A. Jay Gandolfi, PhD
Former Associate Dean, Research & Graduate Studies
Pharmacology & Toxicology
Dr. Gandolfi's research interests are in the molecular and cellular mechanisms of toxicity. Current studies concentrate on the use of in vitro systems to evaluate cell specific injury. Specific studies examine the effects of low-level metal exposure on cell signaling and gene expression and the development of in vitro models to reflect in vivo toxicity. Tissues of interest are the liver, kidney, bladder and prostate.
BA, University of California, Davis, 1968, Chemistry
PhD, Oregon State University, Corvallis, 1972, Biochemistry and Biophysics
PD, Mayo Clinic, Rochester, 1972-75
Meza MM, Kopplin MJ, Burgess JL, Gandolfi AJ. Urinary arsenic methylation profile in children exposed to low arsenic levels through drinking water. Toxicol Environ Chem, 90: 957-970, 2008.
Eblin KE, Bredfeldt TG, Gandolfi AJ. Immortalized human urothelial cells as a model of arsenic-induced bladder cancer. Toxicology, 248:67-76, 2008.
Jensen TJ, Novak P, Eblin KE, Gandolfi AJ, Futscher BW. Epigenetic Remodeling During Arsenical-Induced Malignant Transformation. Carcinogenesis, 29:1500-8, 2008.
Eblin KE, Hau A, Jensen TJ, Futscher BW, Gandolfi AJ. The role of reactive oxygen species in arsenite and monomethylarsonous acid-induced signal transduction in human bladder cells: Acute studies. Toxicology, 250:47-54, 2008.
Eblin KE, Jensen TJ, Wnek SM, Buffington SE, Futscher BW, Gandolif AJ. Reactive oxygen species regulate properties of transformation in UROtsa cells exposed to monomethylarsonous acid by modulating MAPK signaling. Toxicology, 255: 107-114, 2008.
Jensen TJ, Eblin KE, Wozniak RJ, Gandolfi AJ, Futscher BW. Epigenetic mediated transcriptional activation of WNT5a participates in arsenical-associated malignant transformation. Toxicology and Applied Pharmacology, 235: 39-46, 2009.
Buffington SE, Zheng XH, Watts GS, Gandolfi AJ. Malignant transformation of human urothelial cells by low-level monomethylarsonous acid exposure is confirmed by expression of key biomarkers. Toxicology, in press, 2009.
Wnek SM, Medeiros MK, Eblin KE, Gandolfi AJ. Persistence of DNA damage following exposure of human bladder cells to chronic monomethylarsonous acid exposure. Tox Appl Pharm, in press, 2009.
Tsow F, Forzani E, Rai A, Tsui R, Mastroianni S, Knobbe C, Gandolfi AJ, Tao NJ. A wearable and wireless sensor system for real-time monitoring of toxic environmental volatile organic compounds. IEEE Sensors Journal, in press, 2009.