The Ding Lab conducts basic studies on enzyme function, regulation, and genetics, and applies the knowledge gained to translational research for improvements in drug safety and efficacy for major human diseases, or for identification of genetic and environmental factors that influence the risks of chemical toxicity. Current studies are focused on the microsomal cytochrome P450 enzymes in various organ systems. The P450 enzymes metabolize numerous drugs, chemical carcinogens, environmental pollutants, as well as endogenous signaling molecules. The lab has produced a series of novel mouse models with tissue-selective deletion or down-regulation of the P450 reductase gene, as well as mouse models that either have selected mouse P450 genes deleted, and/or produce human P450 enzymes. These animals are being used to model human genetic deficiency, and to explore the role of P450 enzymes in drug response, carcinogenesis, and disease susceptibility. Complementary to studies in animal models, the lab is also studying expression and genetic polymorphisms of human P450 and P450 reductase genes, to identify the genetic basis for interindividual differences in clinical response to drug therapy, and to predict the lung cancer risks from exposures to commonly occurring environmental chemicals.
BS, Biology, Nanjing University (Nanjing, China), 1982
PhD, Biological Chemistry, The University of Michigan Medical School (Ann Arbor, MI)