A. Jay Gandolfi, PhD

Professor Emeritus
Former Associate Dean
Research & Graduate Studies
Department(s): 
Pharmacology & Toxicology

gandolfi@pharmacy.arizona.edu
520-626-6696 520-626-7101
FAX: 520-626-2466
Pharmacy (Skaggs) Building 332

A. Jay Gandolfi, PhD, is professor emeritus in the Department of Pharmacology and Toxicology and the former associate dean for research and graduate studies (1999-2012). Dr. Gandolfi taught drug disposition in both PharmD and the graduate student curricula. He directed the Graduate Council and was director of the NIEHS Superfund Program from 1999-2012.

Dr. Gandolfi's research interests were in the disposition and toxicology of drugs (e.g., anesthetics) and environmental chemicals (e.g., arsenicals) and the development of in vivo and in vitro models for studying mechanisms of toxicity. 

Dr. Gandolfi joined the University of Arizona in 1978 and had appointments in the College of Medicine (Anesthesiology, Pharmacology) and the College of Pharmacy (Pharmacology and Toxicology). He received the College of Pharmacy's Findlay E. Russell MD, PhD, Distinguished Citizen Award in 2007 for services to the college and university. 

Education: 

BA, University of California, Davis, 1968, Chemistry

PhD, Oregon State University, Corvallis, 1972, Biochemistry and Biophysics

PD, Mayo Clinic, Rochester, 1972-75

Publications

Olivas-Calderón E, Recio-Vega R, Gandolfi AJ, Lantz RC, González-Cortes T, Gonzalez-De Alba C, Froines JR, Espinosa-Fematt JA. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):161-7. doi: 10.1016/j.taap.2015.06.001. Epub 2015 Jun 3. PubMed PMID: 26048584.

Ramirez-Andreotta MD, Brusseau ML, Artiola J, Maier RM, Gandolfi AJ. Building a co-created citizen science program with gardeners neighboring a superfund site: The Gardenroots case study. Int Public Health J. 2015 Jan;7(1). pii: 13. PubMed PMID: 25954473; PubMed Central PMCID: PMC4420190.

Carignan CC, Cottingham KL, Jackson BP, Farzan SF, Gandolfi AJ, Punshon T, Folt CL, Karagas MR. Estimated exposure to arsenic in breastfed and formula-fed infants in a United States cohort. Environ Health Perspect. 2015 May;123(5):500-6. doi: 10.1289/ehp.1408789. Epub 2015 Feb 23. Erratum in: Environ Health Perspect. 2015 May;123(5):A117. PubMed PMID: 25707031; PubMed Central PMCID: PMC4421773.

Burchiel SW, Lauer FT, Beswick EJ, Gandolfi AJ, Parvez F, Liu KJ, Hudson LG. Differential susceptibility of human peripheral blood T cells to suppression by environmental levels of sodium arsenite and monomethylarsonous acid. PLoS One. 2014 Oct 1;9(10):e109192. doi: 10.1371/journal.pone.0109192. eCollection 2014. PubMed PMID: 25271956; PubMed Central PMCID: PMC4182801.

Medeiros M, Le TM, Troup D, Novak P, Gandolfi AJ. Expression Of Selected Pathway-Marker Genes In Human Urothelial Cells Exposed Chronically To A Non-Cytotoxic Concentration Of Monomethylarsonous Acid. Toxicol Rep. 2014;1:421-434. PubMed PMID: 25177542; PubMed Central PMCID: PMC4144464.

Ramirez-Andreotta MD, Brusseau ML, Artiola JF, Maier RM, Gandolfi AJ. Environmental Research Translation: enhancing interactions with communities at contaminated sites. Sci Total Environ. 2014 Nov 1;497-498:651-64. doi:10.1016/j.scitotenv.2014.08.021. Epub 2014 Aug 29. PubMed PMID: 25173762; PubMed Central PMCID: PMC4186773.

Recio-Vega R, Gonzalez-Cortes T, Olivas-Calderon E, Lantz RC, Gandolfi AJ, Gonzalez-De Alba C. In utero and early childhood exposure to arsenic decreases lung function in children. J Appl Toxicol. 2015 Apr;35(4):358-66. doi:10.1002/jat.3023. Epub 2014 Aug 15. PubMed PMID: 25131850.

López-Carrillo L, Hernández-Ramírez RU, Gandolfi AJ, Ornelas-Aguirre JM, Torres-Sánchez L, Cebrian ME. Arsenic methylation capacity is associated with breast cancer in northern Mexico. Toxicol Appl Pharmacol. 2014 Oct 1;280(1):53-9. doi: 10.1016/j.taap.2014.07.013. Epub 2014 Jul 22. PubMed PMID: 25062773.

Ezeh PC, Lauer FT, MacKenzie D, McClain S, Liu KJ, Hudson LG, Gandolfi AJ, Burchiel SW. Arsenite selectively inhibits mouse bone marrow lymphoid progenitor cell development in vivo and in vitro and suppresses humoral immunity in vivo. PLoS One. 2014 Apr 8;9(4):e93920. doi: 10.1371/journal.pone.0093920. eCollection 2014. PubMed PMID: 24714590; PubMed Central PMCID: PMC3979857.

Zhou X, Sun X, Mobarak C, Gandolfi AJ, Burchiel SW, Hudson LG, Liu KJ. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol. 2014 Apr 21;27(4):690-8. doi: 10.1021/tx500022j. Epub 2014 Mar 19. PubMed PMID: 24611629; PubMed Central PMCID: PMC3998772.

Ezeh PC, Lauer FT, Mackenzie D, McClain S, Liu KJ, Hudson LG, Gandolfi AJ, Burchiel SW. Arsenite selectively inhibits mouse bone marrow lymphoid progenitor cell development in vivo and in vitro and suppresses humoral immunity in vivo. PLoS One. 2014 Apr 8;9(4):e93920

Zhou X, Sun X, Mobarak C, Gandolfi AJ, Burchiel SW, Hudson LG, Liu KJ. Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins. Chem Res Toxicol. 2014 Apr 21;27(4):690-8.

Gilbert-Diamond D, Li Z, Perry AE, Spencer SK, Gandolfi AJ, Karagas MR. A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA. Environ Health Perspect. 2013 Oct;121(10):1154-60.

Farzan SF, Korrick S, Li Z, Enelow R, Gandolfi AJ, Madan J, Nadeau K, Karagas MR. In utero arsenic exposure and infant infection in a United States cohort: a prospective study. Environ Res. 2013 Oct;126:24-30.

Díaz-Villaseñor A, Cruz L, Cebrián A, Hernández-Ramírez RU, Hiriart M, García-Vargas G, Bassol S, Sordo M, Gandolfi AJ, Klimecki WT, López-Carillo L, Cebrián ME, Ostrosky-Wegman P. Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: a pilot study of risk factors for T2DM. PLoS One. 2013;8(1).

Meza-Montenegro MM, Valenzuela-Quintanar AI, Balderas-Cortés JJ, Yañez-Estrada L, Gutiérrez-Coronado ML, Cuevas-Robles A, Gandolfi AJ. Exposure assessment of organochlorine pesticides, arsenic, and lead in children from the major agricultural areas in Sonora, Mexico. Arch Environ Contam Toxicol. 2013 Apr;64(3):519-27.

Carranza-Rosales P, Santiago-Mauricio MG, Guzmán-Delgado NE, Vargas-Villarreal J, Lozano-Garza G, Viveros-Valdez E, Ortiz-López R, Morán-Martínez J, Gandolfi AJ. Induction of virulence factors, apoptosis, and cytokines in precision-cut hamster liver slices infected with Entamoeba histolytica. Exp Parasitol. 2012 Dec;132(4):424-33.

Meza-Montenegro MM, Gandolfi AJ, Santana-Alcántar ME, Klimecki WT, Aguilar-Apodaca MG, Del Río-Salas R, De la O-Villanueva M, Gómez-Alvarez A, Mendivil-Quijada H, Valencia M, Meza-Figueroa D. Metals in residential soils and cumulative risk assessment in Yaqui and Mayo agricultural valleys, northern Mexico. Sci Total Environ. 2012 Sep 1;433:472-81.

Fei DL, Sanchez-Mejias A, Wang Z, Flaveny C, Long J, Singh S, Rodriguez-Blanco J, Tokhunts R, Giambelli C, Briegel KJ, Schulz WA, Gandolfi AJ, Karagas M, Zimmers TA, Jorda M, Bejarano P, Capobianco AJ, Robbins DJ. Hedgehog signaling regulates bladder cancer growth and tumorigenicity. Cancer Res. 2012 Sep 1;72(17):4449-58.

Canet MJ, Hardwick RN, Lake AD, Kopplin MJ, Scheffer GL, Klimecki WT, Gandolfi AJ, Cherrington NJ. Altered arsenic disposition in experimental nonalcoholic fatty liver disease. Drug Metab Dispos. 2012 Sep;40(9):1817-24. doi: 10.1124/dmd.112.046177.

Yassine H, Kimzey MJ, Galligan MA, Gandolfi AJ, Stump CS, Lau SS. Adjusting for Urinary Creatinine Overestimates Arsenic Concentrations in Diabetics. Cardiorenal Med. 2012 Feb;2(1):26-32.

Meza MM, Kopplin MJ, Burgess JL, Gandolfi AJ. Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicol Environ Chem, 90: 957-970, 2008.

Eblin KE, Bredfeldt TG, Gandolfi AJ. Immortalized human urothelial cells as a model of arsenic-induced bladder cancer. Toxicology, 248:67-76, 2008.

Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW. Epigenetic Remodeling During Arsenical-Induced Malignant Transformation. Carcinogenesis, 29:1500-8, 2008.

Eblin KE, Hau A, Jensen TJ, Futscher BW, Gandolfi AJ. The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies. Toxicology, 250:47-54, 2008.

Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolif AJ. Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. Toxicology, 255: 107-114, 2008.

Jensen TJ, Eblin KE, Wozniak RJ, Gandolfi AJ, Futscher BW. Epigenetic mediated transcriptional activation of WNT5a participates in arsenical-associated malignant transformation. Toxicology and Applied Pharmacology, 235: 39-46, 2009.

Buffington SE, Zheng XH, Watts GS, Gandolfi AJ. Malignant transformation of human urothelial cells by low-level monomethylarsonous acid exposure is confirmed by expression of key biomarkers. Toxicology, in press, 2009.

Wnek SM, Medeiros MK, Eblin KE, Gandolfi AJ. Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid exposure. Tox Appl Pharm, in press, 2009.

Tsow F, Forzani E, Rai A, Tsui R, Mastroianni S, Knobbe C, Gandolfi AJ, Tao NJ. A wearable and wireless sensor system for real-time monitoring of toxic environmental volatile organic compounds. IEEE Sensors Journal, in press, 2009.

Publications
Originally posted: September 9, 2013
Last updated: January 8, 2016
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