A. Jay Gandolfi's Curriculum Vitae (Resume)
E-mail:(gandolfi@pharmacy.arizona.edu)

Gandolfi Laboratory Web Page
College of Pharmacy Main Web Page
Department of Pharmacology and Toxicology Main Web Page
Superfund Main Web Page

B.A., Chemistry, University of California, Davis, CA, 1968

Ph.D., Biochemistry and Biophysics Minor - Toxicology and Pharmacology,

     Oregon State University, Corvallis, OR, 1972

Post Doctoral Fellow, Mayo Clinic, Rochester, MN, 1972-75

1972-1975

Mayo Research Fellow, Department of Anesthesiology, Mayo Clinic

1975-1978

Battelle Northwest. Senior Research Scientist

1978-1983

University of Arizona, Research Assistant Professor, Toxicology and Anesthesiology

1983-1984

University of Arizona, Assistant Professor, Pharmacology and Toxicology

1985-1989

University of Arizona, Associate Professor, Pharmacology and Anesthesiology, College of  Medicine

University of Arizona, Research Associate Professor, Pharmacology and Toxicology,

College of Pharmacy

1989-
             University of Arizona, Professor, Pharmacology and Anesthesiology,

College of Medicine

University of Arizona, Research Professor, Pharmacology and Toxicology,

College of Pharmacy

1993 - 1996

University of Arizona, Chair, Graduate Program in Pharmacology and Toxicology,

Graduate School

1999-

University of Arizona, Associate Dean for Research and Graduate Studies, College of Pharmacy

1999-

University of Arizona, Professor, Pharmacology and Toxicology, College of Pharmacy

1999-
            University of Arizona. Assistant Dean for Research and Graduate Affairs, College of Pharmacy

General Research Interests:

Research interests are in the mechanisms of cellular toxicity and cell death. Current studies concentrate on the use of in vitro systems such as tissue slices to evaluate cell specific injury. Toxicants of interest include: halogenated hydrocarbons, volatile anesthetics, metals, cysteine conjugates, and classical hepatic/renal toxicants. Tissues of interest are the liver and kidney.

Specific Studies:

Metal Toxicology.  Effects of low level exposure to arsenicals on human bladder cells.

In Vitro Toxicology Techniques. Develops in vitro toxicology techniques such as precision-cut tissue slices.

Recent Publications:

Meza M, Kopplin M, Gandolfi AJ. Arsenic drinking water exposure and unirnary excretion among adults in the Yaqui Vally, Sonora, Mexico. Environ Res, 96:119-126, 2004.

Bredfeldt TG, Kopplin M, Gandolfi AJ. Bredfeldt TG, Kopplin M, Gandolfi AJ. Effects of arsenite on UROtsa cells: low-level arsenite causes accumulation of ubiquitinated proteins that is enhanced by reduction in cellular glutathione levels. Tox Appl Pharm, 198:412-418, 2004.

Kirkpatrick DS, Weldon SF, Tsaprailis G, Gygi SP, Liebler DC, Gandolfi AJ. Proteomic identification of ubiquinated proteins from human cells expressing His-tagged ubiquitin. Proteomics, 5:2104-2111, 2005.

Carranza Rosales P, Said-Fernandez S, Sepulveda-Saavedra J, Cruz-Vega DE, Gandolfi AJ. Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line: ultrastructural evidence for an apoptotic mechanism of damage. Toxicology, 210:111-121, 2005.

Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT. Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Env Health Perspective, 113:775-781, 2005.

Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ. Monomethylarsenous acid induces transformation of human bladder cells. Tox Appl Pharm, 216:69-79, 2006.

Peraza MA, Carter DE, Gandolfi AJ. Morphological and functional alterations in human proximal tubular cell line induced by low-level inorganic arsenic: evidence for targeting mitochondria and initiated apoptosis. J Appl Tox 26:356-367, 2006.

Eblin KE, Bowen ME, Cromey D, Bredfeldt TG, Mash EA, Gandolfi AJ. Arsenite and monomethylarsonous acid generate oxidative stress response in human bladder cell culture. Tox Appl Pharm, 217:7-14, 2006.

Eblin KE, Bredfeldt TG, Buffington S, Gandolfi AJ. Mitogenic, pro-inflammatory signal transduction caused by monomethylarsonous acid in UROtsa cells. Tox Sci, 95(2): 321-330, 2007.

Carranza-Rosales P, Guzman-Delgado N, Cruz-Vega D, Balderas-Renteria I, Gandolfi AJ. DMPS protective effect on mitochondrial structure and function in OK cells exposed to toxic concentrations of HgCl2. Cell Biol Toxicology, 23:163-176, 2007

Meza M, Gandolfi AJ, Klimecki WT. Developmental and genetic modulation of arsenic metabolism: a gene by environment interaction? Tox Appl Pharm, E Pub December 23, 2006.

Catania JM, Pershing AM, Gandolfi AJ. Precision-cut tissue chips as an in vitro toxicology system. Tox In Vitro, 21:956-961, 2007.