Ivo Abraham, PhD, RN

Professor, Pharmacy Practice and Science

Ivo Abraham is a professor (part-time) in the Department of Pharmacy Practice. He has also served on the faculty of Case Western Reserve University (Cleveland, Ohio), University of Virginia (Charlottesville, Va.), and (part-time) Katholieke Universiteit Leuven (Leuven, Belgium); and as visiting professor at Universiteit Maastricht (Maastricht, The Netherlands), University of Florida (Gainesville, Fla.), Rijksuniversiteit Groningen (Groningen, The Netherlands), University of Pennsylvania (Philadelphia, Penn.), and Chang Gung University (Kwei-Shan Tao-Yuan, Taiwan).  He has lectured, consulted, and conducted research throughout the Americas, Europe, the Asia-Pacific region, and Africa. Being part-time, he divides his time between the University of Arizona and Matrix45, a biopharmaceutical research and consulting company, where he serves as chief scientist.

For the past decade or so, Dr. Abraham’s research has focused mainly on clinical outcomes and effectiveness research, in particular how variability in (drug-centric) treatment regimens is associated with variability in patient outcomes. However, instead of merely evaluating effectiveness (does the treatment work?), the work of his research group addresses the equally important questions of when does the treatment work (and when not), what influences whether the treatment works, why does the treatment work in some patients but not in others, why does the treatment work with some clinicians but not with others, why is the treatment tolerated by some patients but not by others, and how much of patient outcomes is related to patient vs. clinician or treatment center?  In this process, his group uses a comprehensive framework of treatment patterns and outcomes assessment, vulnerability profiling, hierarchical modeling, (non-)responder analysis, and pharmacovigilance and drawing methodologies and statistical models from other disciplines into biomedical research.  

More recently, frustrated by the abundance of evidence but clinicians’ persistent low adoption of evidence-based guidelines, he and his colleagues started examining how practicing in accordance with evidence-based guidelines is directly associated with patient outcomes.

He has (co-)authored 260+ articles and 60+ chapters, and has (co-)edited 29 books, monographs, and journal issues. Since 1984, his research has been funded by federal funding agencies, foundations, and corporations.   He has served as appointed ad hoc reviewer for the NIH, the NIMH, and the AHRQ. He currently serves as an expert adviser to the Innovative Medicines Initiative, a joint 2 billion euro undertaking of the European Union and the biopharmaceutical industry to stimulate innovation in human therapeutics.

His educational and scientific honors and awards include an Invitational research fellowship from the Japan Society for the Promotion of Science (2007-2008), which he conducted at Hyogo University and Aomori University.

Education: 

BS, Nursing, Katholieke Hogeschool Leuven (Leuven, Belgium)
MS, Psychiatric-Mental Health Nursing, University of Michigan
PhD, Clinical Research, University of Michigan 

Select Publications

2018

Scholpa, N. E., M. K. Lynn, D. Corum, H. A. Boger, and R. G. Schnellmann, "5-HT1F receptor-mediated mitochondrial biogenesis for the treatment of Parkinson's disease.", Br J Pharmacol, vol. 175, issue 2, pp. 348-358, 2018 Jan.

2013

Gesualdo, L., G. London, M. Turner, C. Lee, K. Macdonald, D. Goldsmith, A. Covic, P. Zaoui, C. Combe, J. Mann, et al., "A pharmacoepidemiological study of the multi-level determinants, predictors, and clinical outcomes of biosimilar epoetin alfa for renal anaemia in haemodialysis patients: background and methodology of the MONITOR-CKD5 study.", Intern Emerg Med, vol. 8, issue 5, pp. 389-99, 2013 Aug.
Abraham, I., K. MacDonald, M. Song, G. Ciesielski, C. Pacheco, C. Lee, M. Cholette, K. Kinsey, P. Speaks, C. Hermans, et al., "Patient- and physician-level determinants of blood pressure response to treatment in normal weight and overweight patients (the PREVIEW study).", Nutr Metab Cardiovasc Dis, vol. 23, issue 4, pp. 314-22, 2013 Apr.
Tucker, G., N. K. Clark, and I. Abraham, "Enhancing ED triage to accommodate the special needs of geriatric patients.", J Emerg Nurs, vol. 39, issue 3, pp. 309-14, 2013 May.

2012

Aapro, M., P. Cornes, and I. Abraham, "Comparative cost-efficiency across the European G5 countries of various regimens of filgrastim, biosimilar filgrastim, and pegfilgrastim to reduce the incidence of chemotherapy-induced febrile neutropenia.", J Oncol Pharm Pract, vol. 18, issue 2, pp. 171-9, 2012 Jun.

2011

MacDonald, K., C. S. Lee, H-C. Chen, M. L. Ko, G. E. Fidel, H. Brié, C. Hermans, S. Vancayzeele, S. Reel, P. Van der Niepen, et al., "Gender-specific, multi-level determinants of outcomes of antihypertensive treatment: a sub-analysis of the Belgian PREVIEW study.", J Hum Hypertens, vol. 25, issue 6, pp. 372-82, 2011 Jun.