Cheryl Cropp, PharmD, PhD
Cheryl Cropp holds a joint appointment with the College of Pharmacy and Translational Genomics Research Institute (TGen) at the Phoenix Biomedical Campus as an assistant professor. She joined the College of Pharmacy in January 2015.
Dr. Cropp's research interests are genomic factors affecting drug therapy and the use of “big data” to improve the use of medications, including genetic factors influencing effectiveness and safety. She also has a strong interest in investigating the genetic determinants and health disparities of diseases including cancer and diabetes in families and populations.
Dr. Cropp has expertise in pharmacogenomics and genetic epidemiology, in finding functional variants in healthy and health disparate world populations utilizing unrelated and family data. Overall, this exploration of genetic determinants of disease will aid in understanding the etiology of diseases such as cancer, metabolic and cardiovascular diseases (e.g. dyslipidemia and atherosclerotic diseases) and will assist in narrowing the divide between the morbidity and mortality that currently exists within health disparate populations.
Additionally, Dr. Cropp would like to investigate ways to improve drug therapy through developing more efficacious drugs devoid of serious adverse effects and/or drug interactions. As part of her duties with the University of Arizona College of Pharmacy at the Phoenix Biomedical Campus, Dr. Cropp participates in evaluating the impact of interdisciplinary education and experience, presenting and publishing the results, classroom support through teaching and facilitation, exploring building a research program in pharmacogenomics with the UA College of Pharmacy, including with the Tucson-based faculty, and assisting PharmD students with their academic and scholarly projects when appropriate.
BS, University of Iowa, 1993
PharmD, University of Kentucky, 1995
PhD, University of California, San Francisco, 2009
Postdoctoral Fellowship in Genetic Epidemiology, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health
Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B, Gibney ER, Midtun Ø, Ueland PM, Cropp CD, Kim Y, Wilson AF, Bailey-Wilson JE, Brody LC, Mills JL. Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5’-Phosphate Concentration in Healthy Adults. The Journal of nutrition. 2015;145(7):1386-93.
Szymczak S, Simpson CL, Cropp CD, Bailey-Wilson JE. False-positive Rate in Two-point Parametric Linkage Analysis. BMC Proc 2014;8:S110.
Cropp CD, Robbins CM, Sheng X, Hennis AJ, Carpten JD, Waterman L, Worrell R, Schwantes-An TH, Trend JM, Haiman CA, Leske MC, Wu SY, Bailey-Wilson JE, Nemesure B. 8q24 Risk Alleles and Prostate Cancer in African-Barbadian Men. The Prostate 2014;74(16):1579-88.
Bureau A, Parker MM, Ruczinski I, Taub MA, Marazita ML, Murray JC, Mangold E, Noethen MM, Ludwig KU, Hetmanski JB, Bailey-Wilson JE, Cropp CD, Li Q, Szymczak S, Albacha-Hejazi H, Alqosayer K, Field LL, Wu-Chou YH, Doheny KF, Ling H, Scott AF, Beaty TH. Whole Exome Sequencing of Distant Relatives in Multiplex Families Implicates Rare Variants in Candidate Genes for Oral Clefts. Genetics 2014 May 2. [Epub ahead of print].
Gribble MO, Voruganti VS, Cropp CD, Francesconi KA, Goessler W, Umans JG, Silbergeld EK, Laston SL, Haack K, Kao WHL, Fallin MD, MacCluer JW, Cole SA, Navas-Acien A. SLCO1B1 Variants and Urine Arsenic Metabolites in the Strong Heart Family Study. Toxicol Sci 2013;136:19-25.
Yee SW, Nguyen AN, Brown C, Savic RM, Zhang Y, Castro RA, Cropp CD, Choi JH, Singh D, Tahara H, Stocker SL, Huang Y, Brett CM, Giacomini KM. Reduced Renal Clearance of Cefotaxime in Asians with a Low Frequency Polymorphism of OAT3 (SLC22A8). J Pharm Sci 2013;102:3451-3457.
Dahlin A, Geier E, Stocker SL, Cropp CD, Grigorenko E, Bloomer M, Siegenthaler J, Xu L, Basile AS, Tang-Liu DD, Giacomini KM. Gene Expression Profiling of Transporters in the Solute Carrier and ATP-Binding Cassette Superfamilies in Human Eye Substructures. Mol Pharm 2013;10:650-63. 4
Desch KC, Ozel AB, Siemieniak D, Kalish Y, Shavit JA, Thornburg CD, Sharathkumar AA, McHugh CP, Laurie CC, Crenshaw A, Mirel DB, Kim Y, Cropp CD, Molloy AM, Kirke PN, Bailey-Wilson JE, Wilson AF, Mills JL, Scott JM, Brody LC, Li JZ, Ginsburg D. Linkage Analysis Identifies a Locus for Plasma von Willebrand Factor Undetected by Genome-wide Association. Proc Natl Acad Sci USA 2013;110:588-93.
Simpson CL, Cropp CD, Wahlfors T, Nati H, George A, Jones MPS, Harper U, Ponciano-Jackson D, Tammela T, Schleutker J, Bailey-Wilson JE. Genetic Heterogeneity in Finnish Hereditary Prostate Cancer Using Ordered Subset Analysis. Eur J Hum Genet 2013;21:437-43.
Bailey-Wilson JE, Childs EJ, Cropp CD, Schaid DJ, Xu J, Camp NJ, Cannon-Albright LA, Farnham JM, George A, Powell I, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Mæhle L, Møller P, Eeles R, Easton D, Guy M, Edwards S, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Stanford JL, Karyadi DM, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Lange EM, Cooney KA, Tammela TL, Schleutker J, Maier C, Borchum S, Hoegel J, Grönberg H, Wiklund F, Emanuelsson M, Cancel-Tassin G, Valeri A, Cussenot O, Isaacs WB. Analysis of Xq27-28 Linkage in the International Consortium for Prostate Cancer Genetics (ICPCG) families. BMC Med Genet 2012 June 19;13:46.
Troutman SM, Sissung TM, Cropp CD, Venzon DJ, Spencer SD, Adesunloye BA, Huang X, Karzai FH, Price DK, Figg WD. Racial Disparities in the Association Between Variants on 8q24 and Prostate Cancer: A Systematic Review and Meta-Analysis. The Oncologist 2012;17:312-320.
Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange EM, Cooney KA, Farnham JM, Camp NJ, Cannon-Albright LA, Tammela TL, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, Wiklund F, Emanuelsson M, Grönberg H, Wiley KE, Isaacs SD, Walsh PC, Helfand BT, Kan D, Catalona WJ, Stanford JL, Fitzgerald LM, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Whittemore AS, Oakley-Girvan I, Hsieh CL, Powell I, Bailey-Wilson JE, Cropp CD, Simpson CL, Carpten JD, Seminara D, Zheng SL, Xu J, Giles GG, Severi G, Hopper JL, English DR, Foulkes WD, Maehle L, Moller P, Badzioch MD, Edwards S, Guy M, Eeles R, Easton D, Isaacs WB; International Consortium for Prostate Cancer Genetics. Chromosomes 4 and 8 Implicated in a Genome wide SNP Linkage Scan of 762 Prostate Cancer Families Collected by the ICPCG. Prostate 2012;72:410-426.
Kim Y, Li Q, Cropp CD, Sung H, Cai J, Simpson CL, Perry BC, Dasgupta A, Malley JD, Wilson AF, Bailey-Wilson JE. Performance of Random Forests and Logic Regression Methods Using Mini-Exome Sequence Data. From Genetic Analysis Workshop 17 Boston, MA, USA. 13-16 October 2010 BMC Proc 2011;5:S104-S109.
Sung H, Kim Y, Cai J, Cropp CD, Simpson CL, Li Q, Perry BC, Sorant AJM, Bailey-Wilson JE, Wilson AF. Comparison of Results from Tests of Association in Unrelated Individuals with Uncollapsed and Collapsed Sequence Variants Using Tiled Regression. From Genetic Analysis Workshop 17 Boston, MA, USA. 13-16 October 2011. BMC Proc 2011;5:S15-S19.
Cropp CD, Simpson CL, Wahlfors T, Nati H, George A, Jones MS, Harper U, Ponciano-Jackson D, Tammela T, Bailey-Wilson JE, Schleutker J. Genome-Wide Linkage Scan for Prostate Cancer Susceptibility in Finland: Evidence for Novel Loci on 2q37.2 and Confirmation of Signal on 17q21-22. Int J Cancer 2011;129:2400-2407.
Cropp CD, Yee SW, Giacomini KM. Genetic Variation in Drug Transporters in Ethnic Populations. Clin Pharmacol Ther 2008;84:412-416.
Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. Organic Anion Transporter 2 (SLC22A7) is a Facilitative Transporter of cGMP. Mol Pharmacol 2008;73:1151-1158.
Ensom MHH, Davis GA, Cropp CD, Ensom RJ. Clinical Pharmacokinetics in the 21st Century: Does the Evidence Support Definitive Outcomes? Clin Pharmacokinet 1998;34:265-79.
Finnell DL, Davis GA, Cropp CD, Ensom MHH. Validation of the Hartford Nomogram in Trauma Surgery Patients. Ann Pharmacother 1998;32:417-20.
Cropp CD, Davis, GA, Ensom MHH. Evaluation of Aminoglycoside Pharmacokinetics in Postpartum Patients Using Bayesian Forecasting. Ther Drug Monit 1998;20:68-72.
Cropp CD, Gora-Harper ML. Ondansetron Use for Smoking Cessation. Ann Pharmacother 1995;29:1041-42.