Ivo Abraham, PhD, RN

Professor
Department(s): 
Pharmacy Practice & Science
Center for Health Outcomes & PharmacoEconomic Research

abraham@pharmacy.arizona.edu
520-626-4425
FAX: 520-626-2023
Drachman Hall B306H

Ivo Abraham is professor (part-time) in the Department of Pharmacy Practice. He has also served on the faculty of Case Western Reserve University (Cleveland, Ohio), University of Virginia (Charlottesville, Va.), and (part-time) Katholieke Universiteit Leuven (Leuven, Belgium); and as visiting professor at Universiteit Maastricht (Maastricht, The Netherlands), University of Florida (Gainesville, Fla.), Rijksuniversiteit Groningen (Groningen, The Netherlands), University of Pennsylvania (Philadelphia, Penn.), and Chang Gung University (Kwei-Shan Tao-Yuan, Taiwan).  He has lectured, consulted, and conducted research throughout the Americas, Europe, the Asia-Pacific region, and Africa. Being part-time, he divides his time between the University of Arizona and Matrix45, a biopharmaceutical research and consulting company, where he serves as chief scientist.

For the past decade or so, Dr. Abraham’s research has focused mainly on clinical outcomes and effectiveness research, in particular how variability in (drug-centric) treatment regimens is associated with variability in patient outcomes. However, instead of merely evaluating effectiveness (“does the treatment work?”), the work of his research group addresses the equally important questions of “when does the treatment work, and when not?”, “what influences whether the treatment works?”, “why does the treatment work in some patients but not in others?”, “why does the treatment work with some clinicians but not with others?”, “why is the treatment tolerated by some patients but not by others?”, and “how much of patient outcomes is related to patient vs. clinician or treatment center.”  In this process, his group uses a comprehensive framework of treatment patterns and outcomes assessment, vulnerability profiling, hierarchical modeling, (non-)responder analysis, and pharmacovigilance and drawing methodologies and statistical models from other disciplines into biomedical research.  

More recently, frustrated by the abundance of evidence but clinicians’ persistent low adoption of evidence-based guidelines, he and his colleagues started examining how practicing in accordance with evidence-based guidelines is directly associated with patient outcomes.

He has (co-)authored 260+ articles and 60+ chapters, and has (co-)edited 29 books, monographs, and journal issues. Since 1984, his research has been funded by federal funding agencies, foundations, and corporations.   He has served as appointed and ad hoc reviewer for the NIH, the NIMH, and the AHRQ. He currently serves as expert adviser to the Innovative Medicines Initiative, a joint 2 billion euro undertaking of the European Union and the biopharmaceutical industry to stimulate innovation in human therapeutics.

His educational and scientific honors and awards include an Invitational research fellowship from the Japan Society for the Promotion of Science (2007-2008), which he conducted at Hyogo University and Aomori University.

Education: 

BS, Nursing, Katholieke Hogeschool Leuven (Leuven, Belgium)

MS, Psychiatric-Mental Health Nursing, University of Michigan (Ann Arbor, MI)

PhD, Clinical Research, University of Michigan (Ann Arbor, MI)

Publications

Abraham, I., MacDonald, K., Song, M.K., Ciesielski, G., Pacheco, C., Lee, C., Cholette, M., Kinsey, K., Speaks, P., Hermans, C., Brié, H., Reel, S., Van der Niepen, P., Yee, B., & Vancayzeele, S. (in press). Patient- and physician-level determinants of blood pressure response to treatment in normal and overweight patients. (the PREVIEW Study). Nutrition, Metabolism, & Cardiovascular Diseases.

Aapro, M., Cornes, P., & Abraham, I. (in press). Comparative cost-efficiency across the European G5 countries of various regimens of filgrastim, biosimilar filgrastim, and pegfilgrastim to reduce the incidence of chemotherapy-induced febrile neutropenia. Journal of Oncology Pharmacy Practice.

Gesualdo, L., London, G., Turner, M., Lee, C., MacDonald, K., Covic, A., Zaoui, P., Combe, C., Dellana, F., Muenzberg, M., & Abraham, I. (in press). A pharmacoepidemiological study of the multi-level determinants, predictors, and clinical outcomes of biosimilar epoetin alfa for renal anemia in hemodialysis patients: background and methodology of the MONITOR-CKD5 study. Internal and Emergency Medicine.

Lins, R., Coen, N., Aerts, A., MacDonald, K., Brié, H., Hermans, C., Shen, Y.-M., Lee, C., Vancayzeele, S., Mecum, N., & Abraham, I. (in press). Modeling of blood pressure and total cardiovascular risk outcomes after second-line valsartan therapy: the BSCORE study. Archives of Cardiovascular Disease

Ciesielski, G., Clark, N., & Abraham, I. Enhancing ED triage to accommodate the special needs of geriatric patients. (in press). Journal of Emergency Nursing.

Lins, R., Aerts, A., Coen, N., Hermans, C., MacDonald, K., Lee, C., Shen, Y.-M., Vancayzeele, S., Mecum, N., & Abraham, I. (2011). Effectiveness of amlodipine-valsartan single-pill combinations: Hierarchical modeling of blood pressure and total cardiovascular risk outcomes (the EXCELLENT Study). Annals of Pharmacotherapy, 45,727-739.

MacDonald, K., Lee, C.S., Chen, H.-C., Ko, M., Fidel, G., Brié, H., Hermans, C., Vancayzeele, S., Reel, S., Van der Niepen, P., & Abraham, I. (2011). Gender-specific, multi-level determinants of outcomes of antihypertensive treatment: a sub-analysis of the Belgian PREVIEW Study. Journal of Human Hypertension, 25, 372-382.

Delforge, M., Selleslag, D., Triffet, A., Mineur, P., Bries, G., Graux, C., Trullemans, F., MacDonald, K., Abraham, I., Pluymers, W., & Ravoet, C. (2011). Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes. Annals of Hematology, 90, 655-666.

Mazzeo, F., Duck, L., Joosens, E., Dirix, L., Focan, C., Forget, F., De Geest, S., D’haeyer, J., van Lierde, M.-A., MacDonald, K., Abraham I., & De Grève, J. (2011) Nonadherence to imatinib treatment in patients with gastro-intestinal stromal tumors: the ADAGIO study. Anticancer Research, 31, 1411-1415.

Abraham, I., MacDonald, K., Hermans, C., Aerts, A., Lee, C., Vancayzeele, S. (2011). Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program. Vascular Health and Risk Management, 7, 209-235.

Gascón, P., Aapro, M., Ludwig, H., Rosencher, N., Turner, M., Song, M., MacDonald, K., Lee, C., Muenzberg, M., & Abraham, I. (2011). Background and methodology of MONITOR-GCSF, a pharmaco-epidemiological study of the multi-level determinants, predictors, and clinical outcomes of febrile neutropenia prophylaxis with biosimilar granulocyte-colony stimulating factor filgrastim. Critical Reviews in Oncology and Hematology, 77, 184-197.

Gascón, P., Aapro, M., Ludwig, H., Rosencher, N., Boccadoro, M., Turner, M., MacDonald, K., Muenzberg, M., & Abraham, I. (2011). Update on the MONITOR-GCSF study of biosimilar filgrastim to reduce the incidence of chemotherapy-induced febrile neutropenia in cancer patients: Protocol amendments. Critical Reviews in Oncology and Hematology, 77, 198-200.

Milisen, K., Coussement, J., Boonen, S., Geeraerts, A., Druyts, L., Van Wesenbeeck, A., Abraham, I., & Dejaeger, E. (2011). Initial evidence of the relationships between nursing staff attitudes, resident decisions, and resident adherence and persistence in the use of hip protectors in residential long-term care. International Journal of Nursing Studies, 48, 193-203.

Verpooten, G., Aerts, A., Coen, N., Vancayzeele, S., Hermans, C., Bowles, J., MacDonald, K., Abraham, I., & Lee, C. (2011). Anti-hypertensive effectiveness of aliskiren for the “real-world” management of hypertension: Multi-level modeling of 180-day blood pressure outcomes (the DRIVER study). International Journal of Clinical Practice, 65, 54-63.

Maa, S.-H., Chang, Y.-C., Chou, C.-L., Ho, S.-C., Sheng, T.-F., MacDonald, K., Wang, Y., Shen, Y.-M., & Abraham, I. (2010). Evaluation of the feasibility of a nurse-led school-based asthma management program in Taiwan. Journal of Clinical Nursing, 19, 2415-2423.

Chisholm-Burns, M.A., Lee, J.K., Spivey, C.A., Slack, M., Herrier, R., Hall-Lipsy, E., Zivin, J.G., Abraham, I., Palmer, J., Martin, J.R., Kramer, S.S., & Wunz, T. (2010). U.S. pharmacists’ effect as team members on patient care: Systematic review and meta-analyses. Medical Care, 48, 923-933.

Chisholm-Burns, M.A., Graff Zivin, J., Lee, J.K., Spivey, C.A., Slack, M., Herrier, R.N., Hall-Lipsy, E., Abraham, I., Palmer, J. (2010). Economic effects of pharmacists on health outcomes in the United States: A systematic review. American Journal of Health-System Pharmacy, 67, 1624-1634.

Abraham, I., Lee, C., Song, M., Van der Niepen, P., Vancayzeele, S., Brié, H., Hermans, C., & MacDonald, K. (2010). “Later, lazier, and unluckier”: a heuristic profile of high vulnerability is an independent predictor of uncontrolled blood pressure (the PREVIEW study). International Journal of General Medicine, 3, 163-166.

Abraham, I., Demosthenes, L., MacDonald, K., Reel, S., Lee, C., Van der Niepen, P., Brié, H., Hermans, C., & Vancayzeele, S. (2010). Hierarchical modeling of outcomes of antihypertensive treatment in elderly patients: Findings from the PREVIEW Study. Archives of Gerontology and Geriatrics, 51, 45-53.

Van Erps, J., Aapro, M., MacDonald, K., Soubeyran, P., Turner, M., Warrinnier, H., Albrecht, T., & Abraham, I. (2010). Promoting

evidence-based management of anemia in cancer patients: Concurrent and discriminant validity of RESPOND, a web-based clinical guidance system based on the EORTC guidelines for supportive cancer care. Supportive Care in Cancer, 18, 842-858.

Abraham, I. (2010). Intravenous bisphosphonate treatment and osteonecrosis of the jaw in patients with cancer: wide CIs, Yule-Simpson and King Kong effects, and no therapeutic outcomes. Journal of Clinical Oncology, 28, e143-e144.

Milisen, K., De Busser, T., Kayaert, A., Abraham, I., & Dierckx de Casterlé, B. (2010). The evolving professional nursing self-image of students in Flemish baccalaureate programs: A cross-sectional survey. International Journal of Nursing Studies, 47, 688-698.

Brusselle, G., Michils, A., Louis, R., Dupont, L., Van de Maele, B., Delobbe, A., Pilette, C., Lee, C.S., Gurdain, S., Vancayzeele, S., Lecomte, P., Hermans, C., MacDonald, K., Song, M., & Abraham, I. (2009). “Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: the PERSIST study. Respiratory Medicine, 103, 1633-1642.

Aapro, M., Ludwig, H., Bokemeyer, C., MacDonald, K., Soubeyran, P., Turner, M., Albrecht, T., & Abraham, I. (2009). Modeling of outcomes and response rates to treatment with erythropoiesis stimulating agents in cancer patients

with anemia: Findings from the Anemia Cancer Treatment (A.C.T.) study. Annals of Oncology, 20, 1714-1721.

Ludwig, H., Aapro, M., Bokemeyer, C., MacDonald, K., Soubeyran, P., Turner, M., Albrecht, T., & Abraham, I. (2009). Treatment patterns, outcomes, and response rates in the management of cancer-related anemia in Europe: Findings from the Anemia Cancer Treatment (A.C.T.) study. European Journal of Cancer, 45, 1603-1615.

Noens, L., van Lierde, M.-A., De Bock, R., Verhoef, G., Zachée, P., Berneman, Z., Martiat, Ph., Mineur, Ph., Van Eygen, K., MacDonald, K., De Geest, S., Albrecht, T., & Abraham, I. (2009). Prevalence, determinants, and outcomes of nonadherence to imatinib therapy in patients with chronic myeloid leukemia: The ADAGIO study. Blood, 113, 5401-5411.

Van der Niepen, P., Woestenburg A., Brié, H., Vancayzeele, S., MacDonald, K., Lee, C., Hermans, C., & Abraham, I. (2009). Effectiveness of valsartan for treatment of hypertension: patient profiling and hierarchical modeling of determinants and outcomes (the PREVIEW study). Annals of Pharmacotherapy, 43, 849-861.

Aapro, M., MacDonald, K., Van Erps, J., Soubeyran, P., Turner, M., Warrinnier, H., Albrecht, T., & Abraham, I. (2009). Managing cancer-related anemia in congruence with the EORTC guidelines is an independent predictor of haemoglobin outcome: Initial evidence from the RESPOND study. European Journal of Cancer, 45, 8-11.

Aapro, M., MacDonald, K., Van Erps, J., Soubeyran, P., Turner, M., Muenzberg, M., Dunlop, R., & Abraham, I. (2008). Promoting evidence-based management of anemia in cancer patients: Background, development, and scientific validation of RESPOND, a web-based clinical guidance system based on the EORTC guidelines. Critical Reviews in Oncology and Hematology, 65,

32-42.

Aapro, M., Abraham, I., Bokemeyer, C., Ludwig, H., MacDonald, K., Soubeyran, P., & Turner, M. (2008). The background and methodology of the Anaemia Cancer Treatment (A.C.T.) survey: A retrospective study of practice patterns and outcomes in the management of anemia in cancer patients and their congruence with evidence-based guidelines. Supportive Care in Cancer, 16,

193-200.

Maa, S.-H., Lee, H.-S., Huang Y.-C., Wu, J. W., Tsou, T.-S., MacDonald, K., & Abraham, I. (2008). Incidence density and relative risk of nosocomial infections in a Taiwan children’s hospital, 1999-2003. Infection Control and Hospital Epidemiology, 29, 767-770.

Dobbels, F., Moons, P., Abraham I., Larsen, C., Dupont, L., & De Geest, S. (2008). Measuring symptom experience of side-effects of immunosuppressive drugs: The Modified Transplant Symptom Occurrence and Distress Scale. Transplantation International, 21, 764-773.

Kim, H.-J., & Abraham, I. (2008) Statistical approaches to modeling symptom clusters in cancer patients. Cancer Nursing, 31, E1-E10.

Mets, T., Deblander, A., MacDonald, K. M., Vancayzeele, S., Mukarubibi, F., Sloesen, A., Abraham, I. for the FExT Study Group (2007). Patient and caregiver outcomes after 6±1.5-month of rivastigmine therapy for mild-to-moderate Alzheimer’s disease: The Belgian FExT study. Current Medical Research and Opinion, 23, 2485-2501.

De Geest, W., De Geest, J., De Geest, S., & Abraham, I. (2007). Description, specifications, and ASIC configurations of MemoPatch, a transdermal pulse generator medical device to promote patient adherence to medication regimens. Proceedings of the IEEE Engineering in Medicine and Biology Society, 2007, 1, 508-511.

Aapro, M., Abraham, I., MacDonald, K., Foubert, J., Soubeyran, P., Bokemeyer, C., Van Erps, J., Muenzberg, M., & Turner, M. (2007). Intraclass correlation metrics for the accuracy of algorithmic definitions in a computerized decision-support system for supportive cancer care. Supportive Care in Cancer, 15, 1325-1329.

Siebens, K., Dierckx de Casterlé, B., Abraham, I., Dierckx, K., Braes, T., Darras, E., Dubois, Y., Milisen, K. (2006). The professional self-image of nurses in Belgian hospitals: A cross-sectional questionnaire survey. International Journal of Nursing Studies, 43, 71-82.

Steeman, E., Moons, P., Milisen, K., De Bal, N., De Geest, S., de Froidmont, C., Tellier, V., Gosset, C., & Abraham, I. (2006). Implementation of discharge management for geriatric patients at risk for readmission and institutionalization. International Journal for Quality in Health Care, 18, 352-358.

Boudreau DM, Malone DC, Raebel MR, Fishman PA, Nichols GA, Feldstein AC, Hill A, Boscoe AN, Ben-Joseph R, Magid DJ, Okamoto LJ. Health care utilization and costs by metabolic syndrome risk factors. Metabolic Syndrome and Related Disorders 2009;7(4):305-314.

Brixner DI, Holtorf AP, Neumann PJ, Malone DC, Watkins JB. Standardizing quality assessment of observational studies for decision making in health care. Journal of Managed Care Pharmacy. 2009; 15:275-283.

Brusselle G, Michils A, Louis R, Dupont L, Van de Maele B, Delobbe A, Pilette C, Lee CS, Gurdain S, Vancayzeele S, Lecomte P, Hermans C, MacDonald K, Song M, Abraham I. “Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: the PERSIST study. Respiratory Medicine.2009;103:1633-1642.

Chisholm-Burns MA, Graff Zivin J, Lee JK, Spivey CA, Slack M, Herrier RN, Hall-Lipsy E, Abraham, I, Palmer J. Economic effects of pharmacists on health outcomes in the United States: A systematic review. American Journal of Health-System Pharmacy. 2010; 67:1624-34.

Chisholm-Burns MA, Lee JK, Spivey CA, Slack M, Herrier R, Hall-Lipsy E, Zivin JG, Abraham I, Palmer J, Martin JR, Kramer SS, Wunz T. U.S. pharmacists’ effect as team members on patient care: Systematic review and meta-analyses. Medical Care. 2010; 48:923-33.

Publications
Originally posted: September 9, 2013
Last updated: June 6, 2017
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