Our main focus is to study the regulation of intestinal P450 expression and function by physiological, pathological, and environmental factors, and the P450 function in drug clearance, drug-induced toxicity, and inflammatory bowel disease.
The mammalian intestine provides the first site for metabolism of ingested xenobiotics, including therapeutic drugs, pollutants, and chemical carcinogens. These metabolic functions are performed by a variety of biotransformation enzymes, including the cytochrome P450 superfamily of monooxygenases.
The overall goal of the group is to study the roles of intestinal P450 enzymes in drug bioavailability, chemical toxicology, and intestinal diseases. Current research topics include the regulation of small intestinal drug metabolism by inflammation and other pathologic conditions; the role of tissue-selective P450 enzymes involved in intestinal drug clearance; and the utility of novel transgenic mouse models for studying the in vivo function of intestinal P450 enzymes in drug metabolism, chemical carcinogenesis, and intestinal dysfunction.
These studies will ultimately lead to a better understanding of the environmental and genetic bases of the interindividual differences in susceptibility to adverse drug reactions, and provide new strategies for improvement of therapeutic efficacy and prevention of environmental diseases involving the intestine.
Ph.D. Biological Chemistry, Medical School, The University of Michigan, Ann Arbor, 1984-89, Dissertation Advisor: Dr. K.M.J. Menon
M.S. Biochemistry, School of Medicine, Tulane University, New Orleans 1982-84
B.S. Biology, Fudan University, Shanghai, China 1978-82