PhPr 810H - Clinical Pharmacokinetics Rotation
(Also refer to the general goals and objectives for PhPr 810)
Goals
- Develop an extensive knowledge base of the pharmacokinetics of drugs that are commonly monitored in patients.
- Achieve competence in the application of pharmacokinetic principles to patient care situations.
Objectives
At the completion of this rotation, the student should be able to:
- Define the following pharmacokinetic terms: elimination rate constant, half life, volume of distribution, clearance, one-compartment model, two-compartment model, first-order elimination, and zero-order elimination.
- Identify the therapeutic range, average half-live, and average volume of distribution for all routinely monitored drugs including aminoglycosides, vancomycin, digoxin, quinidine, procainamide, lidocaine, theophylline, phenobarbital, phenytoin, valproic acid, carbamazepine, and primidone.
- Identify the appropriate equation to use in each of the following situations: IV bolus, continuous IV infusion, intermittent IV infusion, multiple oral dosing, and oral dosing with controlled release products.
- Given a specific patient case, calculate the elimination rate constant, volume of distribution, half-life, and clearance prospectively based on average population parameters as well as retrospectively based on serum drug concentrations for the drugs listed in objective #2.
- Given a specific patient case, estimate lean body weight, adjusted body weight, creatinine clearance, and a measured creatinine clearance (with urine collection data).
- Review a patient's medical history and drug therapy and assess the indications for drug therapy, the patient's response to therapy, presence or potential for adverse effects, and appropriateness of monitoring.
- Discuss the effects of renal disease, liver disease, cardiac disease, and obesity on the pharmacokinetics of the drugs listed in objective #2.
- Describe the differences between peritoneal dialysis, hemodialysis and hemoperfusion and the effect of these procedures on the clearance of the drugs listed in objective #2.
- Given a specific patient, identify potential pharmacokinetic drug interactions and discuss the significance of these.
- Discuss Bayesian pharmacokinetic analysis and the role of this method in patient care.
- Evaluate the medical literature with respect to study design and analysis of pharmacokinetic data.
- Utilize appropriate written and verbal communication skills when providing recommendations to patients and health care professionals.