Xinxin Ding, PhD

Department Head, Pharmacology and Toxicology
Professor, Pharmacology & Toxicology

The Ding Lab conducts basic studies on enzyme function, regulation, and genetics, and applies the knowledge gained to translational research for improvements in drug safety and efficacy for major human diseases, or for identification of genetic and environmental factors that influence the risks of chemical toxicity. Current studies are focused on the microsomal cytochrome P450 enzymes in various organ systems. The P450 enzymes metabolize numerous drugs, chemical carcinogens, environmental pollutants, as well as endogenous signaling molecules. The lab has produced a series of novel mouse models with tissue-selective deletion or down-regulation of the P450 reductase gene, as well as mouse models that either have selected mouse P450 genes deleted, and/or produce human P450 enzymes. These animals are being used to model human genetic deficiency, and to explore the role of P450 enzymes in drug response, carcinogenesis, and disease susceptibility. Complementary to studies in animal models, the lab is also studying expression and genetic polymorphisms of human P450 and P450 reductase genes, to identify the genetic basis for interindividual differences in clinical response to drug therapy, and to predict the lung cancer risks from exposures to commonly occurring environmental chemicals.

Education: 

BS, Biology, Nanjing University (Nanjing, China), 1982
PhD, Biological Chemistry, The University of Michigan Medical School (Ann Arbor, MI)

Select Publications

2017

Li, L., S. Carratt, M. Hartog, N. Kovalchik, K. Jia, Y. Wang, Q-Y. Zhang, P. Edwards, L. Van Winkle, and X. Ding, "Human CYP2A13 and CYP2F1 Mediate Naphthalene Toxicity in the Lung and Nasal Mucosa of CYP2A13/2F1-Humanized Mice.", Environ Health Perspect, vol. 125, issue 6, pp. 067004, 2017 06 08. PMCID: PMC5743450  PMID: 28599267
Li, L., X. Bao, Q-Y. Zhang, M. Negishi, and X. Ding, "Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice.", Drug Metab Dispos, vol. 45, issue 8, pp. 977-981, 2017 Aug. PMCID: PMC5518717  PMID: 28546505
Fasullo, M., J. Freedland, N. St John, C. Cera, P. Egner, M. Hartog, and X. Ding, "An in vitro system for measuring genotoxicity mediated by human CYP3A4 in Saccharomyces cerevisiae.", Environ Mol Mutagen, vol. 58, issue 4, pp. 217-227, 2017 05. PMCID: PMC5479318  PMID: 28436563
Guan, X., M. Qin, Y. Zhang, Y. Wang, B. Shen, Z. Ren, X. Ding, W. Dai, and Y. Jiang, "Safety and Efficacy of Megakaryocytes Induced from Hematopoietic Stem Cells in Murine and Nonhuman Primate Models.", Stem Cells Transl Med, vol. 6, issue 3, pp. 897-909, 2017 Mar. PMCID: PMC5442772 
Wang, L., X. Guan, H. Wang, B. Shen, Y. Zhang, Z. Ren, Y. Ma, X. Ding, and Y. Jiang, "A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation.", Stem Cell Res Ther, vol. 8, issue 1, pp. 169, 2017 Jul 18. PMCID: PMC5516306 
Kovalchuk, N., J. Kelty, L. Li, M. Hartog, Q-Y. Zhang, P. Edwards, L. Van Winkle, and X. Ding, "Impact of hepatic P450-mediated biotransformation on the disposition and respiratory tract toxicity of inhaled naphthalene.", Toxicol Appl Pharmacol, vol. 329, pp. 1-8, 2017 08 15.