, McKay BS, Gandolfi AJ, Stamer WD.  Alterations in human trabecular meshwork cell homeostasis by selenium.  Exp Eye Research, 82: 637-647, 2006.

229.  Sierra R, Yenal U, Field JA, Kopplin M, Gandolfi AJ, Garbarino JR.  Anaerobic biotransformation of organoarsenical pesticides, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV).  J. Ag Fd Chem, 54:3959-3966, 2006.

230. Eblin KE, Bowen ME, Cromey D, Bredfeldt TG, Mash EA, Gandolfi AJ.  Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture.  Tox Appl Pharm, 217:7-14, 2006.

231. Eblin KE, Bredfeldt TG, Buffington S, Gandolfi AJ.  Mitogenic, pro-inflammatory signal transduction caused by monomethylarsonous acid in UROtsa cells.  Tox Sci, 95(2): 321-330, 2007.

232. Carranza-Rosales P, Guzman-Delgado N, Cruz-Vega D, Balderas-Renteria I, Gandolfi AJ.  DMPS protective effect on mitochondrial structure and function in OK cells exposed to toxic concentrations of HgCl2.  Cell Biol Toxicology, 23:163-176, 2007.

233. Meza M, Gandolfi AJ, Klimecki WT.  Developmental and genetic modulation of arsenic metabolism:  a gene by environment interaction?  Tox Appl Pharm, 222:381-387, 2007.

234. Catania JM, Pershing AM, Gandolfi AJ.  Precision-cut tissue chips as an in vitro system.  Tox In Vitro, 21:956-961, 2007.

235. Wang X, Sun Z, Chen W, Eblin KE, Gandolfi AJ, Zhang DD.  Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity.  Tox Appl Pharm, 225: 206-213, 2007.   

236.  Meza MM, Kopplin MJ, Burgess JL, Gandolfi AJ.  Urinary arsenic profile in children and adults exposed to low levels through drinking water in Sonora, Mexico. Toxicol Environ Health A, accepted, 2007.

237.  Eblin KE, Bredfeldt TG, Gandolfi AJ.  Possible Mechanisms of Arsenic-Induced Bladder Cancer: A review of UROtsa cells as a model.  Toxicology, 248:67-76, 2008.

238.  Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW.  Epigenetic Remodeling During Arsenical-Induced Malignant Transformation.  Carcinogenesis, 29:1500-8, 2008.

239.  Eblin KE, Hau A, Jensen TJ, Buffington SE, Futscher BW, Gandolfi AJ.  The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies.  Toxicology, 250:47-54, 2008.


D. Non-Refereed Journal Articles

1. Gandolfi AJ. Toxicity of TCE in Tucson well water. Southern Arizona Environmental Council Bulletin 11:2­3, 1982.

2. Gandolfi AJ, Blitt CD, and Weldon S. Discoloration and impurities in isoflurane vaporizer. Anesth Analg 62:366, 1983.

3. Gandolfi AJ and Brown BR. Hypoxia and halothane hepatotoxicity. Anesthesiology 62:859-861, 1983.

4. Gandolfi AJ, Cork RC, and Levy JP. Assay for serum sufentanil level not sensitive. Anesthesiology 65:112, 1986.

5. Gandolfi AJ. Book Review. Alternative to Animal Use in Research, Testing, and Education. American Scientist 74:674-675, 1986.

6. Brendel K, McKee RL, Hruby VJ, Johnson DG, Gandolfi AJ, and Krumdieck CL. Precision cut tissue slices in culture: A new tool in pharmacology. Proc West Pharmacol Soc 30:291-293, 1987.

7. Stefaniak MS, Gandolfi AJ, and Brendel K. Adult rat lung in dynamic organ culture: a new tool in pharmacology. Proc West Pharmacol Soc 31:149-151, 1988.

8. Connors MS, Gandolfi AJ, Krumdieck CL, and Brendel K. Lysosomal and cytosolic enzyme release as a measure of organelle-specific toxicity in cultured rat liver slices. Proc West Pharmacol Soc 31:143-147, 1988.

9. Brendel K and Gandolfi AJ. Predicting Toxicity. Arizona Medicine XLVI:4, 1990.

10. Gandolfi AJ. Guest authors discuss alternatives and challenges. Johns Hopkins Center for Alternatives to Animal Testing 9(1):9, 1991.

11. Kramer TH, Cork RC, and Gandolfi AJ. Pharmacokinetics of sufentanil. Can J Anaesth 36:485-486, 1989.

12. Gandolfi AJ, Brendel K, and Krumdieck CL. Tissue slicing and culturing revisited - An update. Alternatives (Bristol Myers Squibb Newsletter) 2, 1992.

13. Wijeweera JB, Gandolfi AJ, and Brendel K. Toxic interaction of drinking water contaminants. Vinylidene chloride and chloroacetic acid studies in precision-cut rat liver slices. SWEHSC Newletter, Winter 1995/1996.

14. Payne AK and Gandolfi AJ. Enzyme deficiency found in rat pup metabolism of new anesthetic intended for use with children. Southwest Association for Education in Biomedical Research, Newsletter, Volume 1, No. 2, 1994.

15. Furst SM and Gandolfi AJ. Adverse chemical reactions: Autoimmunity. SWEHSC Newsletter, Spring, 1995.

16. Gandolfi AJ and Lind RC. A sensitive animal model for testing the hepatotoxic potential of fluorocarbons. SWEHSC Newsletter, Summer, 1995.

17. Parrish AR, Nagle RB, Cass AE, Dalkin BL, and Gandolfi AJ.  Development of precision-cut human prostate slices as an in vitro model for prostate pathobiology.  SWEHSC Newsletter, Fall 1998.

18. Ito Y, Begay CK, Lind RC, Gandolfi AJ, and McCuskey RS.  Utilization of in vitro microscopy to investigate the protective action of DMSO against chloroform-induced injury.  SWEHSC Newsletter, Fall 1998.

19.  Zheng XH,  Parrish AR, and Gandolfi AJ.  Analysis of differential expressed genes in rabbit renal cortical slices exposed to arsenic compounds.  SWEHSC Newsletter, Winter 99-00.

9.         20.  Efecto de los niveles bajos de arsenico sobre los teijidos.  Boletin – Sociedad Quimica de Mexico, Section Nuevo Leon, Mayo – Junio 2004.

E. Technical Manuals and Reports:

1. Gandolfi AJ, Hodgson WH, and Chandon JG. Design and performance of aerosol exposure system. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp 189­191, (1977).

2. Gandolfi AJ and Shields CA. Effect of intratracheally administered oil shale and spent shale on pulmonary biotransformation enzyme activity. Pacific Northwest Lab Ann Report to ERDA, Part 1, pp. 169-171, (1977).

3. Gandolfi AJ and Shields CA. Absorption of benzo-a-pyrene from intratracheally administered spent shale. Pacific Northwest Labs Ann Report to ERDA, Part 1, pp. 171-173, (1977).

4. Gandolfi AJ and Shields CA. Response of lungs to intratracheally administered oil shale dusts. Pacific Northwest Labs Ann Report to DOE, pp. 5.11-5.14, (1978).

5. Gandolfi AJ. Toxicity of TEE in Tucson well water. Southern Arizona Environmental Coundil Bulletin 11:2-3, 1982.

F. Conference Proceedings - Book Articles

1. Sipes IG and Gandolfi AJ. In vitro comparative bioactivatioin of aliphatic halogenated hydrocarbons. In: Mechanisms of Toxicity and Hazard Evaluation, (Holmstedt, Lauwerys, Mercier, Roberfroid, eds.), Elsevier-North Holland, pp. 501-506, 1980.

2. Sipes IG, Gandolfi AJ, and Brown BR. Halothane-associated hepatitis: Evidence for a direct toxicity. In: Drug Reactions in the Liver, (M Davis, JM Tredger, R Williams, eds), Pitman Medical Limited, London, pp. 219-231, 1981.

3. Sipes IG and Gandolfi AJ. Bioactivation of aliphatic organohalogens: formation, detection, and relevance in Toxicology of the Liver. G. Plaa and R. Leibel (editors) Raven Press, pp. 181-212, 1982.

4. Sipes IG and Gandolfi AJ. Role of reactive intermediates in halothane associated liver injury. In: Reactive Intermediates (R. Snyder et al, editor's) Plenum Press, New York, pp. 603­618, 1982.

5. Weldon ST, Gillespie TJ, and Gandolfi AJ. Gas chromatographic analysis for fentanyl. Methodology in Analytical Toxicology, Vol. 3, (I. Sunshine, Editor) CRC Press, Inc., Boca Raton, FL, pp. 89­93, 1985.

6. Callis AH, Brooks SD, Waters SJ, Gandolfi AJ, Lucas DO, Pohl LR, Satoh H, and Sipes IG. Evidence for a role of the immune response in the pathogenesis of halothane hepatitis. Molecular Mechanisms of Anesthesia, Progress in Anesthesiology, Vol. 3 (S. Roth, editor). Raven Press, pp. 441­451, 1985.

7. Meadows SD, Gandolfi AJ, Nagle RB, and Brendel K. Persistent, progressive renal toxicity in male Swiss-Webster mice following subchronic exposure to 1,2-dichlorovinyl cysteine (DCVC). Renal Heterogeneity and Target Cell Toxicity (P.H. Bach, E.A. Lock, editors) John Wiley & Sons, New York, 1985, pp. 157­160.

8. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Use of isolated rabbit renal tubules to examine inhibition of organic acid/base transport by toxins. Renal Heterogeneity and Target Organ Toxicity (P.H. Bach, E.A. Lock, editors), John Wiley & Sons, New York, 1985, pp. 531­534.

9. Rylander-Yueh LA, Gandolfi AJ, and Brendel K. Inhibition of organic acid/base transport in isolated rabbit renal tubules by nephrotoxins. In: In Vitro Toxicology Volume D3 (A.M. Goldberg, editor). Mary Ann Liebert, Inc., New York, pp. 235­247, 1985.

10. Phelps JS, Gandolfi AJ, Brendel K. Cisplatinum toxicity in rabbit renal proximal tubule suspensions and precision-cut renal cortical slices. In Vitro Toxicology, Vol. 4 (Goldberg AM, editor), pp. 441­420, 1987.

11. Wolfgang GHI, Gandolfi AJ, Brendel K. Regioselective toxicity by dichlorovinyl cysteine in rabbit renal cortical slices. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. (P.H. Bach and E.A. Lock, editors), Guildford, England, pp. 583­589, 1989.

12. Ruegg CE, Gandolfi AJ, Brendel K. Regioselective acute tubular necrosis in renal cortical slices following HgCl2 and K2Cr2O7: Localization and transport studies. In: Nephrotoxicity: Extrapolation from In Vitro to In Vivo Animals to Man. Proceedings of Third International Symposium on Nephrotoxicity. Guildford, England, pp. 107­112, 1989.

13. Wolfgang GHI, Gandolfi AJ, Krumdieck CL, Brendel K. Evaluation of organic nephrotoxins using rabbit renal cortical slices. In: Progress in In Vitro Toxicology Vol. 6 (AM Goldberg, Editor). Mary Ann Leibert, Inc. pp. 291­301, 1988.

14. Azri S, Mata HP, Gandolfi AJ, Brendel K. CCl4-induced cytochrome P­450 loss and lipid peroxidation in rat liver slices. Adv. Exp. Med. Biol. 283:669-674, 1991.

15. Brown AP, Hastings KL, Gandolfi AJ, Brendel K. Covalent binding of a halothane metabolite and neoantigen production in guinea pig liver slices. Adv. Exp. Med. Biol. 283:693-697, 1991.

16. Ghantous H, Fernando J, Gandolfi AJ, Brendel K. Inhibition of protein synthesis and secretion by volatile anesthetics in guinea pig liver slices. Adv. Exp. Med. Biol. 283:725-730, 1991.

17. Hastings KL, Schuman S, Brown AP, Thomas C, Gandolfi AJ. S-ethylthiotrifluoroacetate enhancement of the immune response to halothane in the guinea pig. Adv. Exp. Med. Biol. 283:739-744, 1991.

18. Lind RC and Gandolfi AJ. Covalent binding of oxidative biotransformation reactive intermediates to protein influences halothane-associated hepatotoxicity in guinea pigs. Adv. Exp. Med. Biol. 283:763-766, 1991.

19. Vernetti LA, Gandolfi AJ, Nagle RB. Selective alteration of cytokeratin intermediate filament by cyclosporine A is a lethal toxicity in PtK2 cell cultures. Adv. Exp. Med. Biol. 283:847-851, 1991.

20. Brendel K, Fisher RL, Krumdieck CL, Gandolfi AJ. Precision-cut rat liver slices in dynamic organ culture for structure-toxicity studies. J Amer Col Tox 9:621-627, 1990.

21. Vernetti LA, Sarid D, Gandolfi AJ, Cress AE, Nagle RB, McCuskey R, Hameroff SR. STM images of cytokeratin and binding IgG antibody. In: Scanned Probe Microscopy, AIP Conference Proceedings, Santa Barbara, CA, (H K Wickramasinghe, ed.), American Institute of Physics, New York, pp. 232-234, 1991.

22. Gandolfi AJ. Biotransformation of inhalation anesthetics: Role in producing toxicity. In: Inhalationsanasthesie - eine Standortbestimmung (H Laubenthal, C Puchstein, C Sirtl, eds.), Wissenschaftliche Verlagsabteilung Abbott GmbH, Wiesbaden, Germany, pp. 9-19, 1992.

23. Mehendale HM, Roth RA, Gandolfi AJ, Klaunig JE, Lemasters JJ, Curtis LR. Novel mechanisms in chemically-induced hepatotoxicity. FASEB Journal 8:1285-1295, 1994.

24. Gandolfi AJ. Inhalation Anaesthetics: Toxicity and Metabolism. In: Fluorine in Medicine in the 21st Century. (Conference Proceedings) RAPRA (publishers), Paper number 17, pages 1-10, 1994.

25. Burton CA, Hatlelid K, Divine K, Carter DE, Fernando Q, Brendel K, Gandolfi AJ. Glutathione effects on toxicity and uptake of HgCl2 and NaAsO2 in rabbit renal cortical slices. Environ Health Perspect 103:81-84, 1995.

26. Keith RL, McGuinness SJ, Gandolfi AJ, Lowe TP, Chen Q, Fernando Q. Interaction of metals during their uptake and accumulation in rabbit renal cortical slices. Environ Health Perspect 103:77-80, 1995.

27. McIntyre CC, Leavitt JA, Ashbaugh, MD, Borgardt J, Keith RL, Gandolfi AJ, Qiu L, Lott JR, Fernando Q.  The nuclear microprobe at the University of Arizona, Nuclear Instruments and Methods, 130:45-50, 1997.

28. Keith RL, Gandolfi AJ, McIntyre LC., Jr., Ashbaugh MD, Fernando Q.  Use of the nuclear microprobe at the University of Arizona for the study of heavy metal deposition in rabbit renal tissue.  Nuclear Instruments and Methods, 130:358-361, 1997.

29. Gandolfi AJ.  Hepatotoxicity of hydrofluorocarbons.  In: Abstracts of the Workshop on Toxicity of Alternatives to Chlorofluorocarbons.  (R. S